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利用胎儿MRI预测早期妊娠的深度学习模型

国际医学放射学杂志 2021年第4期44卷 495-495页

作者： Y.Kojita H.Matsuo t.kanda M.Nishio K.Sofue M.Nogami 孙羽

摘要目的比较双顶径(BPD)和前 3 个月获得的胎儿脑MRI,评价一种预测孕龄的深度学习模型。方法机构伦理委员会批准了这项回顾性研究,纳入了 184 个胎儿(平均胎龄:

关键词：深度学习模型 MRI 早期妊娠

平扫MRt1加权影像齿状核高信号:与线性或大环状钆螯合剂应用相关

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国际医学放射学杂志 2015年第4期 383-383页

作者： t.kanda M.Osawa H.Oba K.toyoda J.Kotoku t.Haruyama 苏晓微 Department of Radiology Teikyo University School of Medicine

摘要目的评估平扫MR t1加权影像齿状核(DN)高信号是否与先前使用包含不同类型钆螯合物的钆对比剂(GBCA)存在相关性。材料与方法本研究经机构伦理委员会

关键词：高信号齿状核 DN 环状平扫螯合剂分析试剂

钆对比剂在非肾功能不全受试者脑中的积聚效应:利用电感耦合等离子体质谱法评估尸检大脑标本

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国际医学放射学杂志 2015年第5期 475-475页

作者： t.kanda t.Fukusato M.Matsuda K.toyoda H.Oba J.Kotoku 范舒璇 Department of Radiology Teikyo University School of Medicine

摘要目的利用电感耦合等离子体质谱法评价钆对比剂在受试者脑中,特别是齿状核和苍白球的积聚效应。材料与方法本研究经伦理委员会批准,尸检前获得受试者本人或其亲属知情同意。采用电感耦合等离子体质谱法,对5例钆对比剂的受试者(钆对... 详细信息

摘要目的利用电感耦合等离子体质谱法评价钆对比剂在受试者脑中,特别是齿状核和苍白球的积聚效应。材料与方法本研究经伦理委员会批准,尸检前获得受试者本人或其亲属知情同意。采用电感耦合等离子体质谱法,对5例钆对比剂的受试者(钆对比剂组)和5例无钆对比剂使用的受试者(非钆对比剂组)进行检查。收集的标本经福尔马林固

关键词：对比剂齿状核苍白球受试者肾功能不全肾功能障碍标本电感耦合等离子体质谱法积聚效应尸检

利用扩散张量成像对手足徐动型及痉挛型脑瘫患儿的解剖学评价

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国际医学放射学杂志 2011年第5期 489-489页

作者： S.Yoshida K.Hayakawa K.Oishi S.Mori t.kanda Y.Yamori 张竞文 Department of Radiology Kyoto City Hospital1-2 MlbuHlgashitakada-choNakagyo-kuKyoto 604-8845Japan

目的利用扩散张量成像(DtI)评价手足徐动型脑瘫(CP)患儿及痉挛型脑瘫患儿的深部灰质和白质解剖结构,并探讨不同类型脑瘫患儿的解剖学变化是否与其

关键词：脑瘫患儿深部灰质痉挛型手足徐动神经系统疾病解剖学扩散张量

Late Ordovician Mass Extinction: Earth, fire and ice

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National Science Review 2024年第1期11卷 51-65页

作者： David A.t.Harper Palaeoecosystems Group Department of Earth SciencesDurham University

the Late Ordovician Mass Extinction was the earliest of the ‘big’ five extinction events and the earliest to affect the trajectory of metazoan life. two phases have been identified near the start of the Hirnantian period and in the middle. It was a massive taxonomic extinction, a weak phylogenetic extinction and a relatively benign ecological extinction. A rapid cooling, triggering a major ice age that reduced the temperature of surface waters, prompted a drop in sea level of some 100 m and introduced toxic bottom waters onto the shelves. these symptoms of more fundamental planetary processes have been associated with a range of factors with an underlying driver identified as volcanicity. Volcanic eruptions, and other products, may have extended back in time to at least the Sandbian and early Katian, suggesting the extinctions were more protracted and influential than hitherto documented.

关键词： Ordovician LOME paleoecology palaeobiogeography biotas

Preparation of microparticles and nanoparticles using membrane-assisted dispersion,micromixing,and evaporation processes

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Particuology 2024年第1期84卷 30-44页

作者： Goran t.Vladisavljevic Chemical Engineering Department Loughborough UniversityLoughboroughLeicestershire LE113TUUnited Kingdom

Synthetic microporous membranes are increasingly used for energy-efficient and controlled production of micro-and nanoparticles and micro-and nanoemulsions with tuneable morphology and physico-chemical properties through various micromixing,emulsification,and evaporation processes.In emul-sification processes,the membrane pores are used for dispersed phase injection and size-controlled generation of droplets and droplet-templated particles.In micromixing processes,membrane is utilised as a micromixer for mixing two miscible liquids,usually solvent and antisolvent-rich solutions,which leads to the creation of supersaturation and subsequent nanoprecipitation or crystallisation.In mem-brane evaporation processes,membrane is used to prevent phase dispersion while allowing efficient molecular diffusion of solvent and/or antisolvent vapour through gas-filled pores.Membrane dispersion processes can be operated continuously by decoupling shear stress on the membrane surface from cross flow using tube insets,flow pulsations,swirling flow,membrane oscillations or membrane rotations.Droplet generation and solidification can be performed continuously in a single pass by connecting membrane module with a downstream reactor.Membrane dispersion processes can be used for pro-duction of nanoparticles such as nanovesicles(liposomes,micelles,ethosomes,and niosomes),nanogels,polymeric,lipid and metallic nanoparticles,and nanocrystals.the main advantages of membrane-assisted particle generation are in low energy consumption,controlled geometry and hydrodynamic conditions at the microscale level,flexible throughput due to modular and scalable design of membrane devices,and a wide choice of available microporous membranes with various wall porosities,wetta-bilities,pore sizes,and pore morphologies to suit different applications.

关键词： Nanoparticles Microparticles Nanoemulsions Microemulsions Microporous membrane Crystallisation Flash nanoprecipitation Emulsification Zero liquid discharge

Eliciting CD4-mimicking broadly neutralizing antibodies:new avenues towards the rational design of an HIV vaccine

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Signal transduction and targeted therapy 2024年第3期9卷 836-838页

作者： Frauke Muecksch Oliver t.Fackler Department of Infectious Diseases Heidelberg UniversityMedical Faculty HeidelbergVirologyCenter for Integrative Infectious Disease Research(CIID)HeidelbergGermany Chica and Heinz Schaller(CHS)Research Group Department of Infectious DiseasesVirologyUniversity Hospital HeidelbergHeidelbergGermany Department of Infectious Diseases Heidelberg UniversityMedical Faculty HeidelbergIntegrative VirologyCenter for Integrative Infectious Disease Research(CIID)HeidelbergGermany German Centre for Infection Research(DZIF) Partner Site HeidelbergHeidelbergGermany

In a study recently published in Cell,Saunders et al.report that a new anti-HIV vaccine triggers antibody responses resembling CD4-binding site broadly neutralizing antibody precursors in rhesus macaques.1 this study provides important proof of concept and establishes a framework for the rational design of an effective HIV vaccine.

关键词： al. vaccine rational

the bumpy road of purinergic inhibitors to clinical application in immune-mediated diseases

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Neural Regeneration Research 2024年第6期19卷 1206-1211页

作者： Matihias t.Wyss Christine Heuer Marina Herwerth Institute of Pharmacology and toxicology University of Zurich Neuroscience Center Zurich (ZNZ) University of Zurich and ETH Zurich 3. Neurology Department University Hospital of Zurich

Purinergic signaling plays important roles throughout the body in the regulation of organ functions during and following the disruption of homeostasis. this is also reflected by the widespread expression of two families of purinergic receptors(P1 and P2) with numerous subtypes. In the last few decades, there has been increasing evidence that purinergic signaling plays an important role in the regulation of immune functions. Mainly, signals mediated by P2 receptors have been shown to contribute to immune system-mediated pathologies. thus, interference with P2 receptors may be a promising strategy for the modulation of immune responses. Although only a few clinical studies have been conducted in isolated entities with limited success, preclinical work suggests that the use of P2 receptor inhibitors may bear some promise in various autoimmune diseases. Despite the association of P2 receptors with several disorders from this field, the use of P2 receptor antagonists in clinical therapy is still very scarce. In this narrative review, we briefly review the involvement of the purinergic system in immunological responses and clinical studies on the effect of purinergic inhibition on autoimmune processes. We then open the aperture a bit and show some preclinical studies demonstrating a potential effect of purinergic blockade on autoimmune events. Using suramin, a non-specific purinergic inhibitor, as an example, we further show that off-target effects could be responsible for observed effects in immunological settings, which may have interesting implications. Overall, we believe that it is worthwhile to further investigate this hitherto underexplored area.

关键词： autoimmune diseases neurological disorders purinergic system P2 receptor inhibitors suramin

CompactChain:an efficient stateless chain for UtXO-model blockchain

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Frontiers of Computer Science 2024年第2期18卷 167-179页

作者： B Swaroopa REDDY t Uday Kiran REDDY Department of Electrical Engineering Indian Institute of Technology HyderabadHyderabadTelangana 502285India

In this work,we propose a stateless blockchain called CompactChain,which compacts the entire state of the UtXO(Unspent transaction Output)based blockchain systems into two RSA accumulators.the first accumulator is called transaction Output(tXO)commitment which represents the tXO set.the second one is called Spent transaction Output(StXO)commitment which represents the StXO set.In this work,we discuss three algorithms:(i)to update the tXO and StXO commitments by the miner.the miner also provides the proofs for the correctness of the updated commitments;(ii)to prove the transaction’s validity by providing a membership witness in tXO commitment and non-membership witness against StXO commitment for a coin being spent by a user;(iii)to update the witness for the coin that is not yet spent;the experimental results evaluate the performance of the CompactChain in terms of time taken by a miner to update the commitments and time taken by a validator to verify the commitments and validate the transactions.We compare the performance of CompactChain with the existing state-of-the-art works on stateless blockchains.CompactChain shows a reduction in commitments update complexity and transaction witness size which inturn reduces the mempool size and propagation latency without compromising the system throughput(transactions per second(tPS)).

关键词： stateless blockchain RSA Accumulator StXO commitment tXO commitment UtXO Non-interactive Proof of Exponentiation(NI-PoE) transactions per second(tPS)