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Science China Chemistry 2012年第1期55卷 90-97页

作者： PENG Chao tang Yu-Min li Lei DING Wei DENG Wei PU Jin-Yue liU Wen tang gong-li State Key Laboratory of Bio-organic and Natural Products Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of SciencesShanghai 200032China

Saframycin A(SFM-A),a tetrahydroisoquinoline antibiotic isolated from Streptomyces lavendulae,shows potent anti-proliferation activities against a variety of tumor cell lines,and shares the core structure with ecteinascidin 743(ET-743),the anticancer drug for soft-tissue *** of the SFM-A biosynthetic gene cluster revealed three nonribosomal peptide synthetase genes and a series of genes encoding *** investigate the function of sfmO2 gene,encoding a FAD-dependent monooxygenase/hydroxylase,we constructed the gene replacement mutant(△sfmO2) strain *** TL2007 and the corresponding gene complementation mutant strain *** TL2008.A novel compound,SFM-O,was isolated from the △sfmO2 replacement mutant strain and its structure was characterized by comparison to the HRMS and NMR spectra of *** findings indicated that SfmO2 is responsible for the oxidation of ring A in the biosynthetic pathway of SFM-A,and the new compound SFM-O could be considered as an advanced intermediate in the semisynthesis of ET-743.

关键词： saframycin A biosynthesis SfmO2 oxygenase saframycin O

In vivo investigation of the role of SfmＯ2 in saframycin A biosynthesis by structural characterization of the analogue saframycin Ｏ

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中国科学：化学 2012年第2期42卷 219-220页

作者： PENG Chao tang Yu-Min li Lei DING Wei DENG Wei PU Jin-Yue liU Wen tang gong-li State Key Laboratory of Bio-organic and Natural Products Chemistry Chinese Academy of SciencesShanghai 200032China

关键词：结构表征人力资源管理系统 ET-743 生物合成基因簇森林管理模拟体内淡紫灰链霉菌

Harboring CAR-T cells using an injectable scaffold to treat solid tumors

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National Science Review 2024年第5期11卷 91-92页

作者： li tang Institute of Bioengineering (IBI) école polytechnique fédérale de Lausanne (EPFL)

Genetic expression of chimeric antigen receptors (CAR) enables T cells to target and kill cancer cells in an MHCindependent manner, resulting in a potent antitumor response [1]. To date, more than 10 CAR-T cell products have been approved globally for the treatment of hematologic disorders such as relapsed/refractory B-cell acute lymphoblastic leukemia, non-Hodgkin lymphoma, and multiple myeloma [2,3].

关键词： IMMUNOTHERAPY CANCER

Long-term variation of Arctic Sudden Stratospheric Warmings(SSW) and potential causes

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Earth and Planetary Physics 2024年第5期8卷 742-752页

作者： QingRan li ShaoDong Zhang KaiMing Huang ChunMing Huang Yun gong WenTao tang Zheng Ma School of Electronic Information Wuhan University Guizhou Normal University Key Laboratory of Geospace Environment and Geodesy Ministry of Education State Key Laboratory of Information Engineering in Surveying Mapping and Remote Sensing School of Electronic Information Engineering Jingchu University of Technology

Utilizing the European Centre for Medium-Range Weather Forecast(ECMWF) Reanalysis v5(ERA5), for the first time, we have confirmed close links among Sudden Stratospheric Warmings(SSWs) in the Northern Hemisphere(NH), the polar vortices, and stratospheric Planetary Waves(PWs) by analyzing and comparing their trends. Interestingly, within overall increasing trends, the duration and strength of SSWs exhibit increasing and decreasing trends before and after the winter of 2002, respectively. To reveal possible physical mechanisms driving these trends, we analyzed the long-term trends of the winter(from December to February) polar vortices and of stratospheric PWs with zonal wave number 1. Notably, our results show that in all three time periods(the entire period of 41winters, 1980 to 2020, and the two subperiods — 1980-2002 and 2002-2020) enhancing SSWs were always accompanied by weakening winter polar vortices and strengthening polar PWs like Stationary Planetary Waves(SPWs) and 16-day waves, and vice versa. This is the first proof, based on ERA5 long-term trend data, that weakening polar vortices and enhancing stratospheric PWs(especially SPWs) could cause an increase in SSWs.

关键词： sudden stratospheric warmings stationary planetary waves 16-day waves polar vortrices long-term trend correlation coefficient

Stress sensitivity analysis for a wide-chord fan blade using an adjoint method

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Chinese Journal of Aeronautics 2024年第10期37卷 103-117页

作者： Han YANG Shoujia gong Yi li Junxing tang Dingxi WANG Sheng HUANG Shenren XU School of Power and Energy Northwestern Polytechnical UniversityXi’an 710129China

High-performance compressor design is best achieved with a good trade-off between aerodynamic and structural considerations,which requires efficient and accurate multidisciplinary design and optimization *** advanced compressors are defined with a large design space,their optimization is most efficiently achieved using a gradient-based approach,where the gradient can be computed using an adjoint method,at a cost nearly independent of the dimension of the design *** the adjoint method has been widely used for aerodynamic shape optimization,its use for structural shape optimizations of compressor blades has not been as well *** paper discussed a discrete adjoint solver for structural sensitivity analysis developed within the opensource Computational Structural Mechanics(CSM)software CalculiX,and proposed an efficient stress sensitivity analysis method based on the Finite Element Method(FEM)using *** proposed method is applied to compute the stress sensitivity of a wide-chord fan blade in a highbypass-ratio *** accuracy of the adjoint-based stress sensitivity is verified against central finite *** terms of computational efficiency,the adjoint approach is about 4.5 times more efficient than the conventional approach using finite *** works marks an important step towards fluid-structural coupled adjoint optimization of wide-chord fan blades.

关键词： Adjoint method Multidisciplinary optimization Stress sensitivity analysis Finite element method Shape optimization

Theoretical study on magnetocaloric effect and its electric-field regulation in CrI_(3)/metal heterostructure

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Science China(Physics,Mechanics & Astronomy) 2024年第2期67卷 134-141页

作者： Weiwei He Ziming tang Qihua gong Min Yi Wanlin Guo State Key Laboratory of Mechanics and Control for Aerospace Structures Key Laboratory for Intelligent Nano Materials and Devices of Ministry of EducationInstitute for Frontier ScienceNanjing University of Aeronautics and AstronauticsNanjing 210016China MIIT Key Laboratory of Aerospace Information Materials and Physics College of PhysicsNanjing University of Aeronautics and AstronauticsNanjing 211106China

The extraordinary properties of a heterostructure by stacking atom-thick van der Waals(vdW)magnets have been extensively ***,the magnetocaloric effect(MCE)of heterostructures that are based on monolayer magnets remains to be ***,we deliberate MCE of vd W heterostructure composed of a monolayer CrI_(3)and metal atomic layers(Ag,Hf,Au,and Pb).It is revealed that heterostructure engineering by introducing metal substrate can improve MCE of CrI_(3),particularly boosting relative cooling power to 471.72μJ m^(-2)and adiabatic temperature change to 2.1 K at 5 T for CrI_(3)/*** improved MCE is ascribed to the enhancement of magnetic moment and intralayer exchange coupling in CrI_(3)due to the CrI_(3)/metal heterointerface induced charge *** field is further found to tune MCE of CrI_(3)in heterostructures and could shift the peak temperature by around 10 K in CrI_(3)/Hf,thus manipulating the working temperature window of *** theoretical results could enrich the research on low-dimensional magnetocaloric materials.

关键词： magnetocaloric effect heterostructure metal substrate

Characterization of serum proteomic and inflammatory profiling at early stage of iron deficiency in weaned piglets

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Animal Nutrition 2024年第3期18卷 380-389页

作者： Guang liu Lan li Shuan liu Zhenglin Dong Jian Zhou Chengyan gong Yulong Yin Wenjie tang Dan Wan Laboratory of Animal Nutritional Physiology and Metabolic Process Key Laboratory of Agro-Ecological Processes in Subtropical RegionInstitute of Subtropical AgricultureChinese Academy of SciencesChangsha 410125China Hubei Hongshan Laboratory College of Animal Science and TechnologyHuazhong Agricultural UniversityWuhan 430070China Beijing Dabeinong Technology Group Co. Ltd.Beijing 100080China University of Chinese Academy of Sciences Beijing 101408China Animal Breeding and Genetics Key Laboratory of Sichuan Province Sichuan Animal Science AcademyChengdu 610066China livestock and Poultry Biological Products Key Laboratory of Sichuan Province Sichuan Animtech Feed Co.Ltd.Chengdu 610066China

The objective of this study was to examine the early serum proteomic and inflammatory profiles of weaned piglets subjected to iron *** healthy piglets(Duroc×Landrace×Large Yorkshire,body weight:4.96±0.05 kg)were weaned at 21 days of ***,these animals were randomly allocated to one of two groups,with six replicates in each group(maintaining a male-to-female ratio of 1:1),the control group(administered 100 mg/kg Fe as FeSO_(4)·H_(2)O)and L-Fe group(no additional Fe supplementation).The results showed that 42 days after initiating,compared with control group,routine blood analysis revealed a reduction in serum iron content,red blood cell(RBC)count,hemoglobin(HGB)content,hematocrit(HCT),and mean corpuscular volume(MCV)(P 0.05).During the early stages of iron deficiency,piglets exhibited increased villus height(VH)and the ratio of VH to crypt depth(CD)in the duodenum(Plight chain(FTL)(Plism,transcription,and protein ***,prothrombin,asporin(ASPN),and Rac family small GTPase 3(RAC3)expression was induced,whereas glycoprotein Ib platelet subunit alpha(GPIbA)expression was *** was accompanied by a substantial reduction in serum complement 3(C3)and complement 4(C4)contents(P<0.05),with elevated the contents of interleukin-1β(IL-1β),interleukin-4(IL-4),interleukin-6(IL-6),transforming growth factor-β1(TGF-β1),and tumor necrosis factor-α(TNF-α)(P<0.05).Our findings underscore the essential role of dietary iron supplementation in maintaining iron homeostasis and modulating inflammatory responses in piglets.

关键词： Piglet Iron deficiency Proteomics Inflammatory Cytokine Immune response

Establishing Modular Cell-Free Expression System for the Biosynthesis of Bicyclomycin from a Chemically Synthesized Cyclodipeptide

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Chinese Journal of Chemistry 2024年第4期42卷 384-390页

作者： Yi-Pei liu Yu-Heng Zhao Wen-Qi Zhang lian Wu linjuan Huang gong-li tang Jun-Bin He Shaanxi Natural Carbohydrate Resource Engineering Research Center College of Food Science and TechnologyNorthwest UniversityXi'anShaanxi710069 China State Key Laboratory of Chemical Biology Shanghai Institute of Organic ChemistryUniversity of Chinese Academy of Sciences(CAS)CASShanghai200032 China School of Chemistry and Materials Science Hangzhou Institute for Advanced StudyUniversity of CAS1 Sub-lane XiangshanHangzhouZhejiang310024 China

Cell-free expression systems have emerged as a versatile and powerful platform for metabolic engineering,biosynthesis and synthetic biology ***,successful examples of the synthesis of complex natural products using this system are still ***,a structurally unique and complex diketopiperazine alkaloid,is a clinically promising antibiotic that selectively inhibits the transcription termination factor ***,we established a modular cell-free expression system with cascade catalysis for the biosynthesis of bicyclomycin from a chemically synthesized *** six cell-free expressed biosynthetic enzymes,including five iron-andα-ketoglutarate-dependent dioxygenases and one cytochrome P450 monooxygenase,were active in converting their substrates to the corresponding *** co-expressed enzymes in the cell-free module were able to complete the related partial *** vitro biosynthesis of bicyclomycin was also achieved by reconstituting the entire biosynthetic pathways(i.e.,six enzymes)using the modular cell-free expression *** study demonstrates that the modular cell-free expression system can be used as a robust and promising platformforthe biosynthesis of complex antibiotics.

关键词： Natural products Bicyclomycin Biosynthesis Iron-andα-ketoglutarate-dependent dioxygenases Cytochrome P450 monooxygenase Cell-freeprotein synthesis Enzyme catalysis

Differences between lower extremity joint running kinetics captured by marker-based and markerless systems were speed dependent

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Journal of Sport and Health Science 2024年第4期13卷 569-578页

作者： Hui tang Barry Munkasy li li Department of Health Sciences and Kinesiology Georgia Southern UniversityStatesboroGA 30458USA Department of Kinesiology and Health Education University of Texas at AustinAustinTX 78712USA

Background:The development of computer vision technology has enabled the use of markerless movement tracking for biomechanical *** research has reported the feasibility of markerless systems in motion analysis but has yet to fully explore their utility for capturing faster movements,such as *** studies using markerless systems in clinical and sports settings are still ***,the present study compared running biomechanics estimated by marker-based and markerless *** running speed not only affects sports performance but is also associated with clinical injury prevention,diagnosis,and rehabilitation,we aimed to investigate the effects of speed on the comparison of estimated lower extremity joint moments and powers between markerless and marker-based technologies during treadmill running as a concurrent validating ***:Kinematic data from marker-based/markerless technologies were collected,along with ground reaction force data,from 16 young adults running on an instrumented treadmill at 3 speeds:2.24 m/s,2.91 m/s,and 3.58 m/s(5.0 miles/h,6.5 miles/h,and 8.0 miles/h).Sagittal plane moments and powers of the hip,knee,and ankle were calculated by inverse dynamic *** series analysis and statistical parametric mapping were used to determine system ***:Compared to the marker-based system,the markerless system estimated increased lower extremity joint kinetics with faster speed during the swing phase in most ***:Despite the promising application of markerless technology in clinical settings,systematic markerless overestimation requires focused *** on segment pose estimations,the centers of mass estimated by markerless technologies were farther away from the relevant distal joint centers,which led to greater joint moments and powers estimates by markerless ***-based *** differences were amplified by running speed.

关键词： Biomechanics Motion capture Gait Statistical parametric mapping

Improvements in properties of NdFeB magnets obtained via magnetron sputtering and thermal diffusion

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Journal of Rare Earths 2024年第9期42卷 1710-1716,I0003页

作者： Jin tang Weichao Huang Dan li School of Electronic Engineering Guangxi University of Science and TechnologyLiuzhou545006China China Rare Earth(Guangxi)Jinyuan Rare Earth New Materials Co. Ltd.Hezhou542603China China Rare Earth Group Co. Ltd.Ganzhou341000China Center of Experimental Teaching for Common Courses Panzhihua UniversityPanzhihua617000China

The grain boundary diffusion process(GBDP) of Dy and DyAl on sintered NdFeB magnets was conducted via magnetron-sputtering deposition of Dy and DyAl films to enhance coercivity(H_(cj)),The magnetic properties,microstructure and anti-corrosion properties of Dy-surface-alloying NdFeB magnets obtained via magnetron sputtering and thermal diffusion were *** H_(cj) of the Dy_(95)Al_(5)-NdFeB magnet increases by 32.68%,while the remanence declines ***,X-ray diffraction and microstructural analysis confirm the formation of Dy-rich shells,the higher-magnetic-anisotropy field of hard(Nd_(x)Dy_(1-x))2(FeAl)_(14)B magnetic phases and an optimised grain boundary structu re,contributing to the H_(cj)enhancement of the *** elemental distribution and diffusion mechanism of the magnets are also ***,the corrosion resistance of the Dy_(95)Al_(5)-NdFeB magnet is substantially improved by enhancing the electrochemical stability and optimising the distribution and morphology of the intergranular *** findings of this study are of substantial importance in the development of low-heavy rare-earth sintered NdFeB magnets.

关键词： Magnetron sputtering NdFeB Rare earths Microstructure Magnetic property Corrosion resistance