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World Journal of Diabetes 2024年第8期15卷 1811-1819页

作者： Ling-Hua Shen Yan cui Dong-xia Fu Wei Yang Sheng-Nan Wu Hui-Zhen Wang Hai-Hua Yang Yong-Xing Chen Hai-Yan Wei Department of Endocrinology and Metabolism Henan Key Laboratory of Children's Genetics and Metabolic DiseasesChildren's Hospital Affiliated to Zhengzhou UniversityHenan Children's Hospital Zhengzhou Children's HospitalZhengzhou 450018Henan ProvinceChina

BACKGROUND Transient neonatal diabetes mellitus(TNDM)is a rare form of diabetes mellitus that usually presents within the first 6 mo of *** often enter remission within several months,although relapse can occur later in *** in the ABCC8 gene,which encodes the sulfonylurea receptor 1 of the ATP-sensitive potassium channel in pancreatic beta cells,are associated with TNDM and permanent neonatal *** study describes a novel de novo c.3880C>T heterozygous ABCC8 variant that causes TNDM and can be treated with sulfonylurea *** SUMMARY We retrospectively analyzed 2 Chinese patients with TNDM who were diagnosed,treated,or referred for follow-up between September 2017 and September *** patients were tested for mutations using targeted next-generation *** with neonatal diabetes mellitus caused by a c.3880C>T heterozygous missense variant in the ABCC8 gene have not been reported *** children had an onset of post-infectious diabetic ketoacidosis,which is worth *** a follow-up visit after discontinuing insulin injection,oral glyburide was found to be effective with no adverse *** Early genetic testing of neonatal diabetes mellitus aids in accurate diagnosis and treatment and helps avoid daily insulin injections that may cause pain.

关键词： Neonatal diabetes mellitus ABCC8 Sulfonylurea receptors 1 KATP channels Sulfonylurea Glyburide Insulinulin Case report

Unraveling the nuclear isotope tapestry:Applications,challenges,and future horizons in a dynamic landscape

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Eco-Environment & Health 2024年第2期3卷 208-226页

作者： Hang Yang Qi Feng Weixiang Xu Yadong tang Guoliang Bai Yunli Liu Zisen Liu Shibin xia Zhenbin Wu Yi Zhang State Key Laboratory of Freshwater Ecology and Biotechnology Institute of HydrobiologyChinese Academy of SciencesWuhan 430072China School of Resources and Environmental Engineering Wuhan University of TechnologyWuhan 430070China University of Chinese Academy of Sciences Beijing 100049China

Nuclear isotopes,distinct atoms characterized by varying neutron counts,have profoundly influenced a myriad of sectors,spanning from medical diagnostics and therapeutic interventions to energy production and defense *** multifaceted applications have been celebrated for catalyzing revolutionary breakthroughs,yet these advancements simultaneously introduce intricate challenges that warrant thorough *** challenges encompass safety protocols,potential environmental detriments,and the complex geopolitical landscape surrounding nuclear proliferation and *** comprehensive review embarks on a deep exploration of nuclear isotopes,elucidating their nuanced classifications,wide-ranging applications,intricate governing policies,and the multifaceted impacts of their unintended emissions or ***,the study meticulously examines the cutting-edge remediation techniques currently employed to counteract nuclear contamination while projecting future innovations in this *** weaving together historical context,current applications,and forward-looking perspectives,this review offers a panoramic view of the nuclear isotope *** conclusion,the significance of nuclear isotopes cannot be *** we stand at the crossroads of technological advancement and ethical responsibility,this review underscores the paramount importance of harnessing nuclear isotopes'potential in a manner that prioritizes safety,sustainability,and the greater good of humanity.

关键词： Nuclear isotopes Medical diagnostics Energy production Environmental impact Remediation techniques

Lycorine derivative effectively inhibits the replication of coronaviruses both in vitro and in vivo

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hLife 2024年第2期2卷 75-87页

作者： Liang Shen Jianzhong Zhao Ying xia Junjie Lu Jiali Sun Jian tang Hui Xing Lijuan Yin Yang Yang Chunhua Wang Department of Clinical Laboratory Xiangyang Central HospitalAffiliated Hospital of Hubei University of Arts and ScienceHubeiChina Shenzhen Key Laboratory of Pathogen and Immunity National Clinical Research Center for Infectious DiseaseState Key Discipline of Infectious DiseaseShenzhen Third People’s HospitalSecond Hospital Affiliated to Southern University of Science and TechnologyGuangdongChina Department of Clinical Laboratory Xiangyang No.1 People’s HospitalHubei University of MedicineHubeiChina State Key Laboratory of Food Nutrition and Safety Key Laboratory of Industrial MicrobiologyMinistry of EducationTianjin Key Laboratory of Industry MicrobiologyNational and Local United Engineering Lab of Metabolic Control Fermentation TechnologyChina International Science and Technology Cooperation Base of Food Nutrition/Safety and Medicinal ChemistryCollege of BiotechnologyTianjin University of Science&TechnologyTianjinChina

The established and ongoing prevalence of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and seasonal human coronaviruses(HCoV)like HCoV-OC43,HCoV-NL63,and HCoV-229E,pose a continuous threat to public ***,it is urgently needed to explore antiviral drugs with broad-spectrum anti-coronavirus *** previous studies have revealed that lycorine is a potent broad-spectrum anti-coronavirus drug,a natural alkaloid extracted from Amaryllidaceae with various pharmacological and microbiological ***,it is unsafe to directly use lycorine as a clinical antiviral drug due to the cytotoxicity and induction of cell *** this study,a series of lycorine derivatives were designed and *** of them,named Ly-8,was found to effectively inhibit the replication of different coronavirus strains in vitro,including ***,Ly-8 was also shown to effectively inhibit HCoVOC43 replication in the central nervous system,and provide effective protection against HCoV-OC43 infection in mice with low drug ***,Ly-8-resistant mutants were not observed during the 30 times sequential passages in cell ***,these findings suggest that Ly-8 may be a potential candidate drug for the future development of broad-spectrum anti-coronavirus drugs.

关键词： broad-spectrum antiviral drug lycorine derivative Ly-8

The First Reported Case of Co-Infection with Neisseria Meningitidis and Bordetella Pertussis in the Cerebrospinal Fluid Specimen of a Normal Four-Year-Old Child

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Biomedical and Environmental Sciences 2024年第4期37卷 432-435页

作者： xia xian LI Guo Ming tang Yi WANG Si Quan HE Fei JIANG Yong Zhong YANG Hong Mei JIANG Hong Lin LYU Jing MAO Ling Feng Hubei Key Laboratory of Edible Wild Plants Conservation&Utilization Hubei Normal UniversityHuangshi 430070HubeiChina Hubei Provincial Center for Disease Control and Prevention Wuhan 430079HubeiChina Joint Research Center for Molecular Diagnosis of Severe Infection in Children Binjiang Institute of Zhejiang UniversityHangzhou 310058ZhejiangChina

Pertussis is an acute and highly contagious respiratory disease caused by Bordetella pertussis(***),which occurs in people of all ages and is most dangerous for young children,especially *** introduction of whole-cell pertussis vaccines(wPVs)in the 1950s dramatically reduced the incidence of pertussis worldwide[1].However,over the past two decades,many studies have reported the resurgence of pertussis in different countries[2].Epidemiological surveillance in Hubei Province over the last 3 years revealed a clear increasing trend in the incidence of pertussis during the coronavirus disease 2019(COVID-19)epidemic.

关键词： Pertussis dangerous Hubei

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AI大语言模型背景下的修辞学研究

当代修辞学 2024年第3期 24-36页

作者：崔希亮赵霞北京语言大学国际中文教育研究院北京100083 剑桥大学亚洲与中东学院英国剑桥

本文旨在探讨人工智能背景下当代修辞学的发展及其面临的挑战。文章首先简要介绍大语言模型发展的过程,回顾西方修辞学和中国修辞学的传统理论框架,指出在大语言模型背景下当代修辞学研究的重新定位,内容包括:修辞学的本体研究、学科融... 详细信息

本文旨在探讨人工智能背景下当代修辞学的发展及其面临的挑战。文章首先简要介绍大语言模型发展的过程,回顾西方修辞学和中国修辞学的传统理论框架,指出在大语言模型背景下当代修辞学研究的重新定位,内容包括:修辞学的本体研究、学科融合、情感转向、数字化、认知研究、生态转向。然后从语言理解和生成的角度对五家大语言模型进行了测试。文章发现大语言模型已经具备了一般的语言修辞能力,但是在理解复杂语义关系方面还存在一定的局限性。大语言模型的修辞理解和修辞生成能力给我们的启发是人工智能为修辞学带来了新的研究路径和变革的可能性。最后,文章展望了人工智能与修辞学未来的发展趋势,指出了人工智能大语言模型对修辞学研究可能带来的影响。

关键词：人工智能大语言模型修辞学语言理解与生成

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农地整治对农户收入差距的影响研究

农业技术经济 2024年第8期 20-34页

作者：崔民夏显力西北农林科技大学经济管理学院杨凌712100

本文利用山东、河南两省的830份农户调研数据,采用内生转换模型,在考虑不可观测因素导致的选择性偏误基础上,实证分析农地整治对农户收入水平的影响,并运用Fields分解法检验农地整治对农户收入差距的作用方向及程度。结果表明:第一,基... 详细信息

本文利用山东、河南两省的830份农户调研数据,采用内生转换模型,在考虑不可观测因素导致的选择性偏误基础上,实证分析农地整治对农户收入水平的影响,并运用Fields分解法检验农地整治对农户收入差距的作用方向及程度。结果表明:第一,基于反事实假设,农户若未参与农地整治,其家庭总收入将下降13.1%,即农地整治显著提高了农户的家庭总收入。从收入结构上来看,农地整治对农业收入的促增作用大于非农收入;第二,农地整治扩大农户之间的收入差距;贡献率为26.4%,农地整治不仅没有实现矫正农业收入差距的初衷,反而产生了“逆向分配”的结果;第三,低收入农户参与农地整治程度不足和高收入农户在农地整治中获得更高的收益率,是农地整治扩大农户收入差距的重要原因;第四,农地整治引发了不同收入水平农户社会公平感的分化。因此,在考虑如何通过农地整治增加农户收入时,有必要将问题的焦点从效率延伸到公平,重点关注农地整治中处于相对不利地位的低收入农户的收入增长问题。

关键词：农地整治收入水平收入差距内生转换回归模型(ESR) Fields分解

Src inhibition rescues FUNDC1-mediated neuronal mitophagy in ischaemic stroke

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Stroke & Vascular Neurology 2024年第4期9卷 367-379,I0022-I0031页

作者： Tianchi tang Li-bin Hu Chao Ding Zhihua Zhang Ning Wang Tingting Wang Hang Zhou Siqi xia Linfeng Fan Xiong-jie Fu Feng Yan xiangnan Zhang Gao Chen Jianru Li Department of Neurosurgery Zhejiang University School of Medicine Second Affiliated HospitalHangzhouZhejiangChina 2NeurosurgeryZhejiang University School of Medicine Second Affiliated HospitalHangzhouZhejiangChina 3Zhejiang University School of MedicineHangzhouZhejiangChina 4Zhejiang University Department of PharmacologyHangzhouZhejiangChina

Background Ischaemic stroke triggers neuronal mitophagy,while the involvement of mitophagy receptors in ischaemia/reperfusion(I/R)injury-induced neuronal mitophagy remain not fully ***,we aimed to investigate the involvement of mitophagy receptor FUN14 domain-containing 1(FUNDC1)and its modulation in neuronal mitophagy induced by I/R *** Wild-type and FUNDC1 knockout mice were generated to establish models of neuronal I/R injury,including transient middle cerebral artery occlusion(tMCAO)in vivo and oxygen glucose deprivation/reperfusion in *** outcomes of mice with two genotypes were *** mitophagy was analysed both in vivo and in *** of FUNDC1 and its regulator Src were *** impact of Src on FUNDC1-mediated mitophagy was assessed through administration of Src antagonist *** To our surprise,FUNDC1 knockout mice subjected to tMCAO showed stroke outcomes comparable to those of their wild-type *** neuronal mitophagy could be activated by I/R injury,FUNDC1 deletion did not disrupt neuronal *** activation of FUNDC1,represented by dephosphorylation of Tyr18,was detected in the early stages(within 3hours)of neuronal I/R injury;however,phosphorylated Tyr18 reappeared and even surpassed baseline levels in later stages(after 6hours),accompanied by a decrease in FUNDC1-light chain 3 *** inactivation of FUNDC1 was associated with Src activation,represented by phosphorylation of Tyr416,which changed in parallel with the level of phosphorylated FUNDC1(Tyr18)during neuronal I/R ***,FUNDC1-mediated mitophagy in neurons under I/R conditions can be rescued by pharmacological inhibition of *** FUNDC1 is inactivated by Src during the later stage(after 6hours)of neuronal I/R injury,and rescue of FUNDC1-mediated mitophagy may serve as a potential therapeutic strategy for treating ischaemic stroke.

关键词： FUNDC1 involvement injury

SARS-CoV-2 breakthrough infections following inactivated vaccine vaccination induce few neutralizing antibodies against the currently emerging Omicron XBB variants

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Virologica Sinica 2024年第1期39卷 173-176页

作者： Fan Shen Chun Liang cui-xian Yang Ying Lu An-Qi Li Ying Duan Mi Zhang c Ren-Rong Tian a Xing-Qi Dong Yong-tang Zheng Wei Pang Key Laboratory of Bioactive Peptides of Yunnan Province/Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common DiseasesKunming Institute of ZoologyChinese Academy of SciencesKunming650223China University of Chinese Academy of Sciences Beijing100049China Yunnan Provincial Infectious Disease Hospital Kunming650399China Department of Pathogen Biology and Immunology Faculty of Basic Medical ScienceKunming Medical UniversityKunming650500China

Dear Editor,COVID-19 inactivated vaccines have been extensively administered ***,the majority of the Chinese population has experiencedbreakthrough infections from SARS-CoV-2 ancestral,Delta or Omicronvariants over the past three years,particularly during the wave of Omicron BA.5 and BA.7 variants at the end of 2022(Zhu et al.,2023).Subsequently,new Omicron variants,such as BQ.1,BQ.1.1,XBB,XBB.1/XBB.1.9,and XBB.1.5/XBB.1.9.1,are emerging in China(Yueetal.,2023;Zhu et al.,2023).Therefore,it is an urgentneed and a publichealth imperative to assess the extent of the immunoprotection established in this population.

关键词： breakthrough neutral Omi

Evaluation of the famous classic formula Sanhua decoction based on network pharmacology and multi-component quantitative analysis

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Traditional Medicine Research 2024年第1期9卷 1-13页

作者： Xin Zhang Wan-cui Wang Jin-Kui Zhang Wei-Mei Zhang Peng-Wang Wang Peng-Cheng Lin Yong-Chang Lu xia Li Wen-Yuan Gao College of Pharmacy Qinghai Minzu UniversityXining 810000China Qinghai Key Laboratory of Phytochemistry on Qinghai-Tibet Plateau Qinghai Minzu UniversityXining 810000China School of Pharmaceutical Science and Technology Tianjin UniversityTianjin 300000China Qinghai Engineering Technology Research Center of Modern Tibetan Medicine Creation Qinghai Minzu UniversityXining 810000China

Background:Sanhua decoction has significant effects in the treatment of *** study of the Sanhua decoction material benchmark was carried out to analyze the value transfer relationship between the Chinese herbal pieces and the substance ***:Network pharmacology was employed to investigate the potential active components and molecular mechanisms of Sanhua decoction in the treatment of stroke.15 batches of Sanhua decoction lyophilized powder were prepared using traditional formulas and subjected to high-performance liquid chromatography analysis to generate fingerprints of the Sanhua decoction substance ***,a multi-component quantitative analysis method was established,allowing for the simultaneous determination of ten components,to study the transfer of quantity values between pieces and substance ***:60 active ingredients were screened from Sanhua decoction by network pharmacology,of which gallic acid,magnolol honokiol,physcion,and aloe-emodin may have a greater effect than other active components.63 key targets and 134 pathways were predicted as the potential mechanism of Sanhua decoction in treating *** fingerprint similarity of the Sanhua decoction substance benchmarks was found to be good among the 15 batches,confirming the 19 common *** content of the 10 components was basically *** components’transfer rates were within 30%of their respective ***:This study provided a comprehensive and reliable strategy for the quality evaluation of Sanhua decoction substance benchmarks and held significant importance in improving its application value.

关键词： Sanhua decoction classic famous formula HPLC fingerprinting value transfer network pharmacology

GD-1300上悬式离心机转鼓的应力分析与优化

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机械设计与制造 2009年第6期 220-222页

作者：韦尧兵姜永涛剡昌锋唐翠霞兰州理工大学机电工程学院兰州730050 苏州板硝子电子有限公司苏州215011

运用有限元分析软件ANSYS对上悬式离心机关键部件—转鼓在正常工作状态下进行了分析,找出了该转鼓的危险点所在位置,对转鼓的结构进行了改进;并运用有限元分析软件对改进后的转鼓进行校核。结果表明改进后的结构满足强度和刚度要求。将... 详细信息

运用有限元分析软件ANSYS对上悬式离心机关键部件—转鼓在正常工作状态下进行了分析,找出了该转鼓的危险点所在位置,对转鼓的结构进行了改进;并运用有限元分析软件对改进后的转鼓进行校核。结果表明改进后的结构满足强度和刚度要求。将CAD和ANSYS软件进行联合的方法能够发挥各软件的优势,缩短研发周期,得到精确结果。

关键词：离心机转鼓有限元分析