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Inhibitory effect of saffron on head and neck squamous cell carcinoma via targeting of ESR1 and CCND1 by its active compound crocetin

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Traditional Medicine Research 2024年第7期9卷 25-34页

作者： Xiao-Jie Wang Ming-Jun Zhang Li-mei Cui Zhe-Ying Song Ya-qi Wang Yu-Teng Yang Xiang-Kun Zhao Ya-Kui Mou Yu-mei Li Xi-Cheng Song School of Clinical Medicine Weifang Medical UniversityWeifang 261042China. Department of Otorhinolaryngology Head and Neck SurgeryYantai Yuhuangding HospitalQingdao UniversityYantai 264000China. Shandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases Yantai 264000China. Yantai Key Laboratory of Otorhinolaryngologic Diseases Yantai Yuhuangding HospitalYantai 264000China. The 2nd Medical College of Binzhou Medical University Yantai 264000China.

Background:Traditional Chinese medicine is promising for managing challenging and complex disorders,including cancer,and in particular,saffron is applied in treating various cancer ***,its potential therapeutic efficacy and active components in managing squamous cell carcinoma of the head and neck(HNSCC)remain unclear ***:Using network pharmacology approaches,active ingredients of saffron,their target genes,and HNSCC-related genes were *** analyses were conducted for determining molecular functions and pathways enriched by genes that overlapped between the saffron target gene set and the HNSCC gene *** the four known active ingredients of saffron,crocetin was found to have the strongest inhibitory impact on HNSCC,based on the findings of cell viability and migration ***,the potential target genes of crocetin in HNSCC cells were examined using molecular docking experiments and were confirmed by *** s:Four active ingredients of saffron and 184 of their target genes were ***,a total of 34 overlapping saffron-/HNSCC-associated targets related to the four active ingredients were screened,and crocetin was chosen for further investigation because it had the strongest inhibitory effect on HNSCC *** docking experiments indicated that ESR1 and CCND1 were the target genes of *** results were confirmed through qPCR analysis,in which crocetin was found to lower the expression of the ESR1 and CCND1 genes in AMC-HN-8 and FaDu ***:According to our results,crocetin is a primary active anti-cancer component of saffron that may have potential in the development of novel HNSCC-treating ***,more thorough molecular research is necessary for confirming these results and elucidating the anti-cancer mechanism underlying saffron.

关键词： saffron hub genes crocetin network pharmacology analysis HNSCC ESR1 CCND1

Spatiotemporal drivers of urban water pollution:Assessment of 102 cities across the Yangtze River Basin

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Environmental Science and Ecotechnology 2024年第4期20卷 300-314页

作者： Yi-Lin Zhao Han-Jun Sun Xiao-DanWang Jie Ding mei-Yun Lu Ji-Wei Pang Da-Peng Zhou Ming Liang Nan-qi Ren Shan-Shan Yang State Key Laboratory of Urban Water Resource and Environment School of EnvironmentHarbin Institute of TechnologyHarbin 150090China China Energy Conservation and Environmental Protection Group Beijing 100082China China Energy Conservation and Environmental Protection Group CECEP Digital Technology Co.Ltd.Beijing 100089China China Railway Engineering Design and Consulting Group Co. Ltd.Beijing 100055China

Effective management of large basins necessitates pinpointing the spatial and temporal drivers of primary index exceedances and urban risk factors,offering crucial insights for basin ***,comprehensive examinations of multiple pollutants within the Yangtze River Basin remain *** we introduce a pollution inventory for urban clusters surrounding the Yangtze River Basin,analyzing water quality data from 102 cities during *** assessed the exceedance rates for six pivotal indicators:dissolved oxygen(DO),ammonia nitrogen(NH_(3)-N),chemical oxygen demand(COD),biochemical oxygen demand(BOD),total phosphorus(TP),and the permanganate index(COD_(Mn))for each *** random forest regression and SHapley Additive exPlanations(SHAP)analyses,we identified the spatiotemporal factors influencing these key *** results highlight agricultural activities as the primary contributors to the exceedance of all six indicators,thus pinpointing them as the leading pollution source in the ***,forest coverage,livestock farming,chemical and pharmaceutical sectors,along with meteorological elements like precipitation and temperature,significantly impacted various indicators'***,we delineate five core urban risk components through principal component analysis,which are(1)anthropogenic and industrial activities,(2)agricultural practices and forest extent,(3)climatic variables,(4)livestock rearing,and(5)principal polluting *** cities were subsequently evaluated and categorized based on these risk components,incorporating policy interventions and administrative performance within each *** comprehensive analysis advocates for a customized strategy in addressing the discerned risk factors,especially for cities presenting elevated risk levels.

关键词： Basin management Primary indices Urban risk factors Yangtze river basin Local conditions

Three-dimensional reconstruction of Late Miocene Trapa from eastern Zhejiang Province,China:Insights into its phytogeography and evolution

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Journal of Palaeogeography 2024年第4期13卷 954-970页

作者： Liang Xiao Man Yuan De-Shuang Ji Li-Yan Guo Xiang-Chuan Li Xing Wang Jia-Nan Wang Jia-qi Liang mei-Ting Wang School of Earth Science and Resources and Key Laboratory of Western Mineral Resources and Geological Engineering of the Ministry of EducationChang'an University State Key Laboratory of Palaeobiology and Stratigraphy Nanjing Institute of Geology and PalaeontologyChinese Academy of Sciences Shaanxi Key Laboratory of Early Life and Environments Northwest University State Key Laboratory of Continental Dynamics Northwest University

Abundant plant fossils were found in the Upper Miocene Shengxian Formation,eastern Zhejiang Province,China,among which Trapa belongs to a dominant *** fossil fruits of Trapa were well preserved with abundant ***,due to compaction during fossilization,Trapa fruits were often flattened,leading to the loss of some characteristic ***,a bias in taxonomic and phylogenetic studies would occur when such studies were based on these fruit *** this study,we present the first quantitative three-dimensional reconstruction of compressed Trapa fruit fossils to restore their original morphology prior to *** approach provides a novel perspective for the identification and classification of compressed fruit *** three-dimensional reconstruction of Trapa fruit fossils enabled accurate comparisons with extant *** subsequently identified it as a new species,named Trapa radiatiformis *** ***.,revealing differences from previously known taxa of ***,our comparison suggests that the long lower horns and residual stalk may represent inherent characteristics of early Trapa ***,these traits gradually degenerated during fruit evolution,resulting in morphological simplification during geological *** with primitive features exhibits good resemblance to Trapa natans fruit characteristics,which means it may be an ancestor of *** summarize the palaeogeographic distribution of fossil Trapa using previously published literature and demonstrate that the genus was mostprosperous in the Miocene and exhibited the same distribution as that at ***,through detailed morphological comparisons between Trapa and Hemitrapa fruits,along with phylogenetic analysis within the Primotrapa genus itself,we propose a homology between Trapa and Hemitrapa,suggesting that they could have a common ancestor.

关键词： Trapa Late Miocene Shengxian Formation Three-dimensional reconstruction Phytogeographic history Evolutionary history

Heavy ion energy influence on multiple-cell upsets in small sensitive volumes:from standard to high energies

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Nuclear Science and Techniques 2024年第5期35卷 109-121页

作者： Yang Jiao Li-Hua Mo Jin-Hu Yang Yu-Zhu Liu Ya-Nan Yin Liang Wang qi-Yu Chen Xiao-Yu Yan Shi-Wei Zhao Bo Li You-mei Sun Pei-Xiong Zhao Jie Liu Institute of Modern Physics Chinese Academy of ScienceLanzhou 730000China University of Chinese Academy of Science Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China China Electronics Technology Group Corporation No.58 Research Institute Wuxi 214000China Beijing Microelectronics Technology Institute Beijing 100084China Institute of Microelectronics Chinese Academy of SciencesBeijing 100029China Key Laboratory of Science and Technology on Silicon Devices Chinese Academy of SciencesBeijing 100029China

The 28 nm process has a high cost-performance ratio and has gradually become the standard for the field of radiation-hardened ***,owing to the minimum physical gate length of only 35 nm,the physical area of a standard 6T SRAM unit is approximately 0.16μm^(2),resulting in a significant enhancement of multi-cell charge-sharing ***-cell upsets(MCUs)have become the primary physical mechanism behind single-event upsets(SEUs)in advanced nanometer node *** range of ionization track effects increases with higher ion energies,and spacecraft in orbit primarily experience SEUs caused by high-energy ***,ground accelerator experiments have mainly obtained low-energy ion irradiation ***,the impact of ion energy on the SEU cross section,charge collection mechanisms,and MCU patterns and quantities in advanced nanometer devices remains *** this study,based on the experimental platform of the Heavy Ion Research Facility in Lanzhou,low-and high-energy heavy-ion beams were used to study the SEUs of 28 nm SRAM *** influence of ion energy on the charge collection processes of small-sensitive-volume devices,MCU patterns,and upset cross sections was obtained,and the applicable range of the inverse cosine law was *** findings of this study are an important guide for the accurate evaluation of SEUs in advanced nanometer devices and for the development of radiation-hardening techniques.

关键词： 28 nm static random access memory(SRAM) Energy effects Heavy ion Multiple-cell upset(MCU) Charge collection Inverse cosine law

Feasibility of acupuncture as an adjunct intervention for ovulatory disorder infertility:A systematic review and meta-analysis

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World Journal of Clinical Cases 2024年第22期12卷 5108-5123页

作者： Yu-qi Chen Tao Shen Ying Lv mei-Hong Shen Department of Acupuncture and Tuina Rehabilitation Kunshan Affiliated Hospital of Nanjing University of Traditional Chinese MedicineKunshan 210023Jiangsu ProvinceChina School of Acupuncture-Moxibustion and Tuina Nanjing University of Traditional Chinese MedicineNanjing 210023Jiangsu ProvinceChina Department of Traditional Chinese Medicine Kunshan Rehabilitation HospitalKunshan 215300Jiangsu ProvinceChina

BACKGROUND Acupuncture(AT)is widely used in treatment of ovulatory disorder infertility(ODI),but the safety and efficacy of AT for ODI still lack an evidence-based *** To evaluate the feasibility and effectiveness of AT as an adjunct intervention for *** The Cochrane Library,Embase,PubMed,VIP,China National Knowledge Infrastructure,WanFang Data,and Chinese biomedical literature databases were searched from inception to January 20,*** reviewers independently selected studies,collected data,and evaluated methodological quality through the Cochrane Risk of Bias *** 5.4 was used for meta-analysis,and the Grade system was performed to evaluate the level of evidence for the outcomes of the *** A total of 20 randomized controlled trials with 1677 ODI patients were *** with the clomiphene citrate(CC)group,the AT plus CC group exhibited significant improvement of the pregnancy rate[relative risk(RR)=1.68,95%confidence interval(CI):1.45-1.95,P<0.00001,I^(2)=23%],ovulation rate(RR=1.34,95%CI:1.22-1.47,P<0.00001,I^(2)=32%),serum E2 level[mean difference(MD)=31.36,95%CI:21.83-40.88,P<0.00001,I^(2)=97%],thickness of endometrium(MD=1.76,95%CI:0.71-2.81,P=0.001,I^(2)=98%)and decreasing miscarriage rate(RR=0.25,95%CI:0.09-0.65,P=0.005,I^(2)=0%),serum follicle-stimulating hormone level(MD=-2.10,95%CI:-3.27 to-0.94,P=0.0004,I^(2)=99%),serum luteinizing hormone level(MD=-6.94,95%CI:-9.89 to-4.00,P<0.00001,I^(2)=100%),and serum progesterone level(MD=-1.66,95%CI:-2.98 to-0.34,P=0.01,I^(2)=96%).The AT group had a more favorable effect than CC group for improving pregnancy rate(RR=1.52,95%CI:1.33-1.73,P<0.00001,I^(2)=0%),thickness of endometrium(MD=2.48,95%CI:2.15-2.81,P<0.00001,I^(2)=0%)and reducing miscarriage rate(RR=0.23,95%CI:0.13-0.44,P<0.00001,I^(2)=0%),serum follicle-stimulating hormone level(MD=-0.55,95%CI:-0.86 to-0.24,P=0.0005,I^(2)=0%),and serum progesterone level(MD=-0.24,95%CI:-0.28 to-0.20,P<0.00001).However,the leve

关键词： Acupuncture Ovulatory disorder Infertility Pregnancy Meta-analysis Systematic review

Inflammatory and Immunomodulatory Effects of Tripterygium wilfordii Multiglycoside in Mouse Models of Psoriasis Keratinocytes

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Chinese Journal of Integrative Medicine 2024年第3期30卷 222-229页

作者： ZHANG Shuo LI Hong-jin YANG Chun-mei LIU Liu SUN Xiao-ying WANG Jiao CHEN Si-ting LU Yi HU Man-qi YAN Ge ZHOU Ya-qiong MIAO Xiao LI Xin LI Bin Department of Dermatology Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai200437China Institute of Dermatology Shanghai Academy of Traditional Chinese MedicineShanghai201203China Department of Integrated Traditional Chinese and Western Medicine Shanghai Skin Disease HospitalTongji University School of MedicineShanghai200443China

Objective:To determine the role of Tripterygium wilfordii multiglycoside(TGW) in the treatment of psoriatic dermatitis from a cellular immunological ***:Mouse models of psoriatic dermatitis were established by imiquimod(IMQ).Twelve male BALB/c mice were assigned to MQ or IMQ+TGW groups according to a random number *** changes in vivo were assessed by hematoxylin and eosin *** of immune cells and cytokines in mice,as well as PAM212 cell proliferation in vitro were assessed by flow ***-inflammatory cytokine expression was determined using reverse transcription quantitative polymerase chain ***:TGW significantly ameliorated the severity of IMQ-induced psoriasis-like mouse skin lesions and restrained the activation of CD45^(+)cells,neutrophils and T lymphocytes(all P<0.01).Moreover,TGW significantly attenuated keratinocytes(KCs) proliferation and downregulated the mRNA levels of inflammatory cytokines including interleukin(IL)-17A,IL-23,tumor necrosis factor α,and chemokine(C-X-C motif) ligand 1(P<0.01 or P<0.05).Furthermore,it reduced the number of γδ T17 cells in skin lesion of mice and draining lymph nodes(P<0.01).Conclusions:TGW improved psoriasis-like inflammation by inhibiting KCs proliferation,as well as the associated immune cells and cytokine *** inhibited IL-17 secretion from γδ T cells,which improved the immune-inflammatory microenvironment of psoriasis.

关键词： psoriasis Tripterygium wilfordii multiglycoside γδT cells inflammation Chinese medicine

基于特征分析的政府数据分类分级政策量化评价

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情报资料工作 2024年第1期45卷 78-88页

作者：陈美何祺中南财经政法大学公共管理学院武汉430073

[目的/意义]数字化改革的提出,让数据分类分级的发展走上了“快车道”。近几年,各地政府先后出台多份有关政策来落实。但是,政策的合理性、政策与行业数据的匹配程度等还有待讨论。[方法/过程]文章采用描述性分析、共现词分析、聚类分... 详细信息

[目的/意义]数字化改革的提出,让数据分类分级的发展走上了“快车道”。近几年,各地政府先后出台多份有关政策来落实。但是,政策的合理性、政策与行业数据的匹配程度等还有待讨论。[方法/过程]文章采用描述性分析、共现词分析、聚类分析方法对2016-2021年间各地政府发布的54份数据分类分级政策文本进行研究,并在此基础上构建数据分类分级政策的评价框架,根据一定的规则选取8份具有代表性的政策样本,利用PMC-NMF模型进行量化。[结果/结论]分类分级政策发展速度较快,政策内容也结合了市场行业的实际情况进行制定,较为合理,但在丰富政策内容、强调政策工具的搭配使用、扩大政策适用对象的范围、标准化文件的引用等方面需要进一步完善。

关键词：分类分级政策评价 PMC-NMF模型

同方期刊数据库人大复印报刊资料评论

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铝模板在高层建筑施工中的应用

建筑技术 2015年第9期46卷 850-852页

作者：谭其美张明亮周瑾寻奥林湖南省第六工程有限公司长沙410015 吉首大学城乡资源与规划学院湖南张家界427000

介绍某高层建筑施工的铝模系统的配设验算、安装工艺,分析铝模早拆系统的优越性。通过工程应用证明,使用铝模板大大降低了工程成本,加快了工程进度,且取得了良好的观感质量。

关键词：铝模板高层建筑工程应用

Inducing mitochondriopathy-like damages by transformable nucleopeptide nanoparticles for targeted therapy of bladder cancer

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National Science Review 2024年第4期11卷 216-227页

作者： Da-Yong Hou Ni-Yuan Zhang Lu Wang mei-Yu Lv Xiang-Peng Li Peng Zhang Yue-Ze Wang Lei Shen Xiu-Hai Wu Bo Fu Peng-Yu Guo Zi-qi Wang Dong-Bing Cheng Hao Wang Wanhai Xu NHC and CAMS Key Laboratory of Molecular Probe and Targeted Theranostics Heilongjiang Key Laboratory of Scientific Research in Urology Harbin Medical University Department of Urology Harbin Medical University Cancer Hospital CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in NanoscienceNational Center for Nanoscience and Technology(NCNST) School of Chemistry Chemical Engineering & Life Science Hubei Key Laboratory of Nanomedicine for Neurodegenerative Diseases Wuhan University of Technology

Mitochondriopathy inspired adenosine triphosphate(ATP) depletions have been recognized as a powerful way for controlling tumor growth. Nevertheless, selective sequestration or exhaustion of ATP under complex biological environments remains a prodigious challenge. Harnessing the advantages of in vivo self-assembled nanomaterials, we designed an Intracellular ATP Sequestration(IAS) system to specifically construct nanofibrous nanostructures on the surface of tumor nuclei with exposed ATP binding sites,leading to highly efficient suppression of bladder cancer by induction of mitochondriopathy-like ***, the reported transformable nucleopeptide(NLS-FF-T) self-assembled into nuclear-targeted nanoparticles with ATP binding sites encapsulated inside under aqueous conditions. By interaction with KPNA2, the NLS-FF-T transformed into a nanofibrous-based ATP trapper on the surface of tumor nuclei,which prevented the production of intracellular energy. As a result, multiple bladder tumor cell lines(T24,EJ and RT-112) revealed that the half-maximal inhibitory concentration(IC50) of NLS-FF-T was reduced by approximately 4-fold when compared to NLS-T. Following intravenous administration, NLS-FF-T was found to be dose-dependently accumulated at the tumor site of T24 xenograft mice. More significantly, this IAS system exhibited an extremely antitumor efficacy according to the deterioration of T24 tumors and simultaneously prolonged the overall survival of T24 orthotopic xenograft mice. Together, our findings clearly demonstrated the therapeutic advantages of intracellular ATP sequestration-induced mitochondriopathy-like damages, which provides a potential treatment strategy for malignancies.

关键词： self-assembly nucleopeptide nanomaterial bladder cancer mitochondriopathy