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Effectiveness of co-treatment with traditional Chinese medicine and letrozole for polycystic ovary syndrome:a meta-analysis

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Journal of Integrative Medicine 2017年第2期15卷 95-101页

作者： Qian-wen Ma yong tan The First Clinical Medical College Nanjing University of Chinese Medicine Department of Gynecology Zhenjiang Hospital of Traditional Chinese Medicine

BACKGROUND： Polycystic ovary syndrome （PCOS） is an endocrine disease that affects gynecologica health. Treatment of PCOS remains a big challenge for clinicians. OBJECTIVE： This meta-analysis was developed to compare the efficacy of co-treatment with traditiona Chinese medicine （TCM） and letrozole against letrozole monotherapy in the treatment of PCOS. SEARCH STRATEGY： Randomized controlled trials （RCTs） were electronically retrieved from PubMed, Cochrane Library, China Biomedical Literature Database, China National Knowledge Infrastructure and Wanfang Data; related papers that were not available electronically were manually checked. All papers were assessed according to the Cochrane Handbook for Systematic Reviews of Interventions and the valid data were analyzed using Revman software （The Cochrane Collaboration, Copenhagen, Denmark） INCLUSION CRITERIA： We included RCTs that compared co-treatment with TCM and letrozole against letrozole monotherapy in women with PCOS, which was defined by anovulation, biochemical or clinical hyperandrogenemia and polycystic ovaries. We included trials from all sources. DATA EXTRACTION AND ANALYSIS： Two independent reviewers extracted data, and evaluated study quality according to the Cochrane Handbook for Systematic Reviews of Interventions criteria for RCT, including issues of patient randomization, blinding and bias. RESULTS： Eight RCTs, involving a total of 537 patients, were included in the present study. The meta-analysis showed that the cycle ovulation rate, the pregnancy rate and the total effective rate of symptom treatment were higher in treatments combining TCM with letrozole, compared with letrozole monotherapy. Although the rate of luteinizing hormone （LH）/follicle-stimulating hormone （FSH） and the body mass index of the group receiving combined therapy were lower than in letrozole monotherapy, no statistical difference was found in the LH and FSH level between the two groups. CONCLUSION： Available evidence showed that c

关键词： medicine, Chinese traditional letrozole polycystic ovary syndrome meta-analysis

Effectiveness of nourishing Yin and tonifying Yang sequential therapy in combination with Climen on diminished ovarian reserve: a retrospective study

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Journal of Traditional Chinese Medicine 2020年第1期40卷 150-156页

作者： Sun Yuying tan yong Chen Shuping Department of Reproductive Medicine The First Clinical Medical CollegeNanjing University of Traditional Chinese MedicineNanjingJiangsu 210029China Department of Gynecology Changzhou Hospital of Traditional Chinese MedicineChangzhouJiangsu 213003China

OBJECTIVE:To evaluate the clinical efficacy of nourishing Yin and tonifying Yang sequential therapy(NYTYST)in combination with the Western Medicine Climen in treating diminished ovarian reserve(DOR).METHODS:From September 2014 to September2016,46 patients with DOR who received NYTYST and Climen(treatment group)and 51 patients who received Climen only(control group)at the Jiangsu Provincial Traditional Chinese Medicine Hospital(Nanjing,China)were retrospectively *** and at 3 months after treatment,serum levels of follicle-stimulating hormone(FSH),FSH/luteinizing hormone(LH),estradiol(E2),and anti-Mullerian hormone(AMH),the antral follicle count(AFC),stromal peak systolic velocity(PSV),symptom scores,and the clinical effectiveness rate were measured and compared between the two ***:After treatment,serum levels of FSH,FSH/LH and E2,and symptom scores were significantly decreased compared with before treatment(all P<0.05)in the two *** levels,AFC,and PSV were significantly increased after treatment compared with before treatment in both groups(all P<0.05).Serum levels of FSH,FSH/LH,and E2 after treatment were significantly lower in the treatment group than in the control group(all P<0.05).However,AMH levels and the AFC were significantly higher after treatment in the treatment group than in the control group(both P<0.05).The clinical effectiveness rate was significantly higher in the treatment group than in the control group(87%vs 68.6%,P<0.05).CONCLUSION:NYTYST combined with Climen may be more effective in treating DOR than Climen alone.

关键词： Diminished Ovarian reserve Nourishing Yin Reinforcing Yang Sequential therapy Estradiol valerate,cyproterone acetate drug combination Retrospective studies

Immunoregulatory effects of Tripterygium wilfordii Hook Fand its extracts in clinical practice

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Frontiers of Medicine 2019年第5期13卷 556-563页

作者： Dan Luo Zhengyun Zuo Hongyan Zhao yong tan Cheng Xiao Traditional Chinese Medicine Hospital of Changping District Beijing 102200China Institute of Clinical Medicine China-Japan Friendship HospitalBeijing 100029China Jiangxi University of Traditional Chinese Medicine Nanchang 330004China Experimental Research Center China Academy of Chinese Medical SciencesBeijing 100070China Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijing 100070China

Tripterygium wilfordii Hook F (TwHF) and its extracts have long been used for the treatment of rheumatoid arthritis, autoimmune diseases, and kidney disease due to their anti-inflammatory, immunoregulatory, and other pharmacological effects. However, the clinical immunoregulatory effects of TwHF and its extracts remain unclear, so we reviewed their effects for use in clinical practice. This review provides a comprehensive summary of the recent literature on the immunoregulatory effects of TwHF and its extracts in clinical studies. TwHF and its extracts affect the proliferation and activation of T and B cells;ratio of T cell subsets;inflammatory response of monocytes, macrophages, and immunoglobulins;and secretion of many cytokines. Together, these effects dictate immune function in a variety of diseases. TwHF and its extracts can be used alone or in combination with existing therapies against many immune disorders through immunomodulation.

关键词： Tripterygium mlfordii Hook F immunoregulation clinical studies

人工光环境对雌性豚鼠生殖内分泌的影响及日钟阴阳方的干预作用

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中国中西医结合杂志 2021年第12期41卷 1468-1475页

作者：施加裕谈勇南京中医药大学第一临床医学院南京210029 南京中医药大学附属医院生殖医学科南京210001

目的研究人工光环境对雌性豚鼠生殖内分泌的影响及日钟阴阳方对雌性豚鼠下丘脑中吻素Kisspeptin及吻素受体(KISS1R)的作用机制。方法将3月龄雌性豚鼠按体重的大小从1到36编号,获取随机数字,按余数分为6组,分别为自然光组、自然光食疗组... 详细信息

目的研究人工光环境对雌性豚鼠生殖内分泌的影响及日钟阴阳方对雌性豚鼠下丘脑中吻素Kisspeptin及吻素受体(KISS1R)的作用机制。方法将3月龄雌性豚鼠按体重的大小从1到36编号,获取随机数字,按余数分为6组,分别为自然光组、自然光食疗组、LED灯组、LED灯食疗组、荧光灯组和荧光灯食疗组,每组6只。用日钟阴阳方对自然光食疗组、LED灯食疗组、荧光灯食疗组进行干预12周。饲养12周后,于动情前期取材,HE染色,电镜下观察卵巢形态;ELISA测定豚鼠血清中雌二醇(E2)、促黄体生成素(LH)、促卵泡生成素(FSH)、睾酮(T)、抗苗勒氏管激素(AMH)、泌乳素(PRL)水平;Western Blot测定豚鼠卵巢内雄激素受体(AR)、促黄体生成素受体(LHR)、促卵泡生成素受体(FSHR)及下丘脑中KISS1R的蛋白含量及逆转录聚合酶链式反应法(RT-PCR)测定豚鼠卵巢内AR、LHR、FSHR mRNA及下丘脑中KISS1R mRNA表达水平。结果(1)自然光照组及自然光食疗组可见结构完整的卵母细胞,未见明显病理变化;荧光灯组及LED灯组卵巢卵母细胞消失,见大量炎性细胞浸润;荧光灯食疗组及LED灯食疗组卵巢可见卵母细胞,但卵母细胞周围粒细胞排列疏松,间隙增大。(2)与自然光照组比较,自然光食疗组血清E2、LH、FSH、T、AMH、PRL含量下降,下丘脑内KISS1R及卵巢内LHR、FSHR、AR蛋白含量下降(P<0.05);与荧光灯组比较,荧光灯食疗组血清血清E2、LH、FSH、T、AMH、PRL含量下降,下丘脑内KISS1R及卵巢内LHR、FSHR、AR蛋白含量下降(P<0.05);与LED灯组比较,LED灯食疗组血清E2、LH、FSH、T、AMH、PRL含量均下降,下丘脑内KISS1R及卵巢内LHR、FSHR、AR蛋白含量下降(P<0.05);与自然光照组比较,荧光灯、LED灯组血清E2、LH、FSH、T、AMH、PRL含量上升,下丘脑内KISS1R及卵巢内LHR、FSHR、AR蛋白含量上升(P<0.05);与自然光食疗组比较,荧光灯食疗、LED灯食疗组血清E2、LH、FSH、T、AMH、PRL含量上升,下丘脑内KISS1R及卵巢内LHR、FSHR、AR蛋白含量上升(P<0.05)。结论人工光环境的改变会对豚鼠生殖内分泌造成影响,日钟阴阳方可有效改善豚鼠生殖内分泌紊乱的结局。其可能机制与通过调控豚鼠下丘脑内KISS1R的表达,影响Kisspeptin的分泌有关。

关键词：光环境日钟阴阳方性激素水平吻素吻素受体

谈勇运用滋阴补阳方序贯治疗反复移植失败经验撷菁

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中国中医基础医学杂志 2017年第12期23卷 1783-1784,1789页

作者：季丹谈勇常州市中医医院江苏常州213003 南京中医药大学南京210029

人类辅助生殖技术作为治疗不孕症的主要技术之一,胚胎反复移植失败是影响其妊娠率的关键问题。中医药治疗不孕症历史悠久,中医药结合辅助生殖技术尚处于起步阶段,而在胚胎反复移植失败方面的研究更是少之又少。谈勇教授秉承夏桂成教授... 详细信息

人类辅助生殖技术作为治疗不孕症的主要技术之一,胚胎反复移植失败是影响其妊娠率的关键问题。中医药治疗不孕症历史悠久,中医药结合辅助生殖技术尚处于起步阶段,而在胚胎反复移植失败方面的研究更是少之又少。谈勇教授秉承夏桂成教授补肾调周理论,创滋阴补阳方序贯治法,并将其运用到体外受精-胚胎移植的辅助治疗中,提高了胚胎种植率和临床妊娠率。

关键词：反复移植失败(RIF) 滋阴补阳方序贯

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谈勇效方治验——滋阴补阳方序贯

江苏中医药 2022年第9期54卷 1-2页

作者：谈勇南京中医药大学江苏南京210029

1滋阴补阳方序贯组成:滋阴方——山萸肉10 g,菟丝子12 g,当归10 g,白芍10 g,紫河车10 g。补阳方——巴戟天10 g,淫羊藿10 g,续断15 g,党参15 g,怀山药10 g。功效:滋阴养血,温阳助黄。主治:月经失调、不孕症(肾虚证)。用法:月经净时先服... 详细信息

1滋阴补阳方序贯组成:滋阴方——山萸肉10 g,菟丝子12 g,当归10 g,白芍10 g,紫河车10 g。补阳方——巴戟天10 g,淫羊藿10 g,续断15 g,党参15 g,怀山药10 g。功效:滋阴养血,温阳助黄。主治:月经失调、不孕症(肾虚证)。用法:月经净时先服滋阴方10剂,后服补阳方14剂或至月经来潮。每日1剂,水煎,分2次服。方解:滋阴方中山萸肉补益肝肾。

关键词：月经不调不孕症滋阴补阳方验方名医经验谈勇江苏

Structural and Electrical Characteristics of Amorphous ErAlO Gate Dielectric Films

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Chinese Physics Letters 2012年第8期29卷 244-246页

作者： ZHU Yan-Yan FANG Ze-Bo tan yong-Sheng Department of Physics Shaoxing UniversityShaoxing 312000 Department of Mathematics and Physics Shanghai University of Electric PowerShanghai 200090

Ultrathin high-k dielectric ErAlO films were deposited on Si(100)substrates by using radio-frequency magnetron *** very flat surface of the annealed film with a rms roughness less than 0.25 nm was observed by using an atomic force *** film shows good thermal stability when annealing at 900℃ for 30 s in the O_(2) *** effective dielectric constant of the film is around 15.2,and a low leakage current of 8.4×10^(-5) A/cm^(2) at an electric field of 1 MV/cm was achieved for the film with the equivalent oxide thickness of 2.0 nm after annealing.

关键词： film roughness annealed

Up-regulation of P2X7 Receptors Contributes to Spinal Microglial Activation and the Development of Pain Induced by BmK-I

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Neuroscience Bulletin 2019年第4期35卷 624-636页

作者： Jingjing Zhou Xiaoxue Zhang You Zhou Bin Wu Zhi-yong tan Laboratory of Neuropharmacology and Neurotoxicology Shanghai University Shanghai 200444 China Department of Pharmacology and Toxicology and Stark Neurosciences Research Institute Indiana University School of Medicine Indianapolis IN 46202 USA

Previous work has demonstrated that the sensitization of spinal neurons and microglia is important in the development of pain behaviors induced by BmK I,a Na^+ channel activator and a major peptide component of the venom of the scorpion Buthus martensi Karsch(BmK).We found that the expression of P2X7 receptors(P2X7Rs)was up-regulated in the ipsilateral spinal dorsal horn after BmK I injection in rats.P2X7R was selectively localized in microglia but not astrocytes or ***,interleukin 1β(IL-1β)was selectively up-regulated in microglia in the spinal dorsal horn after BmK I *** injection of P2X7R antagonists largely reduced BmK I-induced spontaneous and evoked pain behaviors,and the up-regulation of P2X7R and IL-1β in the spinal *** data suggested that the up-regulation of P2X7Rs mediates microglial activation in the spinal dorsal horn,and therefore contributes to the development of BmK I-induced pain.

关键词： P2X7 receptor BmK I Spinal dorsal horn Interleukin 1β Microglia Brilliant Blue G

Laser cladding of Ni-based alloy on stainless steel

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中国有色金属学会会刊：英文版 2004年第Z1期14卷 296-300页

作者： XUE Chun-fang TIAN Xin-li tan yong-sheng WU Zhi-yuan Department of Mechanical Engineering Academy of Armored Force Engineering Beijing 100072 China Department of Mechanical Engineering Academy of Armored Force Engineering Beijing 100072 China Key Laboratory for High Energy Density Beam Processing TechnologyGeneral Company of Aeronautics Industry Beijing 100024 China Department of Mechanical Engineering Academy of Armored Force Engineering Beijing 100072 China

The coatings on a stainless steel substrate were conducted by laser cladding of Ni-based alloy, using a 5 kW continuous wave CO2 flow transverse laser. SEM, EDX and X-ray diffraction were used to analyze the microstructure and constituent phases of the obtained coatings by laser cladding with direct injection of the powder into the melt pool. Solidification planar, cellular and dendrite structures were observed in Ni-based alloy coating. There exists an optimum metallurgical bond between Ni-based laser cladding layer and the base material. The high hardness of the Ni-based alloy coating is attributed to the presence of M7C3-type carbides (essentially chromium-riched carbide) dispersed in the γ(Ni,Fe) phase matrix.

关键词： laser cladding Ni-based alloy microstructure