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Particular Chinese contributions to extracorporeal liver surgery

Hepatobiliary & Pancreatic Diseases International 2025年第1期24卷 57-66页

作者： Abudusalamu Aini Qian Lu Hao Wen Wen-Tao Wang Tuerganaili Aji Zhi-yu Chen Lei-Da Zhang Zhan-yu Yang Jia-Yin Yang Hai-Ning Fan Wei-Lin Wang Xiang-Cheng Li yu Zhang Jia-hong Dong Hepatopancreatobiliary Center Organ Transplantation CenterBeijing Tsinghua Changgung HospitalTsinghua UniversityBeijing 102218China Key Laboratory of Digital Intelligence Hepatology(Chinese Ministry of Education) School of Clinical MedicineTsinghua UniversityBeijing 100084China Research Unit of Precision Hepatobiliary Surgery Paradigm Chinese Academy of Medical SciencesBeijing 100010China Institute for Organ Transplantation and Bionics Institute for Precision MedicineSchool of Clinical MedicineTsinghua UniversityBeijing 100010China Hepatobiliary&Echinococcosis Surgery Digestive&Vascular Surgery CenterThe First Affiliated Hospital of Xinjiang Medical UniversityUrumqi 830054China Department of Liver Surgery&Liver Transplantation Center West China Hospital of Sichuan UniversityChengdu 610041China Department of Hepatobiliary Surgery Southwest HospitalThe Army Medical UniversityChongqing 100089China Faculty of Hepato-Pancreato-Biliary Surgery Chinese People’s Army General HospitalBeijing 400038China Liver Transplantation Center&Organ Transplantation Center West China Hospital of Sichuan UniversityChengdu 610041China Hepatopancreatobiliary Surgery School of Clinical MedicineQinghai University Affiliated HospitalXining 810006China Department of Hepatobiliary Surgery The Second Affiliated HospitalZhejiang Univeristy School of MedicineHangzhou 310009China Department of Hepatobiliary Surgery The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China Department of Hepatobiliary Surgery Sichuan Provincial People’s HospitalChengdu 610072China

Extracorporeal liver surgery(ELS), also known as liver autotransplantation, is a hybrid(cross-fertilized) surgery incorporating the technical knowledge from extreme liver and transplant liver surgeries, and recently became more embraced and popularized among leading centers. ELS could be summarized into three major categories, namely, ex-situ liver resection and autotransplantation(ELRA), ante-situm liver resection and autotransplantation(ALRA) and auxiliary partial liver autotransplantation(APLA). The successful development of ELS during the past 37 years is definitely inseparable from continuous effort s done by Chinese surgeons and researchers. Especially, the precision liver surgery paradigm has allowed to transform ELS into a modularized, more simplified, and standardized surgery, to upgrade surgical skills, to improve peri-operative outcome and long-term survival, to increase the capability of surgeons to select more complex diseases and to expand the level of medical service to the population. This review highlights the Chinese contributions to the field of ELS, focusing thereby on features of different surgical types, technical innovations, disease selection and surgical indication, patient prognosis and future perspectives.

关键词： Ex-situ ex-vivo liver resection Ex-situ in-vivo liver resection Semi-ex-vivo liver resection Ex-situ liver resection after in-situ hepatectomy Liver autotransplantation Autologous liver transplantation Bench hepatectomy Back-table liver resection Precision liver surgery

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蒙古族安代美学特征探略

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长春师范大学学报（人文社会科学版） 2009年第1期28卷 152-154页

作者：耿学刚谭宏宇内蒙古民族大学艺术学院内蒙古通辽028000 赤峰学院音乐系内蒙古赤峰024000

安代是科尔沁草原上的一种歌、舞、乐的综合艺术,其发源地为科尔沁草原哲里木盟库伦旗。据考证安代约有三百多年的历史,它来自于人民群众,是劳动人民社会实践生活的升华,群众基础深厚,具有强大的艺术生命力。安代是蒙古人文化历史的一... 详细信息

安代是科尔沁草原上的一种歌、舞、乐的综合艺术,其发源地为科尔沁草原哲里木盟库伦旗。据考证安代约有三百多年的历史,它来自于人民群众,是劳动人民社会实践生活的升华,群众基础深厚,具有强大的艺术生命力。安代是蒙古人文化历史的一种特有形态,同时又具有"艺术美"的共性特征。

关键词：安代紧密性合一性艺术性

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云南电大开放教育人力资源管理课程网络考试改革的效果分析

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云南电大学报 2008年第4期10卷 18-20页

作者：谭玉洪郑胡灵云南广播电视大学经济学院云南昆明650223

根据云南广播电视大学在实施开放教育人力资源管理课程网络考试改革试点的开展情况,为更好地开展基于网络课程考核改革的试点工作,应加大宣传力度,让社会更多了解基于网络考试改革的优点,同时改进基于网络考试改革软件的部份功能,完善... 详细信息

根据云南广播电视大学在实施开放教育人力资源管理课程网络考试改革试点的开展情况,为更好地开展基于网络课程考核改革的试点工作,应加大宣传力度,让社会更多了解基于网络考试改革的优点,同时改进基于网络考试改革软件的部份功能,完善人力资源管理课程形成性考核和终结性考核试题库。

关键词：人力资源管理网络考试效果分析

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缩聚活性的铽配合物合成、表征及其性质

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化学试剂 2006年第3期28卷 129-131页

作者：周新木谈宏宇赵光好徐招弟南昌大学化学系江西南昌330047

通过HCl气体在无水乙醇中,与Tb4O7反应生成无水TbCl3,再与具有胺基的配体反应,合成了一种两端带有胺基的呈缩聚活性的铽配合物。用元素分析、红外光谱和紫外光谱对配合物的组成和结构进行了表征,并借摩尔电导、差热-热重和荧光光谱对配... 详细信息

通过HCl气体在无水乙醇中,与Tb4O7反应生成无水TbCl3,再与具有胺基的配体反应,合成了一种两端带有胺基的呈缩聚活性的铽配合物。用元素分析、红外光谱和紫外光谱对配合物的组成和结构进行了表征,并借摩尔电导、差热-热重和荧光光谱对配合物进行了研究。配合物的起始分解温度为230℃左右,粉末状态下具有较高的荧光强度,单色性好,在DMF中可作为聚合单体应用。

关键词：铽配合物单体共缩聚荧光性质

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In vivo self-assembled bispecific fluorescence probe for early detection of bladder cancer and metastasis

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Science Bulletin 2025年第3期70卷 407-418页

作者： Da-Yong Hou Ni-yuan Zhang Peng Zhang Xiang-Peng Li Jiong-Cheng Wu Mei-yu Lv Zhi-Jia Wang Xing-Jie Hu Jian-Xiao Liang hong-Lei Wang yue-Ze Wang Hui-Hui You hong-Wei An Hao Wang Wanhai Xu NHC Key Laboratory of Molecular Probe and Targeted Theranostics Heilongjiang Key Laboratory of Scientific Research in UrologyHarbin Medical UniversityHarbin 150001China Department of PET-CT/MRI Harbin Medical University Cancer HospitalHarbin 150001China CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in NanoscienceNational Center for Nanoscience and Technology(NCNST)Beijing 100190China

Tumor metastasis accounts for over 90%of tumor-related deaths,prompting the development of fluorescently labeled tumor-specific molecular imaging agents for differentiating tumors from normal ***,early detection of metastasis lesions by tracking tumor markers alone has proven to be ***,we reported a glycopeptide-based bispecific fluorescence probe(bsProbe)for earlier detection of bladder cancer and *** simultaneously recognition(tumor&tumor microenvironment)and in vivo self-assembly,the tumor accumulation of bsProbe(12.3%ID/g)was obviously increased by∼6 fold compared with that in CXCR4 specific fluorescence probe(sProbe),indicating the obvious advantages of bsProbe over existing tumor metastasis detection ***,bsProbe substantially broadens the tumor diagnosis window and enhances the detection signal to noise ratio(SNR:approximately 9.5),permitting early diagnosis of lung micro-metastasis(∼1 mm),precise identifying of tumor boundaries and micro-tumors in orthotopic tumor *** importantly,bsProbe was demonstrated to distinguish malignant from benign specimen with a specificity of 90.48%and sensitivity of 92.22%in 195 clinical specimens of bladder cancer *** together,this novel synergetic targeting(CD206×CXCR4)strategy provides an attractive method for earlier detection of bladder cancer and metastasis,which might be further extended to the imaging-guided surgery of clinical invisible tumors.

关键词： Self-assembly Peptide Nanomaterial Fluorescence imaging Bladder cancer

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Brain activity in different brain areas of patients with diabetic vitreous hemorrhage according to voxel-based morphometry

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International Journal of Ophthalmology(English edition) 2025年第2期18卷 258-267页

作者： Li-Jun Ji Jin-yu Hu Yan-Mei Zeng Qian Ling Jie Zou Cheng Chen Liang-Qi He Xiao-yu Wang hong Wei Xu Chen Yi-Xin Wang Yi Shao Yao yu Department of Ophthalmology Dahua HospitalShanghai 200237China Department of Endocrine and Metabolic the First Affiliated Hospital of Nanchang UniversityJiangxi Clinical Research Centre for Endocrine and Metabolic DiseaseJiangxi Branch of National Clinical Research Center for metabolic DiseaseNanchang 330006Jiangxi ProvinceChina Department of Ophthalmology the First Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina Ophthalmology Centre of Maastricht University Maastricht 6200MSLimburg Provinciethe Netherlands School of optometry and vision science Cardiff UniversityCardiffCF244HQWalesUK Department of Ophthalmology Shanghai General HospitalShanghai Jiao Tong University School of MedicineNational Clinical Research Center for Eye DiseasesShanghai 200080China

AIM:To elucidate the neuropathological mechanisms underlying diabetic vitreous hemorrhage(DVH)and its correlation with clinical ***:Twenty-one individuals with DVH(male/female 12/9;mean age 52.29±11.66y)were selected,alongside 21 appropriately matched controls with diabetes mellitus(DM).Voxel-based morphometry(VBM)techniques were employed to identify aberrant functional regions in the *** operating characteristic(ROC)curves were utilized for classification based on the average VBM values of the two groups,and Pearson correlation analysis was conducted to assess the relationship between average VBM values in distinct brain regions and clinical ***:Relative to the DM controls,DVH patients exhibited reduced VBM values in the right superior temporal pole,the right superior temporal gyrus,the right medial orbital frontal gyrus,and the left superior frontal ***,ROC curve analysis of these four brain regions in DVH patients demonstrated a high degree of accuracy,as indicated by the area under the *** average VBM value in each of these regions exhibited a negative correlation with both the duration of DVH and the score on the Hospital Anxiety and Depression Scale(HADS).CONCLUSION:Pathological alterations in four distinct brain regions are observed in patients with DVH,potentially reflecting neuropathological changes associated with this condition.

关键词： diabetic vitreous hemorrhage voxel-based morphometry Hospital Anxiety and Depression Scale brain areas

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帕金森病患者便秘相关因素分析

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中华神经医学杂志 2011年第11期10卷 1146-1148页

作者：谭红愉陈楚霜吴卓华邵明广州医学院第一附属医院帕金森病与DBS治疗中心广州510120

目的探讨PD患者便秘的相关因素。方法选取PD患者212例，采用便秘量表评定PD患者的便秘程度，详细记录患者的年龄、病程、用药情况，并进行UPDRSDI评分、Hoehn—Yahr分期、汉密顿抑郁量表（HAMD）评分、中文版简易智能精神状态检查量表（... 详细信息

目的探讨PD患者便秘的相关因素。方法选取PD患者212例，采用便秘量表评定PD患者的便秘程度，详细记录患者的年龄、病程、用药情况，并进行UPDRSDI评分、Hoehn—Yahr分期、汉密顿抑郁量表（HAMD）评分、中文版简易智能精神状态检查量表（MMSE）评分，将各项因素与便秘进行偏相关分析，并利用二分类Logistic回归分析筛选PD患者合并便秘的危险因素。结果212例PD患者的年龄、***分期、HAMD总分与便秘有显著的相关关系（P〈0．05），是便秘的危险因素，而性别、病程、盐酸苯海索每日剂量、吡呗地尔每日剂量、左旋多巴每日剂量、UPDRSⅢ评分、MMSE总分与便秘无显著的相关关系（P〉0．05）。结论PD患者便秘与年龄、Hoehn—Yahr分期、HAMD总分有关。

关键词：帕金森病便秘相关因素

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游离齿状突寰枢脱位两种后路融合术比较

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中国矫形外科杂志 2022年第16期30卷 1462-1467页

作者：张杨宋瑞鹏张敏王卫东谭洪宇郑州大学第一附属医院骨科河南郑州450052

[目的]比较寰枢椎融合与颈枕融合治疗后路齿状突游离小骨合并寰枢椎脱位的临床效果。[方法]回顾性分析2010年1月—2015年12月行后路融合术治疗的29例齿状突游离小骨合并寰枢椎脱位患者的临床资料。依据患者具体情况与术前医患沟通结果,2... 详细信息

[目的]比较寰枢椎融合与颈枕融合治疗后路齿状突游离小骨合并寰枢椎脱位的临床效果。[方法]回顾性分析2010年1月—2015年12月行后路融合术治疗的29例齿状突游离小骨合并寰枢椎脱位患者的临床资料。依据患者具体情况与术前医患沟通结果,22例行寰枢椎融合(寰枢组),7例行颈枕融合(颈枕组)。比较两组患者围手术期、随访和影像资料。[结果]两组患者均顺利完成手术,术中均无严重并发症。寰枢融合组切口长度显著小于颈枕融合组(P0.05)。影像方面,与术前相比,术后两组的C_(0~2)角显著增大(P<0.05),而C_(2~7)角和ADI显著减小(P<0.05)。术后寰枢组的ADI均小于颈枕组,其中,术后5年时两组间差异有统计学意义(P<0.05)。[结论]两种术式均安全有效,与颈枕融合相比,寰枢融合可减小手术创伤,更好复位寰枢椎,保留更多颈椎活动度,功能恢复更好。

关键词：游离齿状突寰枢椎脱位寰枢椎融合颈枕融合

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腹腔镜肝囊肿开窗术19例报告

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中国现代手术学杂志 2007年第4期11卷 294-295页

作者：谭洪育吴红龙绍华江西省萍乡湘雅萍矿合作医院萍乡337000

目的探讨腹腔镜肝囊肿开窗术的临床效果。方法对19例肝囊肿病人行腹腔镜下囊肿开窗术,其中单发17例,多发2例;位于右肝14例,位于左肝5例。术前均经B超和CT检查证实,并排除先天性肝胆管囊肿。结果19例均顺利完成手术,无中转开腹,平均手术... 详细信息

目的探讨腹腔镜肝囊肿开窗术的临床效果。方法对19例肝囊肿病人行腹腔镜下囊肿开窗术,其中单发17例,多发2例;位于右肝14例,位于左肝5例。术前均经B超和CT检查证实,并排除先天性肝胆管囊肿。结果19例均顺利完成手术,无中转开腹,平均手术时间40（20～80）min,除1例因引流出少量胆汁而留置引流2周外,其余均在3～4 d后出院。15例随访0.5～6.8年,2例复发,予开腹手术治愈。结论腹腔镜肝囊肿开窗术具有损伤小、术后疼痛轻、恢复快等优点,但应严格掌握手术适应证。

关键词：腹腔镜检查肝囊肿

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Combining deep reinforcement learning with heuristics to solve the traveling salesman problem

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Chinese Physics B 2025年第1期34卷 96-106页

作者： Li hong yu Liu Mengqiao Xu Wenhui Deng School of Software Technology Dalian University of TechnologyDalian 116620China School of Economics and Management Dalian University of TechnologyDalian 116024China

Recent studies employing deep learning to solve the traveling salesman problem(TSP)have mainly focused on learning construction *** methods can improve TSP solutions,but still depend on additional ***,methods that focus on learning improvement heuristics to iteratively refine solutions remain *** improvement heuristics are guided by a manually designed search strategy and may only achieve limited *** paper proposes a novel framework for learning improvement heuristics,which automatically discovers better improvement policies for heuristics to iteratively solve the *** framework first designs a new architecture based on a transformer model to make the policy network parameterized,which introduces an action-dropout layer to prevent action selection from *** then proposes a deep reinforcement learning approach integrating a simulated annealing mechanism(named RL-SA)to learn the pairwise selected policy,aiming to improve the 2-opt algorithm's *** RL-SA leverages the whale optimization algorithm to generate initial solutions for better sampling efficiency and uses the Gaussian perturbation strategy to tackle the sparse reward problem of reinforcement *** experiment results show that the proposed approach is significantly superior to the state-of-the-art learning-based methods,and further reduces the gap between learning-based methods and highly optimized solvers in the benchmark ***,our pre-trained model M can be applied to guide the SA algorithm(named M-SA(ours)),which performs better than existing deep models in small-,medium-,and large-scale TSPLIB ***,the M-SA(ours)achieves excellent generalization performance in a real-world dataset on global liner shipping routes,with the optimization percentages in distance reduction ranging from3.52%to 17.99%.

关键词： traveling salesman problem deep reinforcement learning simulated annealing algorithm transformer model whale optimization algorithm

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