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Chinese Physics Letters 2012年第1期29卷 235-237页

作者： GAO hai-Xia HU rong YANG Yin-tang School of Microelectronics Xidian UniversityXi’an 710071

A novel structure of a ZnO thin-film transistor with a double-gate and double-layer insulator is proposed to improve device *** with the conventional ZnO thin-film transistor structure,the novel thinfilm transistor has a higher on-state current,steeper sub-threshold characteristics and a lower threshold voltage,owing to the double-gate and high-k *** on two-dimensional simulation,the potential channel distribution and the reasons for the improvement in performance are investigated.

关键词： transistor double structure

Cell polarization in ischemic stroke: molecular mechanisms and advances

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Neural Regeneration Research 2025年第3期20卷 632-645页

作者： Yuanwei Li Xiaoxiao Xu Xuan Wu Jiarui Li Shiling Chen Danyang Chen Gaigai Li Zhouping tang Department of Neurology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

Ischemic stroke is a cerebrovascular disease associated with high mortality and disability rates. Since the inflammation and immune response play a central role in driving ischemic damage, it becomes essential to modulate excessive inflammatory reactions to promote cell survival and facilitate tissue repair around the injury site. Various cell types are involved in the inflammatory response, including microglia, astrocytes, and neutrophils, each exhibiting distinct phenotypic profiles upon stimulation. They display either proinflammatory or anti-inflammatory states, a phenomenon known as ‘cell polarization.’ There are two cell polarization therapy strategies. The first involves inducing cells into a neuroprotective phenotype in vitro, then reintroducing them autologously. The second approach utilizes small molecular substances to directly affect cells in vivo. In this review, we elucidate the polarization dynamics of the three reactive cell populations(microglia, astrocytes, and neutrophils) in the context of ischemic stroke, and provide a comprehensive summary of the molecular mechanisms involved in their phenotypic switching. By unraveling the complexity of cell polarization, we hope to offer insights for future research on neuroinflammation and novel therapeutic strategies for ischemic stroke.

关键词： astrocyte polarization immune regulation inflammation ischemic injury microglia polarization neutrophil polarization signaling pathways stroke

Enhanced autophagic clearance of amyloid-βvia histone deacetylase 6-mediated V-ATPase assembly and lysosomal acidification protects against Alzheimer's disease in vitro and in vivo

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Neural Regeneration Research 2025年第9期20卷 2633-2644页

作者： Zhimin Long Chuanhua Ge Yueyang Zhao Yuanjie Liu Qinghua Zeng Qing tang Zhifang Dong Guiqiong He Institute of Neuroscience School of Basic Medical SciencesChongqing Medical UniversityChongqingChina Department of Anatomy Chongqing Medical UniversityChongqingChina Department of Physiology Chongqing Medical UniversityChongqingChina Pediatric Research Institute Children’s Hospital of Chongqing Medical UniversityChongqingChina Ministry of Education Key Laboratory of Child Development and Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina National Clinical Research Center for Child Health and Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina

Recent studies have suggested that abnormal acidification of lysosomes induces autophagic accumulation of amyloid-βin neurons,which is a key step in senile plaque ***,resto ring normal lysosomal function and rebalancing lysosomal acidification in neurons in the brain may be a new treatment strategy for Alzheimer's *** acetylation/deacetylation plays a central role in lysosomal ***,we show that inhibiting the classic microtubule deacetylase histone deacetylase 6 with an histone deacetylase 6 shRNA or thehistone deacetylase 6 inhibitor valproic acid promoted lysosomal reacidification by modulating V-ATPase assembly in Alzheimer's *** rthermore,we found that treatment with valproic acid markedly enhanced *** clearance of amyloid-βaggregates,and ameliorated cognitive deficits in a mouse model of Alzheimer's *** findings demonstrate a previously unknown neuroprotective mechanism in Alzheimer's disease,in which histone deacetylase 6 inhibition by valproic acid increases V-ATPase assembly and lysosomal acidification.

关键词： Alzheimer's disease amyloid-β APP/PS1 mice autophagy cognitive impairment histone deacetylase 6 lysosomal acidification microtubule acetylation valproic acid V-ATPase

Boosting Photocatalytic Performance of Cu-Mn Co-doped CeO_(2) Nanoparticles for Tetracycline Degradation

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 42-48页

作者： XU rongqi MI Jianxin WANG Shulin XU Man ZHU Li BAI Lei tang Dandan LEI Yu Engineering Research Center of Environmental Materials and Membrane Technology of Hubei Province School of Materials Science and EngineeringWuhan Institute of TechnologyWuhan 430205China Shaanxi Coal Chemical Industry Technology Research Institute Co. Ltd.Xi’an 710100China

Cu-Mn co-doped CeO_(2) photocatalyst was successfully synthesized by the sol-gel method to assess its capability in degrading *** and TEM results showed that Cu and Mn were successfully co-doped into CeO_(2) without forming heterostructure,XPS and photoelectrochemical results revealed that Mn ions doping amplified the generation of photo-induced charge carriers,while Cu ions doping significantly facilitated the interfacial charge transfer ***,the optimized Cu3Mn2CeO_(2) nanoparticles exhibited the highest TC removal efficiency,achieved a rate of 78.18%and maintained a stable cycling performance.

关键词： photocatalyst co-doped charge separation water treatment

试验性甲砜霉素中毒对肉鸡血液生化指标的影响

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中国兽医学报 2010年第6期30卷 833-836页

作者：唐海蓉陈仕均王选年银梅刘开永李敬玺林勋然张炳新河南科技学院动物科学院河南新乡453003 河南科技大学食品与生物工程学院河南洛阳471003

选用4日龄AA+肉鸡304只,随机分为4组,分别在饲料中添加0mg/kg(对照组)、500mg/kg(Ⅰ组)、1000mg/kg(Ⅱ组)、1500mg/kg(Ⅲ组)的甲砜霉素。试验期8周。分别在第14、28、42、56天测定肉鸡红细胞数量(RBC)、血红蛋白含量(Hb)、血清总蛋白(TP... 详细信息

选用4日龄AA+肉鸡304只,随机分为4组,分别在饲料中添加0mg/kg(对照组)、500mg/kg(Ⅰ组)、1000mg/kg(Ⅱ组)、1500mg/kg(Ⅲ组)的甲砜霉素。试验期8周。分别在第14、28、42、56天测定肉鸡红细胞数量(RBC)、血红蛋白含量(Hb)、血清总蛋白(TP)、血清白蛋白(ALB)、谷丙转氨酶(ALT)、谷草转氨酶(AST)、尿素氮(BUN)、肌酐(Crea)和血清铁(Fe)含量。结果显示,肉鸡持续采食甲砜霉素后红细胞数量和血红蛋白含量显著降低(P<0.05);血清总蛋白和白蛋白随着试验进程先升高后降低(P<0.05);谷草转氨酶活性显著降低(P<0.05);肌酐和尿素氮极显著升高(P<0.01);血清铁显著升高(P<0.05)。结果表明,甲砜霉素对肉鸡的上述血液指标影响明显,并且存在明显的剂量效应关系。

关键词：肉鸡甲砜霉素中毒血液生化指标

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甲砜霉素对肉鸡睾丸组织结构的影响

湖北农业科学 2013年第8期52卷 1880-1882页

作者：唐海蓉陈仕均刘兴友银梅王选年潘耀谦李敬玺河南科技学院动物科学学院河南新乡453003

将152只4日龄雄性AA+肉鸡随机分为4组,每组38只,分别在饲料中添加0(对照组)、500(试验Ⅰ组)、1 000(试验Ⅱ组)、1 500 mg/kg(试验Ⅲ组)的甲砜霉素,自由采食,试验期2周,对睾丸进行病理形态学观察。2周后测量体重、睾丸重、睾丸脏器系数,... 详细信息

将152只4日龄雄性AA+肉鸡随机分为4组,每组38只,分别在饲料中添加0(对照组)、500(试验Ⅰ组)、1 000(试验Ⅱ组)、1 500 mg/kg(试验Ⅲ组)的甲砜霉素,自由采食,试验期2周,对睾丸进行病理形态学观察。2周后测量体重、睾丸重、睾丸脏器系数,并作睾丸石蜡切片测量曲精细管面积和观察甲砜霉素对肉鸡睾丸的病理组织学影响。结果表明,各试验组肉鸡体重和曲精细管面积以及试验Ⅱ、Ⅲ组试验鸡的睾丸重极显著低于对照组(P<0.01),试验Ⅰ组试验鸡的睾丸重和睾丸脏器系数极显著大于对照组(P<0.01);各试验组肉鸡曲精细管出现不同程度的生精细胞数量减少,精原细胞和睾丸支持细胞发生水泡变性,甚至坏死,结缔组织增生。结果表明,用甲砜霉素添加量500 mg/kg及以上的饲料持续饲喂肉鸡,可对肉鸡的睾丸造成损伤,并且这种损伤在一定范围内存在显著的剂量效应关系。

关键词：肉鸡甲砜霉素睾丸组织结构

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从情景到情境的小学英语对话教学设计研究

教学与管理 2025年第2期 43-46页

作者：李海霞汤焱昊北京联合大学师范学院

《义务教育英语课程标准（2022年版）》提出英语课程目标是培养学生的核心素养，并主张围绕“情境”进行学习来实现目标。但是，教师往往难以区分“情景”和“情境”，在教学实践中用“情景”代替“情境”的做法比较普遍。针对这个问题... 详细信息

《义务教育英语课程标准（2022年版）》提出英语课程目标是培养学生的核心素养，并主张围绕“情境”进行学习来实现目标。但是，教师往往难以区分“情景”和“情境”，在教学实践中用“情景”代替“情境”的做法比较普遍。针对这个问题，结合小学具体教学案例，提出从创设前置情境、连贯情境和拓展性情境三个方面实现从“情景教学”到“情境教学”，从而培养学生核心素养，实现小学英语课程育人目标。

关键词：情景情境对话教学核心素养小学英语

Generalized Uncertainty Principle in the Presence of Extra Dimensions

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Chinese Physics Letters 2011年第9期28卷 76-79页

作者： MU Ben-rong WU Hou-Wen YANG hai-tang School of Physical Electronics University of Electronic Science and Technology of ChinaChengdu 610054

We argue that in the generalized uncertainty principle(GUP)model,the parameterβ0 whose square root,multiplied by Planck lengthℓp,approximates the minimum measurable distance,varies with energy *** the minimal measurable length and extra dimensions are both suggested by quantum gravity theories,we investigate the models based on the GUP and one extra dimension,compactified with radiusρ.We obtain an inspiring relation√β0ℓp/ρ∼O(1).This relation is also consistent with the predictions at Planck scale and the usual quantum mechanics *** also estimate the application range of the GUP *** turns out that the minimum measurable length is exactly the compactification radius of the extra dimension.

关键词： measurable radius quantum

Catalyst–Support Interaction in Polyaniline‑Supported Ni_(3)Fe Oxide to Boost Oxygen Evolution Activities for Rechargeable Zn‑Air Batteries

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Nano-Micro Letters 2025年第1期17卷 176-190页

作者： Xiaohong Zou Qian Lu Mingcong tang Jie Wu Kouer Zhang Wenzhi Li Yunxia Hu Xiaomin Xu Xiao Zhang Zongping Shao Liang An Department of Mechanical Engineering The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARPeople’s Republic of China Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control Jiangsu Collaborative Innovation Center of Atmospheric Environment and Equipment TechnologySchool of Environmental Science and TechnologyNanjing University of Information Science and TechnologyNanjing 210044People’s Republic of China Department of Chemistry The Chinese University of Hong KongMa Lin BuildingShatinHong Kong SAR 999077People’s Republic of China WA School of Mines:Minerals Energy and Chemical Engineering(WASM‑MECE)Curtin UniversityPerthWA 6102Australia Research Institute for Advanced Manufacturing The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARPeople’s Republic of China Research Institute for Smart Energy The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARPeople’s Republic of China

Catalyst–support interaction plays a crucial role in improving the catalytic activity of oxygen evolution reaction(OER).Here we modulate the catalyst–support interaction in polyaniline-supported Ni_(3)Fe oxide(Ni_(3)Fe oxide/PANI)with a robust hetero-interface,which significantly improves oxygen evolution activities with an overpotential of 270 mV at 10 mA cm^(-2)and specific activity of 2.08 mA cm_(ECSA)^(-2)at overpotential of 300 mV,3.84-fold that of Ni_(3)Fe *** is revealed that the catalyst–support interaction between Ni_(3)Fe oxide and PANI support enhances the Ni–O covalency via the interfacial Ni–N bond,thus promoting the charge and mass transfer on Ni_(3)Fe *** the excellent activity and stability,rechargeable Zn-air batteries with optimum Ni_(3)Fe oxide/PANI are assembled,delivering a low charge voltage of 1.95 V to cycle for 400 h at 10 mA cm^(-2).The regulation of the effect of catalyst–support interaction on catalytic activity provides new possibilities for the future design of highly efficient OER catalysts.

关键词： Catalyst-support interaction Supported catalysts Heterointerface Oxygen evolution reaction Zn-air batteries

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海洋标准立项管理对策分析与建议

中国标准化 2023年第16期 91-95页

作者：汤海荣许莉莉郭小勇王玉红陈华国家海洋标准计量中心

海洋标准化是支撑海洋强国建设的战略性、基础性工作。随着海洋标准需求的不断增加,海洋标准立项工作中的问题不断涌现。加强海洋标准立项管理,从源头上为标准质量把关,具有较强的现实意义。本文以工作实际为基础,分析海洋标准立项工作... 详细信息

海洋标准化是支撑海洋强国建设的战略性、基础性工作。随着海洋标准需求的不断增加,海洋标准立项工作中的问题不断涌现。加强海洋标准立项管理,从源头上为标准质量把关,具有较强的现实意义。本文以工作实际为基础,分析海洋标准立项工作中存在的问题,探讨新形势下的管理工作思路,提出有关对策和建议。

关键词：海洋标准立项管理