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Neuroendocrine facets of behavior and toxicology

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Aquaculture and Fisheries 2024年第3期9卷 337-338页

作者： Keith b.tierney balasubramanian Senthilkumaran Department of biological Sciences and the School of Public HealthUniversity of AlbertaEdmontonABT6G 2E9Canada Department of Animal biology School of Life SciencesUniversity of HyderabadP O Central UniversityGachibowliHyderabad500046TelanganaIndia

Professor ***,who I came to know as Senthil,came over to visit the University of Alberta in the summer of 2022 in connection with his Global Ambassador Fellowship program at University of Saskatechewan,***,there was that reason to visit,but there was another one as well,one that tied us *** years before Senthil had been considered for a postdoctoral fellowship with the legend that was Dick ***,it didn’t materialize and then he moved to Japan to do his Post Doc Under *** *** had been Dean and a preeminent endocrinologist at the U of A.I came to know Dick near the end of my PhD;he had brought me out to bamfield Marine Sciences Centre to carryout research using their then-new,and very expensive,simulated *** left an incredible mark on all of us that knew him;he represented all that was wonderful and achievable in *** spent time with him was akin to shaking Sinatra’s hand,at least in the world of biology in that *** this common history,Senthil and I were fast friends.

关键词： Canada shaking carry

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王奎仁石：一种铅的氯化物-亚硒酸盐新矿物

矿物学报 2024年

作者：杨和雄谷湘平谢先德彭捷 R.b.Gibbs R.t.Downs 亚利桑那大学地球科学系江西应用科技学院光华宝石与矿物资源学院中南大学地球科学与信息物理学院中国科学院地球化学研究所矿物学与成矿学重点实验室/广东省矿物物理与材料重点实验室美国蒙特利市CuestaVista大道24号

王奎仁石（wangkuirenite），理想式Pb3Cl2(Se4+O3)2，发现于意大利撒丁岛巴库鲁奇（baccy Rucci）铅-砷老矿山。该新矿物以板状或叶片状晶体产出，与其共生的矿物有兰硒铜矿、沃兰迪石、硒铅矾、铅矾和石英。王奎仁石在透射光下为很淡... 详细信息

王奎仁石（wangkuirenite），理想式Pb3Cl2(Se4+O3)2，发现于意大利撒丁岛巴库鲁奇（baccy Rucci）铅-砷老矿山。该新矿物以板状或叶片状晶体产出，与其共生的矿物有兰硒铜矿、沃兰迪石、硒铅矾、铅矾和石英。王奎仁石在透射光下为很淡的黄色，晶体透明、具玻璃光泽，条痕为白色，性脆，其摩氏硬度约为3。沿（001）面的解理完全，未观察到有双晶或裂理。计算密度为6.48 g/cm3。根据电子探针分析结果和基于每个单元中有8个（O+Cl）原子获得王奎仁石的经验化学式为Pb3.01Cl1.96(Se1.00O3.02)2。王奎仁石是与人工合成Pb3Cl2（Se O3）2相对应的天然矿物，与人工合成的Pb3br2（SeO3）2和Pb3I2（SeO3）2具有相同的晶体结构。王奎仁石属单斜晶系，空间群为C2/c，晶胞参数为a=13.4266（4）,b=5.5826（2）,c=13.0024（4）?，β=94.287（2）o，V=971.87（5）?3,Z=4。王奎仁石晶体结构的特点具有平行于（001）面的Pb2+-(Se4+O3)2–结构层，层间靠阴离子Cl-相互连结起来。结构中一个非对称的单元内，存在有两种不同位置的的Pb2+阳离子（Pb1和Pb2）、一个(Se4+O3)2-阴离子团和一个Cl-阴离子。该Se4+阳离子与3个O原子相结合，形成(Se4+O3)2-三次配位。两个Pb1和Pb2均为8次配位，分别为[PbCl2O6]和[PbCl3O5]，阴离子O和Cl围绕Pb1和Pb2的分布表明，它们的6s2孤对电子是惰性的。王奎仁石是迄今记录到的6个铅的氯化物-亚硒酸盐矿物中的一个成员，在结构和成分上它与萨拉巴斯石[sarrabusite,Pb5CuC l4（SeO3）4]紧密相关。

关键词：王奎仁石铅-氯化物-亚硒酸盐新矿物巴库鲁奇意大利

Ion heat transport in electron cyclotron resonance heated L-mode plasma on the t-10 tokamak

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Plasma Science and technology 2024年第4期26卷 52-60页

作者： V.A.KRUPIN M.R.NURGALIEV A.R.NEMEtS I.A.ZEMtSOV S.D.SUNtSOV t.b.mya.ton D.S.SERGEEV N.A.SOLOVEV D.V.SARYCHEV D.V.RYJAKOV S.N.tUGARINOV N.N.NAUMENKO National Research Centre“Kurchatov Institute” Moscow 123182Russia bauman Moscow State technical University Moscow 105005Russia Institution“Project Center ItER” Moscow 123098Russia JSC“SOLAR” Minsk 220034Belarus

Anomalous ion heat transport is analyzed in the t-10 tokamak plasma heated with electron cyclotron resonance heating(ECRH) in second-harmonic extra-ordinary mode. Predictive modeling with empirical scaling for Ohmical heat conductivity shows that in ECRH plasmas the calculated ion temperature could be overestimated, so an increase of anomalous ion heat transport is required. to study this effect two scans are presented: over the EC resonance position and over the ECRH power. the EC resonance position varies from the high-field side to the low-field side by variation of the toroidal magnetic field. the scan over the heating power is presented with on-axis and mixed ECRH regimes. Discharges with high anomalous ion heat transport are obtained in all considered regimes. In these discharges the power balance ion heat conductivity exceeds the neoclassical level by up to 10 times. the high ion heat transport regimes are distinguished by three parameters: the ratio te/ti, the normalized electron density gradient R/■, and the ion–ion collisionality νii~*. the combination of high te/ti, high νii~*, and R/■=6-10 results in values of normalized anomalous ion heat fluxes up to 10 times higher than in the low transport scenario.

关键词： tokamak L-mode electron cyclotron resonance heating ion heat transport

New trends in diagnosis and management of gallbladder carcinoma

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World Journal of Gastrointestinal Oncology 2024年第1期16卷 13-29页

作者： Efstathios t Pavlidis Ioannis N Galanis theodoros E Pavlidis ^(nd)Propedeutic Department of Surgery Hippokration General HospitalSchool of MedicineAristotle University of ThessalonikiThessaloniki 54642Greece

Gallbladder(Gb)carcinoma,although relatively rare,is the most common biliary tree cholangiocarcinoma with aggressiveness and poor *** is closely associated with cholelithiasis and long-standing large(>3 cm)gallstones in up to 90%of *** other main predisposing factors for Gb carcinoma include molecular factors such as mutated genes,Gb wall calcification(porcelain)or mainly mucosal microcalcifications,and Gb polyps≥1 cm in *** is made by ultrasound,computed tomography(Ct),and,more precisely,magnetic resonance imaging(MRI).Preoperative staging is of great importance in decisionmaking regarding therapeutic *** staging is based on MRI findings,the leading technique for liver metastasis imaging,enhanced three-phase Ct angiography,or magnetic resonance angiography for major vessel *** is also necessary to use positron emission tomography(PEt)-Ct or ^(18)F-FDG PEt-MRI to more accurately detect metastases and any other occult deposits with active metabolic *** laparoscopy may detect dissemination not otherwise found in 20%-28.6%of *** treatment is needed,including surgical resection,targeted therapy by biological agents according to molecular testing gene mapping,chemotherapy,radiation therapy,and *** is of great importance to understand the updated guidelines and current treatment *** extent of surgical intervention depends on the disease stage,ranging from simple cholecystectomy(t1a)to extended resections and including extended cholecystectomy(t1b),with wide lymph node resection in every case or IV-V segmentectomy(t2),hepatic trisegmentectomy or major hepatectomy accompanied by hepaticojejunostomy Roux-Y,and adjacent organ resection if necessary(t3).Laparoscopic or robotic surgery shows fewer postoperative complications and equivalent oncological outcomes when compared to open surgery,but much attention must be paid to avoiding *** addition to surgery,novel targe

关键词： biliary tract neoplasms Extrahepatic cholangiocarcinoma Gallbladder carcinoma Gallbladder diseases biliary tree diseases Gastrointestinal malignancies

Is salmonid migration at risk from chemical information disruption?

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Aquaculture and Fisheries 2024年第3期9卷 378-387页

作者： Keith b.tierney Gregory G.Pyle biological Sciences College of Natural and Applied SciencesEdmontonABT6G 2E9Canada School of Public Health College of Health SciencesEdmontonABT6G 1C9Canada Department of biological Sciences University of LethbridgeLethbridgeABT1K 3M4Canada

Good information is the basis for good *** many invaluable salmon species,chemical information is necessary to guide and fine-tune their migrations to and from freshwater mating grounds.A problem is that salmon of the current world are running a gauntlet of toxic chemicals arising from diverse anthropogenic inputs and these chemicals are known to disrupt *** is sufficient evidence that effluents from cities,mines,agriculture and industry contain chemicals that can rapidly,and sometimes irreversibly,impair the olfactory sense that salmon use to gather *** toxic inputs may not only be strong enough to impair migration,but be strong enough to redirect salmon away from their *** is also evidence that some synthetic chemicals may serve as the basis for ‘new’ information and be useful in making correct migratory *** the plus side,there are examples of new regulations that limit the input of chemicals of known olfactory toxicity,but on the minus side,increased urbanization and global climate change will likely increase the number and/or severity of some neurotoxic *** we identify the specific avenues of chemical risks to information disruption and in so doing prioritize and rank the risks to migrating *** data collected here can be used to lay the foundation for modelling the effects of anthropogenic inputs on information disruption in diverse salmonid species from around the world and therefore help secure their longevity in a changing chemical environment.

关键词： Salmon migration Ocean ranching Chemical information disruption Homing disruption Olfactory toxicity

the signal-transduction pathways of the peripheral olfactory organ and their impairment in vertebrates

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Aquaculture and Fisheries 2024年第3期9卷 388-403页

作者： Arash Shahriari bouthaina Aoudi Keith b.tierney College of Natural and Applied Sciences Faculty of ScienceBiological SciencesEdmontonABT6G 2E9Canada Department of Civil and Environmental Engineering University of AlbertaEdmontonABT6G 1H9Canada College of Health Sciences School of Public HealthEdmontonABT6G 1C9Canada

Animals rely on olfaction to detect and process invaluable chemical information about their *** olfaction to function,chemicals must first be detected,which leads to the activation of signal-transduction pathways at the peripheral olfactory *** the olfactory system is in direct contact with the environment,the system is constantly vulnerable to damage by contaminants entering the atmosphere or *** may have a variety of effects,including disrupting olfactory signals generated during chemical detection,or altering numerous targets along the signal transduction *** any impairment of chemical detection,animals may be unable to rely on olfaction to make correct decisions about their environment and thus their *** other reviews have focussed on olfactory toxicology in general,here we specifically explore how contaminants may affect the signal-transduction pathways at various points and link those changes to olfactory functionality across vertebrates with a focus on fishes.

关键词： Olfaction Signal-transduction Vertebrate Fish

Colonic schistosomiasis mimicking cancer,polyp,and inflammatory bowel disease:Five case reports and review of literature

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World Journal of Gastrointestinal Endoscopy 2024年第8期16卷 472-482页

作者： Sebhatleab t Mulate Abdulsemed M Nur Abel t tasamma Rodas t Annose Esmael M Dawud Kinfe W Ekubazgi Hailemichael D Mekonnen Hidaya Y Mohammed Meron b Hailemeskel Shimelis A Yimer Department of Internal Medicine Addis Ababa UniversityCollege of Health ScienceAddis Ababa 9086Ethiopia Department of Internal Medicine Division of Gastroenterology and HepatologyAddis Ababa UniversityCollege of Health ScienceAddis Ababa 9086Ethiopia Department of Internal Medicine St Paul’s Hospital Millennium Medical CollegeAddis Ababa 9086Ethiopia Department of Internal Medicine Hawassa UniversityHawassa PO Box 05Ethiopia Department of Internal Medicine St Paul’s Hospital Millennium Medical CollegeAddis Ababa 1271Ethiopia Department of Pathology Addis Ababa UniversityCollege of Health ScienceAddis Ababa 9086Ethiopia Department of Pathology St Paul’s Hospital Millennium Medical CollegeAddis Ababa 1271Ethiopia Department of Pathology Ethio Tebib General HospitalAddis Ababa 1111Ethiopia

bACKGROUND Schistosomiasis,officially named as a neglected tropical disease by the World Health Organization,is a serious parasitic disease caused by trematode flukes of the genus *** is a common infectious disease,endemic in more than 78 *** disease can involve various organs and poses far-reaching public health *** SUMMARY Here,we present a series of five patients with variable presentations:an asymptomatic patient who was diagnosed with colonic schistosomiasis upon screening colonoscopy;2 patients with clinical suspicion of colonic cancer;and 2 patients with a clinical diagnosis of inflammatory bowel *** patients were subsequently confirmed to have colonic schistosomiasis after colonoscopy and histopathologic *** clinical manifestations,colonoscopy features and histologic findings of the patients are *** of the patients showed significant clinical improvement following administration of oral *** Intestinal schistosomiasis can present with features mimicking other gastrointestinal *** disease should be a diagnostic consideration in patients who live in or have traveled to endemic areas.

关键词： Schistosomiasis Schistosoma Colon Polyp Ethiopia Case report

Nearest Neighbor Sampling of Point Sets Using Rays

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Communications on Applied Mathematics and Computation 2024年第2期6卷 1131-1174页

作者： Liangchen Liu Louis Ly Colin b.Macdonald Richard tsai Department of Mathematics The University of Texas at Austin2515 SpeedwayAustinTX 78712USA Oden Institute for Computational Engineering and Sciences The University of Texas at Austin201 E24th StAustinTX 78712USA Department of Mathematics University of British Columbia1984 Mathematics RdVancouverBCV6T1Z2Canada

We propose a new framework for the sampling,compression,and analysis of distributions of point sets and other geometric objects embedded in Euclidean *** approach involves constructing a tensor called the RaySense sketch,which captures nearest neighbors from the underlying geometry of points along a set of *** explore various operations that can be performed on the RaySense sketch,leading to different properties and potential *** information about the data set can be extracted from the sketch,independent of the ray *** integrals on point sets can be efficiently computed using the *** also present several examples illustrating applications of the proposed strategy in practical scenarios.

关键词： Point clouds Sampling Classification Registration Deep learning Voronoi cell analysis

A particle-resolved heat-particle-fluid coupling model by DEM-IMb-LbM

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第6期16卷 2267-2281页

作者： Ming Xia Jinlong Fu Y.t.Feng Fengqiang Gong Jin Yu Hunan Key Laboratory of Geomechanics and Engineering Safety Xiangtan UniversityXiangtan411105China Zienkiewicz Institute for Modelling Data and AISwansea UniversitySwanseaSA18EPUK School of Civil Engineering Southeast UniversityNanjing211189China Fujian Research Center for tunneling and Urban Underground Space Engineering Huaqiao UniversityXiamen361021China

Multifield coupling is frequently encountered and also an active area of research in geotechnical *** this work,a particle-resolved direct numerical simulation(PR-DNS)technique is extended to simulate particle-fluid interaction problems involving heat transfer at the grain *** this extended technique,an immersed moving boundary(IMb)scheme is used to couple the discrete element method(DEM)and lattice boltzmann method(LbM),while a recently proposed Dirichlet-type thermal boundary condition is also adapted to account for heat transfer between fluid phase and solid *** resulting DEM-IbM-LbM model is robust to simulate moving curved boundaries with constant temperature in thermal *** facilitate the understanding and implementation of this coupled model for non-isothermal problems,a complete list is given for the conversion of relevant physical variables to lattice ***,benchmark tests,including a single-particle sedimentation and a two-particle drafting-kissing-tumbling(DKt)simulation with heat transfer,are carried out to validate the accuracy of our coupled *** further investigate the role of heat transfer in particle-laden flows,two multiple-particle problems with heat transfer are *** examples demonstrate that the proposed coupling model is a promising high-resolution approach for simulating the heat-particle-fluid coupling at the grain level.

关键词： Particle-fluid interaction Heat transfer Discrete element method(DEM) Lattice boltzmann method(LbM) Dirichlet-type thermal boundary Direct numerical simulation