检索结果-南通市图书馆

Docosahexaenoic acid suppresses arachidonic acid-induced proliferation of LS-174t human colon carcinoma cells

World Journal of Gastroenterology 2009年第9期15卷 1079-1084页

作者： Piet Habbel Karsten H Weylandt Katja Lichopoj Johannes Nowak Martin Purschke Jing-Dong Wang cheng-Wei He Daniel c Baumgart Jing X Kang Department of Medicine Massachusetts General Hospital and Harvard Medical School Boston MA 02114 United States Department of Medicine Division of Gastroenterology and Hepatology Charité Medical Center-Virchow-Hospital Medical School of the Humboldt-University of Berlin 13344 Berlin Germany

AIM： to investigate the impact of arachidonic acid （AA） and docosahexaenoic acid （DHA） and their combination on colon cancer cell growth. MetHODS： the LS-174t colon cancer cell line was used to study the role of the prostaglandin precursor AA and the omega-3 polyunsaturated fatty acid DHA on cell growth. cell viability was assessed in Xtt assays. For analysis of cell cycle and cell death, flow cytometry and DAPI staining were applied. expression of cyclooxygenase-2 （cOX-2）, p21 and bcl-2 in ceils incubated with AA or DHA was examined by real-time Rt-PcR. Prostaglandin e2 （PGe2） generation in the presence of AA and DHA was measured using a PGe2- eLISA. ReSULtS： AA increased cell growth, whereas DHA reduced viability of LS 174t cells in a time- and dosedependent manner. Furthermore, DHA down- regulated mRNA of bcl-2 and up-regulated p21. Interestingly, DHA was able to suppress AA-induced cell proliferation and significantly lowered AA-derived PGe2 formation. DHA also down-regulated cOX-2 expression. In addition to the effect on PGe2 formation, DHA directly reduced PGe2-induced cell proliferation in a dosedependent manner. cONcLUSION： these results suggest that DHA can inhibit the pro-proliferative effect of abundant AA or PGe2.

关键词： colorectal carcinoma colon cancer Omega-3 Omega-6 Polyunsaturated fatty acids Arachidonic acid Docosahexaenoic acid Prostaglandine2 cyclooxygenase-2 Apoptosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

evaluation of safety profile of black shilajit after 91 days repeated administration in rats

引用

Asian Pacific Journal of tropical Biomedicine 2012年第3期2卷 210-214页

作者： Velmurugan c Vivek B Wilson e Bharathi t Sundaram t Department of Pharmacology Sri Krishna Chaithanya College of Pharmacy Department of Pharmacology Sri K.V College of PharmacyM.G RoadChickballapurKarnataka SRF National Institute of Indian Medical HeritageHyderabad Department of Pharmaceutical Biotechnology Sri Krishna Chaithanya College of Pharmacy Department of Pharmaceutics Sri Krishna Chaithanya College of pharmacy

Objective:to evaluate the safety of shilajit by 91 days repeated administration in different dose levels in ***:In this study the albino rats were divided into four groups. Group Ⅰ received vehicle and group Ⅱ,Ⅲ and Ⅳ received 500,2500 and 5000 mg/kg of shilajit, *** animals were sacrificed and subjected to histopathology and iron was estimated by flame atomic absorption spectroscopy and graphite ***:the result showed that there were no significant changes in iron level of treated groups when compared with control except liver(5000 mg/kg) and histological slides of all organs revealed normal except negligible changes in liver and intestine with the highest dose of *** weight of all organs was normal when compared with ***:the result suggests that black shilajit,an Ayurvedic formulation,is safe for long term use as a dietary supplement for a number of disoniers like iron deficiency anaemia.

关键词： Shilajit Graphite furnace Histopathology Flame atomic absorption spectroscopy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A DecADe OF MARINe ZOOPLANKtON ReSeARcH IN cHINA

引用

海洋与湖沼 1959年第4期 219-222页

作者： c.cheng t.c.cheng Institutc of Oceanology Academia Sinica

Marine plankton research, as well as other branches of science, has made great progress after the liberation which is rendered possible through the great attention and support given by the communist Party of china and the Government to scientific research. A considerable amount of plankton samples and data have been accumulated during the past ten years by surveys of fishing grounds, bays and coastal waters, the results of which have been partly published in a number of papers and reports. Since autumn of last year, a very extensive oceanographic survey is being carried out along the entire coast of china. the outcome of this large-scale

关键词： th A DecADe OF MARINe ZOOPLANKtON ReSeARcH IN cHINA high Bay

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

引用

Journal of Integrative Plant Biology 2005年第8期47卷 988-997页

作者： Jie cHeN Gary e HARMAN Afio cOMIS Gen-Wu cheng School of Agriculture and Biology Shanghai Jiaotong University Shanghai 201101 China Department of Horticultural Science Cornell University New York State Agricultural Experiment Station Geneva NY 14456 USA college of Plant Protection Shenyang Agricultural University Shenyang 110161 China

Induced resistance has been evidenced as one of mechanisms of trichoderma to control plant diseases, however, no study showed the change of host proteomics in trichoderma-induced resistance of maize against damping-off caused by Pythium ultimum trow. the mechanism of trichoderma harzianum Rifai for controlling maize seedling disease caused by Pythium ultimum trow was investigated firstly by proteome technique and the result suggested that t. harzianum strain t22 was not only able to promote seedling growth but also protein accumulation. One-dimensional electrophoresis assay showed that more bands appeared on the gel with t22 or t22 combined with P. ultimum （t22 ＋ P. ultimum） treatment than with other treatments. enzyme assay showed that two chitinases of the root sample were more activated in the treatments with t22 than in the other treatments without t22. Proteins in the seedling roots from the various treatments were separated through protein extraction and 2-D electrophoresis technique. In the seedlings produced from the t22-treated seeds, there were 104 up-regulated proteins and 164 down-regulated proteins relative to the control, and 97 and 150, respectively, aftel treatment with t22 ＋ P. ultimum; however, with P. ultimum alone the values were much lower than with the other two treatments. the correlation coefficient values were 0.72, 0.51 and 0.49 for the comparison of protein spot distribution on gel among control with t22, P. ultimum and t22 ＋ P. ultimum, respectively. So it seemed that P. ultimum infection was more effective than t22 in interfering with the host proteome profile. Furthermore, analysis with MALDItOF-MAS showed that some important proteins associated with defensive reactions were identified in t22 or t22 ＋ P. ultimum treatments, including endochitinase, pathogenesis-related protein PRMS （pathogenesis-related maize seed）, GtP-binding protein, isoflavone reductase and other proteins related to respiration. All those proteins are probably part

关键词： maize inbred proteome Pythium ultimum trow trichoderma harzianum

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

cBAF and MYc:decision makers for t cell memory differentiation

引用

Signal transduction and targeted therapy 2023年第1期8卷 1-2页

作者： Kaili Ma Hongcheng cheng Lianjun Zhang cAMS Key Laboratory of Synthetic Biology Regulatory element Institute of Systems MedicineChinese Academy of Medical Sciences and Peking Union Medical College100005BeijingChina Suzhou Institute of Systems Medicine Suzhou215123JiangsuChina Jiangsu center for the collaboration and Innovation of cancer Biotherapy Cancer InstituteXuzhou Medical UniversityXuzhouChina

In a recent paper published in Nature,Guo et al.1 demonstrated that asymmetrically segregated MYc and canonical BRG1/BRM-associated factor(cBAF)at first division of activated cD8^(+)t cells cooperate to dictate t cell fate by remodeling of epigenetics and chromatin *** pharmacological or genetic inhibition of cBAF in chimeric antigen receptor t(cAR-t)cells considerably promotes their anti-tumor capacity in vivo,presumably by biased memory differentiation post transfer(Fig.1).

关键词： remodeling considerably

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Machine Learning Models of Plastic Flow Based on Representation theory

引用

computer Modeling in engineering & Sciences 2018年第12期117卷 309-342页

作者： R.e.Jones J.A.templeton c.M.Sanders J.t.Ostien Sandia National Laboratories P.O.Box 969LivermoreCA 94551USA.

We use machine learning(ML)to infer stress and plastic flow rules using data from representative polycrystalline *** particular,we use so-called deep(multilayer)neural networks(NN)to represent the two response *** ML process does not choose appropriate inputs or outputs,rather it is trained on selected inputs and ***,its discrimination of features is crucially connected to the chosen inputoutput ***,we draw upon classical constitutive modeling to select inputs and enforce well-accepted symmetries and other *** the context of the results of numerous simulations,we discuss the design,stability and accuracy of constitutive NNs trained on typical experimental *** these developments,we enable rapid model building in real-time with experiments,and guide data collection and feature discovery.

关键词： Machine learning constitutive modeling plasticity invariance.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Development of an Automatic Gain controller card for Next Generation eDFAs

引用

光学学报 2003年第S1期23卷 413-414页

作者： c. Y. Liaw t. H. cheng c. Lu M.Akiyama t.Sakai A.Wada Institute for Infocomm Research Unit 230 Innovation Centre Block 2 18 Nanyang Drive Singapore 639798 Fujikura technology Singapore 41 Science Park Road #01-03 Singapore 117610 Fujikura Ltd 1440 Mutsuzaki Sakura Chiba 285-8550 Japan

this paper describes a low cost automatic gain controller card that provides fast transient gain control to maintain the power of the surviving channels when the number of input channels to an erbium-doped fiber ampli... 详细信息

关键词： fiber amplifier gain control low cost

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

tHeORetIcAL StUDY OF HeAt tRANSFeR eNHANceMeNt IN PIPe WItH POROUS BODY

引用

Journal of Hydrodynamics 2001年第1期13卷 111-116页

作者： Gong, W.P. Han, J.t. cheng, F. Dep. of Power eng. Shandong Univ. Jinan 250061 China

A theoretical investigation on the fluid flow and heat transfer in a pipe with porous body of high porosity twisted by metal wire was carried out. A theoretical model of a circular pipe with porous matrix attached at the channel wall and extended inward the centerline was set up. through analyzing the flow in the porous matrix by the Brinkman-extended-Darcy equation and through including the effect of dispersion by adding the dispersion coefficient into the energy equation, the theoretical solutions of velocity distribution and temperature fields were obtained. Finally the effect of the properties of the porous matrix on the flow and heat transfer in the porous body was studied, which indicates that dispersion can really enhance the heat transfer in pipe.

关键词： computer simulation Dispersions Mathematical models Pipe flow Porosity Porous materials

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Hidden spin polarization in the 1t-phase layered transition-metal dichalcogenides MX_2(M = Zr, Hf; X = S, Se, te)

引用

Science Bulletin 2018年第2期63卷 85-91页

作者： cai cheng Jia-tao Sun Xiang-Rong chen Sheng Meng Institute of Atomic and Molecular Physics College of Physical Science and Technology Sichuan University Institute of Physics Chinese Academy of Sciences

the recent discovery of hidden spin polarization emerging in layered materials of specific nonmagnetic crystal is a fascinating phenomenon, though hardly explored yet. Here, we have studied hidden spin tex- tures in layered nonmagnetic 1 t-phase transition-metal dichalcogenides MX2 （M = Zr, Hf; X = S, Se, te） by using first-principles calculations. Spin-layer locking effect, namely, energy-degenerate opposite spins spatially separated in the top and bottom layer respectively, has been identified. In particular, the hidden spin polarization of 13-band can be easily probed, which is strongly affected by the strength of spin-orbit coupling. the hidden spin polarization of k-band locating at high symmetry M point （conduction band minimum） has a strong anisotropy. In the bilayer, the hidden spin polarization is preserved at the upmost Se layer, while being suppressed if the ZrSe2 layer is taken as the symmetry partner. Our results on hidden spin polarization in 1 t-phase dichalcogenides, verifiable by spin-resolved and angle-resolved photoemis- sion spectroscopy （ARPeS）, enrich our understanding of spin physics and provide important clues to search for specific spin polarization in two dimensional materials for spintronic and quantum informa- tion applications.

关键词： Hidden spin polarizationtransition-metal dichalcogenides 1t-phaseHelical spin texturecentrosymmetric

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

conceptual design of an experiment to study dust destruction by astrophysical shock waves

引用

High Power Laser Science and engineering 2018年第3期6卷 9-14页

作者： M. J.-e. Manuel t. temim e. Dwek A. M. Angulo e X. Belancourt R. e Drake c. c. Kuranz M. J. MacDonald B. A. Remington General Atomics 3550 General Atomics Court San Diego CA 92121 USA Space telescope Science Institute 3700 San Martin Drive Baltimore MD 21218 USA Observational cosmology Lab Code 665 NASA Goddard Space Flight Center Greenbelt MD 20771 USA climate and Space Science and engineering University of Michigan Ann Arbor M148109 USA Department of Physics University of California Berkeley CA 94720 USA Lawrence Livermore National Laboratory Livermore CA 94450 USA

A novel laboratory experimental design is described that will investigate the processing of dust grains in astrophysical shocks. Dust is a ubiquitous ingredient in the interstellar medium(ISM) of galaxies; however, its evolutionary cycle is still poorly understood. especially shrouded in mystery is the efficiency of grain destruction by astrophysical shocks generated by expanding supernova remnants. While the evolution of these remnants is fairly well understood, the grain destruction efficiency in these shocks is largely unknown. the experiments described herein will fill this knowledge gap by studying the dust destruction efficiencies for shock velocities in the range ～10–30 km/s(μm/ns), at which most of the grain destruction and processing in the ISM takes place. the experiments focus on the study of grain–grain collisions by accelerating small(～1 μm) dust particles into a large(～5–10 μm diameter) population; this simulates the astrophysical system well in that the more numerous, small grains impact and collide with the large population. Facilities that combine the versatility of high-power optical lasers with the diagnostic capabilities of X-ray free-electron lasers, e.g., the Matter in extreme conditions instrument at the SLAc National Accelerator Laboratory, provide an ideal laboratory environment to create and diagnose dust destruction by astrophysically relevant shocks at the micron scale.

关键词： laboratory astrophysics shock waves dust destruction

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：