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PRGD/PDllA/β-tCP/NGF复合神经导管的制备及其体外降解性能

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中南大学学报（自然科学版） 2009年第2期40卷 406-410页

作者：王永红戴红莲严琼姣李世普武汉理工大学医院湖北武汉430070 武汉理工大学生物材料与工程研究中心湖北武汉430070

将聚合物-RGD多肽接枝聚(乳酸-羟基乙酸l-赖氨酸,PRGD)与聚(D,l-乳酸,PDllA)、β-磷酸三钙(β-tCP)、神经生长因子(NGF)复合制备的新型PRGD/PDllA/β-tCP/NGF复合导管材料在37℃的磷酸缓冲溶液中进行降解试验,研究支架材料在体外降解过... 详细信息

将聚合物-RGD多肽接枝聚(乳酸-羟基乙酸l-赖氨酸,PRGD)与聚(D,l-乳酸,PDllA)、β-磷酸三钙(β-tCP)、神经生长因子(NGF)复合制备的新型PRGD/PDllA/β-tCP/NGF复合导管材料在37℃的磷酸缓冲溶液中进行降解试验,研究支架材料在体外降解过程中相对分子质量、质量、降解介质pH值、微观形貌的变化及NGF的释放规律。研究结果表明:NGF的释放量在30d内可以达到诱导神经组织的功能;加入β-tCP,可以部分中和聚乳酸和PRGD降解产物的酸性,有效调节降解介质的pH值,使其维持在中性。加入PRGD和NGF可促进复合膜的降解,PRGD/PDllA/β-tCP/NGF复合材料比聚乳酸具有更好的降解性能。

关键词： RGD多肽接枝聚(D,l-乳酸) β-磷酸三钙神经生长因子神经导管降解

丝网印刷法制备Y改性CuMn2O4尖晶石涂层研究

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表面技术 2020年第10期49卷 161-168页

作者：张勇张宇涛张耿飞高彬晁奕蒲健长安大学材料科学与工程学院西安710064 长安大学机械工程博士后科研流动站西安710064 奥克兰大学化学与材料工程系新西兰奥克兰1142 华中科技大学材料成形与模具技术国家重点实验室武汉430074

目的提高SOFC金属连接件CuMn2O4尖晶石涂层高温抗氧化性能和导电性能。方法采用溶胶-凝胶法制备Y改性CuMn2O4尖晶石粉末,采用丝网印刷技术在SUS430合金表面制备Y改性CuMn2O4尖晶石涂层。利用XRD、SEM表征Y改性CuMn2O4尖晶石粉体及涂层... 详细信息

目的提高SOFC金属连接件CuMn2O4尖晶石涂层高温抗氧化性能和导电性能。方法采用溶胶-凝胶法制备Y改性CuMn2O4尖晶石粉末,采用丝网印刷技术在SUS430合金表面制备Y改性CuMn2O4尖晶石涂层。利用XRD、SEM表征Y改性CuMn2O4尖晶石粉体及涂层的物相结构及微观形貌。利用氧化增重实验研究Y改性前后CuMn2O4尖晶石涂层试样在800℃空气中氧化168 h的高温氧化行为,通过“四点法”测量涂层在高温氧化过程中的面比电阻值。结果CuMn2O4尖晶石粉末的晶格常数随着稀土Y含量的增大而增大,当Y元素的含量为0.02 mol/l时,晶格常数增幅趋于平缓,此时所得粉体物相结构稳定,结晶程度较好,晶粒尺寸细小且颗粒间团聚现象较少。Y改性前后CuMn2O4尖晶石涂层试样的氧化动力学曲线均遵循抛物线氧化定律,其氧化速率常数分别为9.39×10^−5、6.31×10^−5 mg^2/(cm^4·h)。Y改性CuMn2O4尖晶石涂层试样在800℃氧化168 h时的面比电阻值约为26.2 mΩ·cm^2,低于未改性涂层试样的面比电阻值(约27.3 mΩ·cm^2)。结论Y改性CuMn2O4尖晶石涂层能有效改善金属连接体的高温抗氧化性能和导电性能。

关键词：丝网印刷尖晶石涂层 Y改性高温抗氧化性高温导电性

Clinical significance of tGF-β₁ and β-glucuronidase synchronous detection in human pancreatic cancer

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Hepatobiliary & Pancreatic Diseases International 2002年第2期1卷 309-311页

作者： Yue H. Yang B. Zhang H. Zhu S.-D. Du X.-J. Feng X.-l. Yu Z. Xia Y.-t. Yu J.-P. Department of Digestive Diseases People's Hospital Wuhan University Wuhan 430071 China Dept. of liver and Biliary Surgery Gen. Hosp. Shenyang Military Region Shenyang 110016 China Department of Pathology Chinese Medical University Shenyang 110005 China

Objective: to investigate the relation of transfergrowth factor （tGF-β1） and β-glucuronidase （β-GCD） on the occurrence and progress of ***: the expression of tGF-β1 and β-GCD in thepancreatic cancer tissue and normal pancreatic tissuewas determined synchronously using ABC method ***: the percentage of tGF-β1 positive cells wassignificantly higher in pancreatic cancer tissue （43.8%±5.2%） than in adjacent pancreatic tissue （28.7%±3.6%, P<0.01）. the worse the cancer cells differen-tiated and lymph nodes metastasis, the more over-ex-pression of tGF-β1. the percentage of β-GCD positivecells was also significantly higher in the pancreaticcancer tissue （62.5%±4.1%） than in the adjacentpancreatic tissue （33.5%±2.8%, P<0.01）. the de-gree of over-expression of β-GCD was related to thedegree of cancer cells differentiation, but not to thelymph nodes metastasis. the expression of tGF-β1was significantly correlated with the expression of β-GCD in pancreatic cancer ***: the genesis of pancreatic cancer resultsfrom multi-factor, multi-step and multi-gene varia-tion. the synchronous detection of tGF-β1 and β-GCD helps to determine the malignant degree oftumors and the prognosis of patients with such disease.

关键词： pancreatic cancer transfer growth factor β1 β-glucuronidase

Inorganic Fertilizer Adoption, Use Intensity and Rainfed Rice Yield in Benin

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Open Journal of Soil Science 2020年第1期10卷 1-15页

作者： Firmin N. Anago Dagbenonbakin G. Dieudonné Agbangba C. Emile Oussou C. t. Brice Amadji l. Guillaume laboratory of Soil Sciences School of Plant Production Faculty of Agricultural Sciences University of Abomey-Calavi Cotonou Benin laboratory of Soil Science Water and Environment Research Agricultural Center of Agonkanmey National Institute of Agronomic Research of Benin Cotonou Benin laboratory of Applied Biology Research and Study Polytechnic School of Abomey-Calavi Department of Environment Genius University of Abomey-Calavi Cotonou Benin

Inorganic fertilizers are alternative ways of providing the necessary nutrients to rice crop and increase its productivity. In order to identify the factors determining inorganic fertilizer technology adoption and rainfed rice yield, a survey was carried out among 763 farmers in 11 municipalities in four agriculture development centers (ADC) of Benin. Composite soil samples were collected from 227 farmer fields and analyzed at the laboratory. Rainfed rice yields were determined in these different fields. Data collected was analyzed with R version 3.5.1 software. Results show that inorganic fertilizer technology adoption depends significantly on age, educational status, household size, contribution of rice to household income and organic fertilizer use (0.004 kg⋅ha−1?with a mean of 74.68 kg⋅ha−1. the quantities of inorganic fertilizer applied differ more importantly from one farmer to another and range from 4.58% to 90.5% with a mean of 27.15% of the level recommended by research. However, nitrogen, phosphorous, potassium, organic carbon, pH water, and exchanging capacity cation determine the rainfed rice yield. the policies that aim at promoting inorganic fertilizer among rainfed rice farmers must take into account these factors.

关键词： Endogenous Cropping Systems Double Hurdle Model Regression tree Inorganic Fertilizer

γ-A1_2O_3改性对AlCl_3/γ-Al_2O_3催化剂性能的影响（英文）

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分子催化 2015年第2期29卷 111-117页

作者：蔡艳詹续芹许胜米普科王斯晗徐显明华东理工大学材料科学与工程学院上海市先进聚合物材料重点实验室超细材料制备与应用教育部重点实验室上海200237 中国石油天然气股份有限公司石油化工研究院大庆化工研究中心黑龙江大庆163714

采用HCl和NaOH改性γ-A12O3载体制备AlCl3/γ-A12O3固载催化剂,用吡啶-FtIR和吡啶-tPD技术分析了催化剂的表面酸性(酸中心类型、酸强度和酸量),并以1-癸烯齐聚作为探针反应,研究了催化剂的稳定性以及催化剂对聚合反应的影响.结果表明,... 详细信息

采用HCl和NaOH改性γ-A12O3载体制备AlCl3/γ-A12O3固载催化剂,用吡啶-FtIR和吡啶-tPD技术分析了催化剂的表面酸性(酸中心类型、酸强度和酸量),并以1-癸烯齐聚作为探针反应,研究了催化剂的稳定性以及催化剂对聚合反应的影响.结果表明,催化剂含有两种酸类型,即lewis酸和Brnsted酸,与未改性的催化剂相比,氢氧化钠改性载体制备的催化剂,酸量增大了47%,催化剂催化1-癸烯的齐聚反应活性增加了11.4%;而经盐酸改性制备的催化剂酸量增大112%,催化剂的活性增加了33.6%.酸强度依AlC l3/γ-A12O3,AlC l3/γ-Al2O3(NaO H),AlC l3/γ-Al2O3(HCl)的顺序增强.

关键词：改性固载 γ-氧化铝三氯化铝酸性位

Characterization of Flow Structures Induced by Highly Rough Surface Using Particle Image Velocimetry, Proper Orthogonal Decomposition and Velocity Correlations

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Engineering（科研） 2018年第7期10卷 399-416页

作者： l.RAndersson I.A.S.larsson J.G.I.Hellstrom P.Andreasson A.G.Andersson t.S.lundstrom Division of Fluid and Experimental Mechanics Lulea University of TechnologyLuleaSweden Vattenfall Research and Development AlvkarlebySweden

High Reynolds number flow inside a channel of rectangular cross section is examined using Particle Image Velocimetry. One wall of the channel has been replaced with a surface of a roughness representative to that of real hydropower tunnels, i.e. a random terrain with roughness dimensions typically in the range of ≈10% - 20% of the channels hydraulic radius. the rest of the channel walls can be considered smooth. the rough surface was captured from an existing blasted rock tunnel using high resolution laser scanning and scaled to 1:10. For quantification of the size of the largest flow structures, integral length scales are derived from the auto-correlation functions of the temporally averaged velocity. Additionally, Proper Orthogonal Decomposition (POD) and higher-order statistics are applied to the instantaneous snapshots of the velocity fluctuations. the results show a high spatial heterogeneity of the velocity and other flow characteristics in vicinity of the rough surface, putting outer similarity treatment into jeopardy. Roughness effects are not confined to the vicinity of the rough surface but can be seen in the outer flow throughout the channel, indicating a different behavior than postulated by townsend’s similarity hypothesis. the effects on the flow structures vary depending on the shape and size of the roughness elements leading to a high spatial dependence of the flow above the rough surface. Hence, any spatial averaging, e.g. assuming a characteristic sand grain roughness factor, for determining local flow parameters becomes less applicable in this case.

关键词： CFD Validation Hydraulic Roughness PIV Hydropower

Development and Validation of lC-MS/MS Method for the Quantification of Chiral Separated R-Bicalutamide in Human Plasma

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American Journal of Analytical Chemistry 2013年第2期4卷 63-76页

作者： N. t. Ramarao S. Vidyadhara R. l. C. Sasidhar B. Deepti R. Surendra Yadav Alkem Research Center Navi Mumbai India Chebrolu Hanumaiah Institute of Pharmaceutical Sciences Guntur India GVK Biosciences Hyderabad India Vignan Pharmacy College Guntur India

A simple, rapid, specific and precise liquid chromatography—tandem mass spectrophotometric (lC-MS/MS) method was developed and validated for the quantification of chiral separated R-bicalutamide from S-bicalutamide, in human plasma. topiramate (tPM) was used as internal standard, added to plasma sample prior to extraction using t-butyl methyl ether (tBME). Chromatographic separation was achieved on CHIRAlPAK AD-RH column (150 mm×4.6 mm, 5 μm) with acteonitrile: 0.1% formic acid Buffer (50:50 v/v) as an isocratic mobile phase with a flow rate of 1.0 ml·min-1. Quantitation was performed by transition of 429.0 → 255.0 (m/z) for R-bicalutamide and 338.1 → 77.8 (m/z) for topiramate. the lower limit of quantitation was 20 ng·ml-1with a 100 μl plasma sample. the concentrations of eight working standards showed linearity between 20 to 3200 ng·ml-1(r2≥ 0.9990). Chromatographic separation was achieved within 6 min, compared to the 15 min of previous methods. the average extraction recoveries of 3 quality control concentrations were 98.56% for R-bicalutamide and 92.42% for topiramate. the coefficient of variation was ≤15% for intra- and inter-batch assays. therefore a rapid, specific and sensitive lC-MS/MS method for the quantification of R-bicalutamide in human plasma was developed and validated can be used in the bioequivalence study of this drug.

关键词： lC-MS/MS R-Bicalutamide topiramate Validation Human Plasma

NO介导ABA诱导的玉米叶片叶绿体和质外体的抗氧化防护

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南京农业大学学报 2006年第4期29卷 33-37页

作者：许可飞蒋明义谭明谱南京农业大学生命科学学院江苏南京210095

用硝普钠(SNP,NO供体)和ABA处理玉米幼苗,结果显示,ABA和SNP均增强了玉米叶片中抗氧化酶SOD、CAt、GR和APX的活性;激光共聚焦显微检测显示,ABA能够诱导叶片中NO的合成;NO清除剂PtIO和合成抑制剂l-NAME预处理阻断了ABA诱导的抗氧化酶活... 详细信息

用硝普钠(SNP,NO供体)和ABA处理玉米幼苗,结果显示,ABA和SNP均增强了玉米叶片中抗氧化酶SOD、CAt、GR和APX的活性;激光共聚焦显微检测显示,ABA能够诱导叶片中NO的合成;NO清除剂PtIO和合成抑制剂l-NAME预处理阻断了ABA诱导的抗氧化酶活性的上升及NO的合成。对不同亚细胞区室的研究显示,ABA和NO对质外体和叶绿体中的抗氧化酶系统均表现出诱导效应,而PtIO和l-NAME阻断了这种诱导。上述结果表明,在玉米叶片中,NO介导了ABA的信号转导,诱导叶绿体和质外体中的抗氧化酶系统协同作用,共同提高了叶片的抗氧化防护能力。

关键词： ABA NO 抗氧化防护叶绿体质外体

低钙透析联合血液灌流治疗维持性血液透析患者继发性甲状旁腺功能亢进疗效的观察

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中国现代医学杂志 2010年第22期20卷 3440-3442页

作者：蒲超薛痕杨有京姚小梅四川省雅安市人民医院肾内科四川雅安625000

目的观察低钙透析(1.25mmol/l)联合血液灌流对维持性血液透析患者继发性甲状旁腺功能亢进(SHPt)治疗的效果。方法将32例并发SHPt的透析患者随机分为对照组和治疗组,每组各16人,对照组使用常规血液透析联合活性VitD3治疗;治疗组在VitD3... 详细信息

目的观察低钙透析(1.25mmol/l)联合血液灌流对维持性血液透析患者继发性甲状旁腺功能亢进(SHPt)治疗的效果。方法将32例并发SHPt的透析患者随机分为对照组和治疗组,每组各16人,对照组使用常规血液透析联合活性VitD3治疗;治疗组在VitD3治疗的基础上,使用低钙透析联合血液灌流治疗。观察两组在治疗1月和3月后血清全段甲状旁腺激素(iPtH)、Ca、P和Ca×P变化及观察皮肤瘙痒等症状的改善情况。结果①治疗1月后,治疗组iPtH下降(PtH显著下降(PtH下降(PtH下降比较差异有显著性(1月时Pt有较满意的效果。

关键词：低钙透析血液灌流继发性甲状旁腺功能亢进活性VitD3