检索结果-南通市图书馆

Glycine Attenuates Myocardial Fibrosis in Myocardial Infarction in Rats Partly through Modulating Signal Transducer and Activator of Transcription 3/Nuclear Factor-κB/Transforming Growth Factor-β axis

引用

World Journal of Traditional Chinese Medicine 2024年第2期10卷 263-270页

作者： Ning Li Yong Wang chun Li Xu Chen Xue-Feng Zhang Nan Nan tan Yi-Qin Hong Ming-Yan Shao Bing-Hua tang Dong-Qing Guo School of Life Science Beijing University of Chinese MedicineBeijingChina College of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijingChina Modern Research Center of Traditional Chinese Medicine School of Traditional Chinese Material MedicaBeijing University of Chinese MedicineBeijingChina

Objective: Inflammation and fibrosis are strongly associated with each other. Glycine is present in various traditional Chinese medicines and exhibits anti-inflammatory activity. However, the effects of glycine on myocardial fibrosis(MF) in rats with myocardial infarction(MI) have not been reported. The purpose of this study is to investigate the effects of glycine therapy on MF and comprehend its underlying mechanisms. Materials and Methods: Left anterior descending artery ligation-induced MI in Sprague Dawley rats was leveraged to assess the therapeutic effects of Glycine. Rats received either normal saline or glycine(0.5 mg/g bodyweight) for 7 days. Results: Glycine upregulated cardiac ejection fraction and fractional shortening to improve cardiac function, as evaluated by echocardiography. Histological and immunohistochemical analyses demonstrated that glycine could decrease inflammatory cell infiltration and alleviate collagen deposition. Western blotting revealed that nuclear factor-κB(NF-κB)-mediated inflammatory signaling was also downregulated by glycine treatment. The expression of signal transducer and activator of transcription 3(STAT3), tumor necrosis factor-α, and transforming growth factor-β(TGF-β) was decreased significantly in the glycine-treated group compared to the model group. Thus, glycine plays a protective role against myocardial ischemia and subsequent MF. Conclusion: The protective effects of glycine were achieved partly through STAT3/NF-κB/TGF-β signaling pathway.

关键词： Glycine myocardial fibrosis signal transducer and activator of transcription 3/nuclear factor-κB/transforming growth factor-β

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Blockchain-Based Key Management Scheme Using Rational Secret Sharing

引用

Computers, Materials & Continua 2024年第4期79卷 307-328页

作者： Xingfan Zhao Changgen Peng Weijie tan Kun Niu State Key Laboratory of Public Big Data College of Computer Science and TechnologyGuizhou UniversityGuiyang550025China Guizhou Big Data Academy Guizhou UniversityGuiyang550025China

Traditional blockchain key management schemes store private keys in the same location,which can easily lead to security issues such as a single point of ***,decentralized threshold key management schemes have become a research focus for blockchain private key *** security of private keys for blockchain user wallet is highly related to user identity authentication and digital asset *** threshold blockchain private key management schemes based on verifiable secret sharing have made some progress,but these schemes do not consider participants’self-interested behavior,and require trusted nodes to keep private key fragments,resulting in a narrow application scope and low deployment efficiency,which cannot meet the needs of personal wallet private key escrow and recovery in public *** design a private key management scheme based on rational secret sharing that considers the self-interest of participants in secret sharing protocols,and constrains the behavior of rational participants through reasonable mechanism design,making it more suitable in distributed scenarios such as the public *** proposed scheme achieves the escrow and recovery of personal wallet private keys without the participation of trusted nodes,and simulate its implementation on smart *** to other existing threshold wallet solutions and keymanagement schemes based on password-protected secret sharing(PPSS),the proposed scheme has a wide range of applications,verifiable private key recovery,low communication overhead,higher computational efficiency when users perform one-time multi-key escrow,no need for trusted nodes,and personal rational constraints and anti-collusion attack capabilities.

关键词： Blockchain smart contract rational secret sharing key management

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Informing policy makers in developing countries:Practices and limitations of geriatric home medication review in Malaysia-A qualitative inquiry

引用

Asian Pacific Journal of Tropical Medicine 2024年第1期17卷 21-29,I0001-I0003页

作者： Ahlam Sundus Renukha Sellappans tan Maw Pin Kulliyyah of Pharmacy International Islamic University MalaysiaJalan Sultan Ahmad ShahKuantanPahangMalaysia School of Pharmacy Faculty of Health and Medical SciencesTaylor’s UniversitySubang JayaSelangorMalaysia Department of Medicine Faculty of MedicineUniversity of MalayaKuala LumpurMalaysia

Objective:To explore existing practices and challenges in the delivery of geriatric home medication review(HMR).The study was part of a larger study aimed to offer solution to expand the range of geriatric ***:This study employed qualitative exploratory design through semi-structured individual in-depth interviews with the public pharmacists involved in the delivery of geriatric HMR at public *** purpose of the interviews was to explore challenges faced by them in the delivery of geriatric ***:Based on the emerging themes from the qualitative data,the study reveals that geriatric HMR in Malaysia is integrated as part of multidisciplinary home care visits,encompassing a diverse patient population with various healthcare ***,it faces challenges such as the lack of outcome monitoring,formal training,and workforce *** these hurdles,there is a pressing need for the expansion of this service to better serve the community,and collaboration with community pharmacists holds potential to broaden its ***,the findings suggest that pharmacist-led HMR is both warranted and feasible within the Malaysian healthcare *** order to optimize medicine-use among older people living in the community,approaches for expanding geriatric HMR services in Malaysia must be ***:This study holds profound implications as it attempts to illuminate policy makers in developing countries,enabling them to formulate effective HMR *** considering the challenges highlighted within this research,policy makers can design a comprehensive HMR service that caters adeptly to the healthcare needs of the mass population.

关键词： Home medication review Older adults Malaysia Pharmacists Low-to-middle-income countries

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Protective Effects of Phellodendron Species on Bone Health: A Novel Perspective on Their Potentials in Treating Osteoporosis and Osteoarthritis

引用

Chinese Journal of Integrative Medicine 2024年第4期30卷 379-384页

作者： XIN Li tan Guo-yao ZHANG Qiang ZHANG Qun Good Clinical Practice Development Guangdong Provincial Key Laboratory of Bone and Joint Degeneration DiseasesThe Third Affiliated Hospital of Southern Medical UniversityGuangzhou(510630)China Department of Pharmacy Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou(510120)China

Phellodendron(PN)species,traditionally used in Chinese medicine for centuries,hold promise as a potential treatment for osteoporosis(OP)and osteoarthritis(OA)due to their bioactive *** bioactive compounds,including berberine and palmatine,exhibit anti-inflammatory,antioxidant,and bone-protective properties,contributing to their potential therapeutic benefits in promoting bone health and preventing bone ***,challenges such as the need for standardized preparation and dosing,limited clinical studies,and potential interactions with other medications hinder their clinical ***,the rich history of PN species in Chinese medicine provides a promising foundation for future investigation into their potential as alternative treatments for OP and *** research is needed to fully understand the underlying mechanisms of action and explore the clinical implications of PN for bone health.

关键词： Phellodendron species bone health osteoporosis osteoarthritis review

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Bifunctional interstitial phosphorous doping strategy boosts platinum-zinc alloy for efficient ammonia oxidation reaction and hydrogen evolution reaction

引用

Nano Research 2024年第3期17卷 1182-1189页

作者： Tianqi Yu Kexin tan Jia Wu Yongjin Zou Shibin Yin Guangxi Key Laboratory of Electrochemical Energy Materials School of Chemistry and Chemical EngineeringGuangxi UniversityNanning 530004China Guangxi Key Laboratory of Information Materials Guilin University of Electronic TechnologyGuilin 541004China

It is still a lack of bifunctional catalysts for ammonia oxidation reaction(AOR)and hydrogen evolution reaction(HER)due to their different reaction *** this work,P is doped into PtZn alloy by calcination with NaH_(2)PO_(2) as P source to induce the lattice tensile strain of Pt and the electronic interaction between P and Zn,which optimizes the AOR and HER activity *** sample with the optimal P content can drive the AOR peak current density of 293.6 mA·mgPt^(-1),which is almost 2.7 times of *** HER,the overpotential at^(-1)0 mA·cm^(-2) is only 23 mV with Tafel slope of 34.1 mV·dec^(-1).Furthermore,only 0.59 V is needed to obtain 50 mA·mgPt^(-1) for ammonia electrolysis under a two-electrode ***,this work shows an ingenious method to design bifunctional catalysts for ammonia electrolysis.

关键词： PtZn alloy phosphorous doping ammonia oxidation reaction hydrogen evolution reaction bifunctional catalyst

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Impact of climate change on food security in the Central Asian countries

引用

Science China Earth Sciences 2024年第1期67卷 268-280页

作者： Fang SU Yu LIU Lvfan CHEN Rustam OROZBAEV Liangcheng tan School of Economics and Management Northwest UniversityXi’an 710127China School of Economics and Management Shaanxi University of Science and TechnologyXi’an 710021China State Key Laboratory of Loess and Quaternary Geology Institute of Earth EnvironmentChinese Academy of SciencesXi’an 710061China Institute of Geology National Academy of Sciences of Kyrgyz RepublicBishkek 720040Kyrgyzstan Institute of Global Environmental Change Xi’an Jiaotong UniversityXi’an 710049China

The current and potential impacts of global warming have generated widespread concerns about food security among all sectors of *** Asian countries located deep in the interior of Asia with fragile ecological environments and lower agricultural technology are particularly more prone to severe threats from climate *** on panel data acquired in five Central Asian countries from 1990 to 2019,a C-D-C model was developed to study how climate change affects food security in the region and to predict future *** study found that the level of food security has generally increased for these five Central Asian countries over the past 30 years,with Kazakhstan and Tajikistan having the highest and lowest food security levels,*** average annual temperature and precipitation exhibit an inverted U-shaped relationship with the region’s food security,with the most positive effect on the food security of *** high and low temperatures have significantly affected food security in the studied region,with Turkmenistan experiencing the most significant negative *** number of frost days had no significant effect on food *** analysis of future climate showed that the temperature and precipitation in Central Asia will continue to increase from 2030 to 2090,which will negatively impact the food security of these *** is recommended that the Central Asian countries enhance their understanding of climate risks,strengthen scientific climate research,and develop multiple adaptation strategies in ***,they are encouraged to consolidate international cooperation,reducing greenhouse gas emissions effectively and maintaining the ability to ensure food security.

关键词： Global warming Extreme climate Food security Future forecasts Five Central Asian countries

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Historical Changes and Multi-scenario Prediction of Land Use and Terrestrial Ecosystem Carbon Storage in China

引用

Chinese Geographical Science 2024年第3期34卷 487-503页

作者： AN Yue tan Xuelan REN Hui LI Yinqi ZHOU Zhou College of Resources Hunan Agricultural UniversityChangsha 410128China School of Geographic Science Hunan Normal UniversityChangsha 410081China

Terrestrial carbon storage(CS)plays a crucial role in achieving carbon balance and mitigating global climate *** study employs the Shared Socioeconomic Pathways and Representative Concentration Pathways(SSPs-RCPs)published by the Intergovernmental Panel on Climate Change(IPCC)and incorporates the Policy Control Scenario(PCS)regulated by China’s land management *** Future Land Use Simulation(FLUS)model is employed to generate a 1 km resolution land use/cover change(LUCC)dataset for China in 2030 and *** on the carbon density dataset of China’s terrestrial ecosystems,the study analyses CS changes and their relationship with land use changes spanning from 1990 to *** findings indicate that the quantitative changes in land use in China from 1990 to 2020 are characterised by a reduction in the area proportion of cropland and grassland,along with an increase in the impervious surface and forest *** changing trend is projected to continue under the PCS from 2020 to *** the SSPs-RCPs scenario,the proportion of cropland and impervious surface predominantly increases,while the proportions of forest and grassland continuously *** loss in China’s carbon storage from 1990 to 2020 amounted to 0.53×10^(12)kg,primarily due to the reduced area of cropland and *** the SSPs-RCPs scenario,more significant carbon loss occurs,reaching a peak of8.07×10^(12)kg in the SSP4-RCP3.4 *** loss is mainly concentrated in the southeastern coastal area and the Beijing-TianjinHebei(BTH)region of China,with urbanisation and deforestation identified as the primary *** the future,it is advisable to enhance the protection of forests and grassland while stabilising cropland areas and improving the intensity of urban *** research findings offer valuable data support for China’s land management policy,land space optimisation,and the achievement of dual-carbon targets.

关键词： land use change Future Land Use Simulation(FLUS)model carbon storage carbon density dataset land use scenario China

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Advancing mid-infrared microdisk laser emission with Tm:YAG

引用

Science China(Physics,Mechanics & Astronomy) 2024年第7期67卷 91-96页

作者： Zhaocong Wang Huiqi Li Lei Wang Yang tan Feng Chen School of Physics State Key Laboratory of Crystal MaterialsShandong UniversityJinan 250100China

Mid-infrared microcavity lasers have important applications in biosensing,mid-infrared spectroscopy,and environmental ***,the low output power of existing mid-infrared microcavity lasers hinders their practical *** drawback is attributed to the insufficient laser gain medium,which limits the development of mid-infrared whispering-gallerymode(WGM)*** address this issue,we have employed ion implantation-enhanced etching to fabricate Tm:YAG thin films as effective gain media for mid-infrared WGM *** Tm:YAG thin film,with a thickness of 2μm,exhibits excellent fluorescence ***,the Tm:YAG thin film is processed using focused ion beam to form microdisks with a diameter of 30μ*** 785 nm laser pumping,the maximum output power of the Tm:YAG microdisk at 2023.1 nm is229μW,with a slope efficiency of 2.9%.This work demonstrates the outstanding potential of Tm:YAG as a mid-infrared laser gain medium,providing a new option for the development of mid-infrared lasers.

关键词： microdisk microlaser ultrathin film

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Multi-Time-Scale Resource Allocation Based on Long-Term Contracts and Real-Time Rental Business Models for Shared Energy Storage Systems

引用

Journal of Modern Power Systems and Clean Energy 2024年第2期12卷 454-465页

作者： Yuxuan Zhuang Zhiyi Li Qipeng tan Yongqi Li Minhui Wan College of Electrical Engineering Zhejiang UniversityHangzhouChina China Southern Power Grid Power Generation Company Energy Storage Research Institute GuangzhouChina IEEE

The push for renewable energy emphasizes the need for energy storage systems(ESSs)to mitigate the unpre-dictability and variability of these sources,yet challenges such as high investment costs,sporadic utilization,and demand mismatch hinder their broader *** response,shared energy storage systems(SESSs)offer a more cohesive and efficient use of ESS,providing more accessible and cost-effective energy storage solutions to overcome these *** enhance the profitability of SESSs,this paper designs a multi-time-scale resource allocation strategy based on long-term contracts and real-time rental business *** initially construct a life cycle cost model for SESS and introduce a method to estimate the degradation costs of multiple battery groups by cycling numbers and depth of discharge within the ***,we design various long-term contracts from both capacity and energy perspectives,establishing associated models and real-time rental ***,multi-time-scale resource allocation based on the decomposition of user demand is *** analysis validates that the business model based on long-term contracts excels over models operating solely in the real-time market in economic viability and user satisfaction,effectively reducing battery degradation,and leveraging the aggregation effect for SESS can generate an additional increase of 10.7%in net revenue.

关键词： Capacity allocation long-term contracts shared energy storage system stochastic programming

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Discovery of the choristodere Hyphalosaurus baitaigouensis from the Lower Cretaceous Jiufotang Formation of western Liaoning,China and its paleobiogeographic significance

引用

Journal of Palaeogeography 2024年第3期13卷 547-562页

作者： Li-Jun Zhang Shu-An Ji Hai-chun Zhang South China Sea Culture Museum Hainan Tropical Ocean UniversitySanya 572022Hainan ProvinceChina Key Laboratory of Stratigraphy and Paleontology Ministry of Natural ResourcesInstitute of GeologyChinese Academy of Geological SciencesBeijing 100037China State Key Laboratory of Palaeobiology and Stratigraphy Nanjing Institute of Geology and Palaeontology and Center for Excellence in Life and PaleoenvironmentChinese Academy of SciencesNanjing 210008Jiangsu ProvinceChina

The water-living reptile genus Hyphalosaurus was previously discovered in the Lower Cretaceous Yixian Formation bearing the middle Jehol Biota in western Liaoning,*** complete skeletons of Hyphalosaurus are reported for the first time from the Jiufotang Formation bearing the late Jehol Biota at two sites in western *** show the typical characteristics of Hyphalosaurus baitaigouensis in terms of the contact between some cranial bones and the number of cervical and dorsal vertebrae,and therefore are assigned to *** discovery extends the stratigraphic range of this species from the Yixian Formation to the overlying Jiufotang *** paper further briefly compares the main characteristics of the two skeletons,summarizes the temporal and spatial distribution of Hyphalosaurus,and discusses the palaeogeographic evolution of western Liaoning at the middle and late Jehol Biota stages based on the aquatic habits of Hyphalosaurus and the geological background of western *** analytical results show that the volcanic downwarped lakes,with distinct geographical divisions in western Liaoning during the deposition of the Yixian Formation,had not completely disappeared till the deposition of the Jiufotang *** palaeo-lake in the Fuxin-Yixian Basin underwent the process of generation,expansion and shrinkage during the depositional period of the Yixian Formation and finally merged into a large *** palaeo-Dalinghe River,which connected the main basins in western Liaoning during the depositional period of the Jiufotang Formation,was formed simultaneously.

关键词： Western liaoning Jehol biota Jiufotang formation Hyphalosaurus baitaigouensis Palaeobiogeography

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：