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沉积在α－Al＿2O＿3分形基底上Ag薄膜的特性

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物理学报 1994年第7期43卷 1144-1151页

作者：许宇庆叶高翔王劲松陶向明张其瑞浙江大学物理系杭州大学物理系

报道了采用磁控溅射法在α－Ａｌ＿２Ｏ＿３分形基底上沉积Ａｇ薄膜表面的形貌、结晶状态以及其Ｖ－Ｉ特性．结果表明：分形的Ａｌ＿２Ｏ＿３基底导致Ａｇ薄膜具有起伏不平的结构、较差的结晶状态并且存在大量的孔洞，它们同样受基底温... 详细信息

报道了采用磁控溅射法在α－Ａｌ＿２Ｏ＿３分形基底上沉积Ａｇ薄膜表面的形貌、结晶状态以及其Ｖ－Ｉ特性．结果表明：分形的Ａｌ＿２Ｏ＿３基底导致Ａｇ薄膜具有起伏不平的结构、较差的结晶状态并且存在大量的孔洞，它们同样受基底温度和薄膜厚度的影响．在一定的厚度范围内，Ａｇ薄膜呈现反常的非线性Ｉ（Ｖ）特性，其行为也受薄膜厚度、基底温度和测试环境的强烈影响．

关键词：银薄膜分形薄膜磁控溅射

Changes of Serum Insulin-like Growth Factor-2 Response to Negative Symptom Improvements in Schizophrenia Patients treated with Atypical Antipsychotics

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Current Medical Science 2020年第3期40卷 563-569页

作者： Xue-lin CHao Shu-zhen jIANG jian-wen xiong jin-qiong ZHAN Bo WEI Chun-nuan CHEN Yuan-jian YANG Department of Psychosomatic Medicine The First Affiliated Hospital of Nanchang UniversityNanchang330006China Biological Psychiatry Laboratory Jiangxi Mental Hospital/Affiliated Mental Hospital of Nanchang UniversityNanchang330029China Department of Psychiatry Jiangxi Mental Hospital/Affiliated Mental Hospital of Nanchang UniversityNanchang330029China Department of Neurology The Second Clinical Medical CollegeThe Second Affiliated HospitalFujian Medical UniversityQuanzhou362000China

Accumulating evidence suggests that a disruption of early brain development,in which insulin-like growth factor-2(IGF-2)has a crucial role,may underlie the pathophysiology of *** previous study has shown that decreased serum IGF-2 was correlated with the severity of psychopathology in patients with *** we conducted a prospective observation trial to investigate the effects of atypical antipsychotics on serum IGF-2 level and its relationship with clinical improvements in schizophrenia ***-one schizophrenia patients with acute exacerbation and 30 healthy individuals were recruited in this *** symptoms were assessed using the Positive and Negative Syndrome Scale(PANSS)and serum IGF-2 levels were determined using *** found that schizophrenia patients with acute exacerbation had lower serum IGF-2 levels than control individuals at baseline(Pter 2 months of atypical antipsychotic treatment,a significant improvement in each PANSS subscore and total score was observed in patients(all Pthe serum IGF-2 levels of patients were significantly increased compared with those at baseline(203.13±64.62 vs.426.99±124.26 ng/mL;t=−5.044,Ption analysis revealed that the changes of serum IGF-2 levels in patients were significantly correlated with the improvements of negative symptoms(r=−0.522,P=0.006).Collectively,our findings demonstrated changes of serum IGF-2 response to improvements of negative symptoms in schizophrenia patients treated with atypical antipsychotics,suggesting that serum IGF-2 might be a treatment biomarker for schizophrenia.

关键词： schizophrenia atypical antipsychotic insulin-like growth factor-2 negative symptoms

A novel mutation of the SPG11 gene in hereditary spastic paraplegia with thin corpus callosum

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A novel mutation of the SPG11 gene in hereditary spastic par...

Medicinal Mushroom Growth as Affected by Non-Axenic Casing Soil

第十二次全国医学遗传学学术会议

作者： Ma j xiong LK Guo H Li XH Wang YM Central Lab Bao’anMaternal and Child health Hospital

Background Hereditary spastic paraplegia(HSP) is a clinically and genetically heterogeneous neurodegenerative diseases characterized by progressive spasticity of the lower *** various mutations occured in SPG11 gene have been recently identified causing autosomal recessive HSP with thin corpus callosum(ARHSP-tCC).Method We have performed mutation detection in 15 autosomal recessive HSP families(26 patients) and 18 sporadic cases by sequencing the PCR products spanning the exonic and intron-exon boundary regions of the gene. Result A novel compound heterozygous mutation,c.[5121122insAG]+[6859C>t] (p.[I1708RfsX2]+[Q2287X]),in the gene has been identified in a family from Huizhou city of Guangdong *** genetic analyses of the family showed that the mother carried the mutation of c.[5121122insAG]and the father carried the c.[6859C>t]*** affected son unfortunately inherited bother mutations from the parents,whereas each of his younger brother and sister only inherited one of the *** feature and laboratory investigations show that the son inherited the compound mutations has tCC,cognitive decline and lower motor neuron *** mothernal mutation,c.5121122insAG,caused the reading frame shift through a two-base pair insertion on the splice site of exon *** introduced a premature stop codon at residue 1709(p.I1708RfsX2).the paternal mutation,c.6859C>t, caused the nonsense mutation Q2287X in exon ***,this mutation resulted in truncated *** mutations were not found in control *** analysis suggested that the haplotypes bearing the two mutations co-segregated with ARHSP-tCC in this *** species alignment showed that the two mutations occurred at the highly conserved nucleotides/amino *** modeling of the mutant proteins predicted gross changes at the second structure *** include the loss of 31 motives,introduction of an extra transmembrane domain,the reversal of the d

关键词： Hereditary spastic paraplegia SPGll thin corpus callosum Autosomal recessive.

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Pedosphere 2011年第2期21卷 146-153页

作者： D.C.ZIED M.t.A.MINHONI j.KOPYtOWSKI-FILHO L.BARBOSA M.C.N.ANDRADE Departamento de Produc ao Vegetal (Defesa Fitossanit'aria) Faculdade de Ci encias Agron omicasUniversidade Estadual Paulista18603-970 Botucatu (Brazil) Departamento de Bioestat' stica Instituto de Bioci encia de BotucatuUniversidade Estadual Paulista18618-000 Botucatu (Brazil) Instituto Nacional de Pesquisa da Amaz onia INPA69060-001 Manaus (Brazil)

ten different casing soils were collected from two soils at two depths （0.2 and 2.0 m below soil surface） to examine the relationships between the physical properties of non-axenic casing soil and yield, number and weight of the medicinal mushroom Agamcua blaaei ss. Heinemann. the results showed that soil clay content and bulk density were negatively correlated with the mushroom yield, respectively, but soil silt content and water-holding capacity were found to be positively correlated with the yield. the number of mushrooms was negatively correlated with soil water-holding capacity but positively correlated with soil clay, bulk density and porosity. the weight of mushroom was positively correlated with the content of soil fine sand and negatively correlated with the contents of soil coarse sand, total sand and clay. Neither soil depth nor different soil combinations affected the yield and number of mushrooms, but the mushroom weight was affected by the soil combinations and soil depth, so interplay in the fructification process with the physical characteristics of casing is complicated.

关键词： Agaricus blazei casing layer quality factors soil depth soil particles

ICH-induced inflammatory response upregulats hepcidin expression inhibits brain iron clearance and its mechanism

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ICH-induced inflammatory response upregulats hepcidin expres...

Adoptive transfer of FtY720-treated immature bone marrowderived dendritic cells(BMDCs) significantly reduced the spontaneous resorption rate in the CBA/j ×DBA/2 mouse model

中国神经科学学会第十二届全国学术会议

作者： xiong XY Liu L Wang FX Yang YR Hao jW Wang PF Zhong Q Zhou K xiong A Zhu WY Zhao t Meng ZY Wang YC Gong QW Liao MF Wang j Yang QW Department of Neurology Xinqiao Hospital Third Military Medical University Department of Neurology Key Laboratory of Neurorepair and Regeneration Tianjin and Ministry of Education Tianjin Neurological Institute Tianjin Medical University General Hospital Department of Neurology Weihai Municipal Hospital Department of Anesthesiology/Critical Care Medicine School of Medicine Johns Hopkins University

Objective Reducing the deposited brain iron is one of important measures in treatment of intracerebral hemorrhage（ICH）. Currently, as the mechanism of brain iron metabolism and its regulating and controlling factors after ICH are not clear, the effect of the treatment of reducing iron simply by physical method has larger difference. So exploring the mechanism of brain iron metabolism following ICH and giving the targeted intervention have important roles in the ICH therapy. Methods Parabiosis and ICH models combined with in vivo and in vitro experiments were used to investigate the roles of hepcidin in brain iron metabolism after ICH. Results After ICH, hepcidin-25 was found in serum and primarily in astrocytes. As human hepcidin-25 peptide injected into Wt ICH mice, which aggravated the brain iron efflux, oxidative brain injury, and cognition impairment, but not in Hepc-/-ICH mice. Data obtained in in vitro studies showed that increased hepcidin inhibited the intracellular iron efflux of brain microvascular endothelial cells but was rescued by a hepcidin antagonist, fursultiamine. Using parabiosis ICH models also shows that increased serum hepcidin prevents brain iron efflux. In addition, toll-like receptor 4（tLR4）/My D88 signaling pathway increased hepcidin expression by promoting interleukin-6 expression and signal transducer and activator of transcription 3 phosphorylation. tLR4-/-and My D88-/-mice exhibited improvement in brain iron efflux at 7, 14, and 28 days after ICH, and the tLR4 antagonist（6 R）-6-[N-（2-chloro-4-fluorophenyl） sulfamoyl] cyclohex-1-ene-1-carboxylate significantly decreased brain iron levels at days 14 and 28 after ICH and improved cognition impairment at day 28. Conclusion this study further elucidate the mechanism of brain iron metabolism after ICH, and found tLR4 inhibitors could improve the effect of ICH treatment via inhibiting the hepcidin expression to reduce the deposited brain *** is expected to provide new methods for the tre

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journal of Reproduction and Contraception 2016年第2期27卷 67-75页

作者： Miao xiong jie-ping ZHU Li LI Yang LIU Yu-qin jI jun WANG Department of Obstetrics and Gynecology the Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine

Objective to investigate the effect of FtY720-treated immature bone marrow-derived dendritic cells（BMDCs） on the embryo resorption rate in the CBA/j× DBA/2 abortion mouse *** the dendritic cells（DCs） were derived from bone marrow of DBA/2 mice, and then co-cultured with FtY720. the abortion mouse models were established by mating female CBA/j mice with DBA/2 mice. Via the CBA/j×DBA/2 abortion mouse model, six groups were established, group A： normal pregnancy model; group B： abortion mouse model with no treatment; group C： abortion mouse model injected with DC culture medium（DCCM）; group D： abortion mouse model injected with DC; group E： abortion mouse model injected with FtY720; group F： abortion model mouse injected with FtY720-DC. the differences were compared in the embryo resorption rates of the CBA/j ×DBA/2 abortion mouse model treated with FtY720-DC or different controls observed on gestation day 12 to 14, and then the microenvironment in murine pregnancy was *** the embryo resorption rate was statistically significantly decreased in group D and group E when they compared with group B and group C（P〈0.05, respectively）.Furthermore, the embryo resorption rate in group F showed a statistically significant decrease when compared with the other groups except group A（P〈0.01）. these resultssuggest that FtY720-DCs possess a notable advantage over DCs or FtY720 in reducing the embryo resorption rate of the abortion mouse model. the percentage of th17（IL-17＋CD4＋t cells） in peripheral blood mononuclear cell（PBMC） in the abortion mouse model was 4.35%±0.34% before treated with FtY720-DC, and was1.34%±0.28% after treated with FtY720-DC（P〈0.01）. the percentage of tregs（CD4~＋CD25~＋Foxp3~＋t cells） in PBMC was significantly increased in group F（8.35%±1.80%） as compared with group B（2.68%±0.65%）（P〈0.01）.Conclusion Adoptive transfer of FtY720-DC can statistically significantly reduce the embryo resorption rate in the CBA/j×DBA/2 abortion mouse model.

关键词： embryo resorption rate FtY720 tolerance adoptive transfer spontaneous abortion dendritic cell(DC)

Progress in Electrolyte Engineering of Aqueous Batteries in a Wide temperature Range

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transactions of tianjin University 2023年第5期29卷 321-346页

作者： Lingjun He Chuyuan Lin Peixun xiong Hui Lin Wenbin Lai jingran Zhang Fuyu Xiao Liren Xiao Qingrong Qian Qinghua Chen Lingxing Zeng Engineering Research Center of Polymer Green Recycling of Ministry of Education Fujian Key Laboratory of Pollution Control and Resource ReuseCollege of Environmental and ResourcesFujian Normal UniversityFuzhou 350007China Inorganic Chemistry I Technische Universität DresdenBergstrasse 6601069 DresdenGermany College of Chemistry and Materials Science Fujian Normal UniversityFuzhou 350007China Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education) College of ChemistryNankai UniversityTianjin 300071China

Aqueous rechargeable batteries are safe and environmentally friendly and can be made at a low cost;as such,they are attracting attention in the field of energy ***,the temperature sensitivity of aqueous batteries hinders their practical *** solvent water freezes at low temperatures,and there is a reduction in ionic conductivity,whereas it evaporates rapidly at high temperatures,which causes increased side *** review discusses recent progress in improving the performance of aqueous batteries,mainly with respect to electrolyte engineering and the associated strategies employed to achieve such improvements over a wide temperature *** review focuses on fi ve electrolyte engineer-ing(aqueous high-concentration electrolytes,organic electrolytes,quasi-solid/solid electrolytes,hybrid electrolytes,and eutectic electrolytes)and investigates the mechanisms involved in reducing the solidifi cation point and boiling point of the electrolyte and enhancing the extreme-temperature electrochemical ***,the prospect of further improving the wide temperature range performance of aqueous rechargeable batteries is presented.

关键词： Aqueous batteries Electrolyte engineering Wide temperature range Hydrogen bond

经导管主动脉瓣置换术后二尖瓣环的Ct形态与二尖瓣反流的关系

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国际医学放射学杂志 2021年第6期 734-735页

作者： X.Li A.Hagar X.Wei F.Chen Y.j.Li t.Y.xiong 张梦迪

经导管主动脉瓣置换术(tAVR)病人二尖瓣反流的改良率和预测存在矛盾。目的采用简化的多层螺旋Ct(MSCt)衍生的D形二尖瓣环模型对接受tAVR治疗的病人

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Working-in-tandem mechanism of multi-dopants in enhancing electrocatalytic nitrogen reduction reaction performance of carbon- based materials

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Nano Research 2021年第9期14卷 3234-3239页

作者： Wenqing Zhang Keke Mao jingxiang Low Hengjie Liu Yanan Bo jun Ma Qiaoxi Liu Yawen jiang jiuzhong Yang Yang Pan Zeming Qi Ran Long Li Song Yujie xiong Hefei National Laboratory for Physical Sciences at the Microscale Collaborative Innovation Center of Chemistry for Energy Materials(iChEM)School of Chemistry and Materials Scienceand National Synchrotron Radiation LaboratoryUniversity of Science and Technology of ChinaHefei 230041China School of Energy and Environment Science Anhui University of TechnologyMaanshan 243032China Institute of Energy Hefei Comprehensive National Science CenterHefei 230031China

Developing carbon-based electrocatalysts with excellent N2 adsorption and activation capability holds the key to achieve highly efficient nitrogen reduction reaction(NRR)for reaching its practical ***,we report a highly active electrocatalyst--metal-free pyrrolic-N dominated N,S co-doped carbon(pyrr-NSC)for *** on theoretical and experimental results,it is confirmed that the N and S-dopants practice a working-in-tandem mechanism on pyrr-NSC,where the N-dopants are utilized to create electropositive C sites for enhancing N2 adsorption and the S-dopants are employed to induce electron backdonation for facilitating N2 *** synergistic effect of the pyrrolic-N and S-dopants can also suppress the irritating hydrogen evolution reaction,further boosting the NRR *** work gives an indication that the combination of two different dopants on electrocatalyst can enhance NRR performance by working in the two tandem steps-the adsorption and activation of N2 molecules,providing a new strategy for NRR electrocatalyst design.

关键词： N2 reduction reaction metal-free catalyst heteroatoms doping asymmetric charge distribution electrocatalysis