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浸润性乳腺癌扩散加权成像:与无远处转移生存率之间的关系

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国际医学放射学杂志 2019年第4期 478-478页

作者：殷国良 J.Y.Kim J.J.Kim L.Hwangbo t.kang H.Park Department of Radiology and Busan Cancer Pusan National University Hospital

摘要相比平均表观扩散系数(ADC),联合最小ADC值和ADC差值可能提高扩散加权成像(DWI)对乳腺疾病的诊断能力。目的研究DWI的ADC参数是否与女性无远处转

关键词：浸润性乳腺癌无远处转移生存率扩散加权成像

利用表观扩散系数的全病灶直方图分析对原位导管癌进行危险分层

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国际医学放射学杂志 2019年第2期42卷 248-248页

作者： J.W.Kim J.J.Kim J.W.Lee N.K.Lee G.Lee t.kang 李爽(译) 赵世华(校) Department of Radiology Pusan National University HospitalPusan National University School of Medicine and Medical Research Institute 不详

目的探究表观扩散系数(ADC)全病灶直方图指标对鉴别低危及非低危原位导管癌(DCIS)的价值。方法选取2013—2016年间93例患有单纯DCIS的女性,所有病人接受了术前MRI和DWI。

关键词：表观扩散系数原位导管癌 ADC 直方图

术前PEt/Ct肿瘤的18F-FDG摄取可以预测ER阳性/HER2阴性和HER2阳性型乳腺癌的腋窝淋巴结转移

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国际医学放射学杂志 2015年第3期38卷 305-305页

作者： J.Y.Kim S.H.Lee S.Kim t.kang Y.t.Bae 刘陈汉 Department of Radiology Pusan National University Hospital Pusan National University School of Medicine and Medical Research Institute 1-10 Ami-DongSeo-gu Busan 602-739 Korea

目的评估不同亚型乳腺癌术前PEt/Ct肿瘤FDG摄取与腋窝淋巴结转移(ALNM)的相关性。材料与方法回顾性分析671例接受术前18F-FDG PEt/Ct和手术治疗的浸润

关键词：腋窝 ER F-FDG HER2 淋巴结淋巴组织阳性术前 Ct

计算机辅助诊断的乳腺癌术前MRI动力学特征:与原发性可手术的浸润性乳腺癌病人无病生存率的相关性

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国际医学放射学杂志 2017年第5期 586-586页

作者： J.J.Kim J.Y.Kim H.J.kang J.K.Shin t.kang S.W.Lee 樊响 Department of Radiology Pusan National University Hospital

摘要目的回顾性分析原发性可手术的浸润性乳腺癌病人术前MR成像中计算机辅助诊断(CAD)获得的乳腺癌动力学特征与无病生存率的关系。材料与方法本回顾性研

关键词：浸润性乳腺癌 MRI 计算机辅助诊断原发性动力学特征

常规腹部Ct的辐射剂量变化较大：超剂量的原因及减少剂量的小建议

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国际医学放射学杂志 2024年第3期 378-378页

作者： R.Smith-Bindman t.kang P.W.Chu Y.Wang C.Stewart M.Das 吴玉平

摘要目的描述辐射剂量减少技术在常规腹部Ct中的应用和影响。方法回顾性分析了由95家医院和成像机构提供的有大剂量登记的成人连续常规腹部Ct扫描。将检查分

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Analysis of the anti-t2DM components in dichloromethane fraction of Schisandra sphenanthera and its mechanism

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traditional Medicine Research 2025年第1期10卷 27-43页

作者： Shi-Bo Feng Hai-Hui Jiang Hui-Li kang Yi Jiang Hua-Wei Zhang Xiao-Mei Song Yu-Ze Li Wen-Li Huang Dong-Dong Zhang Chong Deng School of Pharmacy Shaanxi University of Chinese MedicineXianyang 712046China School of Pharmacy and Shaanxi Qinling Application Development and Engineering Center of Chinese Herbal Medicine Shaanxi University of Chinese MedicineXianyang 712046China Key Laboratory for Research and Development of“Qin Medicine”of Shaanxi Administration of traditional Chinese Medicine Xianyang 712046China Shaanxi Key Laboratory of Research and Application of“taibai Qi Yao” Xianyang 712046China

Background:the type 2 diabetes mellitus(t2DM)pharmacodynamic study of various parts of Schisandra sphenanthera was conducted in the previous stage,and it was found that dichloromethane extracted part(SDP)had a significant hypoglycemic ***,the components of SDP were analyzed,and the specific mechanism of its anti-t2DM was ***:We used a high-fat,high-sugar diet in combination with streptozotocin to induce a t2DM rat model,and the model rats were divided into two groups according to body weight and blood ***,oral glucose tolerance test,fasting blood glucose,low density lipoprotein cholesterol,superoxide dismutase,insulin,glycated hemoglobin,total cholesterol,nonesterified free fatty acids,alanine aminotransferase,high-density lipoprotein cholesterol,aspartate aminotransferase,malondialdehyde,and glutathione peroxidase were measured,organ indices were calculated,and pathological sections of pancreas and liver were *** 16S rRNA V3–V4 region of intestinal flora was sequenced to explore the effect of SDP on biochemical indicators and intestinal *** on the above indicators,the anti-t2DM mechanism of SDP in Schisandra sphenanthera was ***:After six weeks of administration,the biochemical indices of diabetic rats were diminished compared to the control *** SDP could significantly increase the gut microbialα-diversity index,resulting in significant changes in the flora of t2DM rats,with increased richness and diversity,reduced harmful flora,and significantly back-regulated the levels of acetic acid,propionic acid,and butyric ***:SDP can improve the symptoms associated with elevated blood glucose,dyslipidemia,elevated fasting insulin levels,and damaged glucose tolerance in *** against t2DM may be through the control of intestinal flora to normalize and exert anti-diabetic effect;its main active components may be lignans and terpenoids.

关键词： Schisandra sphenanthera t2DM intestinal flora HPLC

Outlier Behavior Detection for Indoor Environment Based on t-SNE Clustering

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Computers, Materials & Continua 2021年第9期68卷 3725-3736页

作者： Shinjin kang Soo Kyun Kim School of Games Hongik UniversitySejong30016Korea Department of Computer Engineering Jeju National UniversityJeju63243Korea

In this study,we propose a low-cost system that can detect the space outlier utilization of residents in an indoor *** focus on the users’app usage to analyze unusual behavior,especially in indoor *** is reflected in the behavioral analysis in that the frequency of using smartphones in personal spaces has recently *** system facilitates autonomous data collection from mobile app logs and Google app servers and generates a high-dimensional dataset that can detect outlier *** density-based spatial clustering of applications with noise(DBSCAN)algorithm was applied for effective singular movement *** analyze high-level mobile phone usage,the t-distributed stochastic neighbor embedding(t-SNE)algorithm was *** two clustering algorithms can effectively detect outlier behaviors in terms of movement and app usage in indoor *** experimental results showed that our system enables effective spatial behavioral analysis at a low cost when applied to logs collected in actual living ***,large volumes of data required for outlier detection can be easily *** system can automatically detect the unusual behavior of a user in an indoor *** particular,this study aims to reflect the recent trend of the increasing use of smartphones in indoor spaces to the behavioral analysis.

关键词： Outlier detection trajectory clustering behavior analysis app data smartphone

盐酸青藤碱抑制急性t淋巴细胞白血病CEM细胞株的作用及转录组学分析

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中国组织工程研究 2025年第31期29卷 6674-6680页

作者：康林之刘振帅魏佳旭常娜朱大诚江西中医药大学江西省南昌市330004 延安大学陕西省延安市716000

背景:盐酸青藤碱有抗多种肿瘤的作用,但目前尚不清楚盐酸青藤碱对急性t淋巴细胞白血病的作用。目的:探讨盐酸青藤碱对急性t淋巴细胞白血病CEM细胞的抑制作用。方法:应用不同浓度(0.5,1,2,4 mmol/L)盐酸青藤碱处理CEM细胞,CCK-8检测细胞... 详细信息

背景:盐酸青藤碱有抗多种肿瘤的作用,但目前尚不清楚盐酸青藤碱对急性t淋巴细胞白血病的作用。目的:探讨盐酸青藤碱对急性t淋巴细胞白血病CEM细胞的抑制作用。方法:应用不同浓度(0.5,1,2,4 mmol/L)盐酸青藤碱处理CEM细胞,CCK-8检测细胞增殖抑制率并计算IC50;倒置显微镜和吉姆萨染色观察CEM细胞形态变化;利用RNA-Seq测序分析差异基因表达并进行生物信息学分析。结合转录组测序结果,流式细胞术检测不同浓度(1,2,4 mmol/L)盐酸青藤碱作用后CEM细胞凋亡率;Western blot检测不同浓度(1,2,4 mmol/L)盐酸青藤碱作用后CEM细胞中Bcl-2、Bax、Caspase-9蛋白的表达。结果与结论:①盐酸青藤碱呈剂量和时间依赖性地抑制CEM细胞生长;②盐酸青藤碱干预后CEM细胞数量下降,核固缩;③RNA-seq测序筛出53个异常表达基因,基因本体分析主要富集在细胞过程、细胞解剖实体与粘连关系等,信号通路分析与肿瘤相关的是细胞凋亡;④盐酸青藤碱呈剂量依赖性地促进CEM细胞凋亡;⑤盐酸青藤碱上调CEM细胞中Bax、Caspase-9蛋白表达,下调Bcl-2蛋白表达。由此可见,盐酸青藤碱可诱导CEM细胞凋亡从而抑制细胞增殖,可能与其上调Bax和Caspase-9蛋白表达,以及下调Bcl-2蛋白表达有关。

关键词：盐酸青藤碱急性t淋巴细胞白血病 CEM细胞细胞凋亡 RNA-seq测序增殖抑制工程化细胞

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Metamorphism and geochronology of garnet amphibolite from the Beishan Orogen,southern Central Asian Orogenic Belt:Constraints from P-t path and zircon U-Pb dating

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Geoscience Frontiers 2020年第4期11卷 1189-1201页

作者： Wenbin kang Wei Li Lei kang Yunpeng Dong Dazhi Jiang Jiwei Liang Haoqiang Dong State Key Laboratory of Continental Dynamics Department of GeologyNorthwest UniversityXi’an 710069China Key Laboratory for the Study of Focused Magmatism and Giant Ore Deposits of Ministry of Natural Resources Xi'an Center of China Geological SurveyCGSXi'an 710054ShaanxiChina Department of Earth Sciences Western UniversityLondonOntarioN6A 5B7Canada School of Earth Science&Resources Chang’an UniversityXi’an 710054China

Numerous lenses of garnet amphibolite occur in the garnet-bearing biotite-plagioclase gneiss belt in the Baishan area of the Beishan Orogen,which connects the tianshan Orogen to the west and the Mongolia-Xing’anling Orogen to the *** study of metamorphism in Beishan area is of great significance to explain the tectonic evolution of Beishan *** to the microstructures,mineral relationships,and geothermobarometry,we identified four stages of mineral assemblages from the garnet amphibolite sample:(1) a pre-peak stage,which is recorded by the cores of garnet together with core-inclusions of plagioclase(Pl1);(2) a peak stage,which is recorded by the mantles of garnet together with mantle-inclusions of plagioclase(Pl2)+amphibole(Amp1)+Ilmenite(Ilm1)+biotite(Bt1),developed at temperature-pressure(P-t) conditions of 818.9-836.5℃ and7.3-9.2 kbar;(3) a retrograde stage,which is recorded by garnet rims + plagioclase(Pl3)+amphibole(Amp2)+orthopyroxene(Opx1)+biotite(Bt2)+Ilmenite(Ilm2),developed at P-t conditions of 796.1-836.9℃ and5.6-7.5 kbar;(4) a symplectitic stage,which is recorded by plagioclase(Pl4)+orthopyroxene(Opx2)+amphibole(Amp3)+biotite(Bt3) symplectites,developed at P-t conditions of 732 ±59.6℃ and 6.1 ±0.6 ***,the U-Pb dating of the Beishan garnet amphibolite indicates an age of 301.9 ±4.7 Ma for the protolith and 281.4±8.5 Ma for the peak metamorphic ***,the mineral assemblage,P-t conditions,and zircon U-Pb ages of the Beishan garnet amphibolite define a near-isothermal decompression of a clockwise P-t-t(Pressure-temperature-time) path,indicating the presence of over thickened continental crust in the Huaniushan arc until the Early Permian,then the southern Beishan area underwent a process of thinning of the continental crust.

关键词： Beishan orogen Garnet amphibolite P-t-t path Zircon U-Pb dating