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Resilience conferred by APOE-R136S:a defense bestowed by nature to combat Alzheimer’s disease

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Signal Transduction and Targeted Therapy 2024年第3期9卷 831-832页

作者： Bin Xiao Joshua Kuruvilla Eng-King tan Department of Neurology National Neuroscience InstituteSingaporeSingapore Neuroscience Academic Clinical Program Duke-NUS Medical SchoolSingaporeSingapore Neuroscience and Behavioural Disorders Program Duke-NUS Medical SchoolSingaporeSingapore

In two recent articles published in Nature Neuroscience and Cell,Nelson et al.1 and Chen et al.2 have shown that a rare APOE3 Christchurch(APOE3Ch)variant,R136S,has protective effects on neurodegeneration in various Alzheimer’s disease(AD)model systems through attenuating tau pathology and regulating its related neuroimmune *** et *** Chen et *** provided evidence that identifying the pathophysiologic clues and potential molecular targets from a protective variant such as APOE R136S,can be an attractive viable approach to develop AD therapeutics.

关键词： protective al. Alzheimer

A review of in situ carbon mineralization in basalt

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第4期16卷 1467-1485页

作者： Xiaomin Cao Qi Li Liang Xu Yongsheng tan State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan 430071China University of Chinese Academy of Sciences Beijing 100049China

Global warming has greatly threatened the human living environment and carbon capture and storage(CCS)technology is recognized as a promising way to reduce carbon *** storage is considered a reliable option for long-term carbon *** rich in alkaline earth elements facilitates rapid and permanent CO_(2) fixation as ***,the complex CO_(2)-fluid-basalt interaction poses challenges for assessing carbon storage *** different reaction conditions,the carbonation products and carbonation rates *** mineralization reactions also induce petrophysical and mechanical responses,which have potential risks for the long-term injectivity and the carbon storage safety in basalt *** this paper,recent advances in carbon mineralization storage in basalt based on laboratory research are comprehensively *** assessment methods for carbon storage potential are introduced and the carbon trapping mechanisms are investigated with the identification of the controlling *** in pore structure,permeability and mechanical properties in both static reactions and reactive percolation experiments are also *** study could provide insight into challenges as well as perspectives for future research.

关键词： Carbon mineralization Basalt CO_(2)-fluid-basalt interaction Petrophysical evolution Mechanical response Carbon capture and storage(CCS)

Analysis on carbon emission reduction intensity of fuel cell vehicles from a life-cycle perspective

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Frontiers in Energy 2024年第1期18卷 16-27页

作者： Ziyuan TENG Chao tan Peiyuan LIU Minfang HAN Fuel Cell and Energy Storage Center Department of Energy and Power EngineeringState Key Laboratory of Control and Simulation of Power Systems and Generation EquipmentTsinghua UniversityBeijing 100084China

The hydrogen fuel cell vehicle is rapidly developing in China for carbon reduction and *** paper evaluated the life-cycle cost and carbon emission of hydrogen energy via lots of field surveys,including hydrogen production and packing in chlor-alkali plants,transport by tube trailers,storage and refueling in hydrogen refueling stations(HRSs),and application for use in two different *** also conducted a comparative study for battery electric vehicles(BEVs)and internal combustion engine vehicles(ICEVs).The result indicates that hydrogen fuel cell vehicle(FCV)has the best environmental performance but the highest energy ***,a sufficient hydrogen supply can significantly reduce the carbon intensity and FCV energy cost of the current *** carbon emission for FCV application has the potential to decrease by 73.1%in City A and 43.8%in City *** only takes 11.0%–20.1%of the BEV emission and 8.2%–9.8%of the ICEV *** cost of FCV driving can be reduced by 39.1%in City *** improvement can be obtained with an economical and“greener”hydrogen production pathway.

关键词： hydrogen energy life-cycle assessment(LCA) fuel cell vehicle carbon emission energy cost

General Method of Combining Grover and Simon for Attacking Block Ciphers

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China Communications 2024年第6期21卷 237-245页

作者： Fu Xiangqun Bao Wansu Shi Jianhong Li tan Henan Key Laboratory of Quantum Information and Cryptography PLA SSF IEUZhengzhou 450001China Synergetic Innovation Center of Quantum Information and Quantum Physics University of Science and Technology of ChinaHefei 230026China

The compatibility of different quantum algorithms should be considered when these algorithms are *** this paper,the method of combining Grover and Simon is studied for the first time,under some preconditions or ***,we give two preconditions of applying Grover’s algorithm,which ensure that the success probability of finding the marked element is close to ***,based on these two preconditions,it is found out that the success probability of the quantum algorithm for FXconstruction is far less than ***,we give the design method of the Oracle function,and then present the general method of combining Grover and Simon algorithm for attacking block ciphers,with success probability close to 1.

关键词： block ciphers post-quantum crypto quantum algorithms

Strong invariance principle for a counterbalanced random walk

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Applied Mathematics(A Journal of Chinese Universities) 2024年第2期39卷 370-380页

作者： tan Hui-qun HU Zhi-shui DONG Liang International Institute of Finance School of ManagementUniversity of Science and Technology of ChinaHefei 230026China Center for Basic Teaching and Experiment Nanjing University of Science and TechnologyJiangyin 214443China

We study a counterbalanced random walkS_(n)=X_(1)+…+X_(n),which is a discrete time non-Markovian process andX_(n) are given recursively as *** n≥2,X_(n) is a new independent sample from some fixed law̸=0 with a fixed probability p,andX_(n)=−X_(v(n))with probability 1−p,where v(n)is a uniform random variable on{1;…;n−1}.We apply martingale method to obtain a strong invariance principle forS_(n).

关键词： random walk martingale invariance principle

Fourth-order phase-field modeling for brittle fracture in piezoelectric materials

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Applied Mathematics and Mechanics(English Edition) 2024年第5期45卷 837-856页

作者： Yu tan Fan PENG Chang LIU Daiming PENG Xiangyu LI State Key Laboratory of Geohazard Prevention and Geoenvironment Protection Chengdu University of TechnologyChengdu 610059China College of Science Chang'an UniversityXi'an 710064China Applied Mechanics and Structure Safety Key Laboratory of Sichuan Province School of Mechanics and Aerospace EngineeringSouthwest Jiaotong UniversityChengdu 610031China

Failure analyses of piezoelectric structures and devices are of engineering and scientific *** this paper,a fourth-order phase-field fracture model for piezoelectric solids is developed based on the Hamilton *** typical electric boundary conditions are involved in the present model to characterize the fracture behaviors in various physical situations.A staggered algorithm is used to simulate the crack *** polynomial splines over hierarchical T-meshes(PHT-splines)are adopted as the basis function,which owns the *** numerical simulations are performed to study the influence of the electric boundary conditions and the applied electric field on the fracture behaviors of piezoelectric *** electric boundary conditions may influence crack paths and fracture loads *** present research may be helpful for the reliability evaluation of the piezoelectric structure in the future applications.

关键词： isogeometric analysis(IGA) brittle fracture fourth-order phase-field model piezoelectric solid

Comparative analysis of frictional behavior and mechanism of molybdenum ditelluride with different structures

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Friction 2024年第1期12卷 110-119页

作者： Lina ZHANG Xinfeng tan Jianguo JIAO Dan GUO Jianbin LUO State Key Laboratory of Tribology in Advanced Equipment Tsinghua UniversityBeijing 100084China

Two-dimensional(2D)transition metal dichalcogenides(TMDCs)have layered structures with excellent tribological *** the energy difference between hexagonal-molybdenum ditelluride(2H-MoTe_(2))and distorted octahedral-molybdenum ditelluride(1T′-MoTe_(2))is very small among the transition metal dichalcogenides(TMDCs),MoTe_(2) becomes one of the most promising candidates for phase *** our experiment,we found that the friction force and friction coefficient(COF)of 2H-MoTe_(2) were an order of magnitude smaller than those of 1T′-MoTe_(2) by the atomic force microscope(AFM)*** friction difference between 1T′-MoTe_(2) and 2H-MoTe_(2) was further verified in molecular dynamics(MD)*** density functional theory(DFT)calculations suggest that the friction contrast is related to the difference in sliding energy barrier of the potential energy surface(PES)for a tip sliding across the *** PES obtained from the DFT calculation indicates that the maximum energy barrier and the minimum energy path(MEP)energy barrier of 2H-MoTe_(2) are both smaller than those of 1T′-MoTe_(2),which means that less energy needs to be dissipated during the sliding *** difference in energy barrier of the PES could be ascribed to its larger interlayer spacing and weaker Mo–Te interatomic interactions within the layers of 2H-MoTe_(2) than those of 1T′-MoTe_(2).The obvious friction difference between 1T′-MoTe_(2) and 2H-MoTe_(2) not only provides a new non-destructive means to detect the phase transition by the AFM,but also provides a possibility to tune friction by controlling the phase transition,which has the potential to be applied in extreme environments such as space lubrication.

关键词： friction two-dimensional(2D)materials distorted octahedral-molybdenum ditelluride(1T′-MoTe_(2)) hexagonal-molybdenum ditelluride(2H-MoTe_(2)) phase transition

Copper-catalyzed asymmetric dearomatizing amination of 2-naphthols:Csp^(2)–N coupling via 1,3-reductive elimination

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Science China Chemistry 2024年第8期67卷 2694-2700页

作者： Aying Yihuo Maoping Pu Zheng tan Jibang Liao Jiuqi tan Qi-Lin Zhou Xiaohua Liu Xiaoming Feng Key Laboratory of Green Chemistry&Technology Ministry of EducationCollege of ChemistrySichuan UniversityChengdu 610064China Key Laboratory and Institute of Elemento-Organic Chemistry College of Chemistry Frontiers Science Centerfor New Organic MaterNankai UniversityTianjin300071China

An efficient catalytic asymmetric dearomatizing amination of 2-naphthols and phenols catalyzed by N,N′-dioxide-copper(I)complex as a chiral catalyst was presented.A variety of optically activeβ-naphthalenone compounds with a nitrogen-containing quaternary carbon stereocenter were obtained with high yield and enantioselectivity under mild reaction *** studies indicated that this Csp^(2)–N dearomatizing coupling proceeds via 1,3-reductive elimination of phenolate-Cu~Ⅲ-amino intermediate in five-membered ring transition *** origin of enantioselectivity has also been elucidated based on density functional theory calculations.

关键词： asymmetric catalysis amination dearomatization copper catalysis coupling reaction

Requirements ranking based on crowd-sourcing high-end product USs

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Journal of Systems Engineering and Electronics 2024年第1期35卷 94-104页

作者： MA Yufeng DOU Yajie XU Xiangqian JIA Qingyang tan Yuejin College of Systems Engineering National University of Defense TechnologyChangsha 410003China

Based on the characteristics of high-end products,crowd-sourcing user stories can be seen as an effective means of gathering requirements,involving a large user base and generating a substantial amount of unstructured *** key challenge lies in transforming abstract user needs into specific ones,requiring integration and ***,we propose a topic mining-based approach to categorize,summarize,and rank product requirements from user ***,after determining the number of story categories based on py LDAvis,we initially classify“I want to”phrases within user ***,classic topic models are applied to each category to generate their names,defining each post-classification user story category as a ***,a weighted ranking function is devised to calculate the importance of each ***,we validate the effectiveness and feasibility of the proposed method using 2966 crowd-sourced user stories related to smart home systems.

关键词： high-end product complex system crowd-sourcing user stories topic mining requirements ranking