检索结果-南通市图书馆

Microstructural Stability of a Single Crystal Superalloy DD8 during thermal Exposure

在线全文

学校读者我要写书评

暂无评论

Journal of Materials Science & technology 2008年第1期24卷 127-130页

作者： K.Y.Cheng D.H.Kim Y.S.Yoo C.Y.Jo t.jin Z.Q.Hu SuperalloyDivision Institute of Metal Research Chinese Academy of Sciences Shenyang 110016 China High temperature Materials Group KIMS Changwon Korea Materials test and Characterization Group KIMS Changwon Korea

Microstructural stability of a nickel base single crystal alloy DD8 has been *** heat treated specimen showed good microstructural stability at 950℃.While under the as-cast condition,a kind of rod-like phase precipitated in the interdendritic region of as-cast specimen during thermal *** phase,which has bcc structure,was enriched with ***-calc also predicted precipitation of a bcc phase at around 950℃.the Cr-rich bcc phase was considered asα-Cr and formed due to the segregation of Cr under the as-cast condition.

关键词： DD-8 Single crystal alloy Microstructural stability Alpha chromium

Effects of Alumina on Cristobalite Crystallization and Properties of Silica-Based Ceramic Cores

在线全文

学校读者我要写书评

暂无评论

Journal of Materials Science & technology 2017年第2期33卷 204-209页

作者： J.J.Liang Q.H.Lin X.Zhang t.jin Y.Z.Zhou X.F.Sun B.G.Choi I.S.Kim J.H.Do C.Y.Jo Institute of Metal Research Chinese Academy of SciencesShenyang 110016China Korea Institute of Materials Science Changwon 642-831Republic of Korea

In this work, the influences of alumina addition on cristobalite crystallization and properties of injec- tion molded silica-based ceramic cores were investigated. X-ray diffraction （XRD） was used to characterize phase transformations in the samples, and the XRD result indicated that the addition of alumina pro- moted crystallization of fused silica during sintering at 1180-1220 ℃ and thus increases the amount of cristobalite. the increased amount of cristobalite as well as alumina addition led to much more thermal dilation due to their higher coefficients of thermal expansion than that of fused silica. the flexural strengths at room temperature and 1500 ~C were tested, and it was shown that alumina addition could not affect room temperature strength, but decreased the flexural strength at 1500 ℃. In addition, deflection resis- tance during heating to high temperatures was investigated, and the result indicated that alumina addition speeded up high temperature softening of the samples. XRD and scanning electron microscopy equipped with energy dispersive spectrometry （SEMJEDS） analysis suggested that this softening behavior was related with viscous flow sintering which could be accelerated by the reaction of alumina and silica with a product of mullite.

关键词： Silica-based ceramic cores Alumina Cristobalite crystallization Properties

在线全文

学校读者我要写书评

暂无评论

低温使用的9％Ni钢大锻件的生产

大型铸锻件 1982年第A2期 49-58页

作者： M.Shimazaki t.jin H.Moritani A.S.Melilli S.toney 钟秉书

用调整了化学成分的9％Ni钢(Si,Mo含量低)浇成的一个180t钢锭和一个75t钢锭,卓有成效地锻成了一件特大的空心轴和一件厚300mm的圆盘。在制造这些大锻件的同时,进行了各种研究,如检查化学成分,机械性能,断裂韧性,热成形,超声波检验等,结... 详细信息

用调整了化学成分的9％Ni钢(Si,Mo含量低)浇成的一个180t钢锭和一个75t钢锭,卓有成效地锻成了一件特大的空心轴和一件厚300mm的圆盘。在制造这些大锻件的同时,进行了各种研究,如检查化学成分,机械性能,断裂韧性,热成形,超声波检验等,结果如下:(1)锻件的内部质量优越,AVG法超声波探伤显示的当量缺陷不超过φ0.5mm。(2)尽管锻件的尺寸很大(调质截面),在-196℃时,仍达到了令人满意的高的抗拉强度和良好的断裂韧性,甚至从300mm厚的圆盘中心取出的ISO-V型冲击试样,在此温度下也显示出令人满意的断裂韧性。

关键词： 9%Ni钢大锻件生产低温断裂韧性化学成分超声波检验超声波探伤

Single-cell transcriptomic profiling reveals ZEB1-mediated regulation in microglial subtypes and the impact of exercise on neuroinflammatory responses

在线全文

学校读者我要写书评

暂无评论

traditional Medicine Research 2025年第2期10卷 55-64页

作者： jin-Fang Wu Yi-Sheng Chen Yu-Chun Xie Department of Rehabilitation Medicine Jiangsu Province Geriatric HospitalNanjing 210024China Fujian Key Laboratory of toxicant and Drug toxicology Medical CollegeNingde Normal UniversityNingde 352100China Central Laboratory Jiangsu Province Geriatric HospitalNanjing 210024China

Background:this study aims to identify distinct cellular subtypes within brain tissue using single-cell transcriptomic analysis,focusing on specific biomarkers that differentiate cell types and the effects of traditional and exercise ***:Four samples were analyzed:older control(OC),older exercise(OE),younger control(YC),and younger exercise(YE).Single-cell RNA sequencing was used to distinguish cellular subtypes through their biomarker *** visualization included violin and t-SNE plots to illustrate biomarker expression across cell clusters such as oligodendrocytes,microglia,and ***,BV2 cells were exposed to amyloid-beta fragments to simulate Alzheimer’s disease,assessing the impact of exercise-induced cellular ***:Distinct cellular subtypes were identified:oligodendrocytes(MBP,St18),microglia(Dock8),and astrocytes(Aqp4,Gpc5).Sample OE was predominantly oligodendrocytes,while YE had more astrocytes,inhibitory neurons,and Canal-Retzius *** showed a significant presence of Olfm3+ganglion ***1 gene knockout revealed changes in SMAD family gene expression,which regulate *** stress levels were also ***:this profiling enhances our understanding of brain cellular functions and interactions,potentially informing targeted therapies in neurological *** may influence brain cell immune responses and cell death pathways by regulating specific gene expressions,offering new insights for treating neuroinflammation and degeneration.

关键词： single-cell transcriptomics brain tissue cellular subtypes biomarker expression neuronal diversity

Drosophila models used to simulate human AtP1A1 gene mutations that cause Charcot-Marie-tooth type 2 disease and refractory seizures

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第1期20卷 265-276页

作者： Yao Yuan Lingqi Yu Xudong Zhuang Dongjing Wen jin He jingmei Hong Jiayu Xie Shengan Ling Xiaoyue Du Wenfeng Chen Xinrui Wang Institute of Life Sciences College of Biological Science and EngineeringFuzhou UniversityFuzhouFujian ProvinceChina NHC Key Laboratory of technical Evaluation of Fertility Regulation for Non-human Primate(Fujian Maternity and Child Health Hospital) FuzhouFujian ProvinceChina Medical Research Center Fujian Maternity and Child Health HospitalCollege of Clinical Medicine for Obstetrics&Gynecology and PediatricsFujian Medical UniversityFuzhouFujian ProvinceChina Department of Neurology and Institute of Neurology of the First Affiliated Hospital Institute of Neuroscienceand Fujian Key Laboratory of Molecular NeurologyFujian Medical UniversityFuzhouFujian ProvinceChina

Certain amino acids changes in the human Na^(+)/K^(+)-AtPase pump,AtPase Na^(+)/K^(+)transporting subunit alpha 1(AtP1A1),cause Charcot-Marie-tooth disease type 2(CMt2)disease and refractory *** develop in vivo models to study the role of Na^(+)/K^(+)-AtPase in these diseases,we modified the Drosophila gene homolog,Atpα,to mimic the human AtP1A1 gene mutations that cause *** located within the helical linker region of human AtP1A1(I592t,A597t,P600t,and D601F)were simultaneously introduced into endogenous Drosophila Atpαby CRISPR/Cas9-mediated genome editing,generating the Atpα^(tttF)*** addition,the same strategy was used to generate the corresponding single point mutations in flies(Atpα^(I571t),Atpα^(A576t),Atpα^(P579t),and Atpα^(D580F)).Moreover,a deletion mutation(Atpα^(mut))that causes premature termination of translation was generated as a positive *** these alleles,we found two that could be maintained as homozygotes(Atpα^(I571t)and Atpα^(P579t)).three alleles(Atpα^(A576t),Atpα^(P579)and Atpα^(D580F))can form heterozygotes with the Atpαmut *** found that the Atpαallele carrying these CMt2-associated mutations showed differential phenotypes in *** heterozygous for Atpα^(tttF)mutations have motor performance defects,a reduced lifespan,seizures,and an abnormal neuronal *** Drosophila models will provide a new platform for studying the function and regulation of the sodium-potassium pump.

关键词： AtP1A1 Atpα bang-sensitive paralysis Charcot-Marie-tooth disease type 2 CRISPR/Cas9 homology-directed repair Na^(+)/K^(+)-AtPase point mutation seizures sodium pump

Dynamic Analysis and Numerical Simulation of a Kind of Arrestor Arresting Buckle Propagation by FEM

在线全文

学校读者我要写书评

暂无评论

China Ocean Engineering 1998年第3期13卷 323-332页

作者： Huang, YY Qian, Q jin, t Huazhong Univ Sci & technol Dept Mech Wuhan 430074 Peoples R China

For exact estimation of efficiency of a buckle arrestor, it is necessary to take the effect of structural inertia into account in the analysis of buckle propagation on elastic structures after meeting arrestors. Under this consideration, this paper deals with the dynamics of buckle arrest and its numerical simulation on the basis of the beam system model used by Chater and Hutchinson (1983). the FEM combined with an improving are-length control method is adopted to solve the dynamic equations describing the arresting of buckle propagation. A new group of parameters for arrestor design which differs greatly from that by the quasi-static analysis is obtained. the present results support the conclusion that the inertia of the beam cannot be neglected in such analysis.

关键词： buckle propagation arrestor beam nonlinear foundation finite element method

transport mechanism in chemically reactive hybrid nanofluid flow containing gyrotactic micro-organisms over a curved oscillatory surface

在线全文

学校读者我要写书评

暂无评论

Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 177-192页

作者： M.NAVEED M.IMRAN t.ASGHAR Z.ABBAS Department of Mathematics Division of Science and TechnologyUniversity of Education Department of Mathematics The Islamia University of Bahawalpur

this paper examines the transport analysis, including both heat transfer and mass transfer, in hybrid nanofluid flow containing gyrotactic microorganisms towards a curved oscillatory surface. the influence of magnetic fields is also inspected in terms of their physical characteristics. to depict the phenomena of transport, modified versions of both Fick's and Fourier's laws are used. Additionally, the characteristics of both heterogeneous and homogeneous chemical reactions are also incorporated. Utilizing a curvilinear coordinate system, the flow problem is formulated as partial differential equations(PDEs)for momentum, concentration, microorganism field, and energy. An analytical solution to the obtained flow equations is achieved utilizing the homotopy analysis method(HAM).the effects of significant flow parameters on the pressure and microorganism fields, velocity, oscillation velocity, concentration, and temperature distributions are shown via graphs. Furthermore, the variations in skin friction, mass transfer rate, heat transfer rate, and local motile number due to different involved parameters are presented in tables and are analyzed in detail. Graphical results indicate that the curves of velocity and temperature fields are enhanced as the values of the solid volume fraction variables *** is also verified that the concentration rate field decreases as the values of the homogeneous reaction strength parameter and the radius of curvature parameter increase, and it increases with the Schmidt number and the heterogeneous reaction strength *** outcomes show a favorable response of the motile number to advanced values of the Peclet number, the Schmidt number, the microorganism difference parameter, and the bio-convective Lewis number.

关键词：

New developments in Western blot technology

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2015年第4期26卷 416-418页

作者： Shi jin Robert t.Kennedy Department of Chemistry University of Michigan

Western blotting is a highly valued method for protein identification and relative quantitation in complex samples. It combines size-based electrophoretic separation with immunoaffinity to identify specific proteins. this technique remains popular and has become a workhorse in biochemical research and clinical laboratories. Despite its utility and popularity, this method has many limitations including slow analysis, incompatibility with limited sample application, low throughput and low information content. Recently there has been significant success in improving different aspects of Western blotting. In this review, we provide an overview of the developments in the area of improving conventional Western blotting methods with a focus on recent developments in microfluidic Western blotting. We overview different separation platforms, and discuss studies on protein transfer methods as well as protein immobilization methods and chemistries. We also describe integrated miniaturized platforms that can perform rapid separations and immunodetections.

关键词： Western blotMicrofluidicGel electrophoresislmmunoassay

A new design of groundwater sampling device and its application

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2005年第5期17卷 838-841页

作者： Yih-jin tsai Ming-Ching t. Kuo Department of Environmental Resources Engineering Diwan College of ManagementDepartment of Mineral and Petroleum Engineering "National" Cheng Kung University No. 87-1 Nansh Li Madou Tainan Taiwan ChinaTainan Taiwan China

Compounds in the atmosphere contaminate samples of groundwater. An inexpensive and simple method for collecting groundwater samples is developed to prevent contamination when the background concentration of contaminants is high. this new design of groundwater sampling device involves a glass sampling bottle with a teflon-lined valve at each end. A cleaned and dried sampling bottle was connected to a low flow-rate peristaltic pump with teflon tubing and was filled with water. No headspace volume was remained in the sampling bottle. the sample bottle was then packed in a PVC bag to prevent the target component from infiltrating into the water sample through the valves. In this study, groundwater was sampled at six wells using both the conventional method and the improved method. the analysis of trichlorofluoromethane（ CFC-11 ） concentrations at these six wells indicates that all the groundwater samples obtained by the conventional sampling method were contaminated by CFC-11 from the atmosphere. the improved sampling method greatly eliminated the problems of contamination, preservation and quantitative analysis of natural water.

关键词： groundwater sampling improved method conventional method tritium trichlorofluoromethane(CFC-11 )