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Genetics of Gallstone Disease and their Clinical Significance: A Narrative Review

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Journal of Clinical and translational Hepatology 2024年第3期12卷 316-326页

作者： Christopher J.Costa Minh thu t.Nguyen Haleh Vaziri George y.Wu Department of Medicine University of Connecticut Health CenterFarmingtonCTUSA Division of Gastroenterology and Hepatology University of Connecticut Health CenterFarmingtonCTUSA

Gallstone(GS)disease is common and arises from a combination of genetic and environmental *** genetic abnormalities specifically leading to cholesterol GSs are rare,there are clinically significant gene variants associated with cholesterol *** contrast,most bilirubin GSs can be attributed to genetic *** pathogenesis of cholesterol and bilirubin GSs differs *** GSs are notably influenced by genetic variants within the ABC protein superfamily,including ABCG8,ABCG5,ABCB4,and ABCB11,as well as genes from the apolipoprotein family such as ApoB100 and ApoE(especially the E3/E3 and E3/E4 variants),and members of the MUC ***,bilirubin GSs are associated with genetic variants in highly expressed hepatic genes,notably UGt1A1,ABCC2(MRP2),ABCC3(MRP3),CFtR,and MUC,alongside genetic defects linked to hemolytic anemias and conditions impacting *** genetic cases constitute a small portion of GS disease,recognizing genetic predisposition is essential for proper diagnosis,treatment,and genetic counseling.

关键词： Gallstones Cholelithiasis AtP-binding cassette transporters ABCG8 protein Human UDP-glucuronosyltransferase A1

Ren-integrable and ren-symmetric integrable systems

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Communications in theoretical Physics 2024年第3期76卷 62-69页

作者： S y Lou School of Physical Science and technology Ningbo UniversityNingbo315211China

A new type of symmetry,ren-symmetry,describing anyon physics and corresponding topological physics,is ***-symmetry is a generalization of super-symmetry which is widely applied in super-symmetric physics such as super-symmetric quantum mechanics,super-symmetric gravity,super-symmetric string theory,super-symmetric integrable systems and so *** and Grassmann numbers are,in some sense,dual conceptions,and it turns out that these conceptions coincide for the ren situation,that is,a similar conception of ren-number(R-number)is devised for *** particular,some basic results of the R-number and ren-symmetry are exposed which allow one to derive,in principle,some new types of integrable systems including ren-integrable models and ren-symmetric integrable *** examples of ren-integrable KdV-type systems and ren-symmetric KdV equations are explicitly given.

关键词： symmetries integrable systems anyon physics extended supersymmetry ren-symmetry

Distinct Electrical and Mechanical Responses of a Cu-10Fe Composite Prepared by Hot-Pressed Sintering and Post treatment

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Acta Metallurgica Sinica(English Letters) 2024年第2期37卷 255-265页

作者： X.y.yue S.y.Peng X.Zhang C.N.He y.Z.tian Key Laboratory for Anisotropy and texture of Materials(Ministry of Education) School of Materials Science and EngineeringNortheastern UniversityShenyang110819China School of Materials Science and Engineering and tianjin Key Laboratory of Composite and Functional Materials Tianjin UniversityTianjin300350China Research Centre for Metallic Wires Northeastern UniversityShenyang110819China

A Cu-10wt%Fe composite was prepared through hot-pressed sintering,and the material was subsequently solution *** hot-pressed sintered and solution treated materials were rolled and *** precipitation behavior and performance changes were systematically studied by using scanning electron microscopy and transmission electron *** contrast to the hot-pressed sintered specimen,the solution treatment significantly affects the thermal stability and properties of the Cu-10wt%Fe *** Cu-10wt%Fe composite was prepared after solid solution,cold rolling and aging at 773 K for 1 h,and it obtained excellent tensile strength of 494 MPa,uniform elongation of 16.3%,electrical conductivity of 51.1%IACS and softening temperature of 838 *** for the distinct difference in thermal stability and properties between hot-pressed sintered and solution treated specimens were *** findings provide a theoretical basis for designing high-performance Cu-based in-situ composites by post treatment.

关键词： Cu-Fe composite Hot-pressed sintering thermal stability Strength Electrical conductivity

Creep-induced redistribution of alloying elements in CZ1 zirconium alloys

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Journal of Materials Science & technology 2024年第6期173卷 31-44页

作者： W.t.Lin Q.y.Lv D.Jiao L.B.Zhang J.tan G.Sha J.Hu China Nuclear Power technology Research Institute Shenzhen 518026China School of Material Science and Engineering Nanjing University of Science and TechnologyNanjing 210094China

Introducing minor alloying elements is an effective strategy to improve the corrosion and mechanical properties of zirconium alloys for nuclear *** in-reactor service,external environment and stress can affect the distribution of alloying elements,substantially changing the degradation process of zirconium *** date,there is a lack of in-depth understanding of the interaction between creep and microchemistry ***,we conducted systematic transmission electron microscopy(tEM)and atom probe tomography(APt)investigations to address creep-induced redistribution of alloying elements in CZ1(Zr-Sn-Nb-Fe-Cr-Cu)zirconium alloy with different initial ***,Fe,Sn,and Cu are found to co-segregate at grain *** higher the intermediate annealing temperature,the larger the Gibbsian interfacial excesses of solute elements *** further demonstrate that creep can reduce the excess value of Fe at grain boundaries due to the coarsening of Zr-Fe-Cr second phase particles via grain boundary and dislocation pipe *** the same time,the excess value of Sn is increased by diffusing from the matrix to grain ***,Cu as a minor element in the concentration range of 0.05-0.3 wt.%is found to segregate at dislocations to form the Cottrell atmosphere and develop Cu-rich nanoclusters for suppressing dislocation *** new understanding of the segregation and clustering of minor alloying elements provides guidance for developing zirconium alloys with enhanced creep resistance.

关键词： Zirconium alloy thermal creep Grain boundary segregation Dislocation segregation Cu-rich nanoclusters

Chromomagnetic dipole moments of light quarks in the bestest little Higgs model

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Chinese Physics C 2024年第10期48卷 125-136页

作者： t.Cisneros-Pérez E.Cruz-Albaro A.y.Ojeda-Castañeda S.E.Solís-Núñez Unidad Académica de Ciencias Químicas Universidad Autónoma de ZacatecasApartado Postal C-58598060 ZacatecasMexico Facultad de Física Universidad Autónoma de ZacatecasApartado Postal C-58098060 ZacatecasMexico

In this study,we investigated the anomalous Chromomagnetic Dipole Moment(CMDM),denoted as μ_(q)^(BLHM),of light quarks q=(u,c,d,s,b) within the framework of the Bestest Little Higgs Model(BLHM)as an extension of the Standard Model(SM).Our investigation encompassed novel interactions among the light quarks,heavy quark B,and heavy bosons (W'^(±),H^(±),φ^(±),η^(±))incorporating the extended Cabibbo-Kobayashi-Maskawa(CKM)matrix characteristic of the *** thoroughly explored the permissible parameter space,yielding a spectrum of CMDM values ranging from 10^(-10) to 10^(-3).

关键词： beyond standard model flavor physics chromomagnetic dipole light quarks

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On B(5,20)2-Groups

Algebra Colloquium 2024年第3期31卷 429-440页

作者： E.A.Alhassan y.L.tan y.Li School of Mathematical Sciences Jiangsu UniversityZhenjiangJiangsu 212013China Department of Mathematics Brock UniversitySt.CatharinesOntario L2S 3A1Canada

A finite group G is said to be a B(n,k)group if for any n-element subset[a_(1),…,a_(n)]of G,|{a_(i)a_(j)|1≤i,j≤n}|≤*** is of interest to characterize the structure of B(n,k)groups for n(n+1)/2≤k≤n^(2)-*** B(5,k)groups for 15≤k≤19 have been investigated by several *** this paper,we give a complete characterization of B(5,20)2-groups by showing there are five classes of such groups which are nontrivial and nonabelian.

关键词： B(n,k)groups small squaring property central extension GAP

Reactive destabilization and bidirectional catalyzation for reversible hydrogen storage of LiBH_(4) by novel waxberry-like nano-additive assembled from ultrafine Fe_(3)O_(4) particles

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Journal of Materials Science & technology 2024年第6期173卷 63-71页

作者： S.Wang M.H.Wu y.y.Zhu Z.L.Li y.X.yang y.Z.Li H.F.Liu M.X.Gao Department of Material Science Shenzhen MSU-BIT UniversityShenzhen 518172China State Key Laboratory of Silicon and Advanced Semiconductor Materials&School of Materials Science and Engineering Zhejiang UniversityHangzhou 310027China Institute of Resources Utilization and Rare Earth Development State Key Laboratory of Rare Metals Separation and Comprehensive UtilizationGuangdong Provincial Key Laboratory of Rare Earth Development and ApplicationGuangdong Academy of SciencesGuangzhou 510650China Institute of Science and technology for New Energy Xi’an Technological UniversityXi’an 710021China National Supercomputing Center in Shenzhen Shenzhen 518055China

LiBH_(4) containing 18.5 wt.%H_(2) is an attractive high-capacity hydrogen storage material,however,it suffers from high operation temperature and poor ***,a novel and low-cost bifunctional additive,waxberry-like Fe_(3)O_(4) secondary nanospheres assembled from ultrafine primary Fe_(3)O_(4) nanoparticles,is synthesized,which exhibits significant destabilization and bidirectional catalyzation towards(de)hydrogenation of LiBH_(4).With an optimized addition of 30 wt.% waxberry-like Fe_(3)O_(4),the system initiated dehydrogenation below 100℃ and released a total of 8.1 wt.%H_(2) to 400℃.After 10 cycles,a capacity retention of 70% was achieved,greatly superior to previously reported oxides-modified *** destabilizing and catalyzing mechanisms of waxberry-like Fe_(3)O_(4) on LiBH_(4) were systematically analyzed by phase and microstructural evolutions during dehydrogenation and hydrogenation cycling as well as density functional theory(DFt)*** present work provides new insights in developing advanced nano-additives with unique structural and multifunctional designs towards LiBH4 hydrogen storage.

关键词： LiBH_(4) Hydrogen storage Waxberry-like Fe_(3)O_(4) Destabilization Catalysis

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超大城市空间重构中的“村政城治”

甘肃社会科学 2024年第3期 107-115页

作者：姚尚建华东政法大学政府管理学院上海201620

超大城市的规模扩张意味着广域范围的城市乡村的联动发展。在这一空间重构过程中,城乡关系的分野被忽视了,超大城市借助于交通、项目甚至新城建设“侵入”乡村,从而模糊了城乡边界。随着新城直接面向乡村治理,超大城市实现了“乡政村治... 详细信息

超大城市的规模扩张意味着广域范围的城市乡村的联动发展。在这一空间重构过程中,城乡关系的分野被忽视了,超大城市借助于交通、项目甚至新城建设“侵入”乡村,从而模糊了城乡边界。随着新城直接面向乡村治理,超大城市实现了“乡政村治”向“村政城治”的逻辑转换。在这一过程中,超大城市通过织密权力网络、集中居住等政策强化城市在地性公共服务对于乡村治理的引领,但是这一思路又强化了村庄对于超大城市的依附。超大城市的乡村振兴需要承认城乡关系的历时性特征,系统反思新城建设、乡村发展中的空间、产业与人口关系联动,通过政策均衡实现超大城市生态、生产、生活功能的内在契合。

关键词：城市治理超大城市城乡关系三生空间村政城治

A perspective on age-related changes in cell environment and risk of neurodegenerative diseases

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Neural Regeneration Research 2024年第4期19卷 719-720页

作者： Alice y.Liu Department of Cell Biology and Neuroscience Rutgers State University of New JerseyPiscatawayNJUSA

“Age-related neurodegenerative disease”underscores human age as the primary risk factor for disease development:Alzheimer’s,Parkinson’s,and Huntington’s disease(HD)as *** for the age-dependent delay in disease manifestation,in particular for autosomal dominant forms of the disease,and the underlying cause(s)of specific neuron dysfunction and death to manifest as memory loss,anxiety,depression,and agitation in disease subjects remain *** are interested in understanding age-related changes in cell environment that can modulate the structure,function,aggregation.

关键词： Huntington Alzheimer death