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more common RNAemia in the early stage of severe SARS-CoV-2 BF.7.14 infections in pediatric patients

Biosafety and Health 2024年第1期6卷 5-11页

作者： Yu Sun Runan Zhu Yang Pan ri De Shuang Liu Liping Jia Bing Lv Xiaoyun Li Dongmei Chen Yao Yao Dong Qu Daitao Zhang Linqing Zhao Laboratory of Virology Bejing Key Laboratory of Etiology of Viral Diseases in ChildrenCapital Institute of PediatricsBejing 100020China Institute for Infectious Disease and Endemic Disease Control Bejing Center for Disease Control and Prevention Beijing 100013China Department of Intensive Care Unit Affiliated Children's Hospital of Capital Institute of PediatricsBeijing 100020China

the risk factors of severe infections in children during the severe acute respiratory syndrome coronavirus 2(SARS‐CoV‐2)outbreak in Beijing remain ***‐CoV‐2‐positive children admitted to the intensive care unit(ICU)with collected plasma specimens were enrolled and screened for common pathogens using capillary electrophoresis‐based multiplex PCR from December 12,2022,to January 24,*** SARS‐CoV‐2 subvariants were identified using next‐generation *** was positive for two(positive;P),one(suspicious;S),or no(negative;N)SARS‐CoV‐2 genes were classified as plasmatic RNA‐positive(RNAemia;P+S)or without RNAemia(N).Clinical and laboratory data of the enrolled cases were then collected and *** 34 enrolled children included 26 males and 24 younger than three *** were negative for other respiratory ***.7.14(18/29)was the predominant *** loads in respiratory specimens,hours from symptom onset to the first respiratory specimen collection(time‐variable),with comorbidities and BF.7.14 and BA.5.2 distributions were significantly different in P vs.N and RNAemia *** RNAemia *** most cases,the t lymphocyte ratios decreased,while the cytokine level and the B lymphocyte ratio *** time variables were 2.22±2.05 and 4.00±2.49 days in BF.7.14 and BA.5.2 infections,*** conclusion,SARS‐CoV‐2 was more likely to cause severe infections among males aged≤3 years old with comorbidities during the SARS‐CoV‐2 outbreak in Beijing,while RNAemia is more common in children at the early stage of severe BF.7.14 infections,and most had high cytokine levels and B‐cell activation.

关键词： Severe SARS‐CoV‐2 infection Pediatric patients risk factor RNAemia BF.7.14

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Kinematic analysis of flexible bipedal robotic systems

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Applied mathematics and mechanics(English Edition) 2024年第5期45卷 795-818页

作者： R.FAZEL A.m.SHAFEI S.R.NEKOO Department of mechanical Engineering Shahid Bahonar University of KermanKerman ***Iran Departamento de Ingenieria de Sistemas y Automatica Escuela Técnica Superior de IngenieriaUniversidad de SevillaSeville 41092Spain

In spite of its intrinsic complexities,the passive gait of bipedal robots on a sloping ramp is a subject of interest for numerous *** distinguishes the present research from similar works is the consideration of flexibility in the constituent links of this type of robotic *** is not a far-fetched assumption because in the transient(impact)phase,due to the impulsive forces which are applied to the system,the likelihood of exciting the vibration modes increases ***,the human leg bones that are involved in walking are supported by viscoelastic muscles and ***,for achieving more exact results,it is essential to model the robot links with viscoelastic *** this end,the Gibbs-Appell formulation and Newton's kinematic impact law are used to derive the most general form of the system's dynamic equations in the swing and transient phases of *** most important issue in the passive walking motion of bipedal robots is the determination of the initial robot configuration with which the system could accomplish a periodic and stable gait solely under the effect of gravitational *** extremely unstable nature of the system studied in this paper and the vibrations caused by the impulsive forces induced by the impact of robot feet with the inclined surface are some of the very serious challenges encountered for achieving the above-mentioned *** overcome such challenges,an innovative method that uses a combination of the linearized equations of motion in the swing phase and the algebraic motion equations in the transition phase is presented in this paper to obtain an eigenvalue *** solving this problem,the suitable initial conditions that are necessary for the passive gait of this bipedal robot on a sloping surface are *** effects of the characteristic parameters of elastic links including the modulus of elasticity and the Kelvin-Voigt coefficient on the walking stability of this type of

关键词： bipedal robot flexible link swing phase transient phase eigenvalue problem Kelvin-Voigt coefficient

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Structural effects induced by dialysis-based purification of carbon nanomaterials

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Nano materials Science 2024年第4期6卷 475-483页

作者： A.D.Veloso A.m.Ferraria A.m.Botelho do Rego A.S.Viana A.J.S.Fernandes A.J.Fielding R.A.Videira m.C.Oliveira CQ-VR and Chemistry Department University of Trás-os-Montes e Alto Douro BSIRG iBB-Institute for Bioengineering and BiosciencesDepartment of Chemical Engineeringand Associate Laboratory i4HB-Institute for Health and BioeconomyInstituto Superior TécnicoUniversidade de Lisboa Centro de Química Estrutural Institute of Molecular SciencesDepartamento de Química e BioquímicaFaculdade de CiênciasUniversidade de Lisboa I3N and Physics Department University of AveiroCampus de Santiago Faculty of Science Pharmacy and Biomolecular SchoolLiverpool John Moores University REQUImtE/LAQV Laborat orio de FarmacognosiaDepartamento de QuímicaFaculdade de Farm aciaUniversidade do Porto

Dialysis plays a crucial role in the purification of nanomaterials but its impact on the structural properties of carbon nanomaterials was never ***,a carbon-based nanomaterial generated electrochemically in potassium phosphate buffer,was characterized before and after dialysis against pure *** is shown that dialysis affects the size of the carbon domains,structural organization,surface functionalization,oxidation degree of carbon,and grade of ***,dialysis drives the nanomaterial organization from discrete roundish carbon domains,with sizes ranging from 70 to 160 nm,towards linear stacking structures of small nanoparticles （m）.In parallel,alcohol and ether （epoxide） surface groups evolve into more oxidized carbon groups （e.g.,ketone and ester groups）.Investigation of the as-prepared nanomaterial by electron paramagnetic resonance （EPR） revealed a resonance signal consistent with carbon-oxygen centred ***,this study brings to light the selective affinity of the carbon nanomaterial under study to capture Na+ions,a property greatly enhanced by the dialysis process,and its high ability to trap oxygen,particularly before *** findings open new perspectives for the application of carbon-based nanomaterials and raise awareness of the importance of structural changes that can occur during the purification of carbon-based nanomaterials.

关键词： Nanocarbon Surface functionalization NmR XPS Hydrophilic carbon Paramagnetic

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miniSCIDOm: a scintillator-based tomograph for volumetric dose reconstruction of single laser-driven proton bunches

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High Power Laser Science and Engineering 2024年第2期12卷 41-50页

作者： A.Corvino m.Reimold E.Beyreuther F.-E.Brack F.Kroll J.Pawelke J.D.Schilz m.Schneider U.Schramm m.E.P.Umlandt K.Zeil t.Ziegler J.metzkes-Ng Helmholtz-Zentrum Dresden–Rossendorf DresdenGermany technische Universität Dresden DresdenGermany OncoRay–National Center for Radiation Research in Oncology Faculty of Medicine and University Hospital Carl Gustav CarusTUD Dresden University of TechnologyHelmholtz-Zentrum Dresden–RossendorfDresdenGermany Current affiliation:Institut Curie UniversitéPSLCNRS UMR3347OrsayFrance Current affiliation:Universitätsklinikum Freiburg FreiburgGermany

Laser plasma accelerators(LPAs)enable the generation of intense and short proton bunches on a micrometre scale,thus offering new experimental capabilities to research fields such as ultra-high dose rate radiobiology or material *** spectrally broadband,laser-accelerated proton bunches allow for tailored volumetric dose deposition in a sample via single bunches to excite or probe specific sample *** rising number of such experiments indicates a need for diagnostics providing spatially resolved characterization of dose distributions with volumes of approximately 1 cm^(3) for single proton bunches to allow for fast online *** we present the scintillator-based miniSCIDOm detector for online single-bunch tomographic reconstruction of dose distributions in volumes of up to approximately 1 cm^(3).the detector achieves a spatial resolution below 500μm and a sensitivity of 100 *** detector performance is tested at a proton therapy cyclotron and an LPA proton *** experiments’primary focus is the characterization of the scintillator’s ionization quenching behaviour.

关键词： beam monitoring detectors laser-driven proton beams scintillator-based diagnostics ultra-high dose rate

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Al-Ca-Cu三元合金体系中与铝平衡的金属间化合物

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transactions of Nonferrous metals Society of China 2024年第5期34卷 1380-1392页

作者： t.K.AKOPYAN t.A.SVIriDOVA N.A.BELOV N.V.LEtYAGIN A.V.KOROtItSKIY National University of Science and technology mISiS 4 Leninsky pr.Moscow 119049Russia

对三元Al-Ca-Cu合金体系中与铝固溶体平衡的(Al,Cu)_(4)Ca、Al_(27)Ca_(3)Cu_(7)和Al_(8)CaCu_(4)金属间化合物的结构和性能进行全面分析。基于Al4Ca相中部分Al原子被Cu取代,将(Al,Cu)_(4)Ca金属间化合物视为线性化合物。化合物中铜的... 详细信息

对三元Al-Ca-Cu合金体系中与铝固溶体平衡的(Al,Cu)_(4)Ca、Al_(27)Ca_(3)Cu_(7)和Al_(8)CaCu_(4)金属间化合物的结构和性能进行全面分析。基于Al4Ca相中部分Al原子被Cu取代,将(Al,Cu)_(4)Ca金属间化合物视为线性化合物。化合物中铜的溶解度达到10 at.%(19 wt.%),导致化合物的晶格结构、物理和力学性能发生显著变化。例如,化合物的密度从2.22 g/cm^(3)增加到2.79 g/cm^(3),显微硬度从HV 180增加到HV 250。将Al_(27)Ca_(3)Cu_(7)相视为具有严格化学计量比和BaHg11型初始晶体结构的三元化合物,其空间群为Pm3m,晶格参数为8.514Å,密度为3.45 g/cm^(3)。Al_(8)CaCu_(4)相也是严格化学计量比的三元化合物,具有mn_(12)th型晶格结构,最高的显微硬度(HV 505)和密度(4.57 g/cm^(3))。属于二元(Al)+(Al,Cu)_(4)Ca相场和准二元(Al)+Al_(27)Ca_(3)Cu_(7)截面的合金,有前景作为新型天然铝基复合材料的基材。

关键词：金属间化合物 Al-Ca合金显微组织晶体结构物理性能力学性能

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Protocol for the development and validation of a clinical measurement tool for fear of disease progression and recurrence in cardiac patients

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Chronic Diseases and translational medicine 2024年第3期10卷 195-204页

作者： Sarah t.Clarke michael Le Grande Barbara m.murphy Robert Hester Alun C.Jackson melbourne School of Psychological Sciences University of MelbourneParkvilleVictoriaAustralia Australian Centre for Heart Health MelbourneVictoriaAustralia Centre on Behavioral Health University of Hong KongPokfulamHong KongChina

Introduction: One in two cardiac patients fear having another heart event or their heart condition getting worse. Research in other chronic illnesses demonstrates that screening for fear of progression and recurrence is vital for adequately addressing such concerns in clinical care. the current project aims to develop and validate a measure for fear of progression and recurrence in cardiac ***: the Fear of Cardiac Recurrence and Progression Scale (FCRP) will be developed through a multistep process. An initial item pool will be generated through a review of the literature and existing measures and consultation with and feedback from key informants. the item pool will be tested in a sample of over 250 adults who have ever had an acute coronary event, undergone cardiac surgery, or a chronic cardiac condition. Exploratory factor analysis will be used to identify the underlying factors, and Rasch analysis will be used to reduce the number of items. A short form version of the FCRP will be developed for use as a brief screening tool, informed by clinical relevance and Rasch psychometric ***: While many cardiac patients experience fears related to the progression or recurrence of their illness, there remains the need for a validated tool with which these concerns can be identified and measured. It is expected that the design and validation of the FCRP will aid identification of cardiac patients suffering from clinically significant levels of fear of progression and recurrence and facilitate the design of tailored psychological interventions to target these fears.

关键词： anxiety cardiac anxiety cardiac recovery cardiac rehabilitation depression fear of progression fear of recurrence psychological measurement psychosocial screening

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Adenovirus F40/41 Gastroenteritis-Associated Emphysematous Gastritis:A Case Report

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Infectious Diseases & Immunity 2024年第2期4卷 93-95页

作者： maulik K.Lathiya Abigail t.La Nou maria E.Linnaus Susan m.Cullinan Emergency Department Mayo Clinic Health SystemEau Claire 54703WIUSA Critical Care medicine Mayo Clinic Health SystemEau Claire 54703WIUSA General Surgery Department Mayo Clinic Health SystemEau Claire 54703WIUSA

Emphysematous gastritis(EG)is a rare form of gastritis characterized by gastric wall *** is associated with a high mortality *** case report describes a patient with a history of atrial fibrillation treated with apixaban,prior stroke,and schizoaffective disorder who showed epigastric tenderness on ***,no peritonitis signs were recorded,and laboratory values revealed high lactate levels and the presence of adenovirus F40/*** computed tomography scan showed extensive portal venous gas in the left hepatic lobe of the liver,as well as pneumatosis involving the entire stomach,indicating *** diagnosis was histologically confirmed and initially managed medically,which proved inefficacious,necessitating surgical intervention in the form of a laparotomy and esophagojejunostomy with Roux-en-Y *** case report suggests a potential association between EG and adenovirus F40/41–induced gastroenteritis,thereby emphasizing the challenging nature of *** underscores the need for comprehensive research to enhance our understanding of its underlying causes and effective treatment strategies.

关键词： Emphysema Gastritis Human adenovirus F40/41 Immunocompromised

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Effect of special types of bread with select herbal components on postprandial glucose levels in diabetic patients

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World Journal of Diabetes 2024年第4期15卷 664-674页

作者： Drasko m Gostiljac Srdjan S Popovic Vesna Dimitrijevic-Sreckovic Sasa m Ilic Jelena A Jevtovic Dragan m Nikolic Ivan A Soldatovic Clinic for Endocrinology Diabetes and Metabolic DiseasesUniversity Clinical Centre of SerbiaBelgrade 11000Serbia Faculty of medicine University of BelgradeBelgrade 11000Serbia Clinic for Gastroenterology and Hepatology University Clinical Centre of SerbiaBelgrade 11000Serbia Clinic for Endocrinology Diabetes and Metabolic Diseases-Laboratory for Human Pancreatic Islets CultureUniversity Clinical Centre of SerbiaBelgrade 11000Serbia

BACKGROUND Nutrition recommendations in patients with type 2 diabetes mellitus(t2Dm)are to consume rye or integral bread instead of white bread.A positive effect on glucoregulation has been achieved by enriching food with various biologically active substances of herbal origin,so we formulated an herbal mixture that can be used as a supplement for a special type of bread(StB)to achieve better effects on postprandial glucose and insulin levels in patients with *** to compare organoleptic characteristics and effects of two types of bread on postprandial glucose and insulin levels in t2Dm *** this trial included 97 patients with t2Dm.A parallel group of 16 healthy subjects was also *** participants were given 50 g of rye bread and the same amount of a StB with an herbal mixture on 2 consecutive *** blood glucose and insulin levels were compared at the 30^(th),60^(th),90^(th) and 120th min.A questionnaire was used for subjective estimation of the organoleptic and satiety features of the two types of *** Compared to patients who consumed rye bread,significantly lower postprandial blood glucose and insulin concentrations were found in t2Dm patients who consumed *** relevant differences were found among the healthy *** estimated organoleptic and satiety characteristics are better for StB than for rye *** StB have better effects than rye bread on postprandial glucoregulation in t2Dm *** estimated organoleptic and satiety characteristics are better for StB than for rye ***,StB can be recommended for nutrition in t2Dm patients.

关键词： Special types of bread Postprandial glucoregulation Insulin Nutrition type 2 diabetes mellitus

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羟基氧化铁分离法回收钕铁硼废料的实验研究

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中国稀土学报 2024年第5期42卷 955-961,I0004页

作者：阳启华吴金玲王日张文娟中稀(凉山)稀土有限公司四川凉山615000 北京科技大学冶金与生态工程学院北京100083

钕铁硼废料是重要的稀土二次资源,其回收的技术难点在于稀土元素与主要杂质铁的有效分离。本研究采用羟基氧化铁分离法回收钕铁硼废料,通过控制浸出过程的双氧水浓度、浸出温度、底液HCl浓度、H_(2)O_(2)流量、终点pH值、液固比等条件,... 详细信息

钕铁硼废料是重要的稀土二次资源,其回收的技术难点在于稀土元素与主要杂质铁的有效分离。本研究采用羟基氧化铁分离法回收钕铁硼废料,通过控制浸出过程的双氧水浓度、浸出温度、底液HCl浓度、H_(2)O_(2)流量、终点pH值、液固比等条件,实现了稀土的选择性浸出。在工艺条件:H_(2)O_(2)浓度333.00 g·L^(-1),浸出温度75℃,底液HCl浓度0.71 mol·L^(-1),H_(2)O_(2)流量29.40×10^(-3)g·min^(-1),终点pH值3.0~3.5,液固比4.56 mL/g,得到稀土氧化物(REO)浸出率99.26%,镨钕氧化物浸出率99.52%,Co浸出率90.53%,酸浸液浸出选择性s(Fe_(2)O_(3),REO)m分析表明,酸浸渣的主要物相为晶型羟基氧化铁。

关键词：钕铁硼废料羟基氧化铁分离法浸出率浸出选择性

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胰岛素不同给药方式对2型糖尿病患者血糖控制效果及低血糖发生率的影响

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医学信息 2024年第17期37卷 109-112页

作者：洪日成余干县人民医院药剂科

目的研究胰岛素不同给药方式对2型糖尿病（t2Dm）患者血糖控制效果及低血糖发生率的影响。方法以2020年5月-2023年5月余干县人民医院收治的60例t2Dm患者为研究对象，行随机数字表法分为CSII组与mDI组，各30例。CSII组给予持续皮下胰... 详细信息

目的研究胰岛素不同给药方式对2型糖尿病（t2Dm）患者血糖控制效果及低血糖发生率的影响。方法以2020年5月-2023年5月余干县人民医院收治的60例t2Dm患者为研究对象，行随机数字表法分为CSII组与mDI组，各30例。CSII组给予持续皮下胰岛素输注（CSII）治疗，mDI组则应用多次胰岛素注射（mDI）治疗，比较两组血糖控制效果（血糖达标率、血糖达标时间）、血糖水平[糖化血红蛋白（HbA1c）、空腹血糖（FPG）、餐后2 h血糖（2hPBG）]、血糖波动情况[最大血糖波动幅度（LAGE）、餐后血糖波动幅度（PPGE）]、胰岛功能[空腹胰岛素（FINS）、胰岛素抵抗指数（HOmA-IR）]及不良反应。结果两组血糖达标率比较，差异无统计学意义（P>0.05），但CSII组血糖达标时间短于mDI组（PmDI组（PmDI组（PmA-IR低于治疗前，且CSII组FINS高于mDI组，HOmA-IR低于mDI组（PmDI组（PmDI均可控制t2Dm患者的血糖水平，其中CSII血糖达标时间更短、降糖作用更好，可减少日间血糖波动，改善患者胰岛功能，降低不良反应发生风险。

关键词： 2型糖尿病持续皮下胰岛素输注多次胰岛素注射血糖控制效果低血糖

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