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Prehabilitation prior to intestinal resection in Crohn’s disease patients:An opinion review

World journal of Gastroenterology 2022年第22期28卷 2403-2416页

作者： Michiel t j Bak Marit F E Ruiterkamp Oddeke van Ruler Marjo j E Campmans-Kuijpers Bart C Bongers Nico L U van Meeteren C janneke van der Woude Laurents P S Stassen Annemarie C de Vries Department of Gastroenterology and Hepatology Erasmus University Medical Center RotterdamRotterdam 3015 GDNetherlands Department of Surgery IJsselland HospitalCapelle aan den IJssel 2906 ZCNetherlands Department of Surgery Erasmus University Medical Center RotterdamRotterdam 3015 GDNetherlands Department of Gastroenterology and Hepatology University Medical Center Groningen and University of GroningenGroningen 9713 GZNetherlands Department of Nutrition and Movement Sciences School of Nutrition and Translational Research in MetabolismMaastricht UniversityMaastricht 6200 MDNetherlands Department of Epidemiology Care and Public Health Research InstituteMaastricht UniversityMaastricht 6200 MDNetherlands Department of Anaesthesiology Erasmus MC University Medical Center RotterdamRotterdam 3015 GDNetherlands Department of Surgery Maastricht University Medical CenterMaastricht 6229 HXNetherlands

Patients with Crohn’s disease(CD)are at a considerable risk for intestinal *** 25%of patients with CD will undergo an intestinal resection within 10 years of *** complications after CD surgery have been reported in 20%-47%of the *** general and CD-related risk factors are associated with postoperative complications,and comprise non-modifiable(e.g.,age)and potentially modifiable risk factors(e.g.,malnutrition).Prehabilitation focuses on the preoperative period with strategies designed to optimize modifiable risk factors concerning the physical and mental condition of the individual *** aim of prehabilitation is to enhance postoperative recovery and return to or even improve preoperative functional *** improvement of nutritional status,physical fitness,cessation of smoking,psychological support,and critical revision of preoperative use of CD medication are important *** of the effect on postoperative outcome in CD patients are scarce,and guidelines lack recommendations on tailored *** this opinion review,we review the current evidence on the impact of screening and management of nutritional status,physical fitness,CD medication and laboratory values on the postoperative course following an intestinal resection in CD *** addition,we aim to provide guidance for individualized multimodal prehabilitation in clinical practice concerning these modifiable factors.

关键词： Crohn’s disease Prehabilitation strategies Nutrition Physical fitness Medication Laboratory values

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癫痫伴慢波睡眠期持续棘慢波(CSWS)患者的治疗:北美治疗选择的调查

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癫痫杂志 2016年第5期2卷 446-453页

作者： Sánchez Fernández I Chapman K Peters jM Klehm j jackson mc Berg At Loddenkemper t 童馨(译) 慕洁(审) 不详

现有文献没能为癫痫伴慢波睡眠期持续棘慢波(Continuous spikes and waves duringsleep,CSWS)患者的治疗方法提供充分的证据.文章的目的在于描述北美临床医生在面对CSWS患者时做出的治疗选择.在美国癫痫学会(American Epilepsy Society,... 详细信息

现有文献没能为癫痫伴慢波睡眠期持续棘慢波(Continuous spikes and waves duringsleep,CSWS)患者的治疗方法提供充分的证据.文章的目的在于描述北美临床医生在面对CSWS患者时做出的治疗选择.在美国癫痫学会(American Epilepsy Society,AES)成员中进行了关于CSWS治疗选择的问卷调查,调查包含24项题目.问卷中描述了CSWS的治疗临床情境.题目询问的是在该临床情境下的治疗选择.被调查人通过在线调查网站(***)自行填写问卷收集.完成问卷共计232份,81%的调查对象认为明显的睡眠棘波增强应当治疗.睡眠棘波增强在经过有效治疗之后,调查对象表示16%的患者的认知功能有>75%的改善,52%的患者有25%~75%的改善,20%的患者有<25%的改善,还有12%的调查对象称患者的认知功能并没有明确的改变.减少睡眠诱发的痫样放电增强的首选疗法分别为:高剂量苯二氮类药物(47%)、丙戊酸(26%)和皮质类固醇(15%).次选疗法分别为:丙戊酸(26%)、高剂量苯二氮卓类药物(24%)和皮质类固醇(23%).在高剂量苯二氮卓类药物中,最常用的是地西泮,第一夜用1 mg/kg,之后用0.5 mg/(kg·d).丙戊酸的常用剂量为30 ~49 mg/(kg·d).在皮质类固醇中,最常用的是口服泼尼松2 mg/(kg·d).终止治疗的疗效指标有(从强到弱排列):脑电图上癫痫样放电的相应改变、认知功能好转、发作减少.在培训水平及临床经验不同的调查对象中,结果是一致的.在儿童和成人神经科医生之间,存在着概念和治疗方法的差异.大部分临床医生认为睡眠期明显增强的痫样放电是应当治疗的.调查对象们没有就最佳疗法的问题达成一致,但可选疗法包括了:高剂量苯二氮卓类药物、丙戊酸、左乙拉西坦和皮质类固醇.

关键词：抗癫痫药物脑电图癫痫癫痫发作睡眠治疗

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水当量直径和体型特异性剂量估算对Ct管电压的依赖性

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国际医学放射学杂志 2022年第4期 479-479页

作者： C.H.mc Collough S.L.mc Collough j.j.Schneider t.R.Moen j.M.Weaver t.j.Vrieze 刘泽

摘要体型特异性剂量估算（SSDE）是一种以关注病人的Ct剂量测量方法。然而，显示用于计算SSDE的体型相关系数（fsize值）主要是通过使用模型来确定的；仅使用了8～15

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Complete eradication of hepatic metastasis from colorectal cancer by Yttrium-90 SIRt

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World journal of Gastroenterology 2007年第21期13卷 3016-3019页

作者： Sean Garrean Amanda Muhs james t Bui Michael j Blend Charles Owens William S Helton Nocif j Espat Department of Surgery the University of Illinois at Chicago840 S. Wood St. MC 958Chicago IL 60612United States Department of Interventional Radiology University of Illinois at Chicago1740 W. Taylor StRoom 4283. MC 931Chicago IL 60612United States Department of Nuclear Medicine University of Illinois at Chicago1740 W. Taylor StRoom 4283. MC 931Chicago IL 60612United States

Yttrium-90 (Y-90) radioembolization,also known as selective internal radiation therapy (SIRt),is a regional hepatic therapy used in the treatment of unresectable colorectal cancer (CRC) liver metastases. In SIRt,Y-90 impregnated microspheres are injected into the VASCULAR SUPPLY of hepatic tumor,leading to selective irradiation and necrosis of tumor tISSUE. While several studies demonstrate improved local control and survival with SIRt,the specific indications for this therapy have yet to be defined. typically,SIRt is given in combination with chemotherapy as multimodal treatment for unresectable hepatic CRC. However,it HAS ALSO FOUND INCREASING USE as a salvage therapy in chemo-refractory patients. Herein,the authors describe their experience with SIRt as "stand alone" therapy in a surgically-prohibitive,chemotherapy naive patient with hepatic CRC metastasis. the results suggest that Y-90 SIRt may have potential applications beyond its usual role as a palliative or salvage therapy for unresectable hepatic CRC.

关键词： Yttrium-90, SIRt Radioembolization Hepatic metastasis Ablation

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皮肤原发性腺样囊性癌中MYB的改变和免疫表型特征分析

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临床与实验病理学杂志 2016年第1期32卷 44-44页

作者： North j P mc Calmont t H Fehr A 魏建国许春伟浙江省绍兴市人民医院病理科绍兴312000 解放军307医院病理科北京100071

研究发现许多器官均可发生腺样囊性癌，其预后取决于原发肿瘤的位点。与发生在唾腺或泪腺的腺样囊性癌相比，皮肤原发性腺样囊性癌的预后较好。唾腺、乳腺和泪腺的腺样囊性癌已经发现可通过基因融合或其它机制激活MYB，然而目前未见皮... 详细信息

研究发现许多器官均可发生腺样囊性癌，其预后取决于原发肿瘤的位点。与发生在唾腺或泪腺的腺样囊性癌相比，皮肤原发性腺样囊性癌的预后较好。唾腺、乳腺和泪腺的腺样囊性癌已经发现可通过基因融合或其它机制激活MYB，然而目前未见皮肤腺样囊性癌中有关该机制的描述。作者分析了19例皮肤原发性腺样囊性癌、2例框周腺样囊性癌和12例唾腺腺样囊性癌的组织病理和免疫表型特征，并通过免疫组化和分子生物学方法对皮肤原发性腺样囊性癌中MYB的激活情况进行评估。

关键词：腺样囊性癌免疫表型特征原发性皮肤分子生物学方法原发肿瘤基因融合作者分析

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原发性皮肤腺样囊性癌的MYB基因状态及免疫组化研究

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临床与实验病理学杂志 2016年第2期32卷 192-192页

作者： North j P mc Calmont t H Fehr A 许文静余英豪南京军区福州总医院病理科福州350025 解放军第四七六医院病理科福州350002

North j P, mcCalmont t H, Fehr A, et al. Detection of MYB alterations and other immunohistochemical markers in primary cutaneous adenoid cystic carcinoma. Am j Surg Pathol, 2015, 39（10）：1347 -56. 腺样囊性癌（ACC）可发生于全身不同器官，其预后在很大程度上取决于肿瘤的原发部位。与唾液腺或泪腺ACC不同，原发性皮肤ACC预后更好。在唾液腺、乳腺、泪腺ACC中均可检出MYB基因的活化，但在皮肤ACC中尚未见相关报道。为此，作者分析了19例原发性皮肤，2例眶周及12例唾液腺ACC的组织病理学特征和免疫组化表达状态，并通过免疫组化和分子生物学方法对原发性皮肤ACC的MYB基因活化状态进行了评估。

关键词：腺样囊性癌活化状态免疫组化原发性 B基因皮肤 MY 组织病理学特征

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Simulation of Fusion Plasmas:Current Status and Future Direction

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Plasma Science and technology 2007年第3期9卷 312-387页

作者： D.A.Batchelor M.Beck A.Becoulet R.V.Budny C.S.Chang P.H.Diamond j.Q.Dong G.Y.FU A.Fukuyama t.S.Hahm D.E.Keyes Y.Kishimoto S.Klasky L.L.Lao K.Li Z.Lin B.Ludaescher j.Manickam N.Nakajima t.Ozeki N.Podhorszki W.M.tang M.A.Vouk R.E.Waltz S.j.Wang H.R.Wilson X.Q.Xu M.Yagi F.Zonca Oak Ridge National Laboratory Oak RidgeTN 37831USA 1122 Volunteer Blvd Suite 203KnoxvilleTN 37996-3450USA AssociationEURAtOM-CEA sur la Fusio n Contr■lée CEA Cadarache13108 Saint Paul lez Durance CedexFrance Princeton Plasma Physics Laboratory Princeton UniversityPrincetonNJ 08543USA Courant Institute of Mathematical Sciences New York University251 Mercer StreetNew YorkNY 10012USA University of California at San Diego Dept.of Physics and Center for Astrophysics and Space SciencesLa JollaCA 92093USA Southwestern Institute of Physics Chengdu 610041China Department of Nuclear Engineering Kyoto UniversityKyoto 606-8501Japan Columbia University Department of Applied Physics and Applied MathematicsMC 4701New YorkNY 10027USA Department of Fundamental Energy Science Graduate School of Energy ScienceKyoto UniversityGokashoUjiKyoto 611-0011Japan General Atomics P.O.Box 85608San DiegoCA 92186USA Department of Computer Science Princeton University PrincetonNJ 08544USA Department of Physics and Astronomy University of CaliforniaIrvineCA 92697USA Department of Computer Science University of California DavisCA95616USA National Institute for Fusion Science TokiGifu 509-5292Japan japan Atomic Energy Agency Naka Fusion Research EstablishmentNaka-machiIbaraki-kenJapan Department of Computer Science North Carolina State UniversityRaleighNC 27695USA Department of Physics Fudan University200433 ShanghaiChina Department of Physics University of YorkHeslingtonYork YO10 5DD UK Lawrence Livermore National Laboratory LivermoreCA 94550USA Research Institute for Applied Mechanics Kyushu UniversityKasuga 816-8580Japan Associazione Euratom-ENEA sulla fusione CR FrascatiCasella Postale 65-00044FrascatiItaly

I. Introduction (Z. Lin, G. Y. Fu, j. Q. Dong) II. Role of theory and simulation in fusion sciences 1. the Impact of theory and simulation on tokomak experiments (H. R. Wilson, t.S. Hahm and F. Zonca) 2. tokomak transport Physics for the Era of ItER: Issues for Simulations (P.H. Diamond and t.S. Hahm) III. Status of fusion simulation and modeling 1. Nonlinear Governing Equations for Plasma Simulations (t. S. Hahm) 2. Equilibrium and stability (L.L. Lao, j. Manickam) 3. transport modeling (R.E. Waltz) 4. Nonlinear MHD (G.Y. Fu) 5. turbulence (Z. Lin and R.E. Waltz) 6. RF heating and current drive (D.A. Batchelor) 7. Edge physics Simulations (X.Q. Xu and C.S. Chang) 8. Energetic particle physics (F. Zonca, G.Y. Fu and S.j. Wang) 9. time-dependent Integrated Modeling (R.V. Budny) 10. Validation and verification (j. Manickam) IV. Major initiatives on fusion simulation 1. US Scientific Discovery through Advanced Computing (SciDAC) Program & Fusion Energy Science (W. tang) 2. EU Integrated tokamak Modelling (ItM) task Force (A. Becoulet) 3. Fusion Simulations Activities in japan (A. Fukuyama, N. Nakajima, Y. Kishimoto, t. Ozeki, and M. Yagi) V. Cross-disciplinary research in fusion simulation 1. Applied mathematics: Models, Discretizations, and Solvers (D.E. Keyes) 2. Computational Science (K. Li) 3. Scientific Data and Workflow Management (S. Klasky, M. Beck, B. Ludaescher, N. Podhorszki, M.A. Vouk) 4. Collaborative tools (j. Manickam)

关键词： mode ItER

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深部岩浆洋决定了地幔氧化状态

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矿物岩石地球化学通报 2020年第2期39卷 326-326页

作者：夏群科 Armstrong K Frost D j mc Cammon C A Rubie D C Ballaran t B 不详

地幔氧化状态对于地球的大气成分和地球内部的物理化学性质均产生了重要影响。在地质历史时期,地幔氧化状态的演化过程中最为突出的阶段发生在地球最初的10亿年内:地幔在核幔分异中对应着非常还原的条件;约35亿年,科马提岩的V/Sc值和Cr... 详细信息

地幔氧化状态对于地球的大气成分和地球内部的物理化学性质均产生了重要影响。在地质历史时期,地幔氧化状态的演化过程中最为突出的阶段发生在地球最初的10亿年内:地幔在核幔分异中对应着非常还原的条件;约35亿年,科马提岩的V/Sc值和Cr含量等氧逸度指标表明地幔的氧化状态较核幔分异时已经上升了5个数量级。而地幔氧化状态在随后的30多亿年中保持稳定。对于早期地幔快速氧化的机制目前还存在争议,而岩浆洋的氧化状态可以为该科学问题提供解释。

关键词：氧化状态大气成分地球内部地质历史时期科马提岩快速氧化物理化学性质氧逸度

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OPtIMUM RAtIO AND PLACEMENt OF FISH AND BIVALVES IN INtEGRAtED MARICULtURE

OPTIMUM RATIO AND PLACEMENT OF FISH AND BIVALVES IN INTEGRAT...

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第三世界生态高峰会

作者： t.Klanj ek j.Klanj ek M.jusup t.Legovi Ru■er Bo kovi Institute Bijeni ka cesta 54 POB 180 HR-10002 Zagreb Croatia Ru■er Bo kovi Institute Bijeni ka cesta 54 POB 180 HR-10002 Zagreb Croatia Ru■er Bo kovi Institute Bijeni ka cesta 54 POB 180 HR-10002 Zagreb Croatia Ru■er Bo kovi Institute Bijeni ka cesta 54 POB 180 HR-10002 Zagreb Croatia

Fish mariculture is usually placed in coastal areas thus adding to the antbropogenic impacts on already stressed coastal *** limited ability of the environment to assimilate the additional stress limits mariculture *** maximum mariculture production with an acceptable ecological impact is called ecological carrying capacity(ECC).We seek to increase ECC as defined by mc Kindsey et al.(2006)for fish mariculture by integrating commercially viable fish and bivalve *** mariculture has been proposed and

关键词： ECC OPtIMUM RAtIO AND PLACEMENt OF FISH AND BIVALVES IN INtEGRAtED MARICULtURE

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Search for two-neutrino double-beta decay of 136Xe to the 01+excited state of136Ba with the complete EXO-200 dataset

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Chinese Physics C 2023年第10期47卷 5-13页

作者： S.Al Kharusi G.Anton I.Badhrees P.S.Barbeau D.Beck V.Belov t.Bhatta M.Breidenbach t.Brunner G.F.Cao W.R.Cen C.Chambers B.Cleveland M.Coon A.Craycraft t.Daniels L.Darroch S.j.Daugherty j.Davis S.Delaquis A.Der Mesrobian-Kabakian R.De Voe j.Dilling A.Dolgolenko M.j.Dolinski j.Echevers W.Fairbank jr. D.Fairbank j.Farine S.Feyzbakhsh P.Fierlinger Y.S.Fu D.Fudenberg P.Gautam R.Gornea G.Gratta C.Hall E.V.Hansen j.Hoessl P.Hufschmidt M.Hughes A.Iverson A.jamil C.jessiman M.j.jewell A.johnson A.Karelin L.j.Kaufman t.Koffas R.Krücken A.Kuchenkov K.S.Kumar Y.Lan A.Larson B.G.Lenardo D.S.Leonard G.S.Li S.Li Z.Li C.Licciardi Y.H.Lin R.Mac Lellan t.mc Elroy t.Michel B.Mong D.C.Moore K.Murray O.Njoya O.Nusair A.Odian I.Ostrovskiy A.Perna A.Piepke A.Pocar F.Retière A.L.Robinson P.C.Rowson j.Runge S.Schmidt D.Sinclair K.Skarpaas A.K.Soma V.Stekhanov M.tarka S.thibado j.todd t.tolba t.I.totev R.tsang B.Veenstra V.Veeraraghavan P.Vogel j.-L.Vuilleumier M.Wagenpfeil j.Watkins M.Weber L.j.Wen U.Wichoski G.Wrede S.X.Wu Q.Xia D.R.Yahne L.Yang Y.-R.Yen O.Ya.Zeldovich t.Ziegler EXO-200 Collaboration Physics Department McGill University Erlangen Centre for Astroparticle Physics (ECAP) Friedrich-Alexander-University Erlangen-Nürnberg Physics Department Carleton University King Abdulaziz City for Science and technology Department of Physics Duke University and Triangle Universities Nuclear Laboratory (TUNL) Physics Department University of Illinois Institute for theoretical and Experimental Physics named by A.I.Alikhanov of National Research Centre “Kurchatov Institute” a division of National Research Center “Kurchatov Institute” Department of Physics University of South Dakota Department of Physics and Astronomy University of Kentucky SLAC National Accelerator Laboratory tRIUMF Institute of High Energy Physics Witmem technology Co. Ltd. Department of Physics Laurentian University Also at SNOLAB Physics Department Colorado State University Department of Physics and Physical Oceanography University of North Carolina at Wilmington Physics Department and CEEM Indiana University Carleton University Commissariat àl’Energie Atomique et auxénergies alternatives Physics Department Stanford University Department of Physics Drexel University University of California Amherst Center for Fundamental Interactions and Physics Department University of Massachusetts technische Universit?t München Physikdepartment and Excellence Cluster Universe Qventus Department of Physics University of Virginia Physics Department University of Maryland Department of Physics at the University of California Department of Physics and Astronomy University of Alabama Wright Laboratory Department of Physics Yale University Department of Physics Princeton University IBS Center for Underground Physics Physics Department University of California SNOLAB Department of Physics and Astronomy Stony Brook University SUNY SCIPP University of California Institute for Experimental Physics Hamburg University Department of Physics and Astronomy Iowa State University Kellogg Lab Caltech LHEP Albert Einstein Center University of Ber

A new search for two-neutrino double-beta(2vββ) decay of136Xe to the 01+excited state of136Ba is performed with the full EXO-200 dataset.A deep learning-based convolutional neural network is used to discriminate signal from background *** detection efficiency is increased relative to previous searches by EXO-200 by more than a factor of *** the addition of the Phase Ⅱ dataset taken with an upgraded detector,the median 90%confidence level half-life sensitivity of 2vββ decay to the 01+state of136Ba is 2.9 × 1024yr using a total136Xe exposure of 234.1 kg *** statistically significant evidence for 2vββ decay to the 01+state is observed,leading to a lower limit of t1/22v(0+→01+)>1.4×1024yr at 90% confidence level,improved by 70% relative to the current world’s best constraint.

关键词： EXO-200 experiment neutrinoless double beta decay excited state

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