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目的探讨混合多维MR成像的分区分析是否可应用于诊断前列腺癌并明确其侵袭性。材料与方法对22例前列腺癌病人行术前3.0 t MR成像。对不同回波时间（47、75、100 ms）和不同b值（0、750、1 500 s/mm2）分别进行组合,获得混合多维MR成像横断面影像,并形成与每个体素相关的3×3阵列数据。将混合数据拟合到三区信号模型,计算各分区的表观扩散系数（ADC）和t2值,计算前列腺各区带组织间质、上皮和腺泡腔的体积。测量经前列腺切除术确诊的恶性肿瘤组织的兴趣区（n=28）和正常前列腺组织（n=71）的体积分数、常规ADC和t2值。采用受试者操作特征（ROC）曲线分析评估各种参数对前列腺癌和前列腺良性组织的鉴别价值。结果与正常组织相比较,混合多维MRI显示前列腺癌上皮组织的体积分数明显增加（分别为23.2%±7.1%∶48.8%±9.2%）,腺泡腔（26.4%±14.1%∶14.0%±5.2%）和基质（50.5%±15.7%∶37.2%±9.1%）的体积分数减小。前列腺各区带组织成分的体积分数显示,Gleason评分与Spearman评分相关系数较t2值（ρ=-0.292,P=0.132）和ADC值（ρ=-0.315,P=0.102）更高（上皮:ρ=0.652,P=0.000 1;基质:ρ=-0.439,P=0.20;腺泡腔:ρ=-0.390,P=0.040）。ROC曲线下面积显示区分前列腺癌与正常前列腺组织时,上皮体积分数（0.991）差异最高,其次为腺泡腔体积分数（0.800）和基质体积分数（0.789）。结论当前列腺癌存在时,前列腺腺泡腔、基质和上皮组织的体积分数显著改变。混合多维MR成像可对这些参数进行无创性测量,并可能有助于提高前列腺癌的诊断并明确其侵袭性。

关键词： MR 上皮组织前列腺癌体积分数无创性

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Effect of interface on mid-infrared photothermal response of MoS2 thin film grown by pulsed laser deposition

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Nano Research 2017年第10期10卷 3571-3584页

作者： Ankur Goswami Priyesh Dhandaria Soupitak Pal Ryan McGee Faheem Khan Zeljka antic Ravi Gaikwad Kovur Prashanthi thomas thundat Department of Chemical and Materials Engineering University of Alberta Edmonton T6G 1H9 Canada Department of Chemical Engineering University of California Santa Barbara 93106-5070 USA

this study reports on the mid-infrared （mid-IR） photothermal response of multilayer MoS2 thin films grown on crystalline （p-type silicon and c-axis- oriented single crystal sapphire） and amorphous （Si/SiO2 and Si/SiN） substrates by pulsed laser deposition （PLD）. the photothermal response of the MoS2 films is measured as the changes in the resistance of the MoS2 films when irradiated with a mid-IR （7 to 8.2 μm） source. We show that enhancing the temperature coefficient of resistance （tCR） of the MoS2 thin films is possible by controlling the film-substrate interface through a proper choice of substrate and growth conditions. the thin films grown by PLD are characterized using X-ray diffraction, Raman, atomic force microscopy, X-ray photoelectron microscopy, and transmission electron microscopy. the high-resolution transmission electron microscopy （HRtEM） images show that the MoS2 films grow on sapphire substrates in a layer-by-layer manner with misfit dislocations. the layer growth morphology is disrupted when the films are grown on substrates with a diamond cubic structure （e.g., silicon） because of twin growth formation. the growth morphology on amorphous substrates, such as Si/SiO2 or Si/SiN, is very different. the PLD-grown MoS2 films on silicon show higher tCR （-2.9% K^-1 at 296 K）, higher mid-IR sensitivity （△R/R = 5.2%）, and higher responsivity （8.7 V·W^-1） compared to both the PLD-grown films on other substrates and the mechanically exfoliated MoS2 flakes transferred to different substrates.

关键词： MoS2 pulsed laser deposition phototherrnal effect infrared (IR) detector interface

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Somatostatin receptor scintigraphy in the follow up of neuroendocrine neoplasms of appendix

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World Journal of Clinical Cases 2020年第17期8卷 3697-3707页

作者： Jelena Saponjski Djuro Macut Dragana Sobic-Saranovic Sanja Ognjanovic Ivana Bozic antic Djordje Pavlovic Vera Artiko Center for Nuclear Medicine Clinical Center of SerbiaBelgrade 11000Serbia Clinic for Endocrinology Diabetes and Metabolic DiseasesClinical Center of SerbiaFaculty of MedicineUniversity of BelgradeBelgrade 11000Serbia Center for Nuclear Medicine Clinical Center of Serbia Faculty of Medicine University of BelgradeBelgrade 11000Serbia University Children's Clinic Belgrade 11000Serbia

BACKGROUND Neuroendocrine tumors of appendix(ANEts)known as carcinoids,are rare endocrine neoplasms originated from enterochromaffin cells of gastrointestinal *** are the third most frequent(16.7%)gastrointestinal neuroendocrine tumors,with the incidence of 0.08-0.2 cases/100000 during one *** ANEts occur in 0.2%-0.7%of emergency surgical resections because of suspected appendicitis which is usually the first manifestation of *** there are a lot of papers about application of somatostatin receptor scintigraphy in gastrointestinal neuroendocrine tumors,there are very rare sporadic cases described about ANEts *** to establish the role of somatostatin receptor scintigraphy(SRS)in the management of patients with neuroendocrine tumors of appendix(ANEt).MEtHODS the total of 35 patients was investigated,23 females and 12 males,average age(43.7±17.3 years).All patients had histological diagnosis of ANEt(34 carcinoids of appendix and one tubular carcinoid).Majority of tumors have been found incidentally during surgery of:Acute appendicitis(n=15),perforated appendicitis(n=2),ileus(n=3),hysterectomy(n=3),ruptured ovarian cyst(n=2),caecal volvulus(n=1),while 9 patients had diagnosis of appendiceal tumor before the *** patients had tumor grade(G)G1,12 G2 and 6 *** right hemicolectomy was performed in 13,while the rest of the patients had appendectomy *** was done early(2 h)and late(24 h)after *** of 740 MBq technetium-99 m ethylenediamine-N,N’-diacetic acid Hydrazinonicotinyl-tyr3-Octreotide(technetium-99 m-tektrotyd,Polatom,Poland).SRS was performed for restaging in all the patients after *** there were 12 true positive(tP),19 true negative,3 false positive and 1 false negative SRS *** of the method was 92.31%,specificity was 86.36%,positive predictive value was 80.00%,negative predictive value was 95.00%and accuracy 88.57%.Receiver operating characteristics analysis showed t

关键词： Somatostatin receptor scintigraphy Carcinoid Appendix Follow up Nuclear medicine Radionuclide

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GAtA3是否在区域性转移灶中保持表达:一组原发和转移性尿路上皮癌的配对研究

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临床与实验病理学杂志 2014年第2期30卷 122-122页

作者： Zhao L antic t Witten D 陈远钦余英豪解放军第180医院病理科泉州362000 南京军区福州总医院病理科福州350025

转录因子GAtA3被证实在尿路上皮癌（UC）中高表达，然而GAtA3与UC相关性标志物CD7及p63的表达关系尚未见系统性报道，亦未见GAtA3在区域性转移灶中表达的敏感性评估。本组将69例膀胱肿瘤的原发灶及转移灶相配对制作成高密度组织芯片，包... 详细信息

转录因子GAtA3被证实在尿路上皮癌（UC）中高表达，然而GAtA3与UC相关性标志物CD7及p63的表达关系尚未见系统性报道，亦未见GAtA3在区域性转移灶中表达的敏感性评估。本组将69例膀胱肿瘤的原发灶及转移灶相配对制作成高密度组织芯片，包含48例单纯乳头状、9例平坦型UC，9例具有腺样、小细胞、鳞状、巨细胞及浆样特征的混合性癌，以及3例腺癌。免疫表型：GAtA3在UC原发灶[62／69（90％）]及淋巴结转移灶[64／69（93％）]中表达，在转移灶中的表达强度明显高于原发灶（P=0．03）。

关键词：淋巴结转移灶 GAtA3 尿路上皮癌区域性配对转移性原发灶转录因子

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定量分析多参数前列腺MR影像:鉴别前列腺癌和正常组织,并与Gleason分级关联——一项计算机辅助诊断发展研究

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国际医学放射学杂志 2013年第4期 380-380页

作者： Y. Peng Y. Jiang C. Yang J.B. Brown t. antic I. Sethi 刘学焕 Department of Radiology University of Chicago5841 S Maryland Ave MC2026 ChicagoIL 60637

目的评价通过t2加权、扩散加权和动态对比增强多参数MR成像获得的大量参数用以计算机辅助诊断(CAD)前列腺癌并评价其侵袭性的潜在应用价值。材料与方法本研究经机构审查委员会批准并符合HIPAA标准。通过直肠内线圈获得48例前列腺癌病人... 详细信息

目的评价通过t2加权、扩散加权和动态对比增强多参数MR成像获得的大量参数用以计算机辅助诊断(CAD)前列腺癌并评价其侵袭性的潜在应用价值。材料与方法本研究经机构审查委员会批准并符合HIPAA标准。通过直肠内线圈获得48例前列腺癌病人(年龄44～73岁,中位数62.5岁)接受前列腺切除术前多参数MR影像。一名放射医师和一名病理医师以组织学与MR表现相对照鉴定104个感兴趣区(ROI)(614个癌性ROI,43个正常ROI)。通过线性判别性分析法单独及联合分析第10百分位数、平均表观扩散系数(ADC)值、t2加权信号强度偏态直方图、tofts Ktrans,以受试者操作特征曲线分析曲线下面积(AUC)作为区分癌性灶与正常灶的参考值。计算癌性灶Gleason分级和影像特征间Spearman秩相关系数(r)。结果 AUC(最大似然估计±标准误)值鉴别前列腺癌与正常组织在第10百分位数ADC、平均ADC、t2加权偏态及Ktrans分别为0.92±0.03、0.8±0.03、0.86±0.04和0.69±0.04。联合第10百分位数ADC、平均ADC和t2加权偏态在鉴别前列腺癌与正常组织的AUC值为0.95±0.02。Gleason评分(GS)与第10百分位数ADC(ρ=20.34,P=0.008)、平均ADC(ρ=20.30,P=0.02)和Ktrans(ρ=0.38,P=0.004)中度相关。结论联合第10百分位数ADC、平均ADC和t2加权偏态应用CAD有望鉴别前列腺癌与正常组织。ADC影像特征和Ktrans与GS中度相关。

关键词：前列腺癌偏态 CAD 多参数 Gleason 计算机辅助诊断计算机辅助技术 MR

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Cavernosal nerve functionality evaluation after magnetic resonance imaging-guided transurethral ultrasound treatment of the prostate

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World Journal of Radiology 2015年第12期7卷 521-530页

作者： Steffen Sammet Ari Partanen Ambereen Yousuf Christina L Sammet Emily V Ward Craig Wardrip Marek Niekrasz tatjana antic Aria Razmaria Keyvan Farahani Shunmugavelu Sokka Gregory Karczmar Aytekin Oto Department of Radiology University of Chicago Committee on Medical Physics University of Chicago Department of Medical Imaging Lurie Children’s Hospital Department of Surgery University of Chicago Department of Pathology University of Chicago National Cancer Institute

AIM: to evaluate the feasibility of using therapeutic ultrasound as an alternative treatment option for organconfined prostate cancer. MEtHODS: In this study, a trans-urethral therapeutic ultrasound applicator in combination with 3t magnetic resonance imaging(MRI) guidance was used for realtime multi-planar MRI-based temperature monitoring and temperature feedback control of prostatic tissue thermal ablation in vivo. We evaluated the feasibility and safety of MRI-guided trans-urethral ultrasound to effectively and accurately ablate prostate tissue while minimizing the damage to surrounding tissues in eight canine prostates. MRI was used to plan sonications, monitor temperature changes during therapy, and to evaluate treatment outcome. Real-time temperature and thermal dose maps were calculated using the proton resonance frequency shift technique and were displayed as two-dimensional color-coded overlays on top of the anatomical images. After ultrasound treatment, an evaluation of the integrity of cavernosal nerves was performed during prostatectomy with a nerve stimulator that measured tumescence response quantitatively and indicated intact cavernous nerve functionality. Planned sonication volumes were visually correlated to MRI ablation volumes and corresponding histo-pathological sections after prostatectomy. RESULtS: A total of 16 sonications were performed in 8 canines. MR images acquired before ultrasound treatment were used to localize the prostate and to prescribe sonication targets in all canines. temperature elevations corresponded within 1 degree of the targeted sonication angle, as well as with the width and length of the active transducer elements. the ultrasound treatment procedures were automatically interrupted when the temperature in the target zone reached 56 ℃. In all canines erectile responses were evaluated with a cavernous nerve stimulator post-treatment and showed a tumescence response after stimulation with an electric current. these results i

关键词： Ultrasound therapy thermal tissue ablation Prostate Magnetic resonance imaging guided therapy Intra-operative Histology Validation

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