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Pre-Cryogenian integrative stratigraphy,biotas,and paleogeographical evolution of the Qinghai-Tibetan Plateau and its surrounding areas

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Science China Earth Sciences 2024年第4期67卷 899-918页

作者： Peiyuan HU Qingguo ZHAI Guochun ZHAO Peter A.CAWOOD yue tang Yiming LIU Institute of Geology Chinese Academy of Geological SciencesBeijing 100037China Department of Earth Sciences University of Hong KongPokfulam RoadHong Kong 999077China State Key Laboratory of Continental Dynamics Department of GeologyNorthwest UniversityXi’an 710069China School of Earth Atmosphere&EnvironmentMonash UniversityMelbourneVIC 3800Australia

The composition and geological evolution of pre-Cryogenian material in the Tibetan Plateau and its surrounding areas have played an important role in studying the formation and evolution of early supercontinents on *** paper systematically summarizes the characteristics of pre-Cryogenian sedimentation,paleontology,magmatism,and metamorphism in the Tibetan Plateau and its surrounding *** on existing data,the records of pre-Cryogenian sedimentation and paleontology are mainly concentrated in the Meso-Neoproterozoic,with relatively few records from the Paleoproterozoic or *** oldest geological record is the Hadean detrital zircons in the metamorphosed sedimentary rocks of the Himalaya and Qamdo areas(ca.4.0 Ga).The Tibetan Plateau and surrounding areas preserve records related to the formation and evolution of the Kenor supercraton,and the Columbia,Rodinia,and Gondwana ***-Cryogenian basements can be divided into three types:Tarim-,Yangtze-,and *** Tarim-type basement has a paleogeographic affinity with the northern margins of the Australian and Indian continents and lacks detrital zircon age peaks and magmatic-metamorphic records related to the Rodinia assembly(ca.1.3-0.9 Ga).The Yangtze-type basement records volcanic activity related to global cooling in the latest pre-Cryogenian period and contains Meso-Neoproterozoic stromatolite and micropaleoflora fossils,as well as magmaticmetamorphic records related to Rodinia assembly(ca.1.1-1.0 Ga).The Lhasa-type basement is characterized by Neoproterozoic rift-related sediment records(ca.900 Ma)and high-pressure metamorphic events(ca.650 Ma),with a prominent peak of detrital zircon ages of ca.1.2-1.1 *** is likely to have a paleogeographic affinity with the African continent.

关键词： Tibetan Plateau Pre-Cryogenian Sedimentation Fossils Paleogeographic evolution

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AN INTERVIEW WITH PROFESSORS tang CHENG AND yue HUA

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China's Tibet 2013年第5期24卷 42-46页

作者： Chu Qiao yue Hua

On the morning of May 16th in the Village of Jarlama,in the Township Village of Achok in the County of Hongyuan,our interview team finally found Professor tang Cheng and his team *** are experts on veterinary medicine from the School of Life Sciences and Technology in the Southwest University for *** days before,Professor tang Cheng received a call from the

关键词：面试生命科学学院实验设备牦牛犊电话

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Identification of anti-gastric cancer effects and molecular mechanisms of resveratrol: From network pharmacology and bioinformatics to experimental validation

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 493-513页

作者： Ying-Qian Ma Ming Zhang Zhen-Hua Sun Hong-yue tang Ying Wang Jiang-Xue Liu Zhan-Xue Zhang Chao Wang Department of Oncology Hebei General HospitalShijiazhuang 050051Hebei ProvinceChina School of Graduate Studies Hebei Medical UniversityShijiazhuang 050017Hebei ProvinceChina Clinical Medical Research Center Hebei General HospitalShijiazhuang 050051Hebei ProvinceChina Department of Gastrointestinal Surgery Second Hospital of Hebei Medical UniversityShijiazhuang 050000Hebei ProvinceChina

BACKGROUND Gastric cancer(GC)is one of the most aggressive malignancies with limited therapeutic options and a poor ***,a non-flavonoid poly-phenolic compound found in a variety of Chinese medicinal materials,has shown excellent anti-GC ***,its exact mechanisms of action in GC have not been *** To identify the effects of resveratrol on GC progression and explore the related molecular *** Action targets of resveratrol and GC-related targets were screened from public *** overlapping targets between the two were confirmed using a Venn diagram,and a“Resveratrol-Target-GC”network was constructed using Cyto-scape software version *** protein-protein interaction(PPI)network was constructed using STRING database and core targets were identified by PPI network *** Database for Annotation,Visualization and Integrated A total of 378 resveratrol action targets and 2154 GC disease targets were obtained from public databases,and 181 intersection targets between the two were screened by Venn *** top 20 core targets were identified by PPI network analysis of the overlapping *** function analysis mainly involved protein binding,identical protein binding,cytoplasm,nucleus,negative regulation of apoptotic process and response to xenobiotic *** enrichment analysis suggested that the involved signaling pathways mainly included PI3K-AKT signaling pathway,MAPK signaling pathway,IL-17 signaling pathway,TNF signaling pathway,ErbB signaling pathway,*** murine osteosarcoma viral oncogene homolog(FOS)and matrix metallopeptidase 9(MMP9)were selected by differential expression analysis,and they were closely associated with immune *** docking results showed that resveratrol docked well with these two *** treatment arrested the cell cycle at the S phase,induced apoptosis,and weakened viability,migration and invasion in a dose-dependent ***,re

关键词： Resveratrol Gastric cancer Network pharmacology Bioinformatics Molecular docking

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Plexin domain-containing 1 may be a biomarker of poor prognosis in hepatocellular carcinoma patients,may mediate immune evasion

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 2091-2112页

作者： Ming-yue tang Xue Shen Run-Sheng Yuan Hui-Yuan Li Xin-Wei Li Yi-Ming Jing yue Zhang Hong-Hong Shen Zi-Shu Wang Lei Zhou Yun-Chuan Yang He-Xin Wen Fang Su Department of Medical Oncology The First Affiliated Hospital of Bengbu Medical CollegeBengbu 233000Anhui ProvinceChina Otolaryngology and Head and Neck Surgery The First Affiliated Hospital of Bengbu Medical CollegeBengbu 233000Anhui ProvinceChina Department of Neurology The First Affiliated Hospital of Bengbu Medical CollegeBengbu 233000Anhui ProvinceChina Department of Hepatobiliary Surgery The First Affiliated Hospital of Bengbu Medical CollegeBengbu 233000Anhui ProvinceChina Department of Gastrointestinal Surgery The First Affiliated Hospital of Bengbu Medical CollegeBengbu 233000Anhui ProvinceChina

BACKGROUND For the first time,we investigated the oncological role of plexin domain-containing 1(PLXDC1),also known as tumor endothelial marker 7(TEM7),in hepatocellular carcinoma(HCC).AIM To investigate the oncological profile of PLXDC1 in *** Based on The Cancer Genome Atlas database,we analyzed the expression of PLXDC1 in *** immunohistochemistry,quantitative real-time polymerase chain reaction(qRT-PCR),and Western blotting,we validated our *** prognostic value of PLXDC1 in HCC was analyzed by assessing its correlation with clinicopathological features,such as patient survival,methylation level,tumor immune microenvironment features,and immune cell surface checkpoint ***,to assess the immune evasion potential of PLXDC1 in HCC,we used the tumor immune dysfunction and exclusion(TIDE)website and immunohistochemical staining *** Based on immunohistochemistry,qRT-PCR,and Western blot assays,overexpression of PLXDC1 in HCC was associated with poor *** and multivariate Cox analyses indicated that PLXDC1 might be an independent prognostic *** HCC patients with high methylation levels,the prognosis was worse than in patients with low methylation *** enrichment analysis of HCC tissues indicated that genes upregulated in the high-PLXDC1 subgroup were enriched in mesenchymal and immune activation signaling,and TIDE assessment showed that the risk of immune evasion was significantly higher in the high-PLXDC1 subgroup compared to the low-PLXDC1 *** high-risk group had a significantly lower immune evasion rate as well as a poor prognosis,and PLXDC1-related risk scores were also associated with a poor *** As a result of this study analyzing PLXDC1 from multiple biological perspectives,it was revealed that it is a biomarker of poor prognosis for HCC patients,and that it plays a role in determining immune evasion status.

关键词： Plexin domain-containing 1 Biomarker Immune evasion Prognosis Immunotherapy Hepatocellular carcinoma

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Rapid identification of full-length genome and tracing variations of monkeypox virus in clinical specimens based on mNGS and amplicon sequencing

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Virologica Sinica 2024年第1期39卷 134-143页

作者： Changcheng Wu Ruhan A Sheng Ye Fei Ye Weibang Huo Roujian Lu yue tang Jianwei Yang Xuehong Meng Yun tang Shuang Chen Li Zhao Baoying Huang Zhongxian Zhang Yuda Chen Dongfang Li Wenling Wang Ke-jia Shan Jian Lu Wenjie Tan NHC Key Laboratory of Biosafety National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing100052China Chongqing Municipal Key Laboratory for High Pathogenic Microbes Chongqing Center for Disease Control and PreventionChongqing400042China MGI BGI-ShenzhenShenzhen518083China Thermo Fisher Scientific Beijing100013China School of Public Health Baotou Medical CollegeBaotou014030China BGI PathoGenesis Pharmaceutical Technology Shenzhen518000China State Key Laboratory of Protein and Plant Gene Research Center for BioinformaticsSchool of Life SciencesPeking UniversityBeijing100871China College of Life Sciences University of Chinese Academy of SciencesBeijing100049China

The monkeypox virus(MPXV)has triggered a current outbreak *** sequencing of MPXV and rapid tracing of genetic variants will benefit disease diagnosis and *** is a significant challenge but necessary to optimize the strategy and application of rapid full-length genome identification and to track variations of MPXV in clinical specimens with low viral loads,as it is one of the DNA viruses with the largest genome and the most AT-biased,and has a significant number of tandem *** we evaluated the performance of metagenomic and amplicon sequencing techniques,and three sequencing platforms in MPXV genome sequencing based on multiple clinical specimens of five mpox cases in Chinese *** rapidly identified the full-length genome of MPXV with the assembly of accurate tandem repeats in multiple clinical *** sequencing enables cost-effective and rapid sequencing of clinical specimens to obtain high-quality MPXV ***-generation sequencing facilitates the assembly of the terminal tandem repeat regions in the monkeypox virus genome and corrects a common misassembly in published ***,several intra-host single nucleotide variations were identified in the first imported mpox *** study offers an evaluation of various strategies aimed at identifying the complete genome of MPXV in clinical *** findings of this study will significantly enhance the surveillance of MPXV.

关键词： Monkeypox virus(MPXV) Metagenomic Next generation sequencing Amplicon Third-generation sequencing

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Protein tyrosine phosphatase non-receptor Ⅱ:A possible biomarker of poor prognosis and mediator of immune evasion in hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2024年第9期16卷 3913-3931页

作者： Hui-Yuan Li Yi-Ming Jing Xue Shen Ming-yue tang Hong-Hong Shen Xin-Wei Li Zi-Shu Wang Fang Su Department of Medical Oncology The First Affiliated Hospital of Bengbu Medical UniversityBengbu 233000Anhui ProvinceChina Department of Neurology The First Affiliated Hospital of Bengbu Medical UniversityBengbu 233000Anhui ProvinceChina

BACKGROUND The incidence of primary liver cancer is increasing year by *** 2022 alone,more than 900000 people were diagnosed with liver cancer worldwide,with hepatocellular carcinoma(HCC)accounting for 75%-85%of *** is the most common primary liver *** has the highest incidence and mortality rate of HCC in the world,and it is one of the malignant tumors that seriously threaten the health of Chinese *** onset of liver cancer is occult,the early cases lack typical clinical symptoms,and most of the patients are already in the middle and late stage when ***,it is very important to find new markers for the early detection and diagnosis of liver cancer,improve the therapeutic effect,and improve the prognosis of *** tyrosine phosphatase non-receptor 2(PTPN2)has been shown to be associated with colorectal cancer,triple-negative breast cancer,non-small cell lung cancer,and prostate cancer,but its biological role and function in tumors remain to be further *** To combine the results of relevant data obtained from The Cancer Genome Atlas(TCGA)to provide the first in-depth analysis of the biological role of PTPN2 in *** The expression of PTPN2 in HCC was first analyzed based on the TCGA database,and the findings were then verified by immunohistochemical staining,quantitative real-time polymerase chain reaction(qRT-PCR),and *** value of PTPN2 in predicting the survival of patients with HCC was assessed by analyzing the relationship between PTPN2 expression in HCC tissues and clinicopathological ***,the potential of PTPN2 affecting immune escape of liver cancer was evaluated by tumor immune dysfunction and exclusion and immunohistochemical *** The results of immunohistochemical staining,qRT-PCR,and immunoblotting in combination with TCGA database analysis showed that PTPN2 was highly expressed and associated with a poor prognosis in HCC *** Encyclopedia of Ge

关键词： Protein tyrosine phosphatase non-receptor 2 Hepatocellular carcinoma Immune evasion Biomarker Immunotherapy Prognosis

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兆瓦级高速永磁电机新型转子冷却结构研究

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电机与控制学报 2024年第5期28卷 38-47页

作者：蔡蔚牛金花唐跃哈尔滨理工大学电气与电子工程学院黑龙江哈尔滨150080

兆瓦级高速永磁电机转子侧无强迫冷却措施时转子侧温升高、永磁体失磁风险高,基于此问题,提出一种新型的加强筋转子轴向通风结构,该结构能够提高转子侧的壁面对流散热系数、提升转子侧的散热能力、降低电机温度。以一台1 MW、18000 r/mi... 详细信息

兆瓦级高速永磁电机转子侧无强迫冷却措施时转子侧温升高、永磁体失磁风险高,基于此问题,提出一种新型的加强筋转子轴向通风结构,该结构能够提高转子侧的壁面对流散热系数、提升转子侧的散热能力、降低电机温度。以一台1 MW、18000 r/min的高速永磁电机为例,建立该电机的三维全域流固耦合求解模型,基于计算流体力学和有限元法对电机流体场与温度场进行分析,揭示电机在额定工况下的流体与温度分布规律。将新冷却结构与传统冷却结构的散热性能及温升变化进行对比,验证新型冷却结构在提升电机散热性能方面的有效性。最后,分析入口风速对电机最高温度的影响,得到适合该冷却结构的入口风速范围,为外部风压设备的选择提供理论支撑。

关键词：兆瓦级高速永磁电机电机损耗转子通风冷却流体场温度场冷却结构优化

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Serum LDL Promotes Microglial Activation and Exacerbates Demyelinating Injury in Neuromyelitis Optica Spectrum Disorder

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Neuroscience Bulletin 2024年第8期40卷 1104-1114页

作者： Man Chen Yun‑Hui Chu Wen‑Xiang Yu Yun‑Fan You yue tang Xiao‑Wei Pang Hang Zhang Ke Shang Gang Deng Luo‑Qi Zhou Sheng Yang Wei Wang Jun Xiao Dai‑Shi Tian Chuan Qin Department of Neurology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Hubei Key Laboratory of Neural Injury and Functional Reconstruction Huazhong University of Science and TechnologyWuhan 430030China Department of Neurology Hainan General HospitalHainan Affiliated Hospital of Hainan Medical UniversityHaikou 570311China

Neuromyelitis optica spectrum disorder(NMOSD)is an autoimmune inflammatory demyelinating disease of the central nervous system(CNS)accompanied by blood-brain barrier(BBB)*** in microglial lipid metabolism is believed to be closely associated with the neuropathology of ***,there is limited evidence on the functional relevance of circulating lipids in CNS demyelination,cellular metabolism,and microglial ***,we found that serum low-density lipoprotein(LDL)was positively correlated with markers of neurological damage in NMOSD *** addition,we demonstrated in a mouse model of NMOSD that LDL penetrates the CNS through the leaky BBB,directly activating *** activation leads to excessive phagocytosis of myelin debris,inhibition of lipid metabolism,and increased glycolysis,ultimately exacerbating myelin *** also found that therapeutic interventions aimed at reducing circulating LDL effectively reversed the lipid metabolic dysfunction in microglia and mitigated the demyelinating injury in *** findings shed light on the molecular and cellular mechanisms underlying the positive correlation between serum LDL and neurological damage,highlighting the potential therapeutic target for lowering circulating lipids to alleviate the acute demyelinating injury in NMOSD.

关键词： Neuromyelitis optica spectrum disorder Low-density lipoprotein Microglia

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开发区与僵尸企业形成:促进还是抑制

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科学学研究 2024年第3期42卷 605-613页

作者：唐锦玥罗守贵上海交通大学安泰经济与管理学院上海200030 上海市知识竞争力与区域发展研究中心上海200030

僵尸企业的存在降低了经济发展的质量,扭曲了资源配置,清退僵尸企业和抑制僵尸企业的形成是经济高质量发展的客观要求,也是区域经济健康发展的必然选择。与已有研究主要关注制造业中僵尸企业存在情况有所不同,本文基于2008-2018年上海... 详细信息

僵尸企业的存在降低了经济发展的质量,扭曲了资源配置,清退僵尸企业和抑制僵尸企业的形成是经济高质量发展的客观要求,也是区域经济健康发展的必然选择。与已有研究主要关注制造业中僵尸企业存在情况有所不同,本文基于2008-2018年上海市科技企业数据库,探讨了开发区政策对僵尸企业形成的影响。研究发现,样本中僵尸企业占比为12.8%,开发区抑制了僵尸企业的形成,使得企业成为僵尸企业的概率降低0.6%。替换被解释变量、改用倾向得分匹配、控制样本区位后重新估计,结果依然稳健。机制研究表明,开发区通过促进创新抑制了企业成为僵尸,但开发区直接的财政补贴资源增加会提高企业成为僵尸企业的概率。为此,建议应科学识别僵尸企业,采取更多普惠性政策来规避僵尸企业的机会主义寻租倾向,营造创新集聚和正外部性强的可持续发展环境。

关键词：僵尸企业开发区科技企业上海市

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中国式现代化视域下文化产业发展新维度

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艺术百家 2024年第1期40卷 41-47页

作者：唐月民山东艺术学院艺术管理学院山东济南250300

文化产业发展需要面向现代化。在中国式现代化视域下,主体、目标、价值、客体、空间五个维度赋予了文化产业新意蕴。人口规模巨大、全体人民共同富裕、物质文明和精神文明相协调、人与自然和谐共生、走和平发展道路是理解文化产业新维... 详细信息

文化产业发展需要面向现代化。在中国式现代化视域下,主体、目标、价值、客体、空间五个维度赋予了文化产业新意蕴。人口规模巨大、全体人民共同富裕、物质文明和精神文明相协调、人与自然和谐共生、走和平发展道路是理解文化产业新维度的核心。文化产业是现代化建设的重要一极,在不同国家和地区,文化产业发展面对的挑战各不相同,而文化产业新维度为文化产业现代化道路提供了新思路,立足人类命运共同体理念,发展既有民族特色又有世界眼光的文化产业是解决文化产业现代化难题的关键要素。

关键词：中国式现代化文化产业新维度文化产业现代化

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