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Beginning from the end:the presynaptic terminal as a pathomechanism hub in frontotemporal dementia and amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第11期20卷 3217-3218页

作者： laura Huggon Emma l.Clayton UK Dementia Research Institute at King’s College london LondonUK Department of Basic and Clinical Neuroscience Institute of Psychiatry Psychology&NeuroscienceKing’s College LondonLondonUK

Frontotemporal dementia and amyotrophic lateral sclerosis:Frontotemporal dementia(F t D)and amyo t rophic lateral sclerosis(AlS)are neurodegenerative diseases with significant overlapping *** these neurodegenerative diseases affect different neuronal populations(with FtD affecting neurons of the frontal and temporal lobes,and AlS affecting upper and lower motor neurons),these two diseases are complexly *** and AlS exist on a disease spectrum,with shared genetic causes,clinical presentations,and pathologies.

关键词： diseases amyotrophic sclerosis

Multiple sclerosis is at a checkpoint: advancing the program

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Neural Regeneration Research 2025年第3期20卷 811-812页

作者： Brandon C.Smith Jessica l.Williams Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Biological Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Multiple sclerosis(MS) is a chronic inflammatory and demyelinating disease of the central nervous system(CNS). Patients with MS experience sensory and motor function loss due to myelin and/or axon damage perpetuated b... 详细信息

关键词： Hauser sclerosis damage

Generation of brain vascular heterogeneity:recent advances from the perspective of angiogenesis

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Neural Regeneration Research 2025年第7期20卷 2013-2014页

作者： Nathanael J.lee Ryota l.Matsuoka Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Molecular Medicine Cleveland Clinic Lerner College of MedicineCase Western Reserve UniversityClevelandOHUSA

Heterogeneous proper t i es of vascular endothelial cells in the brain:the brain displays large energy dynamics and consumption,and this high level of metabolic demands is fulfilled by a continuous supply of glucose and oxygen through its vascular *** vasculature consists of highly divergent blood vessel branches,giving rise to a dense network of capillaries that supply blood to all cells across the *** elaborated vascular network is thought to develop via angiogenesis,a process in which new blood vessels grow from pre-existing *** capillaries exhibit organotypic features distinct from other tissues and are formed primarily by two major endothelial cell(EC)types:those that form the semi-permeable blood-brain barrier(BBB)and those that develop highly permeable pores known as fenestrae(Matsuoka et al.,2022).the structural and functional differences between BBB and fenestrated vascular ECs represent a fundamental feature of brain vasculature and form the foundation for both brain function and homeostasis.

关键词： angiogenesis homeostasis network

the protective effect of vitamin E on gastric mucosal injury in rats with cirrhosis of the liver

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Chinese Medical Journal 1999年第1期 57-61页

作者： Cantürk nz, Cantürk Z, Utkan nz, Yenisey C, zbilim G, Gelen t and Yalman Y

Objective to evaluate the functional and morphologic features of stomach in liver cirrhosis model and the cytoprotective effects of Vitamin E. Methods Experimental cirrhosis was induced in rats by subcutaneous administration of 0.4 ml CCl 4 (diluted 1∶4 with olive oil) per kilogram of body weight twice a week for 12 weeks. Rats were divided into three groups. Group 1 was control. Group 2 consisted cirrhotic rats induced by CCl 4 and Group 3 cirrhotic rats treated with Vitamin E (intramuscularly 100 mg/kg per day during study). At the end of 12 weeks, gastric mucosal injury was produced by instillation of absolute alcohol via an orogastric tube. After 3 hours, each animal was sacrificed. the stomachs were macroscopically, microscopically and biochemically analyzed. Results Macroscopic and microscopic area of gastric mucosal injury were significantly larger in cirrhotic rats (Ptric mucosal injury was more serious in cirrhotic rats as compared with Group 1. With vitamin E treatment, tissue Malondialdehyde (MDA) and glutathione levels were significantly lower in group 3 as compared with group 2 (Plusion Gastric mucosa in cirrhotic rats has distinctive histological and functional abnormalities. these abnormalities can be reversed by Vitamin E or other antioxidants.

关键词： liver cirrhosis · alpha tocopherol · stomach · lipid peroxidation

Security threat and Vulnerability Assessment and Measurement in Secure Software Development

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Computers, Materials & Continua 2022年第6期71卷 5039-5059页

作者： Mamoona Humayun nz Jhanjhi Maram Fahhad Almufareh Muhammad Ibrahim Khalil Department of Information Systems College of Computer and Information SciencesJouf UniversityAl-JoufKSA School of Computer Science and Engineering(SCE) Taylor’s UniversitySelangorMalaysia Department of Computer Science Bahria UniversityIslamabadPakistan

Security is critical to the success of software,particularly in today’s fast-paced,technology-driven *** ensures that data,code,and services maintain their CIA(Confidentiality,Integrity,and Availability).this is only possible if security is taken into account at all stages of the SDlC(Software Development life Cycle).Various approaches to software quality have been developed,such as CMMI(Capabilitymaturitymodel integration).However,there exists no explicit solution for incorporating security into all phases of *** of the major causes of pervasive vulnerabilities is a failure to prioritize *** the most proactive companies use the“patch and penetrate”strategy,inwhich security is accessed once the job is *** cost,time overrun,not integrating testing and input in SDlC,usage of third-party tools and components,and lack of knowledge are all reasons for not paying attention to the security angle during the SDlC,despite the fact that secure software development is essential for business continuity and survival in today’s ICt *** is a need to implement best practices in SDlC to address security at all *** fill this gap,we have provided a detailed overview of secure software development practices while taking care of project costs and *** proposed a secure SDlC framework based on the identified practices,which integrates the best security practices in various SDlC phases.A mathematical model is used to validate the proposed framework.A case study and findings show that the proposed system aids in the integration of security best practices into the overall SDlC,resulting in more secure applications.

关键词： Security secure software development software development life cycle(SDlC) confidentiality integrity availability

Iot Wireless Intrusion Detection and Network traffic Analysis

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Computer Systems Science & Engineering 2022年第3期40卷 865-879页

作者： Vasaki Ponnusamy Aun Yichiet nz Jhanjhi Mamoona humayun MaramFahhad Almufareh University tunku Abdul Rahman Kampar31900Malaysia School of Computer Science and Engineering(SCE) Taylor’s UniversitySelangorMalaysia Department of Information Systems College of Computer and Information SciencesJouf UniversityAl-JoufSaudi Arabia

Enhancement in wireless networks had given users the ability to use the Internet without a physical connection to the *** every Internet of things(Iot)devices such as smartphones,drones,and cameras use wireless technology(Infrared,Bluetooth,IrDA,IEEE 802.11,etc.)to establish multiple interdevice connections *** the flexibility of the wireless network,one can set up numerous ad-hoc networks on-demand,connecting hundreds to thousands of users,increasing productivity and profitability ***,the number of network attacks in wireless networks that exploit such flexibilities in setting and tearing down networks has become very *** can launch attacks since there is no first line of defense in an ad hoc network setup besides the standard IEEE802.11 WPA2 *** feasible countermeasure is to deploy intrusion detection systems at the edge of these ad hoc networks(Network-based IDS)or at the node level(Host-based IDS).the challenge here is that there is no readily available benchmark data available for Iot network *** this benchmark data is very tedious as Iot can work on multiple platforms and networks,and crafting and labelling such dataset is very *** research aims to study the characteristics of existing datasets available such as KDD-Cup and NSl-KDD,and their suitability for wireless IDS *** hypothesize that network features are parametrically different depending on the types of network and assigning weight dynamically to these features can potentially improve the subsequent threat *** paper analyses packet and flow features for the data packet captured on a wireless network rather than a wired *** domain heuristcs and early classification results,the paper had identified 19 header fields exclusive to wireless network that contain high information gain to be used as Ml features in Wireless IDS.

关键词： Iot machine learning traffic features IDS KDD-CUP NSl-KDD

transport mechanism in chemically reactive hybrid nanofluid flow containing gyrotactic micro-organisms over a curved oscillatory surface

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 177-192页

作者： M.NAVEED M.IMRAN t.ASGHAR Z.ABBAS Department of Mathematics Division of Science and TechnologyUniversity of Education Department of Mathematics The Islamia University of Bahawalpur

this paper examines the transport analysis, including both heat transfer and mass transfer, in hybrid nanofluid flow containing gyrotactic microorganisms towards a curved oscillatory surface. the influence of magnetic fields is also inspected in terms of their physical characteristics. to depict the phenomena of transport, modified versions of both Fick's and Fourier's laws are used. Additionally, the characteristics of both heterogeneous and homogeneous chemical reactions are also incorporated. Utilizing a curvilinear coordinate system, the flow problem is formulated as partial differential equations(PDEs)for momentum, concentration, microorganism field, and energy. An analytical solution to the obtained flow equations is achieved utilizing the homotopy analysis method(HAM).the effects of significant flow parameters on the pressure and microorganism fields, velocity, oscillation velocity, concentration, and temperature distributions are shown via graphs. Furthermore, the variations in skin friction, mass transfer rate, heat transfer rate, and local motile number due to different involved parameters are presented in tables and are analyzed in detail. Graphical results indicate that the curves of velocity and temperature fields are enhanced as the values of the solid volume fraction variables *** is also verified that the concentration rate field decreases as the values of the homogeneous reaction strength parameter and the radius of curvature parameter increase, and it increases with the Schmidt number and the heterogeneous reaction strength *** outcomes show a favorable response of the motile number to advanced values of the Peclet number, the Schmidt number, the microorganism difference parameter, and the bio-convective lewis number.

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Antibody engineering: facing new challenges in cancer therapy

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Acta Pharmacologica Sinica 2005年第6期26卷 641-648页

作者： laura S■nz ■ngel M CUEStA Mana COMPtE luis ■lVAREZ-VAllINA servicio de Inmunologia Hospital Universitario Puerta de Hterro Madrid Spntn servicio de Inmunologia Hospital Universitario Puerta de Hterro Madrid Spntn servicio de Inmunologia Hospital Universitario Puerta de Hterro Madrid Spntn servicio de Inmunologia Hospital Universitario Puerta de Hterro Madrid Spntn

Antibody-based therapeutics are beginning to realize the promise enclosed in their early denomination as "magic bullets". Initial disappointment has turned into clinical and commercial success, and engineered antibodies currently represent over 30% of biopharmaceuticals in clinical trials. Recent structural and functional data have allowed the design of a new generation of therapeutic antibodies, with strategies ranging from complement-mediated and antibody-dependant cellular cytotoxicity enhancement to improved cytotoxic payloads using toxins, drugs, radionucleids and viral delivery. this review considers the structure of different types of recombinant antibodies, their mechanism of action and how their efficacy has been increased using a broad array of approaches. We will also focus on the additional benefits offered by the use of gene therapy methods for the in vivo production of therapeutic antibodies.

关键词： immunoglobulin fragments monoclonal antibodies antibody formation gene therapy recombinant proteins biomedical engineering

Exploring Students Engagement towards the learning Management System (lMS) Using learning Analytics

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Computer Systems Science & Engineering 2021年第4期37卷 73-87页

作者： Shahrul Nizam Ismail Suraya Hamid Muneer Ahmad A.Alaboudi nz Jhanjhi Department of Information Systems Faculty of Computer Science&Information TechnologyUniversity MalayaKuala Lumpur50603Malaysia Department of Information systems College of Computer and Information SciencesShaqra UniversitySaudi Arabia School of Computer Science and Engineering SCETaylor’s UniversitySubang Jaya47500Malaysia

learning analytics is a rapidly evolving research discipline that uses theinsights generated from data analysis to support learners as well as optimize boththe learning process and environment. this paper studied students’ engagementlevel of the learning Management System (lMS) via a learning analytics tool,student’s approach in managing their studies and possible learning analytic methods to analyze student data. Moreover, extensive systematic literature review(SlR) was employed for the selection, sorting and exclusion of articles fromdiverse renowned sources. the findings show that most of the engagement inlMS are driven by educators. Additionally, we have discussed the factors inlMS, causes of low engagement and ways of increasing engagement factorsvia the learning Analytics approach. Nevertheless, apart from recognizing thelearning Analytics approach as being a successful method and technique for analyzing the lMS data, this research further highlighted the possibility of mergingthe learning analytics technique with the lMS engagement in every institution asbeing a direction for future research.

关键词： learning analytics student engagement learning management system systematic literature review