检索结果-南通市图书馆

A new type of lipophilic hydrophobic self-repairing cellulose insulating paper developed with ST-110/FAS/PTFE ternary system as coating substrate

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

High Voltage 2024年第2期9卷 474-483页

作者： Zhenglin Zeng Jinshan Qin Zuhao Wang Weimin Tan chao tang College of Engineering and Technology Southwest UniversityChongqingChina International R&D Center for New Technologies of Smart Grid and Equipment ChongqingChina

The moisture generated by the ageing of the oil-paper insulating system can easily lead to the deterioration of the performance of the insulating *** order to alleviate the impact of moisture on the performance of the insulating paper,we developed a kind of lipophilic hydrophobic self-repairing cellulose insulating paper(new insulating paper)based on the ternary system of polytetrafluoroethylene,fluorocarbon surfactant and fluorinated alkyl silane,and accelerated thermal ageing test for 45 days at 130°C was carried *** experimental results show that the new insulating paper with excellent lipophilic property can realise hydrophobic self-repairing through heat treatment after physical *** tensile strength and elongation at break of the new insulating paper increased by 5%–8%and 6.25%–27%respectively compared with the original cellulose insulating *** the end of ageing,the relative dielectric constant and dielectric loss factor of new insulating paper are 10.4%and 9.9%lower than that of the original cel-lulose insulating paper,while the breakdown voltage is 6.8%*** acid and moisture content produced during the ageing process of the insulating oil impregnated with new insulating paper are also less,indicating that the coating can delay the ageing of the insulating paper.

关键词： coating moisture cellulose

Serum metabolic profiling implicates mTOR activation and insulin resistance in the development of pulmonary hypertension in a rat model of pressure overload-induced heart failure

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genes & Diseases 2024年第5期11卷 109-112页

作者： Qi Zhou chao tang Xinke Xu Junhao Hu Shengsen Yao Bo Dong Xiaojing Wu Department of Cardiology of the Fifth Affiliated Hospital of Southern Medical University GuangzhouGuangdong 510999China Cardiovascular Department of Shenzhen University General Hospital ShenzhenGuangdong 518055China Cardiovascular Department of Chongqing Medical University Second Affiliated Hospital Chongqing 400010China

Pulmonary hypertension(PH)due to left heart failure(HF)accounts for approximately half of PH cases *** has been demonstrated that PH is a frequent complication of HF but is difficult to recognize in its early stage because it is characterized by nonspecific symptoms including shortness of breath and decreased tolerance of ***,nearly all multicentric clinical trials targeting pulmonary circulation in PH-HF have reported negative results.1 Thus,there are no effective methods for diagnosing early PH,and the current treatment of PH-HF is insufficient.

关键词： hypertension Serum resistance

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

体检者甲状腺结节检出情况及影响因素分析

中国社区医师 2024年第19期40卷 154-156页

作者：唐超贵州航天医院贵州遵义563000

目的:统计体检者甲状腺结节检出情况,分析其影响因素。方法:选择2022年1月—2023年1月贵州航天医院400名体检者作为研究对象,收集其临床资料,统计不同年龄段、性别体检者甲状腺结节患病率,分析体检者甲状腺结节患病的影响因素。结果:40... 详细信息

目的:统计体检者甲状腺结节检出情况,分析其影响因素。方法:选择2022年1月—2023年1月贵州航天医院400名体检者作为研究对象,收集其临床资料,统计不同年龄段、性别体检者甲状腺结节患病率,分析体检者甲状腺结节患病的影响因素。结果:400名体检者中,198名患有甲状腺结节,患病率为49.5%(198/400);其中男性患病率43.9%(87/198),女性患病率56.1%(111/198),男性体检者患病率低于女性;男性甲状腺结节患者50~59岁发病率较高,女性甲状腺结节患者40~49岁发病率较高。性别、年龄、饮酒情况、高血压患病情况、糖尿病患病情况、促甲状腺激素水平是甲状腺结节患病的独立影响因素(P<0.05)。结论:甲状腺结节的发生和饮酒、高血压、糖尿病、促甲状腺激素水平有关,临床应对高危人群做好日常健康指导工作,预防甲状腺结节的发生。

关键词：健康体检甲状腺结节健康管理指导影响因素

GNAS mutations suppress cell invasion by activating MEG3 in growth hormone–secreting pituitary adenoma

在线全文

学校读者我要写书评

暂无评论

Oncology Research 2024年第6期32卷 1079-1091页

作者： chao tang CHUNYU ZHONG JUNHAO ZHU FENG YUAN JIN YANG YONG XU CHIYUAN MA Department of Neurosurgery Affiliated Jinling HospitalMedical School of Nanjing UniversityNanjing210002China Department of Neurosurgery Children’s Hospital of Nanjing Medical UniversityNanjing210019China Affiliated Eye Hospital Nanjing Medical UniversityNanjing210029China Department of Neurosurgery Jinling HospitalSouthern Medical UniversityNanjing210002China Department of Neurosurgery Jinling HospitalNanjing Medical UniversityNanjing210002China

Approximately 30%–40%of growth hormone–secreting pituitary adenomas(GHPAs)harbor somatic activating mutations in GNAS(αsubunit of stimulatory G protein).Mutations in GNAS are associated with clinical features of smaller and less invasive ***,the role of GNAS mutations in the invasiveness of GHPAs is *** mutations were detected in GHPAs using a standard polymerase chain reaction(PCR)sequencing *** expression of mutation-associated maternally expressed gene 3(MEG3)was evaluated with ***3 was manipulated in GH3 cells using a lentiviral expression *** invasion ability was measured using a Transwell assay,and epithelial–mesenchymal transition(EMT)-associated proteins were quantified by immunofluorescence and western ***,a tumor cell xenograft mouse model was used to verify the effect of MEG3 on tumor growth and *** invasiveness of GHPAs was significantly decreased in mice with mutated GNAS compared with that in mice with wild-type ***,the invasiveness of mutant GNASexpressing GH3 cells ***3 is uniquely expressed at high levels in GHPAs harboring mutated ***,MEG3 upregulation inhibited tumor cell invasion,and conversely,MEG3 downregulation increased tumor cell ***,GNAS mutations inhibit EMT in ***3 in mutated GNAS cells prevented cell invasion through the inactivation of the Wnt/β-catenin signaling pathway,which was further validated in *** data suggest that GNAS mutations may suppress cell invasion in GHPAs by regulating EMT through the activation of the MEG3/Wnt/β-catenin signaling pathway.

关键词： GHPAs GNAS mutation MEG3 β-catenin EMT

Experimental Study on Engineering Behavior of Solidified Soil for Scour Repair and Protection

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

China Ocean Engineering 2024年第4期38卷 625-635页

作者： WU Xiao-ni LI Ru-yu SHU Jian tang chao CHEN Jin-jian WANG Hui-li JIANG Hai-li WANG Xiao State Key Laboratory of Ocean Engineering Department of Civil EngineeringShanghai Jiao Tong UniversityShanghai 200240China Shanghai Road and Bridge Group Co. Ltd.Shanghai 200433China Shanghai Engineering Research Center of Urban Infrastructure Renewal Shanghai 200032China Jiangsu Kunze Technology Co. Ltd.Nanjing 210000China

A new scour countermeasure using solidified slurry for offshore foundation has been proposed *** solidified slurry is pumped to seabed area around foundation for scour protection or pumped into the developed scour holes for scour repair as the fluidized material solidifies *** the pumping operation and solidification,the engineering behaviors of solidified slurry require to be considered synthetically for the reliable application in scour repair and protection of ocean engineering such as the pumpability related flow value,flow diffusion behavior related rheological property,anti-scour performance related retention rate in solidification and bearing capacity related strength property after *** this study,a series of laboratory tests are conducted to investigate the effects of mix proportion(initial water content and binder content)on the flow value,rheological properties,density,retention rate of solidified slurry and unconfined compressive strength(UCS).The results reveal that the flow value increases with the water content and decreases with the binder *** the solidified slurry exhibits Bingham plastic behavior when the shear rate is larger than 5 s^(-1).The Bingham model has been employed to fit the rheology test results,and empirical formulas for obtaining the density,yield stress and viscosity are established,providing scientific support for the numerical assessment of flow and diffusion of solidified *** rate of solidified slurry decreases with the water flow velocity and flow value,which means the pumpability of solidified slurry is contrary to anti-scour *** unconfined compressive strength after solidification reduces as the water content increases and binder content decreases.A design and application procedure of solidified soil for scour repair and protection is also proposed for engineering reference.

关键词： scour repair and protection solidified soil pumpability strength flow properties anti-scour performance

在线全文

学校读者我要写书评

暂无评论

面向DNA甲基化修饰分析的质谱技术

化学通报 2024年第1期87卷 27-35页

作者：唐朝罗群江汉大学环境与健康学院武汉430056 中国科学院化学研究所北京100190

DNA甲基化作为表观遗传修饰中一种重要的调控方式,通过调控基因的表达,从而影响机体内一系列的生物学过程。色谱-质谱法是研究DNA甲基化修饰的重要研究手段。随着对哺乳动物DNA甲基化的生物学功能的深入研究,应用于研究表观遗传修饰的... 详细信息

DNA甲基化作为表观遗传修饰中一种重要的调控方式,通过调控基因的表达,从而影响机体内一系列的生物学过程。色谱-质谱法是研究DNA甲基化修饰的重要研究手段。随着对哺乳动物DNA甲基化的生物学功能的深入研究,应用于研究表观遗传修饰的手段与仪器设备越来越先进。为了对DNA修饰进行定性与定量的分析检测,除了高效液相色谱整合不同种类质量分析器的质谱联用(HPLC-MS)技术外,目前还开发应用了基质辅助激光解析质谱技术(MALDI-ToF-MS)和气相色谱-质谱联用技术(GC-MS),从而极大拓展了DNA甲基化修饰研究的手段。本文对分析表观遗传DNA甲基化修饰的质谱技术发展进行综述,希望为DNA甲基化修饰分析提供有价值的研究策略。

关键词：表观遗传修饰 DNA甲基化同位素标记液相色谱与质谱联用技术

共生理论视域下循证教学与教育科研成果转化的关系审视

在线全文

学校读者我要写书评

暂无评论

黑龙江高教研究 2024年第9期42卷 1-7页

作者：唐明超首都师范大学北京100037

在奋力推进中国式教育现代化背景下,关于循证教学的讨论已然成为热点。澄清循证教学与教育科研成果转化的关系,对深入开展循证教育理论与实践研究具有现实意义。基于共生理论建构关系分析框架,系统梳理循证教学的缘起与实践逻辑,对照教... 详细信息

在奋力推进中国式教育现代化背景下,关于循证教学的讨论已然成为热点。澄清循证教学与教育科研成果转化的关系,对深入开展循证教育理论与实践研究具有现实意义。基于共生理论建构关系分析框架,系统梳理循证教学的缘起与实践逻辑,对照教育科研成果转化的价值与路径,剖析二者的共生关系与现实张力,给出改进建议。研究表明,循证教学与教育科研成果转化共同作用于课堂教学改进与学校教育质量提升,呈现连续性的非对称互惠共生关系;相比教育科研成果转化,循证教学处于更加突出和优势的地位。追求二者一体化互惠共生发展,需要从教师素养发展、教研制度创新、循证文化形塑、信息化平台建设等视角推动循证教学落地课堂发挥实效,干预共生关系的进化。

关键词：循证教学教育科研成果转化关系研究共生理论

在线全文

学校读者我要写书评

暂无评论

边境安全风险中信息迷雾的生成机理研究

情报理论与实践 2024年第10期47卷 74-81页

作者：张雨轩唐超中国人民警察大学研究生院河北廊坊065000 中国人民警察大学智慧警务学院河北廊坊065000

[目的/意义]针对边境安全风险中信息迷雾的生成机理进行研究,有利于明晰信息迷雾对边境安全造成的影响,进一步探讨如何透过信息迷雾把控边境安全风险。[方法/过程]在深入边境地区调研的基础上,以信息熵理论和情报感知理论为指导,归纳出... 详细信息

[目的/意义]针对边境安全风险中信息迷雾的生成机理进行研究,有利于明晰信息迷雾对边境安全造成的影响,进一步探讨如何透过信息迷雾把控边境安全风险。[方法/过程]在深入边境地区调研的基础上,以信息熵理论和情报感知理论为指导,归纳出边境安全风险中信息迷雾的生成机理。在此基础上,提出边境安全风险的情报感知—响应策略。[结果/结论]边境安全风险中信息迷雾的生成机理由议题构建、编写表达以及传播组成。据此可提出应对边境安全风险中信息迷雾的情报感知响应策略,即事实库建设、智能扫描与监测、持续感知、分类响应。

关键词：边境安全风险信息迷雾机理研究情报感知响应

同方期刊数据库

基于密集台阵的近场与远场地震动迟滞相干函数模型分析

在线全文

学校读者我要写书评

暂无评论

工程力学 2024年第10期41卷 128-141页

作者：胡进军汤超中国地震局工程力学研究所地震工程与工程振动重点实验室黑龙江哈尔滨150080 地震灾害防治应急管理部重点实验室黑龙江哈尔滨150080

迟滞相干性是表征地震动空间变化特性的一个重要指标,为研究近场与远场地震动的迟滞相干性的空间变化特性及其差异,基于美国UPSAR台阵记录的2004年Parkfield M_(w)6.0地震的近场记录,以及中国自贡台阵记录的2008年汶川M_(s)8.0地震的远... 详细信息

迟滞相干性是表征地震动空间变化特性的一个重要指标,为研究近场与远场地震动的迟滞相干性的空间变化特性及其差异,基于美国UPSAR台阵记录的2004年Parkfield M_(w)6.0地震的近场记录,以及中国自贡台阵记录的2008年汶川M_(s)8.0地震的远场记录,分别分析了两个密集台阵近场和远场地震动的水平向和竖向相干函数随距离、频率的变化规律,对比了近场和远场地震动迟滞相干性的差异;将基于实际数据的迟滞相干性值与常用的三种相干模型进行拟合分析,揭示了不同相干模型的优势和局限性。结果表明:近场与远场地震动的相干性衰减速度有明显差异,在低频和近距离时,远场记录的相干性要明显大于近场记录;相干性随着距离和频率的衰减速度不同,相干函数模型需要对频率和距离项使用不同的参数描述;现有模型对近场和远场地震动的拟合效果差异较大,对远场记录的拟合效果要优于近场记录;三种模型对同一事件的拟合效果不同,多参数模型效果最好,双参数模型其次,单参数模型适用性较差。研究结果可为近场和远场区相干性模型的选用提供依据。

关键词：迟滞相干性近场地震动远场地震动密集台阵功率谱密度