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Investigation of the influences of asphaltene deposition on oilfield development using reservoir simulation

Petroleum Exploration and development 2022年第5期49卷 1138-1149页

作者： tananykhin d s sTRUCHKOV I A KHORMALI A ROsCHIN P V saint-Petersburg Mining University Saint-Petersburg 199106Russia LLC Tyumen Petroleum Research Center Tyumen 625000Russia department of Chemistry Faculty of Basic Sciences and EngineeringGonbad Kavous UniversityGonbad Kavous 49717-99151Iran LLC samaraNIPIneft Samara 443010Russia

This paper investigates the deposition of asphaltenes in the porous medium of the studied field in Russia and predicts production profiles based on uncertainty evaluation. This problem can be solved by dynamic modeling, during which production profiles are estimated in two scenarios: with and without the activation of the asphaltene option. Calculations are carried out for two development scenarios: field operation under natural depletion and water injection into the aquifer as a reservoir pressure maintenance system. A full-scale compositional reservoir simulation model of the Russian oilfield was created. Within a dynamic simulation, the asphaltene option was activated and the asphaltene behavior in oil and porous medium was tuned according to our own special laboratory experiments. The model was also matched to production historical data, and a pattern model was prepared using the full-scale simulation model. Technological and the asphaltene option parameters were used in sensitivity and an uncertainty evaluation. Furthermore, probable production profiles within a forecast period were estimated. The sensitivity analysis of the pattern model to input parameters of the asphaltene option allowed determining the following heavy-hitters on the objective function: the molar weight of dissolved asphaltenes as a function of pressure, the asphaltene dissociation rate, the asphaltene adsorption coefficient and the critical velocity of oil movement in the reservoir. Under the natural depletion scenario, our simulations show a significant decrease in reservoir pressure and the formation of drawdown cones leading to asphaltene deposition in the bottom-hole area of production wells, decreasing their productivity. Water injection generally allows us to significantly reduce the volume of asphaltene phase transitions and has a positive effect on cumulative oil production. Injecting water into aquifer can keep the formation pressure long above the pressure for asphaltene precipitation, preventing the asphaltene deposition resul

关键词： oilfield development asphaltene deposition uncertainty evaluation sensitivity analysis compositional reservoir simulation

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基于数值模拟研究沥青质沉积对油田开发的影响

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石油勘探与开发 2022年第5期49卷 987-995页

作者： tananykhin d s sTRUCHKOV I A KHORMALI A ROsCHIN P V 俄罗斯圣彼得堡矿业大学石油学院俄罗斯圣彼得堡199106 独联体秋明石油研究中心俄罗斯秋明625000 伊朗冈巴德卡沃斯大学伊朗冈巴德卡沃斯49717-99151 独联体samaraNIPIneft公司俄罗斯萨马拉443010

以俄罗斯某油田为例,建立了全油田组分油藏模型,通过动态模拟研究了沥青质在研究区内多孔介质中的沉积,并基于不确定性评估预测了生产剖面。模拟中考虑了激活和不激活沥青质选项这两种情况,以及衰竭式开采和注水保压开采这两种开发方式... 详细信息

以俄罗斯某油田为例,建立了全油田组分油藏模型,通过动态模拟研究了沥青质在研究区内多孔介质中的沉积,并基于不确定性评估预测了生产剖面。模拟中考虑了激活和不激活沥青质选项这两种情况,以及衰竭式开采和注水保压开采这两种开发方式。激活沥青质选项时,根据室内实验结果调整沥青质在原油和多孔介质中的动态特征。通过对沥青质选项参数的敏感性分析确定了对多变量历史拟合目标函数影响最大的输入参数,包括决定溶解沥青质摩尔分数的系数、沥青质解离率、沥青质吸附系数和油层中原油流动临界速率。研究表明:在衰竭式开采条件下,油藏压力显著下降并形成压降漏斗,导致生产井井底沥青质沉积,产能降低;通过注水可以显著减少沥青质沉积量,提高累计产油量;水层注水可使地层压力长期保持在沥青质初始析出压力以上,并避免油水相互作用促进沥青质沉积,因而相对油层注水累计产油量较高。

关键词：油田开发沥青质沉积不确定性评估敏感性分析组分模拟

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Generalized polynomial chaos expansion by reanalysis using static condensation based on substructuring

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Applied Mathematics and Mechanics(English Edition) 2024年第5期45卷 819-836页

作者： d.LEE s.CHANG J.LEE department of Automotive Engineering Hanyang UniversitySeoul 04763Republic of Korea school of Mechanical Engineering Chungnam National UniversityDaejeon 34134Republic of Korea department of Mechanical Robotics and Energy EngineeringDongguk UniversitySeoul 04620Republic of Korea

This paper presents a new computational method for forward uncertainty quantification(UQ)analyses on large-scale structural systems in the presence of arbitrary and dependent random inputs.The method consists of a generalized polynomial chaos expansion(GPCE)for statistical moment and reliability analyses associated with the stochastic output and a static reanalysis method to generate the input-output data set.In the reanalysis,we employ substructuring for a structure to isolate its local regions that vary due to random inputs.This allows for avoiding repeated computations of invariant substructures while generating the input-output data set.Combining substructuring with static condensation further improves the computational efficiency of the reanalysis without losing accuracy.Consequently,the GPCE with the static reanalysis method can achieve significant computational saving,thus mitigating the curse of dimensionality to some degree for UQ under high-dimensional inputs.The numerical results obtained from a simple structure indicate that the proposed method for UQ produces accurate solutions more efficiently than the GPCE using full finite element analyses(FEAs).We also demonstrate the efficiency and scalability of the proposed method by executing UQ for a large-scale wing-box structure under ten-dimensional(all-dependent)random inputs.

关键词： forward uncertainty quantification(UQ) generalized polynomial chaos expansion(GPCE) static reanalysis method static condensation substructuring

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Flexible ultra-thin super-resolution endoscopy

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science China(Physics,Mechanics & Astronomy) 2024年第3期67卷 171-172页

作者： George s.d.Gordon department of Electrical and Electronic Engineering University of NottinghamNottingham NG7 2RDUK

In recent years, multimode fiber(MMF) has become an important tool for high-resolution endoscopic imaging in narrow channels(e.g., in the brain via needles or inside blood vessels) due to its high mode density and fine diameter, typically stacle to widespread deployment in applications is that realistic perturbations, including bending, twisting and changes in temperature, cause unacceptable image degradation.

关键词： fiber resolution typically

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Ion heat transport in electron cyclotron resonance heated L-mode plasma on the T-10 tokamak

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Plasma science and Technology 2024年第4期26卷 52-60页

作者： V.A.KRUPIN M.R.NURGALIEV A.R.NEMETs I.A.ZEMTsOV s.d.sUNTsOV T.B.MYALTON d.s.sERGEEV N.A.sOLOVEV d.V.sARYCHEV d.V.RYJAKOV s.N.TUGARINOV N.N.NAUMENKO National Research Centre“Kurchatov Institute” Moscow 123182Russia Bauman Moscow state Technical University Moscow 105005Russia Institution“Project Center ITER” Moscow 123098Russia JsC“sOLAR” Minsk 220034Belarus

Anomalous ion heat transport is analyzed in the T-10 tokamak plasma heated with electron cyclotron resonance heating(ECRH) in second-harmonic extra-ordinary mode. Predictive modeling with empirical scaling for Ohmical heat conductivity shows that in ECRH plasmas the calculated ion temperature could be overestimated, so an increase of anomalous ion heat transport is required. To study this effect two scans are presented: over the EC resonance position and over the ECRH power. The EC resonance position varies from the high-field side to the low-field side by variation of the toroidal magnetic field. The scan over the heating power is presented with on-axis and mixed ECRH regimes. discharges with high anomalous ion heat transport are obtained in all considered regimes. In these discharges the power balance ion heat conductivity exceeds the neoclassical level by up to 10 times. The high ion heat transport regimes are distinguished by three parameters: the ratio Te/Ti, the normalized electron density gradient R/■, and the ion–ion collisionality νii~*. The combination of high Te/Ti, high νii~*, and R/■=6-10 results in values of normalized anomalous ion heat fluxes up to 10 times higher than in the low transport scenario.

关键词： tokamak L-mode electron cyclotron resonance heating ion heat transport

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The dorsal root ganglion as a target for neurorestoration in neuropathic pain

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Neural Regeneration Research 2024年第2期19卷 296-301页

作者： Guillermo Estivill-Torrús Ana Belen Martínez-Padilla Lourdes sánchez-salido Anne Baron-Van Evercooren Beatriz García-díaz Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina(IBIMA Plataforma BIONANd) MálagaSpain Unidad Clínica de Neurociencias Hospital Regional Universitario de MálagaMálagaSpain departamento de Biología Molecular y Bioquímica Universidad de MálagaSpain sorbonne Université Institut du Cerveau-Paris Brain Institute-ICMINSERMCNRSAP-HPHôpital Pitié-SalpêtrièreParisFrance

Neuropathic pain is a severe and chronic condition widely found in the general population.The reason for this is the extensive variety of damage or diseases that can spark this unpleasant constant feeling in patients.during the processing of pain,the dorsal root ganglia constitute an important region where dorsal root ganglion neurons play a crucial role in the transmission and propagation of sensory electrical stimulation.Furthermore,the dorsal root ganglia have recently exhibited a regenerative capacity that should not be neglected in the understanding of the development and resolution of neuropathic pain and in the elucidation of innovative therapies.Here,we will review the complex interplay between cells(satellite glial cells and inflammatory cells)and factors(cytokines,neurotrophic factors and genetic factors)that takes place within the dorsal root ganglia and accounts for the generation of the aberrant excitation of primary sensory neurons occurring in neuropathic pain.More importantly,we will summarize an updated view of the current pharmacologic and nonpharmacologic therapies targeting the dorsal root ganglia for the treatment of neuropathic pain.

关键词： cytokines dorsal root ganglia genetic factors neuropathic pain neurotrophic factors pharmacologic and nonpharmacologic therapies satellite glial cells sensory neurons

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The magnetosheath at high spectral resolution

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Earth and Planetary Physics 2024年第1期8卷 234-246页

作者： K.d.Küntz d.Koutroumpa W.R.dunn A.Foster F.s.Porter d.G.sibeck B.Walsh The Henry A.Rowland department of Physics and Astronomy Johns Hopkins University3701 San Martin DriveBaltimoreMD21218USA NAsA Goddard space Flight Center 8800 Greenbelt RoadGreenbeltMD 20771USA LATMOs-OVsQ CNRSUVSQ Paris-SaclaySorbonne Université11 Boulevard d’Alembert78280GuyancourtFrance department of Physics and Astronomy University College LondonLondonUK The Centre for Planetary science at UCL/Birkbeck Gower StreetLondon WC1E 6BTUK Center for Astrophysics Harvard University&Smithsonian Institution60 Garden StreetCambridgeMA 02138USA Center for space Physics Boston University110 Cummington MallBostonMAUSA

While we eagerly anticipate sMILE’s(solar wind Magnetosphere Ionosphere Link Explorer)unprecedented X-ray observations of the Earth’s magnetosheath and the initiation of a new era of magnetospheric research,it seems appropriate to look ahead to the abilities of the next generation of astrophysics missions.Of these,the Line Emission Mapper(LEM),a large aperture micro-calorimeter based mission,is currently planned to be able to observe the magnetosheath at high spectral resolution(~2 eV).With a field of view of~30′,LEM will allow higher spatial resolution and higher cadence measurement of the motion of a very small portion of the magnetopause over relatively short periods of time(multiple hours),complementing sMILE’s global mapping.LEM’s strength is its spectral resolution.It will be able to measure the abundance of a broad range of elements and ionization states,many of which are inaccessible to current in situ instruments,and will be able to separate the emission from the magnetosheath from the emission from the cosmic X-ray background using the difference in their relative velocities.

关键词： magnetosheath charge exchange solar wind abundances

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Liquid biopsy for gastric cancer:Techniques,applications,and future directions

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World Journal of Gastroenterology 2024年第12期30卷 1680-1705页

作者： Cristina díaz del Arco M Jesús Fernández Aceñero Luis Ortega Medina department of surgical Pathology Health Research Institute of the Hospital Clínico San CarlosHospital Clínico San CarlosMadrid 28040Spain department of Legal Medicine Psychiatry and PathologyUniversidad Complutense de MadridMadrid 28040Spain

After the study of circulating tumor cells in blood through liquid biopsy(LB),this technique has evolved to encompass the analysis of multiple materials originating from the tumor,such as nucleic acids,extracellular vesicles,tumor-educated platelets,and other metabolites.Additionally,research has extended to include the examination of samples other than blood or plasma,such as saliva,gastric juice,urine,or stool.LB techniques are diverse,intricate,and variable.They must be highly sensitive,and pre-analytical,patient,and tumor-related factors significantly influence the detection threshold,diagnostic method selection,and potential results.Consequently,the implementation of LB in clinical practice still faces several challenges.The potential applications of LB range from early cancer detection to guiding targeted therapy or immunotherapy in both early and advanced cancer cases,monitoring treatment response,early identification of relapses,or assessing patient risk.On the other hand,gastric cancer(GC)is a disease often diagnosed at advanced stages.despite recent advances in molecular understanding,the currently available treatment options have not substantially improved the prognosis for many of these patients.The application of LB in GC could be highly valuable as a non-invasive method for early diagnosis and for enhancing the management and outcomes of these patients.In this comprehensive review,from a pathologist’s perspective,we provide an overview of the main options available in LB,delve into the fundamental principles of the most studied techniques,explore the potential utility of LB application in the context of GC,and address the obstacles that need to be overcome in the future to make this innovative technique a game-changer in cancer diagnosis and treatment within clinical practice.

关键词： Liquid biopsy Gastric cancer Circulating tumor cells Cell-free dNA Circulating tumor dNA Molecular

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Metabolomics for the diagnosis of bladder cancer: A systematic review

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Asian Journal of Urology 2024年第2期11卷 221-241页

作者： Herney Andrés García-Perdomo Angélica María dávila-Raigoza Fernando Korkes division of Urology/Urooncology Department of SurgerySchool of MedicineUniversidad del ValleCaliColombia UROGIV Research Group School of MedicineUniversidad del ValleCaliColombia Urologic Oncology Division of UrologyABC Medical SchoolSao PauloBrazil

Objective: Metabolomics has been extensively utilized in bladder cancer (BCa) research, employing mass spectrometry and nuclear magnetic resonance spectroscopy to compare various variables (tissues, serum, blood, and urine). This study aimed to identify potential biomarkers for early BCa diagnosis.Methods: A search strategy was designed to identify clinical trials, descriptive and analytical observational studies from databases such as Medline, Embase, Cochrane Central Register of Controlled Trials, and Latin American and Caribbean Literature in Health sciences. Inclusion criteria comprised studies involving BCa tissue, serum, blood, or urine profiling using widely adopted metabolomics techniques like mass spectrometry and nuclear magnetic resonance. Primary outcomes included description of metabolites and metabolomics profiling in BCa patients and the association of metabolites and metabolomics profiling with BCa diagnosis compared to control patients. The risk of bias was assessed using the Quality Assessment of studies of diagnostic Accuracy.Results: The search strategy yielded 2832 studies, of which 30 case-control studies were included. Urine was predominantly used as the primary sample for metabolite identification. Risk of bias was often unclear inpatient selection, blinding of the index test, and reference standard assessment, but no applicability concerns were observed. Metabolites and metabolomics profiles associated with BCa diagnosis were identified in glucose, amino acids, nucleotides, lipids, and aldehydes metabolism.Conclusion: The identified metabolites in urine included citric acid, valine, tryptophan, taurine, aspartic acid, uridine, ribose, phosphocholine, and carnitine. Tissue samples exhibited elevated levels of lactic acid, amino acids, and lipids. Consistent findings across tissue, urine, and serum samples revealed downregulation of citric acid and upregulation of lactic acid, valine, tryptophan, taurine, glutamine, aspartic acid, uridine, ribose, and phosphocholine.

关键词： Metabolite Metabolomics Bladder cancer Metabolomicsprofile

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Estradiol increases cortical and trabecular bone accrual and bone strength in an adolescent male-to-female mouse model of gender-affirming hormone therapy

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Bone Research 2024年第1期12卷 95-106页

作者： Tian Nie Varun s.Venkatesh suzanne Golub Kathryn s.stok Haniyeh Hemmatian Reena desai david J.Handelsman Jeffrey d.Zajac Mathis Grossmann Rachel A.davey department of Medicine Austin HealthUniversity of MelbourneHeidelbergVIC 3084Australia department of Biomedical Engineering University of MelbourneParkvilleVIC 3010Australia ANZAC Research Institute University of Sydney and AndrologyConcord Repatriation General HospitalConcordNSW 2137Australia

The effects of gender-affirming hormone therapy on the skeletal integrity and fracture risk in transitioning adolescent trans girls are unknown.To address this knowledge gap,we developed a mouse model to simulate male-to-female transition in human adolescents in whom puberty is first arrested by using gonadotrophin-releasing hormone analogs with subsequent estradiol treatment.Puberty was suppressed by orchidectomy in male mice at 5 weeks of age.At 3 weeks post-surgery,male-to-female mice were treated with a high dose of estradiol(~0.85 mg)by intraperitoneal silastic implantation for 12 weeks.Controls included intact and orchidectomized males at 3 weeks post-surgery,vehicle-treated intact males,intact females and orchidectomized males at 12 weeks post-treatment.Compared to male controls,orchidectomized males exhibited decreased peak bone mass accrual and a decreased maximal force the bone could withstand prior to fracture.Estradiol treatment in orchidectomized male-to-female mice compared to mice in all control groups was associated with an increased cortical thickness in the mid-diaphysis,while the periosteal circumference increased to a level that was intermediate between intact male and female controls,resulting in increased maximal force and stiffness.In trabecular bone,estradiol treatment increased newly formed trabeculae arising from the growth plate as well as mineralizing surface/bone surface and bone formation rate,consistent with the anabolic action of estradiol on osteoblast proliferation.These data support the concept that skeletal integrity can be preserved and that long-term fractures may be prevented in trans girls treated with GnRHa and a sufficiently high dose of GAHT.Further study is needed to identify an optimal dose of estradiol that protects the bone without adverse side effects.

关键词： treatment treatment strength

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