检索结果-南通市图书馆

Synthesis of novel β-amino ketones containing a p-aminobenzoic acid moiety and evaluation of their antidiabetic activities

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2013年第4期56卷 490-504页

作者： tang guangxia YAN JuFang FAN Li XU Jin SONG XiaoLi JIANG Li LUO LingFei YANG DaCheng School of Chemistry and Chemical Engineering Southwest University Drug Screening Center Chengdu Di Ao Pharmaceutical Group Co. Ltd. Schlumberger Technology Corporation School of Life Science Southwest University

The synthesis of two series of [3-amino ketones containing a p-aminobenzoic acid moiety （TM.1 and TM-2） using a modified protocol of the Mannich reaction is reported. The molecular structures of a total of tweenty three new target compounds were characterized by ~H NMR, 1~C NMR, ESI-MS and HR-MS. Subsequently, their antidiabetic activities were screened in vitro. The c^-glucodase inhibition （c^-GI） activity of compound le reached a remarkable level of 66.50%. The peroxisome proliferator- activated receptor （PPAR） relative activation activities of six compounds are above 80%, and in particular 2i displays an un- precedentedly high PPAR of 130.91%. The structure-activity relationships of the compounds were established. 2i is also sub- ject to further in-depth investigation.

关键词： diabetes mellitus ot-glucosidase peroxisome proliferator-activated receptor β-amino ketone Mannich reaction

劳动参与与中老年人卫生服务利用的关联分析——以健康水平为中介变量

在线全文

学校读者我要写书评

暂无评论

卫生经济研究 2024年第6期41卷 44-48页

作者：贡悦汤少梁倪语初董慧秋倪光夏南京中医药大学卫生经济管理学院江苏南京210023 南京中医药大学针灸推拿学院江苏南京210023

目的:在人口老龄化程度加深和渐进式延迟退休背景下,了解劳动参与与中老年人卫生服务利用之间的关系。方法:使用Logistic回归、负二项回归等方法,探究劳动参与对中老年人卫生服务利用的影响;以健康水平为中介变量,分析劳动参与对中老年... 详细信息

目的:在人口老龄化程度加深和渐进式延迟退休背景下,了解劳动参与与中老年人卫生服务利用之间的关系。方法:使用Logistic回归、负二项回归等方法,探究劳动参与对中老年人卫生服务利用的影响;以健康水平为中介变量,分析劳动参与对中老年人卫生服务利用的影响路径。结果:劳动参与对中老年人卫生服务利用存在显著的负向影响,中介分析显示,劳动参与与中老年人健康水平之间存在显著的正相关关系,可能会降低中老年人卫生服务利用率。结论:老龄化背景下,我国应科学推进延迟退休政策,在提高中老年人劳动参与率的同时,改善其健康水平,减少不必要的卫生服务利用,从而减轻医保基金负担,增加社会福祉。

关键词：劳动参与卫生服务利用中老年人健康水平

在线全文

学校读者我要写书评

暂无评论

教育转型形势下计算机网络课程教学改革实践

计算机教育 2011年第23期 26-29页

作者：王光霞唐慧林信息工程大学电子技术学院河南郑州450002

围绕教育转型形势下计算机网络课程教学改革实践,分析计算机网络课程教学中存在的问题,提出以深度加工教学内容为基础、以更新教学方法模式为重点、以改革课程考核方法为保证的教学改革思路,详细论述课程教学内容、教学模式、考核方法... 详细信息

围绕教育转型形势下计算机网络课程教学改革实践,分析计算机网络课程教学中存在的问题,提出以深度加工教学内容为基础、以更新教学方法模式为重点、以改革课程考核方法为保证的教学改革思路,详细论述课程教学内容、教学模式、考核方法的改革措施,实践证明此项教改对教育转型新坐标下高等院校计算机网络课程及其他课程教学均具有借鉴和推广价值。

关键词：教育转型教学改革教学内容教学模式考核方法

维普期刊数据库博看期刊

2010 年太和县艾滋病高危人群哨点监测分析

在线全文

学校读者我要写书评

暂无评论

中国当代医药 2011年第28期18卷 151-153页

作者：孙效强唐广侠毛太生张永俊毛宁安徽省太和县艾滋病综合防治示范区工作办公室安徽太和236600 安徽省太和县人民医院皮肤性病科安徽太和236604

目的:为了解暗娼人群中艾滋病(acquired immune deficiency syndrome,AIDS)病毒的感染状况、行为特征及相关信息,分析本县艾滋病流行趋势,为艾滋病疫情估计及预测提供信息;为评价艾滋病预防与控制效果提供依据。方法:调查暗娼人群354名... 详细信息

目的:为了解暗娼人群中艾滋病(acquired immune deficiency syndrome,AIDS)病毒的感染状况、行为特征及相关信息,分析本县艾滋病流行趋势,为艾滋病疫情估计及预测提供信息;为评价艾滋病预防与控制效果提供依据。方法:调查暗娼人群354名,主要来源于桑拿洗浴中心和美容洗脚屋。按年龄统计,最小的为17岁,最大的为55岁,平均年龄为29.8岁,主要年龄分布为21～40岁;按婚姻状况统计,以再婚和未婚的为主;按文化程度统计,以初中为主;按户籍所在地统计,本省和外省人数各占55.4%和44.6%,分布于17个省市自治区;按民族统计,共有9个民族,其中以汉族为主,占92.1%。结果:曾做过艾滋病检测的有125名,知道检测结果的有107名。本次调查共抽血354份,HIV抗体筛查采用ELISA法,检测结果均为阴性;梅毒采用RPR法筛查,筛查阳性4例,阳性率为1.1%;丙肝抗体筛查采用ELISA法,筛查阳性4例,阳性率为1.1%。结论:要全面落实各项艾滋病预防控制措施,进一步扩大监测检测覆盖面,最大限度发现艾滋病病毒感染者。

关键词：暗娼人群艾滋病基线调查监测分析

Anti-fouling ultrafiltration membrane prepared from polysulfone-graft-methyl acrylate copolymers by UV-induced grafting method

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2008年第5期20卷 565-570页

作者： HUA Helin LI Na WU Linlin ZHONG Hui WU guangxia YUAN Zonghuan LIN Xiangwei tang Lianyi Research Center for Eco-Environmental Science Chinese Academy of Sciences Beijing 100085 China Department of Environment and Chemistry Engineering Nanchang Hangkong University Nanchang 330034 China The Greatwall Pharmaceutical Factory of Beijing Beijing 100071 China

Membrane fouling is one of the most important challenges faced in membrane ultrafiltration operations. The copolymers of polysulfone-graft-methyl acrylate were synthesized by homogeneous photo-initiated graft copolymerization. The variables affecting the degree of grafting, such as the time of UV （Ultraviolet-visible） irradiation and the concentrations of the methyl acrylate and photoinitiator, were investigated. The graft copolymer membranes were prepared by the phase inversion method. The chemical and morphological changes were characterized by attenuated total reflection-Fourier transform infrared spectroscopy （ATR/FT-IR）, scanning electron microscopy, and water contact angles measurements. Results revealed that methyl acrylate groups were present on the membranes and the graft degree of methyl acrylate had remarkable effect on the performance of membranes. Pure water contact angle on the membrane surface decreases with the increase of methyl acrylate graft degree, which indicated that the hydrophilicity of graft copolymer membranes was improved. The permeation fluxes of pure water and bovine serum albumin solution were measured to evaluate the antifouling property of graft copolymer membranes, the results of which have shown an enhancement of antifouling property for graft copolymer membranes.

关键词： polysulfone methyl acrylate UV irradiation graft polymerization

乡村振兴背景下黄河流域农村居民点分布格局的时空演变及其驱动力分析

在线全文

学校读者我要写书评

暂无评论

测绘通报 2024年第1期 96-101页

作者：单雅敏李贺颖张建辰唐岭军郭建忠王光霞王家耀张瀚雯郑浩华河南大学地理与环境学院河南开封475004 河南大学河南省时空大数据产业技术研究院河南郑州450046 河南大学黄河中下游地理空间技术教育部重点实验室河南开封475004 自然资源部城市国土资源监测与仿真重点实验室广东深圳518040 河南大学河南省时空大数据平台技术创新中心河南郑州450046 深圳市规划和自然资源数据管理中心广东深圳518040

本文利用景观指数、核密度估计、土地转移矩阵和地理探测器的方法,以城市群为研究单元,分析了1980-2020年黄河流域农村居民点的时空演变特征和驱动力。结果表明:①农村居民点总体用地规模在不断扩大,主要由旱地转换而来;中原城市群农村... 详细信息

本文利用景观指数、核密度估计、土地转移矩阵和地理探测器的方法,以城市群为研究单元,分析了1980-2020年黄河流域农村居民点的时空演变特征和驱动力。结果表明:①农村居民点总体用地规模在不断扩大,主要由旱地转换而来;中原城市群农村居民点密度变化最大;除关中平原城市群外,其他6个城市群农村居民点的形状变得更为规则。②农村居民点空间分布为“东南部聚集,西部、北部较分散”,呈现出更为密集的发展趋势,中原城市群变化最为明显。③农村居民点主要分布在高程1 km以下、距河流2~5 km处,其规模与距道路的距离成反比;道路是影响兰西、宁夏沿黄、关中平原和山东半岛城市群居民点分布的主要因素,而高程是影响呼包鄂榆、晋中和中原城市群居民点分布的主要因素。

关键词：黄河流域城市群农村居民点时空演变驱动力

Overexpression of the nuclear protein gene AtDUF4 increases organ size in Arabidopsis thaliana and Brassica napus

在线全文

学校读者我要写书评

暂无评论

Journal of Genetics and Genomics 2018年第8期45卷 459-462页

作者： guangxia Chen Xi Cao Zhaoxia Ma Yu tang Yuejuan Zeng Liqun Chen De Ye Xue-Qin Zhang College of Biological Sciences China Agricultural University Department of Endocrinology Beijing Tongren Hospital Capital Medical University Yunnan Key Laboratory for Basic Research on Bone and Joint Diseases & Yunnan Stem Cell Translational Research Center Kunming University Center for Plant Biology School of Life Sciences Tsinghua University

Organ size is an important trait of many crops that is influenced by internal and environmental signals and controlled by a combina- tion of factors during organogenesis （I（rizek, 2009）. The final size of plant organs is determined by two successive but overlapping pro- cesses： cell division, which increases cell number, and cell expan- sion, which determines final cell size （Anastasiou and Lenhard, 2007）. Some genes have been identified to control organ size by regulating cell division and for cell expansion in plants.

关键词： UF Overexpression of the nuclear protein gene AtDUF4 increases organ size in Arabidopsis thaliana and Brassica napus

HIV-1 can infect northern pig-tailed macaques(Macaca leonina) and form viral reservoirs in vivo

在线全文

学校读者我要写书评

暂无评论

Science Bulletin 2017年第19期62卷 1315-1324页

作者： Wei Pang Gao-Hong Zhang Jin Jiang Hong-Yi Zheng Lin-Tao Zhang Xiao-Liang Zhang Jia-Hao Song Ming-Xu Zhang Jia-Wu Zhu Ai-Hua Lei Ren-Rong Tian Xiao-Ming Liu Liguo Zhang guangxia Gao Lishan Su Yong-tang Zheng Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province Kunming Institute of ZoologyChinese Academy of Sciences University of Chinese Academy of Sciences Institute of Health Sciences Anhui University South China Institute of Endangered Animal Guandong Academy of Sciences Key Laboratory of Infection and Immunity Institute of BiophysicsChinese Academy of Sciences Department of Microbiology and Immunology School of MedicineThe University of North Carolina at Chapel Hill

Viral reservoirs of HIV-1 are a major obstacle for curing AIDS. The novel animal models that can be directly infected with HIV-I will contribute to develop effective strategies for eradicating infections. Here, we inoculated 4 northern pig-tailed macaques （NPM） with the HIV-1 strain HIV-1NL4.3 and moni- tored the infection for approximately 3 years （150 weeks）. The HIV-l-infected NPMs showed transient viremia for about 10 weeks after infection. However, cell-associated proviral DNA and viral RNA persisted in the peripheral blood and lymphoid organs for about 3 years. Moreover, replication-competent HIV-1 could be successfully recovered from peripheral blood mononuclear cells （PBMCs） during long-term infection. The numbers of resting CD4~ T cells in HIV-1 infected NPMs harboring proviruses fell within a range of 2- to 3-1oglo per million cells, and these proviruses could be reactivated both ex vivo and in vivo in response to co-stimulation with the latency-reversing agents JQ1 and prostratin. Our results suggested that NPMs can be infected with HIV-1 and a long-term viral reservoir was formed in NPMs, which might serve as a potential model for HIV-1 reservoir research.

关键词： Northern pig-tailed macaquesHIV-1 Viral reservoir JQ1 Prostratin

自拟清热祛瘀益肾汤联合环磷酰胺治疗早期狼疮性肾炎疗效观察

在线全文

学校读者我要写书评

暂无评论

现代中西医结合杂志 2017年第31期26卷 3432-3434页

作者：汤婷倪光夏南京中医药大学附属江苏省第二中医院江苏南京210000 江苏省南京市高淳中医院江苏南京210000 南京中医药大学第二临床学院江苏南京210000

目的观察自拟清热祛瘀益肾汤联合环磷酰胺治疗早期狼疮性肾炎的临床疗效。方法将100例早期狼疮性肾炎患者随机分为对照组与观察组,每组50例。对照组给予环磷酰胺静脉滴注,观察组在对照组治疗基础上给予自拟清热祛瘀益肾汤口服,观察2组... 详细信息

目的观察自拟清热祛瘀益肾汤联合环磷酰胺治疗早期狼疮性肾炎的临床疗效。方法将100例早期狼疮性肾炎患者随机分为对照组与观察组,每组50例。对照组给予环磷酰胺静脉滴注,观察组在对照组治疗基础上给予自拟清热祛瘀益肾汤口服,观察2组临床疗效及治疗前后肾功能指标水平、系统性红斑狼疮疾病活动度(SLEDAI)评分、中医证候评分变化情况,统计2组不良反应发生情况。结果治疗1个疗程后,观察组临床总有效率显著高于对照组(P<0.05);观察组治疗后的24 h尿蛋白定量、血清肌酐、血清尿素氮、血尿酸水平、SLEDAI评分、中医证候评分均显著低于对照组;2组治疗期间均未出现明显不良反应。结论自拟清热祛瘀益肾汤联合环磷酰胺治疗早期狼疮性肾炎临床疗效确切,可显著改善肾功能与中医症状,且安全可靠。

关键词：狼疮性肾炎自拟清热祛瘀益肾汤肾功能中医症状