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Human leukocyte antigen compatibility and incidence of donorspecific antibodies in pediatric liver transplant recipients

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World Journal of Gastroenterology 2024年第33期30卷 3837-3845页

作者： Melina U Melere Flavia H Feier Jorge Neumann Antônio N Kalil Juliana de M Montagner Luiza s Nader Carolina s da silva Marco Aurélio F Junior Gabriela P Coral Guilherme P Bobsin Cristina t Ferreira Department of Hepatology and Liver transplantation Santa Casa de Porto AlegrePorto Alegre 90050170Rio Grande do SulBrazil Department of Hepato-biliary-pancreatic surgery and Liver transplantation Irmandade Santa Casa de Misericórdia de Porto AlegrePorto Alegre 90020-090Rio Grande do SulBrazil Postgraduation Program in Medicine:Hepatology Federal University of Health Sciences of Porto AlegrePorto Alegre 90050-170Rio Grande do SulBrazil Laboratory of transplantation Immunology Irmandade Santa Casa de Misericórdia de Porto AlegrePorto Alegre 90020-090Rio Grande do SulBrazil

BACKGROUND Antibody-mediated rejection following liver transplantation(Lt)has been increasingly recognized,particularly with respect to the emergence of de novo donor-specific antibodies(DsAs)and their impact on graft *** substantial evidence for adult populations exists,research focusing on pediatric Lt outcomes remains *** to investigate the prevalence of human leukocyte antigen(HLA)mismatches and DsA and evaluate their association with rejection episodes after pediatric *** A cohort of pediatric Lt recipients underwent HLA testing at santa Casa de Porto Alegre,Brazil,between December 2013 and December *** patients who survived for>30 days after Lt with at least one DsA analysis were *** classes I and II and cross-matches were *** presence of de novo DsA(dnDsA)was evaluated at least 3 months after Lt using the Luminex®single antigen bead method,with a positive reaction threshold set at 1000 *** episodes were confirmed by liver *** Overall,67 transplanted children were analyzed;61 received grafts from living donors,85%of whom were related to ***-transplant DsA(class I or II)was detected in 28.3%of patients,and dnDsA was detected in 48.4%.the median time to DsA detection after Lt was 19.7[interquartile range(IQR):4.3-35.6]*** rejection occurred in 13 patients at follow-up,with C4d positivity observed in 5/13 Liver *** median time to rejection was 7.8(IQR:5.7-12.8)*** presence of dnDsA was significantly associated with rejection(36%vs 3%,Pthe rejection-free survival rates at 12 and 24 months were 76%vs 100%and 58%vs 95%for patients with dnDsA anti-DQ vs those without,*** Our findings highlight the importance of incorporating DsA assessment into pre-and post-transplantation protocols for pediatric Lt *** implications may include immunosuppression minimization strategies based on this analysis in pediatric Lt recip

关键词： Human leukocyte antigens Donor-specific antibodies Liver transplantation Pediatric Rejection

the Radcliffe Wave Parameters from Data on Open star Clusters

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Research in Astronomy and Astrophysics 2024年第3期24卷 106-109页

作者： V.V.Bobylev A.t.Bajkova Pulkovo Astronomical Observatory St-Petersburg 196140Russia

A spectral analysis of the vertical positions and velocities of 374 open star clusters(OsCs)was carried *** took these OsCs from the Hunt and Reffert catalog;they have an average age of about 10 million years,and are located on the galactic plane XY in a narrow zone inclined by 25°to the galactic axis *** following estimates of the parameters of the Radcliffe wave were obtained:(a)the maximum value in periodic perturbations of vertical coordinates Z_(max)=92±10pc with the wavelength of these perturbations λ_(z)=4.82±0.09 kpc;(b)the maximum value of the velocity of vertical disturbances Wmax=4.36±0.12km s^(-1) with disturbance wavelengthλ_(W)=1.78±0.02 *** that the results of the vertical velocity analysis are first-class in accuracy and completely new.

关键词： (Galaxy) local interstellar matter-Galaxy structure-(Galaxy) solar neighborhood

the soft X-ray Imager(sXI)on the sMILE Mission

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Earth and Planetary Physics 2024年第1期8卷 5-14页

作者： s.sembay A.L.Alme D.Agnolon t.Arnold A.Beardmore A.Belén Balado Margeli C.Bicknell C.Bouldin G.Branduardi-Raymont t.Crawford J.P.Breuer t.Buggey G.Butcher R.Canchal J.A.Carter A.Cheney Y.Collado-Vega H.Connor t.Crawford N.Eaton C.Feldman C.Forsyth t.Frantzen G.Galgóczi J.Garcia G.Y.Genov C.Gordillo H-P.Gröbelbauer M.Guedel Y.Guo M.Hailey D.Hall R.Hampson J.Hasiba O.Hetherington A.Holland s-Y.Hsieh M.W.J.Hubbard H.Jeszenszky M.Jones t.Kennedy K.Koch-Mehrin s.Kögl s.Krucker K.D.Kuntz C.Lakin G.Laky O.Lylund A.Martindale J.Miguel Mas Hesse R.Nakamura K.Oksavik N.Østgaard H.Ottacher R.Ottensamer C.Pagani s.Parsons P.Patel J.Pearson G.Peikert F.s.Porter t.Pouliantis B.H.Qureshi W.Raab G.Randal A.M.Read N.M.M.Roque M.E.Rostad C.Runciman s.sachdev A.samsonov M.soman D.sibeck s.smit J.søndergaard R.speight s.stavland M.steller tianRan sun J.thornhill W.thomas K.Ullaland B.Walsh D.Walton C.Wang s.Yang school of Physics and Astronomy University of LeicesterLeicesterLE17RHUK space Park Leicester University of LeicesterLeicesterLE17RHUK Mullard space science Laboratory University College LondonDorkingRH56NTUK Centre for Electronic Imaging Open UniversityMilton KeynesMK76 AAUK Birkeland Centre for space science Department of Physics and TechnologyUniv.of BergenN-5007 BergenNorway University of Vienna A-1010 ViennaAustria space Research Institute Austrian Academy of SciencesA-8042 GrazAustria National Institute of Aerospace technology MadridSpain EstEC European Space Agency2201 AZ NoordwijkNetherlands state Key Laboratory of space Weather National Space Science CentreBeijing 100190China University of Applied sciences and Arts Northwestern switzerland CH-5210 WindischSwitzerland Koegl space GmbH CH-8157 DielsdorfSwitzerland space Acoustics GmbH CH-8157 DielsdorfSwitzerland Zurich University of Applied sciences 8400 WinterhurSwitzerland Genov solutions N-5172 LoddefjordNorway stM Engineering N-5165 LaksevagNorway John Hopkins University Applied Physics Laboratory MD 20723USA NAsA/Goddard space Flight Centre MD 20771USA Center for space Physics Boston UniversityBostonMA 02215USA Department of theoretical Physics and Astrophysics Masaryk University60177 BrnoCzech Republic Institute of Physics E¨otvo¨s Lor´and University1053 BudapestHungary Aerospace Information Research Institute Chinese Academy of SciencesBeijing 100045China Centro de Astrobiologia(CAB) CSIC-INTAMadridSpain

the soft X-ray Imager(sXI)is part of the scientific payload of the solar wind Magnetosphere Ionosphere Link Explorer(sMILE)*** is a joint science mission between the European space Agency(EsA)and the Chinese Academy of sciences(CAs)and is due for launch in *** is a compact X-ray telescope with a wide field-of-view(FOV)capable of encompassing large portions of Earth’s magnetosphere from the vantage point of the sMILE *** is sensitive to the soft X-rays produced by the solar Wind Charge eXchange(sWCX)process produced when heavy ions of solar wind origin interact with neutral particles in Earth’s *** provides a mechanism for boundary detection within the magnetosphere,such as the position of Earth’s magnetopause,because the solar wind heavy ions have a very low density in regions of closed magnetic field *** sensitivity of the sXI is such that it can potentially track movements of the magnetopause on timescales of a few minutes and the orbit of sMILE will enable such movements to be tracked for segments lasting many *** is led by the University of Leicester in the United Kingdom(UK)with collaborating organisations on hardware,software and science support within the UK,Europe,China and the United states.

关键词： soft X-ray Imaging micropore optics large area CCD

Evaluation of slope stability through rock mass classification and kinematic analysis of some major slopes along NH-1A from Ramban to Banihal, North Western Himalayas

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第1期16卷 167-182页

作者： Amit Jaiswal A.K.Verma t.N.singh Department of Civil and Environmental Engineering Indian Institute of Technology PatnaPatna801106India

the network of Himalayan roadways and highways connects some remote regions of valleys or hill slopes,which is vital for India’s socio-economic *** to natural and artificial factors,frequency of slope instabilities along the networks has been increasing over last few *** of stability of natural and artificial slopes due to construction of these connecting road networks is significant in safely executing these roads throughout the *** rock mass classification methods are generally used to assess the strength and deformability of rock *** study assesses slope stability along the NH-1A of Ramban district of North Western *** structurally and non-structurally controlled rock mass classification systems have been applied to assess the stability conditions of 14 *** evaluating the stability of these slopes,kinematic analysis was performed along with geological strength index(GsI),rock mass rating(RMR),continuous slope mass rating(CosMR),slope mass rating(sMR),and Q-slope in the present *** sMR gives three slopes as completely unstable while CosMR suggests four slopes as completely *** stability of all slopes was also analyzed using a design chart under dynamic and static conditions by slope stability rating(ssR)for the factor of safety(Fos)of 1.2 and 1 respectively.Q-slope with probability of failure(PoF)1%gives two slopes as stable *** slope angle has been determined based on the Q-slope safe angle equation and ssR design chart based on the *** value ranges given by different empirical classifications were RMR(37-74),GsI(27.3-58.5),sMR(11-59),and CosMR(3.39-74.56).Good relationship was found among RMR&ssR and RMR&GsI with correlation coefficient(R 2)value of 0.815 and 0.6866,***,a comparative stability of all these slopes based on the above classification has been performed to identify the most critical slope along this road.

关键词： Rock mass classification Kinematic analysis slope stability Himalayan road static and dynamic conditions

C19MC miRNA-520G induces sP100 antiviral gene transcription and inhibits melanin production in skin cutaneous melanoma

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Genes & Diseases 2024年第1期11卷 60-63页

作者： Goodwin G.Jinesh Marian t.smallin Nino Mtchedlidze Isha Godwin Marco Napoli Nicole Hackel Manali s.Phadke Avani A.Deshpande Xiaobo Li John H.Lockhart Jaden R.Baldwin suehelay Acevedo-Acevedo Yifeng Gao Michelle A.Reiser Keiran s.M.smalley Elsa R.Flores Andrew s.Brohl Department of Molecular Oncology H.Lee Moffitt Cancer Center&Research InstituteTampaFL 33612USA Molecular Medicine Program H.Lee Moffitt Cancer Center&Research InstituteTampaFL 33612USA saveetha Medical College ChennaiTamil Nadu 602105India tumor Biology Department H.Lee Moffitt Cancer Center&Research InstituteTampaFL 33612USA sarcoma Department H.Lee Moffitt Cancer Center&Research InstituteTampaFL 33612USA

sP100 is an antiviral protein that restricts the productive stage of human papillomavirus(HPV)and multiple other viruses,and viruses in turn block sUMO-1-mediated stabilization of sP100 and promotes its degradation(table s1).Interferon(IFN)signaling could still produce more sP100 through transcription to counteract viruses.1 Viruses also disable the transcriptional up-regulation of sP100 to achieve persistent infection in hosts.

关键词： sP100 melanoma stabilization

Development of endemicity and conservation importance indices for tropical forests and the floral diversity assessment of *** in Benguet,Philippines

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Journal of Mountain science 2024年第3期21卷 786-804页

作者： Johndale Rein t.BULLONG Jim P.sILVERIO Joanna I.ALAFAG Maricel A.GURON Jones t.NAPALDEt Department of Environmental science Benguet State UniversityLa Trinidad 2601Philippines Department of Biology Benguet State UniversityLa Trinidad 2601Philippines

the scientific community faces the challenge of measuring progress toward biodiversity targets and indices have been traditionally ***,recent inventories in secondary tropical mountain forests using traditional biodiversity indices have yielded results that are indistinct with primary *** shows the need to develop complementary indices that goes beyond species count but integrates the distribution and conservation status of the *** study developed endemicity and conservation importance index for tropical forest that incorporated the distribution and conservation status of the *** indices were applied to ***,a remnant primary mossy forest in Buguias,Benguet,Philippines,that resulted to endemicity index of 81.07 and conservation importance index of *** these with secondary forest sites with comparable shannon-Wiener,simpson,Evenness and Margalef’s indices,our endemicity and conservation indices clearly differentiates primary forest(our study site)with higher values from secondary forests with much lower ***,we are proposing these indices for a direct but scientifically-informed identification of specific sites for conservation and protection in tropical ***,our study documented a total of 168 vascular plant species(79 endemic and 12 locally threatened species)in *** are of tropical elements for both generic and species levels with some temperate elements that could be attributed to the site's high elevation and semi-temperate *** are important baseline information for conservation plans and monitoring of tropical mossy forests.

关键词： Endemicity index Conservation importance index Cordillera Central Range Floristic element Jaccard Index of similarity

Excellent photoluminescence and electrochemical properties of sm^(3+) doped Ca_(2)Mgsi_(2)O_(7) nanophosphor:Display and electrochemical sensor applications

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Journal of Rare Earths 2024年第6期42卷 1046-1055,I0002页

作者： R.B.Basavaraj K.sureshkumar D.P.Aarti M.B.Madhusudana Reddy G.Nagaraju t.Ramakrishnappa G.R.Navyashree K.R.Venkatesha Babu K.s.Hemalatha Department of Physics BMS Institute of Technology and ManagementBangalore560064India Department of Chemistry BMS Institute of Technology and ManagementBangalore560064India Department of Chemistry School of Applied SciencesREVA UniversityBangalore560064India Energy Materials ResearchLaboratory Department of ChemistrySiddaganga Institute of TechnologyTumakuru57203KarnatakaIndia school of Physical sciences REVA UniversityBangalore560057Indi Department of Physics Govt.Science CollegeBengaluru560001India Department of Physics Maharani Science College for WomenMaharani Cluster UniversityBengaluru560001India

A series of orange-red light emitting Ca_(2)Mgsi_(2)O_(7):sm^(3+)nanopowders were fabricated via low-cost ecofriendly green combustion technique using Aloe vera gel as *** phase purity of the samples were confirmed by the powder X-ray diffraction(PXRD)*** single-phase tetragonal structure is observed from the PXRD results with no additional impurity *** band gap energy of the fabricated powders was estimated by diffuse reflectance spectra(DRs)and is found to be in the range of 4.01-5.98 eV.A high resolution scanning electron microscope(sEM)was used to study the morphological behaviour of the ***-like structures are observed from the sEM *** particle size was evaluated by transmission electron microscopy(tEM)and is found to be~50 *** interplanar distance is found to be 0.53 *** properties were systematically studied in *** phosphors are successfully excited at 403 nm NUV light,producing reddish-orange characteristic *** emission peaks are centered at 558(^(4)G_(5/2)→^(6)H_(5/2)),607(^(4)G_(5/2)→^(6)H_(7/2))and 645 nm(^(4)G_(5/2)→^(6)H_(9/2)),*** the observed peaks the red emanation(^(4)G_(5/2)→^(6)H_(7/2))is stronger than the orange emission(^(4)G_(5/2)→^(6)H_(5/2))in the current *** photoluminescent concentration quenching is noticed above 5 mol%sm^(3+)ion doping *** dipole-dipole interaction resulting in cross relaxation is found to be the principal cause of concentration quenching *** color features such as Commission Internationale de I’Eclairage(CIE)and correlated color temperature(CCt)were studied in *** optimized chromaticity coordinates were estimated to be(0.6363,0.3632),which fall in the reddish-orange *** average CCt value obtained is 3362 *** average color purity is found to be~82%.sm^(3+)incorporated Ca_(2)Mgsi_(2)O_(7) samples are possible contender for single white light generation commercial candidates owing to

关键词： Green combustion Photoluminescence Orange-red emission Color purity sensors Rare earths

the emerging role of exercise as a cancer treatment

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Journal of sport and Health science 2024年第4期13卷 443-444页

作者： Kerry s.Courneya Faculty of Kinesiology Sportand RecreationCollege of Health SciencesUniversity of AlbertaEdmontonAlbertaT6G 2H9Canada

Over the past few decades,exercise oncology has emerged as an important subfield within exercise *** that time,substantial progress has been made in understanding the role of exercise in people newly diagnosed with ca... 详细信息

关键词： cancer treatment exercise

^(4)He monolayer on graphene:a quantum Monte Carlo study

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Communications in theoretical Physics 2024年第9期76卷 149-157页

作者： s Yu M Boninsegni Department of Physics University of AlbertaEdmontonAlbertaT6G 2H5Canada

We revisit the problem of adsorption of a single^(4)He layer on graphene,focusing on the commensurate(C_(1/3))crystalline phase,specifically on whether it may possess a nonzero superfluid response,and on the existence of superfluid phases,either(metastable)liquid or vacancy-doped *** make use of canonical quantum Monte Carlo simulations at zero and finite temperature,based on a realistic microscopic model of the *** results confirm the absence of any superfluid response in the commensurate crystal,and that no thermodynamically stable uniform phase exists at lower *** evidence of a possibly long-lived,metastable superfluid phase at C_(1/3)coverage is ***,the results of ground-state projection methods and finite-temperature simulations are entirely consistent.

关键词： superfluidity low-dimensional systems quantum Monte Carlo helium supersolids