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Chinese Medical Journal 2009年第21期122卷 2672-2674页

作者： tan lin-hua DU Li-zhong HE Xiao-jun SUN Mei-yue ZHANG Ze-wei lin Ru Department of Surgical Intensive Care Unit Children's Hospital Zhejiang University School of Medicine Hangzhou Zhejiang 310003 China Department of Cardiothoracic Surgery Children's Hospital Zhejiang University School of Medicine Hangzhou Zhejiang 310003 China

Extracorporeal membrane oxygenation （ECMO） can play an important role by providing short-term circulatory support to enable myocardial recovery in patients with life-threatening heart failure. Currently, over 4000 children who received ECMO for cardiac support have been reported to the Extracorporeal Life Support Registry, with the majority1 of patients placed on ECMO following cardiac surgery. It has been recently reported that the overall survival rate of approximately 40% in children requiring ECMO after repair of congenital heart lesions.1-3 The risk of mortality was significantly increased in boys, patients younger than 1 month old,

关键词： extracorporeal membrane oxygenation newborn heart failure

Toward understanding the microstructure characteristics,phase selection and magnetic properties of laser additive manufactured Nd-Fe-B permanent magnets

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International Journal of Extreme Manufacturing 2024年第1期6卷 277-294页

作者： Bo Yao Nan Kang Xiangyu Li Dou Li Mohamed EL Mansori Jing Chen Haiou Yang hua tan Xin lin State Key Laboratory of Solidiffcation Processing Northwestern Polytechnical UniversityXi’anShaanxi 710072People’s Republic of China Arts et Metiers Institute of Technology MSMPHESAM UniversitéF-51006 Chˆalons-en-ChampagneFrance Key Laboratory of Metal High Performance Additive Manufacturing and Innovative Design MIIT ChinaNorthwestern Polytechnical UniversityXi’anShaanxi 710072People’s Republic of China Texas A&M Engineering Experiment Station Institute for Manufacturing SystemsCollege StationTX 77843United States of America

Nd-Fe-B permanent magnets play a crucial role in energy conversion and electronic *** essential magnetic properties of Nd-Fe-B magnets,particularly coercivity and remanent magnetization,are significantly infuenced by the phase characteristics and *** this work,Nd-Fe-B magnets were manufactured using vacuum induction melting(VIM),laser directed energy deposition(LDED)and laser powder bed fusion(LPBF)*** evolution and phase selection of Nd-Fe-B magnets were then clarified in *** results indicated that the solidification velocity(V)and cooling rate(R)are key factors in the phase *** terms of the VIM-casting Nd-Fe-B magnet,a large volume fraction of theα-Fe soft magnetic phase(39.7 vol.%)and Nd2Fe17Bxmetastable phase(34.7 vol.%)areformed due to the low R(2.3×10-1?C s-1),whereas only a minor fraction of the Nd2Fe14B hard magnetic phase(5.15 vol.%)is *** the LDED-processed Nd-Fe-B deposit,although the Nd2Fe14B hard magnetic phase also had a low value(3.4 vol.%)as the values of V(10-2m s-1)and R(1.45×106?C s-1)in the LPBF process resulted in the substantial formation of the Nd2Fe14B hard magnetic phase(55.8 vol.%)directly from the liquid,while theα-Fe soft magnetic phase and Nd2Fe17Bxmetastable phase precipitation are suppressed in the LPBF-processed Nd-Fe-B ***,crystallographic texture analysis reveals that the LPBF-processedNd-Fe-B magnets exhibit isotropic magnetic ***,the LPBF-processed Nd-Fe-B deposit,exhibiting a coercivity of 656 k A m-1,remanence of 0.79 T and maximum energy product of 71.5 k J m-3,achieved an acceptable magnetic perfor

关键词： laser additive manufacturing(LAM) Nd-Fe-B permanent magnets numerical simulation microstructure magnetic properties

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Severe pediatric COVID‑19:a review from the clinical and immunopathophysiological perspectives

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World Journal of Pediatrics 2024年第4期20卷 307-324页

作者： Yi‑Kan Sun Can Wang Pei‑Quan lin Lei Hu Jing Ye Zhi‑Gang Gao Ru lin Hao‑Min Li Qiang Shu Li‑Su huang lin‑hua tan Children's Hospital Zhejiang University School of MedicineHangzhou 310052China The Second Affiliated Hospital Zhejiang University School of MedicineHangzhou 310030China Surgical Intensive Care Unit Children’s HospitalZhejiang University School of MedicineHangzhou 310052China Department of General Surgery Children’s HospitalZhejiang University School of MedicineHangzhou 310052China Department of Cardiopulmonary and Extracorporeal Life Support Children’s HospitalZhejiang University School of MedicineHangzhou 310052China Clinical Data Center Children’s HospitalZhejiang University School of MedicineHangzhou 310052China Department of Cardiac Surgery Children’s HospitalZhejiang University School of MedicineHangzhou 310052China National Clinical Research Center for Child Health Children’s HospitalZhejiang University School of MedicineHangzhou 310052China Department of Infectious Diseases Children’s HospitalZhejiang University School of MedicineHangzhou 310052China

Background Coronavirus disease 2019(COVID-19)tends to have mild presentations in ***,severe and critical cases do arise in the pediatric population with debilitating systemic impacts and can be fatal at times,meriting further attention from ***,the intricate interactions between the pathogen virulence factors and host defense mechanisms are believed to play indispensable roles in severe COVID-19 pathophysiology but remain incompletely *** sources A comprehensive literature review was conducted for pertinent publications by reviewers independently using the PubMed,Embase,and Wanfang *** keywords included“COVID-19 in children”,“severe pediatric COVID-19”,and“critical illness in children with COVID-19”.Results Risks of developing severe COVID-19 in children escalate with increasing numbers of co-morbidities and an unvaccinated *** respiratory distress stress and necrotizing pneumonia are prominent pulmonary manifestations,while various forms of cardiovascular and neurological involvement may also be *** immunological processes are implicated in the host response to COVID-19 including the type I interferon and inflammasome pathways,whose dysregulation in severe and critical diseases translates into adverse clinical *** inflammatory syndrome in children(MIS-C),a potentially life-threatening immune-mediated condition chronologically associated with COVID-19 exposure,denotes another scientific and clinical conundrum that exemplifies the complexity of pediatric *** the considerable dissimilarities between the pediatric and adult immune systems,clinical trials dedicated to children are lacking and current management recommendations are largely adapted from adult *** Severe pediatric COVID-19 can affect multiple organ *** dysregulated immune pathways in severe COVID-19 shape the disease course,epitomize the vast functional diversity of the

关键词： Immunopathophysiology MIS-C Pediatric critical care Severe pediatric COVID-19

Precise determination of the pole position of the exotic Z_(c)(3900)

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Science China(Physics,Mechanics & Astronomy) 2024年第9期67卷 84-90页

作者： Yun-hua Chen Meng-lin Du Feng-Kun Guo School of Mathematics and Physics University of Science and Technology BeijingBeijing 100083China School of Physics University of Electronic Science and Technology of ChinaChengdu 611731China CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China Peng huanwu Collaborative Center for Research and Education Beihang UniversityBeijing 100191China

We perform a unified description of the experimental data of the π^(+)π^(-)and J/ψπ^(±)invariant mass spectra for e^(+)e^(-)→J/ψπ^(+)π^(-)and the D^(0)D^(*-)mass spectrum for e^(+)e^(-)→D^(0)D^(*-)π^(+)at e^(+)e^(-)center-of-mass energies 4.23 and 4.26 *** analysis takes into account open-charm meson loops that contain triangle singularities,the J/ψπ-DD^(*)coupled-channel interaction respecting unitarity,and the strong ππ-KK final state interaction using dispersion *** analysis leads to a precise determination of the Z_(c)(3900)pole with the pole mass and width(3880.7±1.7_(stat)±22.4_(syst))MeV and(35.9±1.4_(stat)±15.3_(syst))MeV,respectively,and hints at that the DD^(*)molecular and non-molecular components are of similar importance in the Z_(c)(3900)formation.

关键词： exotic hadrons dispersion relations final state interaction triangle singularity

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知识产权制度变革与发展之再思考

苏州大学学报（哲学社会科学版） 2011年第3期32卷 101-106,191-192页

作者：谭华霖北京航空航天大学法学院北京100191

知识产权作为一个集合概念出现具有很强的历史偶然性,随着技术的发展和其他辅助手段在知识产权公示中发挥的作用逐渐增强,知识产权本身也在不断发生着变化。知识产权客体的不断突破,主体呈现多元化,权利内容持续扩张,管理模式的演进,知... 详细信息

知识产权作为一个集合概念出现具有很强的历史偶然性,随着技术的发展和其他辅助手段在知识产权公示中发挥的作用逐渐增强,知识产权本身也在不断发生着变化。知识产权客体的不断突破,主体呈现多元化,权利内容持续扩张,管理模式的演进,知识产权法哲学的嬗变反映了变革中的知识产权制度发展脉络,知识产权立法和政策的制定要充分考虑这些因素并予以回应。

关键词：知识产权制度变革权利扩张管理模式

UPLC-Q-TOF/MS-Based Serum Metabolomics Reveals Potential Anti-tumor Mechanism of Banxia Xiexin Decoction in Colorectal Cancer Mice

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Chinese Journal of Integrative Medicine 2024年第7期30卷 623-632页

作者： YUE Yin-zi LI Ming-xuan WANG Xiao-hui QIN Yuan-yuan WANG Ya-hui tan Jin-hua SU Lian-lin YAN Shuai Department of General Surgery Suzhou TCM Hospital Affiliated to Nanjing University of Chinese MedicineSuzhou215009China School of Pharmacy Nanjing University of Chinese MedicineNanjing210023China Department of General Surgery Bayinguoleng Mongolian Autonomous Prefecture People’s HospitalXinjiang Uygur Autonomous RegionKorla841000China Department of Pharmacy Suzhou TCM Hospital Affiliated to Nanjing University of Chinese MedicineSuzhou215009China Department of Anorectal Surgery Suzhou TCM Hospital Affiliated to Nanjing University of Chinese MedicineSuzhou215009China

Objective To clarify the potential mechanism of Banxia Xiexin Decoction(BXD)on colorectal cancer(CRC)from the perspective of *** Forty male C57BL/6 mice were randomly divided into normal control(NC),azoxymethane/dextran sulfate sodium(AOM/DSS)model,low-dose BXD(L-BXD),high-dose BXD(H-BXD)and mesalamine(MS)groups according to a random number table,8 mice in each *** cancer model was induced by AOM/*** was administered daily at doses of 3.915(L-BXD)and 15.66 g/kg(H-BXD)by gavage for consecutive 21 days,and 100 mg/kg MS was used as positive *** the entire modeling cycle,colon length of mice was measured and quantity of colorectal tumors were *** spleen and thymus index were determined by calculating the spleen/thymus weight to body *** cytokine and changes of serum metabolites were analyzed by enzyme-linked immunosorbent assay kits and ultra performance liquid chromatography-quadrupole/time-of-flight mass spectrometry(UPLC-Q/TOF-MS),*** Notably,BXD supplementation protected against weight loss,mitigated tumor formation,and diminished histologic damage in mice treated with AOM/DSS(P<0.05 or P<0.01).Moreover,BXD suppressed expression of serum inflammatory enzymes,and improved the spleen and thymus index(P<0.05).Compared with the normal group,102 kinds of differential metabolites were screened in the AOM/DSS group,including 48 potential biomarkers,involving 18 main metabolic *** 18 potential biomarkers related to CRC were identified,and the anti-CRC mechanism of BXD was closely related to D-glutamine and D-glutamate metabolism,phenylalanine,tyrosine and tryptophan biosynthesis,arginine biosynthesis,nitrogen metabolism and so *** BXD exerts partial protective effects on AOM/DSS-induced CRC by reducing inflammation,protecting organism immunity ability,and regulating amino acid metabolism.

关键词： colorectal cancer metabolomics ultra performance liquid chromatography-quadrupole/time-of-flight mass spectrometry azoxymethane dextran sulfate sodium Banxia Xiexin Decoction Chinese medicine

血浆S100A12与婴幼儿体外循环术后非感染性肺部并发症的相关性研究

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中华急诊医学杂志 2012年第10期21卷 1134-1139页

作者：刘喜旺舒强陈迟施珊珊石卓俞建根林茹谈林华陈齐兴浙江大学医学院附属儿童医院心胸外科、生殖遗传教育部重点实验室杭州310003 浙江大学医学院附属第一医院

目的动态观察婴幼儿体外循环（CPB）围术期血浆中S100A12和可溶性晚期糖基化终末产物受体（sRAGE）水平变化，探讨其在婴幼儿CPB术后非感染性肺部并发症（NPC）早期预测中的作用。方法采用病例对照研究。选取2011年6月1日至7月31日，在... 详细信息

目的动态观察婴幼儿体外循环（CPB）围术期血浆中S100A12和可溶性晚期糖基化终末产物受体（sRAGE）水平变化，探讨其在婴幼儿CPB术后非感染性肺部并发症（NPC）早期预测中的作用。方法采用病例对照研究。选取2011年6月1日至7月31日，在浙江大学附属儿童医院行CPB下心内直视矫治术、年龄〈3岁的先天性心脏病患儿。排除术前肺部有炎症性疾病和肝肾功能异常的患儿。根据术后是否出现胸腔积液、乳糜胸、部分肺不张、肺动脉高压危象、气道紊乱、气胸、纵膈积气、膈神经麻痹，20例被分为NPC组，40例被分为no-NPC组。于手术前，CPB前，CPB后，手术后1、12和24h,采用ELISA法检测血浆中S100A12和sRAGE浓度。两组之间的浓度差异采用t检验；多因素Logistic回归分析检验S100A12和sRAGE在术后NPC早期预测中的作用，并以优势比（OR）及95%可信区间（95%CI）表示相对危险度；以P〈0.05为差异具有统计学意义。结果血桨中S100A1212和sEAGE浓度在CPB后立刻明显升高（P〈0.01）。术后24h后血浆中sRAGE水平明显低于术前水（P〉〈0.05），而S100A12仍明显高于术前水平（P〈0.01）。CPB术后即刻，MPC组血浆中S100A12和sRAGE水平明显高于no-NPC组（P〈0.05）。术后24hNPC组血浆中S100A12水平仍明显高于no-NPC组（P〈0.05），而两组患儿血浆中sRAGE水平无明显差异（P〉0.05）。逐步法Logistic回归分析，CPB后即刻血浆中S100A12水平与术后NPC的发生明显相关（0R=1.042,95%Cl：1.010-1.076，P=0.011）。CPB后即刻血浆中S100A12与术后机械通气时间（r=0.47,P〈0.01）、住ICU时间（r=0.363，P=0.008）和住院时间（r=0.402，P=0.002）明显相关。结论婴幼儿CPB术后血浆中S100A12和sRAGE水平立刻明显升高。血浆中S100A12是婴幼儿CPB术后NPC发生和预后的早期预测指标。

关键词： S100A12 可溶性晚期糖基化终末产物(sRAGE) 非感染性肺部并发症体外循环心脏手术先天性心脏病婴幼儿病历对照相关性.

Effect of Mo and cold forging deformation on strength and ductility of cobalt-based alloy L605

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Journal of Iron and Steel Research International 2024年第7期31卷 1811-1823页

作者： Zhong-lin Wang Zhi-hua Gong Quan Li Han-sheng Bao School of Materials and Metallurgy Inner Mongolia University of Science and TechnologyBaotou 014017Inner MongoliaChina Institute of Special Steels Central Iron and Steel Research Institute Co.Ltd.Beijing 100081China

Mo element was added to cobalt-based alloy L605,and cold forging deformation was *** effects of the addition and cold forging deformation on the microstructure and mechanical properties of the alloy were studied by thermodynamic calculation,electron backscatter diffraction,transmission electron microscopy,and X-ray *** stacking fault energy(SFE)of the alloy decreased after the addition,and the formation of stacking faults and intersections were promoted to improve the strength and *** tensile strength of the alloy with Mo increased from 1190 to 1702 MPa after 24%cold deformation,producing significant work *** strengthening mechanism is strain-induced martensitic transformation(SIMT)and deformation *** alloy,combined with Mo and after 24%deformation,had both high strength and ductility in comparison with the original cobalt-based alloy *** is attributed to the lower SFE which caused the increase in stacking fault *** the tensile process,theε-hcp phase was easily generated at the stacking fault to reduce the stress concentration and increase the *** SIMT by adjusting the density of stacking faults can improve the mechanical properties of cobalt-based ***ε-hcp phase,the interaction between deformation twins and dislocations,and the interaction between e-hcp phases during cold forging deformation caused local stress concentration,lowering ductility and toughness.

关键词： Cobalt-based alloy-Stacking fault energy Strain-induced martensitic transformation Deformation twin Cold forging deformation

Cr-catalyzed allylic C(sp^(3))–H addition to aldehydes enabled by photoinduced ligand-to-metal charge transfer

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Science China Chemistry 2024年第5期67卷 1589-1595页

作者： Xianrong Zeng Feng-hua Zhang Runchen Lai Xiaoyu lin Zhaobin Wang Key Laboratory of Precise Synthesis of Functional Molecules of Zhejiang Province Department of ChemistrySchool of Science and Research Center for Industries of the FutureWestlake UniversityHangzhou 310030China Institute of Natural Sciences Westlake Institute for Advanced StudyHangzhou 310024China Key Laboratory of Precise Synthesis of Functional Molecules of Zhejiang Province Instrumentation and Service Center for Molecular SciencesWestlake UniversityHangzhou 310024China

Photoinduced ligand-to-metal charge transfer(LMCT) has emerged as an effective strategy for synthesizing organic molecules in a sustainable manner. However, the majority of existing reports on selective C(sp^(3))–H bond functionalization via photoinduced LMCT focus on the use of late transition metals or rare-earth metals for radical additions or cross-couplings. In contrast, the utilization of photoinduced LMCT with 3d early transition metals poses a significant challenge. Herein, we describe an unprecedented approach to allylic C(sp^(3))–H addition to aldehydes, employing chromium(Cr) complexes as catalysts through visible-light-induced LMCT. By investigating the reaction pathway through various mechanistic studies, including radical trapping, kinetic isotope effect(KIE) analysis, and transient absorption spectroscopy, valuable insights have been gained. The proposed mechanism suggests the intermediacy of bromine radicals through homolysis of the Cr–Br bond. Notably, this protocol expands our understanding of the photochemical properties of earth-abundant Cr complexes.

关键词： Cr catalysis photoinduced ligand-to-metal charge transfer hydrogen-atom transfer carbonyl addition

Evaluation of suitability,adaptability,and reserve potential of construction land on the Qinghai-Tibet Plateau

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Journal of Geographical Sciences 2024年第1期34卷 41-61页

作者： YANG hua XU Yong ZHOU Kan WANG Lijia XU lin Key Laboratory of Regional Sustainable Development Modeling Institute of Geographic Sciences and Natural Resources ResearchCASBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China

Construction land is the leading carrier of human activities such as production and *** the construction land suitability(CLS)on the Qinghai-Tibet Plateau(QTP)holds significant implications for harmonizing the relationship between ecological protection and human activity and promoting population and industry layout ***,no relevant studies provide a complete CLS assessment of the *** this study,we developed a model-based CLS evaluation framework coupling of pattern and process to calculate the global CLS on the QTP based on a previously developed CLS evaluation ***,using the land-use data of 1990,2000,2010,and 2020,we examined the adaptability of existing construction land(ECL)to the CLS assessment result through the adaptability index and vertical gradient index and further analyzed the limitations of maladaptive construction ***,we calculated the potential area of reserve suitable construction *** article includes four conclusions:(1)The highly suitable,suitable,moderately suitable,marginally suitable,and unsuitable CLS classes cover areas of 0.33×10^(4)km^(2),10.42×10^(4)km^(2),18.06×10^(4)km^(2),24.12×10^(4)km^(2),and 205.29×10^(4)km^(2),*** approximately 11%of the study area on the QTP is suitable for large-scale permanent construction land,and approximately 79.50%of the area is unsuitable under current economic and technological conditions.(2)The ECL adaptability index is 85.16%,85.93%,85.18%,and 78.01%during 1990–2020,respectively,with an average adaptability index exceeding 80%on the *** ECL distribution generally conforms to construction land suitable space characteristics but with a significant spatial difference.(3)From 1990 to 2020,the maladaptive ECL was dominated by rural settlement land,transport land,and special land,with a rapidly increasing proportion of urban and other construction *** maladaptive ECL is constrained by both elevation and slope in the southern Qinghai Pla

关键词： land resource construction land suitability existing construction land adaptability human activity Qinghai-Tibet Plateau