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Acceptor-engineering tailored type-Ⅰ photosensitizer with aggregation-induced NIR-II emission for cancer multimodal phototheranostics

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Science China Chemistry 2024年第8期67卷 2647-2660页

作者： Jiangao Li Niu Niu Deliang Wang Xue Liu Yi qin Lei Wang ben Zhong tang Dong Wang Center for AIE Research Shenzhen Key Laboratory of Polymer Science and TechnologyGuangdong Research Center for Interfacial Engineering of Functional MaterialsCollege of Materials Science and EngineeringShenzhen UniversityShenzhen 518060China Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target Clinical Pharmacologythe State Key Laboratory of Respiratory DiseaseSchool of Pharmaceutical Sciences and the Fifth Affiliated HospitalGuangzhou Medical UniversityGuangzhou 511436China School of Science and Engineering Shenzhen Institute of Aggregate Science and TechnologyThe Chinese University of Hong KongShenzhen(CUHK-Shenzhen)Shenzhen 518172China

Exploration of single molecular species synchronously featured by long excitation/emission wavelength, accurate diagnosis, and effective therapy, remains supremely appealing to implement high-performance cancer phototheranostics. However, those previously established phototheranostic agents are undiversified and stereotyped in terms of structural skeleton, and generally exhibit insufficient phototheranostic outcomes. Herein, we innovatively utilized indanone-condensed thiadiazolo[3,4-g]quinoxaline(ITQ) as electron acceptor to construct novel photosensitizer with second near-infrared(NIR-II) emission. Experimental study and theoretical calculation demonstrated that comparing with the counterparts constituting by widely employed NIR-II building block benzobisthiadiazole(BBTD) and 6,7-diphenylthiadiazoloquinoxaline(DPTQ), ITQ-based photosensitizer(TITQ) showed superior aggregation-induced emission(AIE) characteristics, much stronger type-I reactive oxygen species(ROS) production, and prominent photothermal conversion capacity. Furthermore, TITQ nanoparticles with excellent biocompatibility were capable of effectively accumulating in the tumor site and visualizing tumor through fluorescence-photoacoustic-photothermal trimodal imaging with highly spatiotemporal resolution, and completely eliminating tumor by type-I photodynamic-photothermal therapy.

关键词： phototheranostics aggregation-induced emission NIR-Ⅱfluorescence acceptor engineering photodynamic-photothermal therapy

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Preparing lipid nanoparticles with tunable drug loading capacity and morphology via improved sequential nanoprecipitation

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Science China Chemistry 2024年第5期67卷 1373-1374页

作者： Haoran Wang ben Zhong tang Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction Department of Chemistry.Institute of Molecular Functional MaterialsState Key Laboratory of NeuroscienceDivision of Biomedical Engineering and Division of Life ScienceThe Hong Kong University of Science and TechnologyHong Kong 999077China School of Science and Engineering Shenzhen Institute of Aggregate Science and Technology The Chinese University of Hong KongShenzhen(CUHK-Shenzhen)Shenzhen 518172China

Nanotechnology hailed as a revolutionary new technology of the 21st century, has ignited a wave of innovation across diverse fields spanning chemistry, physics, materials science,medicine, engineering, and electronics. In 2016, Nature published an article titled “The nanolight revolution is coming”, underscoring that “virus-sized particles that emit light in every color could transform applications ranging from television displays to cancer treatment”.

关键词： sized loading treatment

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Inorganic ionic polymerization:From biomineralization to materials manufacturing

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Nano Research 2024年第2期17卷 550-569页

作者： Yanhua Sang Kexin qin Ruikang tang Zhaoming Liu Department of Chemistry Zhejiang UniversityHangzhou 310058China

Biomineralization process regulates the growth of inorganic minerals by complex molecules,proteins,and cells,endowing bio-materials with marvels structures and excellent *** intricate structures and compositions found in biominerals have inspired scientists to design and synthesize numerous artificial biomimetic *** methodology for controlling the formation of inorganics plays a pivotal role in achieving biomimetic structures and ***,the current approach predominantly relies on the classical nucleation theory,which hinders the precise preparation of inorganic materials by replicating the biomineralization ***,the development of“inorganic ionic polymerization”strategy has enabled us to regulate the arrangement of inorganic ions from solution to solid phase,which establishes an artificial way to produce inorganic materials analogous to the biomineralization *** on inorganic ionic polymerization,a series of achievements have been realized for the biomimetic preparation,including moldable construction of inorganic materials,hard tissue regeneration,and high-performance biomimetic ***,the utilization of inorganic ionic polymerization has also facilitated the production of numerous advanced materials,including novel structures that exceed the current knowledge of materials *** inorganic ionic polymerization system provides new artificial strategies and methodologies for the controllable synthesis of inorganics,which mimics the biomineralization process,paving the way for the future development of more high-performance materials.

关键词： biomineralization inorganic ionic polymerization biomimetic materials crystal growth synthetic methodology

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Two-dimensional porous carbon derived from pollen with enlarged interlayer distance enhanced electrocatalytic oxidation of n-valeraldehyde to octane

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Nano Research 2024年第5期17卷 3455-3461页

作者： Meichun qin Chaolong Liu Shouhen Xu Jianguo tang Institute of Hybrid Materials National Center of International Joint Research for Hybrid Materials TechnologyNational Base of International Sci.and Tech.Cooperation on Hybrid MaterialsCollege of Materials Science and EngineeringQingdao UniversityQingdao266071China Department of Pharmaceutics School of PharmacyQingdao UniversityQingdao266071China

Electrocatalytic n-valeraldehyde oxidation reaction was an inexpensive and eco-friendly method to control n-valeraldehyde contamination and produce high value-added ***,low-cost and readily available electrocatalysts with high current efficiency were urgently ***,two-dimensional porous carbon derived from pollen with enlarged interlayer distance was built by alkali activation method,applying in electrocatalytic n-valeraldehyde oxidation *** enlarged interlayer distance was verified by X-ray diffraction(XRD)and high-angle annular dark-field scanning transmission electron microscope(HAADF-STEM).Electrocatalytic experiments consequences showed activated biomass derived carbon possessed a higher electrocatalytic activity and octane selectivity than unactivated *** tests and in situ infrared experiments demonstrated that enlarged interlayer distance was positively correlated with specific surface area of catalysts,large specific surface area provided abundant absorption sites,facilitated the adsorption for n-valeraldehyde,and further promoted the transformation of n-valeraldehyde to *** work also provides a new avenue for creating high-performance electrocatalysts in terms of lattice engineering.

关键词： biomass derived carbon lattice expansion high specific surface area upgrade of n-valeraldehyde

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A deep multimodal fusion and multitasking trajectory prediction model for typhoon trajectory prediction to reduce flight scheduling cancellation

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Journal of Systems Engineering and Electronics 2024年第3期35卷 666-678页

作者： tang Jun qin Wanting PAN qingtao LAO Songyang College of Systems Engineering National University of Defense TechnologyChangsha 410000China

Natural events have had a significant impact on overall flight activity,and the aviation industry plays a vital role in helping society cope with the impact of these *** one of the most impactful weather typhoon seasons appears and continues,airlines operating in threatened areas and passengers having travel plans during this time period will pay close attention to the development of tropical *** paper proposes a deep multimodal fusion and multitasking trajectory prediction model that can improve the reliability of typhoon trajectory prediction and reduce the quantity of flight scheduling *** deep multimodal fusion module is formed by deep fusion of the feature output by multiple submodal fusion modules,and the multitask generation module uses longitude and latitude as two related tasks for simultaneous *** more dependable data accuracy,problems can be analysed rapidly and more efficiently,enabling better decision-making with a proactive versus reactive *** multiple modalities coexist,features can be extracted from them simultaneously to supplement each other’s *** actual case study,the typhoon Lichma that swept China in 2019,has demonstrated that the algorithm can effectively reduce the number of unnecessary flight cancellations compared to existing flight scheduling and assist the new generation of flight scheduling systems under extreme weather.

关键词： flight scheduling optimization deep multimodal fusion multitasking trajectory prediction typhoon weather flight cancellation prediction reliability

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Multiscale modeling of gas-induced fracturing in anisotropic clayey rocks

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第6期16卷 2091-2110页

作者： Jianxiong Yang Jianfeng Liu Zhengyuan qin Xuhai tang Houquan Zhang State Key Laboratory of Hydraulics and Mountain River Engineering College of Water Resource and HydropowerSichuan UniversityChengdu610042China School of Resources and Safety Engineering Wuhan Institute of TechnologyWuhan430073China School of Civil Engineering Wuhan UniversityWuhan430072China State Key Laboratory of Intelligent Construction and Healthy Operation and Maintenance of Deep Underground Engineering China University of Mining and TechnologyXuzhou221116China

In the context of repositories for nuclear waste,understanding the behavior of gas migration through clayey rocks with inherent anisotropy is crucial for assessing the safety of geological disposal *** primary mechanism for gas breakthrough is the opening of micro-fractures due to high gas *** occurs at gas pressures lower than the combined strength of the rock and its minimum principal stress under external loading *** investigate the mechanism of microscale mode-I ruptures,it is essential to incorporate a multiscale approach that includes subcritical microcracks in the modeling *** this contribution,we derive the model from microstructures that contain periodically distributed microcracks within a porous *** damage evolution law is coupled with the macroscopic poroelastic system by employing the asymptotic homogenization method and considering the inherent hydro-mechanical(HM)anisotropy at the *** resulting permeability change induced by fracture opening is implicitly integrated into the gas flow *** examples are presented to validate the developed model step by *** analysis of local macroscopic response is undertaken to underscore the influence of factors such as strain rate,initial damage,and applied stress,on the gas migration *** examples of direct tension tests are used to demonstrate the model’s efficacy in describing localized failure ***,the simulation results for preferential gas flow reveal the robustness of the two-scale model in explicitly depicting gas-induced fracturing in anisotropic clayey *** model successfully captures the common behaviors observed in laboratory experiments,such as a sudden drop in gas injection pressure,rapid build-up of downstream gas pressure,and steady-state gas flow following gas breakthrough.

关键词： Deep geological repositories Mode-I microcracks Time-dependent damage Fracturing process Anisotropic rock

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A new type of lipophilic hydrophobic self-repairing cellulose insulating paper developed with ST-110/FAS/PTFE ternary system as coating substrate

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High Voltage 2024年第2期9卷 474-483页

作者： Zhenglin Zeng Jinshan qin Zuhao Wang Weimin Tan Chao tang College of Engineering and Technology Southwest UniversityChongqingChina International R&D Center for New Technologies of Smart Grid and Equipment ChongqingChina

The moisture generated by the ageing of the oil-paper insulating system can easily lead to the deterioration of the performance of the insulating *** order to alleviate the impact of moisture on the performance of the insulating paper,we developed a kind of lipophilic hydrophobic self-repairing cellulose insulating paper(new insulating paper)based on the ternary system of polytetrafluoroethylene,fluorocarbon surfactant and fluorinated alkyl silane,and accelerated thermal ageing test for 45 days at 130°C was carried *** experimental results show that the new insulating paper with excellent lipophilic property can realise hydrophobic self-repairing through heat treatment after physical *** tensile strength and elongation at break of the new insulating paper increased by 5%–8%and 6.25%–27%respectively compared with the original cellulose insulating *** the end of ageing,the relative dielectric constant and dielectric loss factor of new insulating paper are 10.4%and 9.9%lower than that of the original cel-lulose insulating paper,while the breakdown voltage is 6.8%*** acid and moisture content produced during the ageing process of the insulating oil impregnated with new insulating paper are also less,indicating that the coating can delay the ageing of the insulating paper.

关键词： coating moisture cellulose

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Response and assembly of abundant and rare taxa in Zaopei under different combination patterns of Daqu and pit mud:from microbial ecology to Baijiu brewing microecosystem

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Food Science and Human Wellness 2024年第3期13卷 1439-1452页

作者： Yu Mu Jun Huang Rongqing Zhou Suyi Zhang Hui qin Hanlan tang Qianglin Pan Huifang tang College of Biomass Science and Engineering Sichuan UniversityChengdu 610065China National Engineering Research Center of Solid-State Manufacturing Luzhou 646000China Luzhou Laojiao Co. Ltd.Luzhou 646699China

The quality and aroma of strong-flavor Baijiu are mainly dependent on Daqu,pit mud(PM),and the interaction of ***,little is known about how their combination patterns affect the microbiome and metabolome of Zaopei,especially the metabolic function of rare ***,an experiment on industrial size was designed to assess the effects of 6 combinations(3 kinds of Daqu×2 kinds of PM)on the composition and assembly of different taxa,as well as the flavor *** results showed that Zaopei's microbiota was composed of a few abundant taxa and enormous rare taxa,and rare bacterial and abundant fungal subcommunities were significantly affected by combination *** assembly processes of abundant/rare taxa and bacterial/fungal communities were distinct,and environmental changes mediated the balance between stochastic and deterministic processes in rare bacteria ***,specific combination patterns improved the flavor quality of Zaopei by enhancing the interspecies interaction,which was closely related to rare taxa,especially rare *** findings highlighted that rare bacteria might be the keystone in involving community interaction and maintaining metabolic function,which provided a scientific foundation for better understanding and regulating the brewing microbiota from the viewpoint of microbial ecology.

关键词： Bioaugmented Daqu Artificial pit mud Abundant and rare taxa Community assembly Metabolic function

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Full waveform inversion based on hybrid gradient

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Petroleum Science 2024年第3期21卷 1660-1670页

作者： Chuang Xie Zhi-Liang qin Jian-Hua Wang Peng Song Heng-Guang Shen Sheng-Qi Yu ben-Jun Ma Xue-qin Liu qingdao Innovation and Development Base Harbin Engineering University qingdao Innovation and Development Center Harbin Engineering University CNOOC Research Institute Co. Ltd. College of Marine Geoscience Ocean University of China Weihai Sunfull Geophysical Exploration Equipment Co. Ltd.

The low-wavenumber components in the gradient of full waveform inversion(FWI) play a vital role in the stability of the inversion. However, when FWI is implemented in some high frequencies and current models are not far away from the real velocity model, an excessive number of low-wavenumber components in the gradient will also reduce the convergence rate and inversion accuracy. To solve this problem, this paper firstly derives a formula of scattering angle weighted gradient in FWI, then proposes a hybrid gradient. The hybrid gradient combines the conventional gradient of FWI with the scattering angle weighted gradient in each inversion frequency band based on an empirical formula derived *** weighted hybrid mode, we can retain some low-wavenumber components in the initial lowfrequency inversion to ensure the stability of the inversion, and use more high-wavenumber components in the high-frequency inversion to improve the convergence rate. The results of synthetic data experiment demonstrate that compared to the conventional FWI, the FWI based on the proposed hybrid gradient can effectively reduce the low-wavenumber components in the gradient under the premise of ensuring inversion stability. It also greatly enhances the convergence rate and inversion accuracy,especially in the deep part of the model. And the field marine seismic data experiment also illustrates that the FWI based on hybrid gradient(HGFWI) has good stability and adaptability.

关键词： Full waveform inversion Hybrid gradient Scattering angle weighted Low-wavenumber component

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Precise Planar-Twisted Molecular Engineering to Construct Semiconducting Polymers with Balanced Absorption and Quantum Yield for Efficient Phototheranostics

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Research 2024年第2期2023卷 227-238页

作者： Xiang Su Zhirong Bao Wei Xie Deliang Wang Ting Han Dong Wang ben Zhong tang Center for AIE Research Shenzhen Key Laboratory of Polymer Science and TechnologyGuangdong Research Center for Interfacial Engineering of Functional MaterialsCollege of Materials Science and EngineeringShenzhen UniversityShenzhen 518060China School of Biomedical and Pharmaceutical Sciences Guangdong University of TechnologyGuangzhou 510006China Department of Radiation and Medical Oncology Hubei Key Laboratory of Tumor Biological BehaviorsHubei Cancer Clinical Study CenterZhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Materials Chemistry Huzhou UniversityHuzhou 313000China School of Science and Engineering Shenzhen Institute of Aggregate Science and TechnologyThe Chinese University of Hong KongShenzhenGuangdong 518172China

Semiconducting polymers(SPs)have shown great feasibility as candidates for near-infrared-II(NIR-Ⅱ)fluorescence imaging-navigated photothermal therapy due to their strong light-harvesting ability and flexible ***,the fluorescence signal of traditional SPs tends to quench in their aggregate states owing to the strongπ-πstacking,which can lead to the radiative decay pathway shutting *** address this issue,aggregation-induced emission effect has been used as a rational tactic to boost the aggregate-state fluorescence of NIR-Ⅱ*** this contribution,we developed a precise molecular engineering tactic based on the block copolymerizations that integrate planar and twisted segments into one conjugated polymer backbone,providing great flexibility in tuning the photophysical properties and photothermal conversion capacity of *** monomers featured with twisted and planar architectures,respectively,were tactfully incorporated via a ternary copolymerization approach to produce a series of new *** optimal copolymer(SP2)synchronously shows desirable absorption ability and good NIR-Ⅱquantum yield on the premise of maintaining typical aggregation-induced emission characteristics,resulting in balanced NIR-Ⅱfluorescence brightness and photothermal ***-dispersible nanoparticles fabricated from the optimal SP2 show efficient photothermal therapeutic effects both in vitro and in *** in vivo investigation reveals the distinguished NIR-Ⅱfluorescence imaging performance of SP2 nanoparticles and their photothermal ablation toward tumor with prominent tumor accumulation ability and excellent biocompatibility.

关键词： property. conducting twisted

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