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某在建小区地下室顶板施工道路加固验算分析

建筑技术开发 2015年第6期42卷 36-39页

作者：张明亮谭其美周瑾符征宇湖南省第六工程有限公司长沙410015 吉首大学城乡资源与规划学院湖南张家界427000

某在建小区施工现场场地狭小,施工阶段拟在地下室顶板设置临时施工道路以满足主体施工所需的混凝土浇筑及材料运输要求。为保证工程结构安全,对临时道路区域顶板跨中挠度、裂缝宽度进行了验算分析并采取了相应加固措施,同时对加固架体... 详细信息

某在建小区施工现场场地狭小,施工阶段拟在地下室顶板设置临时施工道路以满足主体施工所需的混凝土浇筑及材料运输要求。为保证工程结构安全,对临时道路区域顶板跨中挠度、裂缝宽度进行了验算分析并采取了相应加固措施,同时对加固架体立杆的受压稳定性进行了验算,均满足结构安全要求。施工时取材方便,加固方法简单,经过工程实践证明,达到结构安全可靠效果,可供类似工程参考。

关键词：地下室顶板施工道路验算分析

OsNLP3 enhances grain weight and reduces grain chalkiness in rice

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Plant Communications 2024年第10期5卷 82-99页

作者： Liang-qi Sun Yu Bai Jie Wu Shi-Jun Fan Si-Yan Chen Zheng-Yi Zhang Jin-qiu Xia Shi-mei Wang Yu-Ping Wang Peng qin Shi-Gui Li Ping Xu Zhong Zhao ChengBin Xiang Zi-Sheng Zhang Division of Life Sciences and Medicine Division of Molecular&Cell BiophysicsHefei National Science Center for Interdisciplinary Sciences at the MicroscaleUniversity of Science and Technology of ChinaThe Innovation Academy of Seed DesignChinese Academy of SciencesHefeiAnhui Province 230027China Experimental Center of Engineering and Materials Science University of Science and Technology of ChinaHefei 230027China Rice Research Institute Anhui Academy of Agricultural ScienceHefeiChina State Key Laboratory of Crop Gene Exploration and Utilization in Southwest China Rice Research InstituteSichuan Agricultural UniversityChengduSichuanChina Shanghai Key Laboratory of Plant Functional Genomics and Resources Shanghai Chenshan Botanical GardenShanghai Chenshan Plant Science Research CenterChinese Academy of SciencesShanghaiChina

Grain weight,a key determinant of yield in rice(Oryza sativa L.),is governed primarily by genetic factors,whereas grain chalkiness,a detriment to grain quality,is intertwined with environmental factors such as mineral ***(N)is recognized for its effect on grain chalkiness,but the underlying molecular mechanisms remain to be *** study revealed the pivotal role of rice NODULE INCEPTION-LIKE PROTEIN 3(OsNLP3)in simultaneously regulating grain weight and grain *** investigation showed that loss of OsNLP3 leads to a reduction in both grain weight and dimension,in contrast to the enhancement observed with OsNLP3 ***3 directly suppresses the expression of OsCEP6.1 and OsNF-YA8,which were identified as negative regulators associated with grain ***,two novel regulatory modules,OsNLP3-OsCEP6.1 and OsNLP3-OsNF-YA8,were identified as key players in grain weight ***,the OsNLP3-OsNF-YA8 module not only increases grain weight but also mitigates grain chalkiness in response to *** research clarifies the molecular mechanisms that orchestrate grain weight through the OsNLP3-OsCEP6.1 and OsNLP3-OsNF-YA8 modules,highlighting the pivotal role of the OsNLP3-OsNF-YA8 module in alleviating grain *** findings reveal potential targets for simultaneous enhancement of rice yield and quality.

关键词： OsNLP3 OsCEP6.1 OsNF-YA8 grain weight grain chalkiness rice Oryza sativa L.

Bioinformatics Analysis of the Relationship between Dilated Cardiomyopathy and Chronic Heart Failure

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Journal of Biosciences and Medicines 2024年第8期12卷 333-346页

作者： Lanqing Yu Haidong Zhou Bailu Deng Jiaochang Wei mei Zhang Chongyao Xu Guiyun Wei Junxiu Zhou Jun Huang qi Lu Shaowu Ye Graduate School Youjiang Medical University for Nationalities Baise China Clinical Medical College Affiliated Hospital of Youjiang Medical University for Nationalities Baise China Department of Internal Medicine The Peoples Hospital of Wuzhou Wuzhou China Pharmaceutical College Guangxi Medical University Nanning China Department of Pharmacy Guangxi Zhuang Autonomous Region Maternal and Child Health Hospital Nanning China Department of Pharmacy Baise Maternal and Child Hospital Baise China Orthopedic Trauma Napo Peoples Hospital Baise China Department of Internal Medicine Wuzhou Gongren Hospital Wuzhou China

Objective: To screen and analyze the differentially expressed genes between dilated cardiomyopathy (DCM) and chronic heart failure (CHF) based on bioinformatics methods. Methods: The Gene Expression Omnibus (GEO) database was used for data retrieval, and the chip data GSE3585 was downloaded, which was the original data of DCM and normal control group. At the same time, the chip data GSE76701 was downloaded, which was the original data of CHF and control group. Differentially expressed mRNAs (DEmRNAs) were screened by R language limma package, the data were standardized, and the common differentially expressed genes were screened. GO function and KEGG pathway enrichment analysis were performed on the common differentially expressed genes. String11.0 online tool was used for data analysis to obtain differentially expressed genes, and the results were imported into Cytoscape 3.9.1 software. The results were imported into Cytoscape 3.9.1 software, and the common expression gene module was obtained by MOCDE algorithm. Nine Hub genes were obtained by 10 algorithms such as MCC. Results: A total of 248 differentially expressed genes were screened. GO analysis showed that differentially expressed genes were mainly concentrated in 9 different physiological and pathological processes. KEGG analysis showed that the main signaling pathways involved in differentially expressed genes were 2, and 9 key differentially expressed genes were predicted: NPPB, NPPA, MYH6, FRZB, ASPN, SFRP4, RPS4Y1, DDX3Y. Conclusion: This study preliminarily explored the molecular mechanism of DCM and CHF, and obtained the common differentially expressed genes of the two diseases. Further experimental studies are needed to verify the correlation between gene expression and clinicopathological features. Provide new ideas for clinical drug treatment research.

关键词： Dilated Cardiomyopathy Chronic Heart Failure Bioinformatics Analysis Differentially Expressed Genes

褶皱缺陷对复合材料拉伸性能的影响规律:试验及数值模型

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力学学报 2024年第6期56卷 1740-1751页

作者：凌圣博姚启王乐蓬梅杰吴振西北工业大学航空学院西安710072 强度和结构完整性全国重点实验室西安710065

复合材料层合板在制造过程中会不可避免地产生各类缺陷,纤维褶皱缺陷是最为常见的缺陷形式之一.为了探究褶皱缺陷对复合材料层合板纤维方向拉伸性能的影响,制备了不含褶皱缺陷的高强玻璃纤维复合材料试验件,以及4种含有纤维褶皱缺陷的... 详细信息

复合材料层合板在制造过程中会不可避免地产生各类缺陷,纤维褶皱缺陷是最为常见的缺陷形式之一.为了探究褶皱缺陷对复合材料层合板纤维方向拉伸性能的影响,制备了不含褶皱缺陷的高强玻璃纤维复合材料试验件,以及4种含有纤维褶皱缺陷的试验件.对制备的5组试验件进行了准静态拉伸试验,通过数字图像相关(DIC)技术测量了试验件的位移及应变.通过试验,研究了褶皱高宽比、褶皱角度对静强度及失效模式的影响.试验发现,含褶皱缺陷复合材料的静强度相比无缺陷复合材料降低40%以上,并且褶皱高宽比越大,或褶皱夹角越大,复合材料的静强度越低.与此同时,发现褶皱缺陷会显著改变复合材料的失效模式,使得原本单向纤维增强复合材料在纵向拉伸载荷作用下的炸裂失效变为纤维断裂失效和轻微的炸裂失效.此外,为了建立复合材料静强度与褶皱几何参数(高宽比和褶皱角度)之间的关系,使用多可信度机器学习算法构建了褶皱缺陷对复合材料静强度的影响模型,通过有限的试验数据预测了不同褶皱缺陷对复合材料静强度的影响规律.结果表明,构建的模型仅用极少的试验数据即可准确反应褶皱高宽比和褶皱角度对复合材料拉伸强度的影响,为研究含缺陷复合材料的力学性能提供了新方法.

关键词：复合材料层合板褶皱缺陷多可信度机器学习失效模式静强度

未来气候情景下甘南草地土壤有机碳密度的时空预测与分析

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环境科学 2024年第6期45卷 3308-3317页

作者：李钊张美玲张锐祺田景王晨甘肃农业大学理学院数量生物学研究中心兰州730070

研究草地土壤有机碳密度的时间和空间分布特征,并探究有机碳密度与影响因素之间的关系,对甘南自治州草地生态系统管理和维护具有重要意义,有助于实现“双碳”目标,促进碳汇和减缓气候变化.以甘肃省甘南藏族自治州为研究对象,基于SSP126... 详细信息

研究草地土壤有机碳密度的时间和空间分布特征,并探究有机碳密度与影响因素之间的关系,对甘南自治州草地生态系统管理和维护具有重要意义,有助于实现“双碳”目标,促进碳汇和减缓气候变化.以甘肃省甘南藏族自治州为研究对象,基于SSP126和SSP585这两种CMIP6未来气候情景数据,运用CENTURY模型模拟预测2023~2100年甘南草地土壤有机碳密度的时空变化,结果表明:①2023~2100年,总有机碳密度、缓性有机碳密度、惰性有机碳密度均呈现下降趋势,活性有机碳密度先波动下降再波动上升.同时,SSP585情景下的总有机碳、活性、缓性和惰性有机碳密度均高于SSP126情景;②MannKendall突变分析表明土壤总有机碳密度之差(Δsomtc)的突变发生在2030年;土壤活性碳密度之差(Δsom1c)的突变发生在2027年;③研究期内,在SSP126情景下,甘南州草地土壤有机碳密度平均值为7505.69 g·m^(-2),在SSP585情景下则为7551.87g·m^(-2).甘南州草地土壤有机碳密度整体呈现西部高东部低,变异系数整体比较稳定的特点;④偏相关分析结果表明未来气候情景下,降水与土壤有机碳密度呈正相关,温度与土壤有机碳密度呈显著负相关;⑤Theil-Sen Median趋势分析和MannKendall检验结果表明,在两个气候情景下,甘南州的土壤有机碳密度整体呈现下降趋势,其中碌曲县的下降趋势相对最快,迭部县最缓慢.

关键词：土壤有机碳密度(SOCD) CENTURY模型气候情景时空分布趋势分析

基于网络调查问卷的骨髓增殖性肿瘤患者感染新型冠状病毒后病情影响因素分析

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中华内科杂志 2024年第4期63卷 371-377页

作者：齐飞扬宝梅高汉林江倩北京大学人民医院、北京大学血液病研究所、国家血液系统疾病临床医学研究中心北京100044 北京大学人民医院青岛医院青岛266109

目的探究新型冠状病毒SARS-CoV-2奥密克戎变异株大流行期间骨髓增殖性肿瘤(MPN)患者发生新型冠状病毒感染(COVID-19)的影响因素。方法横断面研究。2022年12月15日至2023年3月15日在SARS-CoV-2奥密克戎变异株大流行期间通过在线问卷调查... 详细信息

目的探究新型冠状病毒SARS-CoV-2奥密克戎变异株大流行期间骨髓增殖性肿瘤(MPN)患者发生新型冠状病毒感染(COVID-19)的影响因素。方法横断面研究。2022年12月15日至2023年3月15日在SARS-CoV-2奥密克戎变异株大流行期间通过在线问卷调查收集于北京大学人民医院就诊的MPN患者的COVID-19相关数据, 所有问卷和临床资料经医疗助理进行核对后, 通过多因素logistic回归分析探究COVID-19的患病率及疾病严重程度的影响因素。结果共纳入239例MPN患者, 包括原发性血小板增多症(ET)90例(37.7%)、真性红细胞增多症(PV)50例(20.9%)、骨髓纤维化(MF)99例(41.4%)。MF中原发性MF 87例(87.9%), PV后MF 5例(5.1%), ET后MF 7例(7.1%)。在此次疫情期间, 239例(100%)患者均罹患COVID-19, 其中轻型226例(94.6%), 普通型、重型、危重型分别有4例(1.7%)、7例(2.9%)、2例(0.8%);死亡2例(0.8%), 均为重型, 分别为MF和ET患者。多因素分析显示, 年龄增加(OR=2.36, 95%CI 1.24~4.49)、MPN分型为MF(OR=10.22, 95%CI 1.13~92.80)、伴除MPN外的其他慢性疾病(OR=5.25, 95%CI 1.25~22.03)是MPN患者发生普通型、重型或危重型COVID-19的影响因素。在MF患者中, MF风险分层与COVID-19严重程度显著相关, 风险分层更高的患者COVID-19严重性更高(P=0.034)。结论 SARS-CoV-2奥密克戎变异株大流行期间, 年龄较大、患MF(尤其是高风险分层)或伴除MPN外的其他慢性疾病是MPN患者发生普通型、重型或危重型COVID-19的危险因素。

关键词：骨髓增殖性疾病新型冠状病毒感染 Logistic模型骨髓增殖性肿瘤 SARS-CoV-2奥密克戎变异株

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沉浸式虚拟现实促进学习迁移的设计研究

远程教育杂志 2024年第3期42卷 93-101页

作者：张琪龙陶陶梅傲雪淮北师范大学教育学院安徽淮北235000 华中师范大学人工智能教育学部湖北武汉430079

促进迁移的场景设计是沉浸式虚拟现实研究的关键。在对沉浸式虚拟现实的迁移类型、沉浸式场景保真度以及迁移能力的影响因素等梳理的基础上,研究借鉴“沉浸式学习环境模型”和“沉浸式学习场景要素”,构建促进学习迁移的沉浸式场景设计... 详细信息

促进迁移的场景设计是沉浸式虚拟现实研究的关键。在对沉浸式虚拟现实的迁移类型、沉浸式场景保真度以及迁移能力的影响因素等梳理的基础上,研究借鉴“沉浸式学习环境模型”和“沉浸式学习场景要素”,构建促进学习迁移的沉浸式场景设计框架。设计框架包括多层级互动、沉浸式体验、生成性策略、建构性活动和反思性引导等五个核心特征,基于此开发沉浸式探究场景,采用基于设计的研究方法进行迭代设计,利用重复测量方差分析验证迭代设计的有效性,设计沉浸式学习流程并开展实验研究。研究结果表明,虚拟实验组提升了学生程序性知识习得水平迁移效率和自我效能感,通过沉浸式学习和基于模拟的体验能够提升学生在真实环境中有效应用教学法的能力。

关键词：沉浸式虚拟现实沉浸式场景探究教学法学习迁移基于设计的研究

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Bone Research 2024年第1期12卷 122-136页

作者： Nan-Yu Zou Ran Liu mei Huang Yu-Rui Jiao Jie Wei Yangzi Jiang Wen-Zhen He Min Huang Yi-Li Xu Ling Liu Yu-Chen Sun Mi Yang qi Guo Yan Huang Tian Su Ye Xiao Wei-Shan Wang Chao Zeng Guang-Hua Lei Xiang-Hang Luo Chang-Jun Li Department of Endocrinology Endocrinology Research CenterXiangya Hospital of Central South UniversityChangshaHunan 410008China Department of Orthopaedics Xiangya Hospital of Central South UniversityChangshaHunan 410008China Department of Epidemiology and Health Statistics Xiangya School of Public HealthCentral South UniversityChangshaChina Hunan Key Laboratory of Joint Degeneration and Injury ChangshaHunan 410008China Key Laboratory of Aging-related Bone and Joint Diseases Prevention and Treatment Ministry of EducationXiangya HospitalCentral South UniversityChangshaChina School of Biomedical Sciences Institute for Tissue Engineering and Regenerative MedicineFaculty of MedicineThe Chinese University of Hong KongHong Kong SARChina Department of Orthopaedics The First Affiliated Hospital of Shihezi UniversityShiheziXinjiangChina National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunan 410008China

Skeletal stem/progenitor cell(SSPC)senescence is a major cause of decreased bone regenerative potential with aging,but the causes of SSPC senescence remain *** this study,we revealed that macrophages in calluses secrete prosenescent factors,including grancalcin(GCA),during aging,which triggers SSPC senescence and impairs fracture *** injection of human rGCA in young mice induced SSPC senescence and delayed fracture *** deletion of Gca in monocytes/macrophages was sufficient to rejuvenate fracture repair in aged mice and alleviate SSPC ***,GCA binds to the plexin-B2 receptor and activates Arg2-mediated mitochondrial dysfunction,resulting in cellular *** of Plxnb2 in SSPCs impaired fracture *** of GCA-neutralizing antibody enhanced fracture healing in aged ***,our study revealed that senescent macrophages within calluses secrete GCA to trigger SSPC secondary senescence,and GCA neutralization represents a promising therapy for nonunion or delayed union in elderly individuals.

关键词： healing union senescence

Milestone progress of the HEPS booster commissioning

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Nuclear Science and Techniques 2024年第1期35卷 170-177页

作者： Yue-mei Peng Jian-She Cao Jin-Hui Chen Hai-Yi Dong Ping He Yi Jiao Ling Kang Wen Kang Jian Li Jing-Yi Li Guo-Ping Lin Fang Liu Feng-Li Long Cai Meng Xin qi Hua-Min Qu Yan-Feng Sui Sheng Wang Gang Xu qiang Ye Jing Zhang Pei Zhang Wei-Min Pan Key Laboratory of Particle Acceleration Physics and Technology Institute of High Energy PhysicsChinese Academy of Sciences19B Yuquan RoadShijingshan DistrictBeijing 100049China University of the Chinese Academy of Sciences 19A Yuquan RoadShijingshan DistrictBeijing 100049China

The high-energy photon source(HEPS)is the first fourth-generation synchrotron light source facility in *** HEPS injector consists of a linear accelerator(Linac)and a full energy *** booster captures the electron beam from the Linac and increases its energy to the value required for the storage *** full-energy beam could be injected to the storage ring directly or after“high-energy accumulation.”On November 17,2023,the key booster parameters successfully reached their corresponding target *** milestone results were achieved based on numerous contributions,including nearly a decade of physical design,years of equipment development and installation,and months of beam *** measured at the extraction energy of 6 GeV,the averaged beam current and emittance reached 8.57 mA with 5 bunches and 30.37 nm rad with a single-bunch charge of 5.58 nC,compared with the corresponding target values of 6.6 mA and 35 nm rad,*** paper presents the physical design,equipment development,installation,and commissioning process of the HEPS booster.

关键词： High energy photon source Booster Beam commissioning