检索结果-南通市图书馆

An innovative approach for integrated airline network and aircraft family optimization

Chinese Journal of Aeronautics 2020年第2期33卷 634-663页

作者： JoséALEXANDRE t.g.fregnani Bento S.DE MAttOS JoséA.HERNANDES Department of Aeronautical Engineering Technological Institute of Aeronautics12228-900 Sao Jose dos CamposBrazil

the determination of optimal aerial transport networks and their associated flight frequencies is crucial for the strategic planning of airlines,as well as for carrying out market research,to establish target markets,and for aircraft and crew *** addition,optimum airplane types for the selected networks are crucial to improve revenue and to provide reduced operating *** present study proposes an innovative approach to determine the optimal aerial transport network simultaneously with the determination of the optimum fleet for that network,composed of three types of airplanes(network and vehicle integrated design).the network profit is *** passenger’s demands between the airports are determined via a gravitational *** embedded linear programming solution is responsible for obtaining potential optimal network *** optimum fleet combination is determined from a database of candidate aircraft designs via genetic algorithm.A truly realistic airplane representation is made possible thanks to accurate surrogate models for engine and aerodynamics is *** accurate engine deck encompassing a compression map and an innovative engine weight calculation besides an aerodynamical artificial neural network module enable a high degree of accuracy for the mission *** proposed methodology is applied to obtain the optimum network comprised of twenty main Brazilian airports and corresponding fleet.

关键词： Air transport Aircraft design Airline economics Airline network optimization Multidisciplinary design optimization

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Molecular Analyses of Early-Onset gastric Cancer in Brazilian Patients: <i>tP</i>53 Mutations, Cadherin-Catenin and Mucins Proteins Expression

引用

Journal of Cancer therapy 2013年第1期4卷 33-42页

作者： Edaise Maria da Silva J. H. t. g. fregnani ghyslaine Martel Wilson Luiz Costa Jr. Felipe José Fernández Coimbra Maria Isabel Waddington Achatz Pierre Hainaut Fernando Augusto Soares Department of Anatomic Pathology Hospital AC Camargo Sao Paulo Brazil Research and teaching Institute Barretos Cancer Hospital Barretos Brazil International Agency for Research on Cancer Molecular Carcinogenesis Group Lyon France Department of Abdominal Surgery Hospital AC Camargo Sao Paulo Brazil Department of Oncogenetics Hospital AC Camargo Sao Paulo Brazil.

Early gastric carcinomas may develop with a molecular profile differing from sporadic carcinomas occurring at a later age. In this study, we analyzed a retrospective series of 88 patients with gastric adenocarcinoma diagnosed before the age of 45 years for the presence of tP53 mutations, clinicopathological features and immunohistochemistry to evaluate the expression of markers considered to be important in gastric carcinogenesis (E-cadherin, β-catenin, MUC1, MUC2, MUC5AC, MUC6 and p53). the majority of proportion of tumors were diffuse-type (70%) and advanced stage (56%). Familial history of cancer was positive in 21% of the cases. there was a significant association between altered expression of E-cadherin and β-catenin, and between p53 expression and perineural invasion. tP53 mutations were detected in 14.5% of evaluated cases, including a germline mutation (p.R337H) in a 12-year old patient. Overall survival analysis showed significant differences in relation with tumor stage and histopathology. the evaluated biomarkers did not present prognostic value in non-exploratory multivariate analyses. the low frequency of tP53 mutations in this series suggests these alterations are not a major molecular event in gastric cancer occurring at early age, although the identification of a case with germline p.R337H mutation is consistent with the hypothesis that a small proportion of early, apparently sporadic gastric cancer, may be associated with widespread Brazilian founder mutations. Further studies are needed to evaluate the prognostic significance of markers for specific groups of patients according to tumor histology and familial history.

关键词： Early-Onset gastric Cancer Young Patients Cellular Adhesion tP53 Mutations

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Evaluation of HPV Molecular tests in Primary Screening for Cervical Cancer in Brazil

引用

Open Journal of Obstetrics and gynecology 2014年第8期4卷 470-478页

作者： José E.Levi Adhemar Longatto-Filho José Eluf-Neto Célia L.Rodrigues Cristina M.Oliveira Adriana C.Carloni Adriana t.Lorenzi Maricy tacla José H.fregnani Alexandre M.Ab’Saber Cristovam Scapulatempo Luisa LVilla National Institute of Science and technology for the Diseases Associated to Papillomaviruses(INCt-HPV) Sao PauloBrazil Virology Lab Tropical Medicine InstituteUniversidade de Sao PauloSao PauloBrazil Laboratory of Medical Investigation(LIM)14 Faculdade de MedicinaUniversidade de Sao PauloSao PauloBrazil ICVS/3B’s-Pt government Associate Laboratory Life and Health Sciences Research Institute(ICVS)School of Health SciencesUniversity of MinhoBragaPortugal Molecular Oncology Research Center Pio XII FoundationBarretosBrazil Department of Preventive Medicine Faculdade de MedicinaUniversidade de Sao PauloSao PauloBrazil Department of Infectious Diseases Faculdade de MedicinaUniversidade de Sao PauloSao PauloBrazil Department of ginecology and Obstetrics Faculdade de MedicinaUniversidade de São PauloSao PauloBrazil Center for the Researcher Support Pio XII FoundationBarretos Cancer HospitalBarretosBrazil Department of Pathology Faculdade de MedicinaUniversidade de Sao PauloSao PauloBrazil Department of Radiology Center on Translational Oncology InvestigationSao Paulo State Cancer InstituteFaculdade de MedicinaUniversidade de Sao PauloSao PauloBrazil Santa Casa de Sao Paulo Medical School Sao PauloBrazil

Background: Incorporation of HPV tests into cervical cancer screening programs may be advantageous over conventional cytology, especially in developing nations, where the largest burden of cervical cancer is observed. Objectives: to conduct an evaluation of commercially available molecular HPV tests in Brazilian women. Study design: two groups were recruited: group A was composed of 511 women referred to the clinics because of a previous abnormal Pap test while group B consisted of 2464 subjects under routine screening. Cervical samples were collected using SurePath liquid cytology (LBC) device, and split into aliquots which were submitted to molecular testing by Hybrid Capture and cobas HPV. Colposcopy and biopsies were made according to the standard guidelines, directed by cytological diagnosis. Results: Prevalence of HSIL was 5.97% and 0.7% in group A and B respectively. High-Risk HPV DNA was found in about 9% of group B women, while in group A this frequency was 24%. Having CIN3+ as the study end-point, the negative predictive values for molecular methods were above 99.8%. All “in-situ” and invasive cervical carcinomas were detected by both HPV nucleic acid assays. Conclusion: Use of HPV DNA testing was feasible and highly sensitive in cancer screening settings of Brazil.

关键词： High-Risk HPV test HPV-DNA Cervical Cancer Screening

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：