检索结果-南通市图书馆

Co-doping effects on magnetism and superconductivity in the 112-type EuFeAs2 system

在线全文

学校读者我要写书评

暂无评论

Science China(Physics,Mechanics & Astronomy) 2021年第6期64卷 98-105页

作者： Jia yu tong Liu BinBin Ruan Kang Zhao QingSong yang MengHu Zhou ZhiAn Ren Institute of Physics and Bejing National Laboratory for Condensed Matter Physics Chinese Academy of SciencesBejing 100190China School of Physical Sciences University of Chinese Academy of SciencesBejing 100049China Songshan Lake Materials Laboratory Dongguan 523808China School of Physics Sun Yat-sen UniversityGuangzhou 510275China

the discovery of EuFeAs_(2),currently the only charge-neutral parent phase of the 112-type iron-pnictide system,provides a new platform for the study of elemental doping effects on magnetism and superconductivity(SC).In this study,a series of polycrystalline EuFe_(1-y)Co_(y)As_(2)and Eu_(0.9)Pr_(0.1)Fe_(1-y)Co_(y)As_(2)samples are synthesized through solid-state reaction,and the evolutions of SC and magnetism with Co doping in EuFeAs_(2)and Eu_(0.9)Pr_(0.1)FeAs_(2)are investigated by electrical transport and magnetic susceptibility *** EuFe_(1-y)Co_(y)As_(2),the Eu-related antiferromagnetic(AFM)transition around 40 K is barely affected by Co doping,while the Fe-related spin density wave(SDW)transition temperature drops ***,SC is induced by a trace amount of Co doping,with a highest transition temperature t_(c)~28 K found in EuFe0.9Co0.1As_(2).For the Eu_(0.9)Pr_(0.1)Fe1-yCo_(y)As_(2)series,the magnetism and superconductivity show similar evolutions upon Co doping,and the highest t_(c)is enhanced to 30.6 K with an optimum doping level y~*** results shed light on the competition between SC and SDW with Co doping in the 112-type EuFeAs_(2)system.

关键词： EuFeAs_(2) iron-based superconductors superconductivity magnetism

Influence of the layered Moon and Earth’s orientation on lunar rotation

在线全文

学校读者我要写书评

暂无评论

Research in Astronomy and Astrophysics 2020年第2期20卷 45-52页

作者： yong-Zhang yang Jin-Song Ping Jian-Guo yan Jin-Ling Li State Key Laboratory of Information Engineering in Surveying Mapping and Remote SensingWuhan UniversityWuhan 430070China Instituto de Astronomia y Ciencias Flanetarias de Atacama Universidad de AtacamaCopayapu 485Chile National Astronomical Observatories Chinese Academy of SciencesBeijing 100012China Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China University of Chinese Academy of Sciences Beijing 100049China

One of the most efficient ways to probe the lunar inner structure at present is through the study of its *** and range rate(Doppler) data between the Chang’E-3 lander and station on the Earth were collected from the beginning of the Chang’E-3 lunar mission in *** observation data,taken together with the existing lunar laser ranging data,provide a new approach to extend research on the Earth-Moon *** high precision of current observation data imposes exacting demands,making it necessary to include previously neglected *** this paper,motivated by progress of the Chinese lunar exploration project and to use its data in the near future,two lunar models:a one-layer model and a two-layer model with a fluid core,were applied to the rotational equations based on our implemented algorithm of the Moon’s *** was a difference of about 0.5′′in φ and ψ,but 0.2′′in θ between the two *** result confirms that stratification of the inner structure of the Moon can be inferred from rotation *** also added precise Earth rotation parameters in our model;the results show that this factor is negligible at present,due to the limited precision of the existing *** results will help us understand the rotational process clearly and build a more realistic Earth-Moon model when we combine Lunar Laser Ranging data with high precision radio data to fit lunar motion in the near future.

关键词： Moon rotation model numerical integration Earth orientation parameters

Immu-Mela:An open resource for exploring immunotherapy-related multidimensional genomic profiles in melanoma

在线全文

学校读者我要写书评

暂无评论

Journal of Genetics and Genomics 2021年第5期48卷 361-368页

作者： Jing yang Shilin Zhao Jing Wang Quanhu Sheng Qi Liu yu Shyr Center for Quantitative Sciences Vanderbilt University Medical CenterNashville TN 37203USA Department of Biostatistics Vanderbilt University Medical CenterNashville TN 37203USA

there are increasing studies aimed to reveal genomic hallmarks predictive of immune checkpoint blockade(ICB)treatment response,which generated a large number of data and provided an unprecedented opportunity to identify response-related features and evaluate their robustness across ***,those valuable data sets are not easily accessible to the research *** take full advantage of existing large-scale immuno-genomic profiles,we developed Immu-Mela(http://***/database/Immu-Mela/),a multidimensional immuno-genomic portal that provides interactive exploration of associations between ICB responsiveness and multi-omics features in melanoma,including genetic,transcriptomics,immune cells,and single-cell ***-Mela also enables integrative analysis of any two genomic *** demonstrated the value of Immu-Mela by identifying known and novel genomic features associated with ICB *** addition,Immu-Mela allows users to upload their data sets(unrestricted to any cancer types)and co-analyze with existing data to identify and validate signatures of ***-Mela reduces barriers between researchers and complex genomic data,facilitating discoveries in cancer immunotherapy.

关键词： Immunotherapy PD-1/PD-L1 blockade CtLA-4 blockade Immune checkpoint Multidimensional genomics Biomarker Melanoma

From borophosphate to fluoroborophosphate:a rational design of fluorine-induced birefringence enhancement

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2021年第9期64卷 1498-1503页

作者： Wenyao Zhang Zhizhong Zhang Wenqi Jin Ruonan Zhang Meng Cheng Zhihua yang Shilie Pan CAS Key Laboratory of Functional Materials and Devices for Special Environments Xinjiang Technical Institute of Physics&ChemistryCASXinjiang Key Laboratory of Electronic Information Materials and DevicesUrumqi830011China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing100049China

the introduction of oxofluoride anion into anionic group assists to tune optical properties owing to the change of coordination,electronegativity,and according anionic ***,we proposed a rational design of new compounds by fluorine-driven structure and optical property evolution.A new borophosphate Ba_(2)BP_(3)O_(11)with the monoclinic space group P2_(1/c) has been synthesized in the sealed ***_(2)BP_(3)O_(11)exhibits a rare P-O-P bridge formation,which is the first example in alkaline-earth metal *** further substituting[BO_(4)]^(3-)with[BO_(3)F]^(4-),the first alkaline-earth metal/lead fluoroborophosphates M_(2)BP_(2)O_(8)F(M=Ba and Pb)with the same space group were *** the scissors effect of fluorine,in M_(2)BP_(2)O_(8)F(M=Ba and Pb),a BO_(3)F tetrahedron corner-sharing with three PO_(4)tetrahedra forms 1D chains along the b-axial direction,which are filled by MO_(n)(M=Ba/Pb,n=5,6,8)distorted *** first principles calculation shows that the borophosphate Ba_(2)BP_(3)O_(11)has a birefringence about 0.013@1,064 nm,while the fluoroborophosphates M_(2)BP_(2)O_(8)F(M=Ba and Pb)have the values of 0.035 and 0.043@1,064 nm,*** an apparent enhancement in birefringence is derived from synergies of the oxyfluoride and *** introduction of fluorine-containing heteroanionic groups provides a feasible strategy to design novel promising optical materials.

关键词： borophosphate fluoroborophosphates P-O-P bridges formation birefringence

Sex-determining Region of y Chromosome-related High-mobility-group Box 2 in Malignant tumors： Current Opinions and Anticancer therapy

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2015年第3期128卷 384-389页

作者： Shi-Guang Cao Zong-Juan Ming yu-Ping Zhang Shuan-ying yang Department of Respiratory Medicine Second Affiliated HospitaL Xi'an Jiaotong University Xi'an Shaanxi 710004 China

Objective： to gain insight into the mechanism by which sex-determining region of y chromosome （SRy）-related high-mobility-group box 2 （SOX2） involved in carcinogenesis and cancer stem cells （CSCs）. Data Sources： the data used in this review were mainly published in English from 2000 to present obtained from PubMed. the search terms were ＂SOX2,＂＂cancer,＂＂tumor＂ or ＂CSCs.＂ Study Selection： Articles studying the mitochondria-related pathologic mechanism and treatment of glaucoma were selected and reviewed. Results： SOX2, a transcription factor that is the key in maintaining pluripotent properties of stem cells, is a member of SRV-related high-mobility group domain proteins. SOX2 participates in many biological processes, such as modulation of cell proliferation, regulation of cell death signaling, cell apoptosis, and most importantly, tumor formation and development. Although SOX2 has been implicated in the biology of various tumors and CSCs, the findings are highly controversial, and information regarding the underlying mechanism remains limited. Moreover, the mechanism by which SOX2 involved in carcinogenesis and tumor progression is rather unclear yet. Conclusions： Here, we review the important biological functions of SOX2 in different tumors and CSCs, and the function of SOX2 signaling in the pathobiology ofneoplasia, such as Wnt/β-catenin signaling pathway, Hippo signaling pathway, Survivin signaling pathway, P13K/Akt signaling pathway, and so on. targeting towards SOX2 may be an effective therapeutic strategy for cancer therapy.

关键词： Anticancer therapy Cancer Cancer Stem Cell Signaling Sex-determining Region of y Chromosome-related High-mobility-group Box 2

Gefapixant,a Novel P2X3 Antagonist,Protects against Post Myocardial Infarction Cardiac Dysfunction and Remodeling Via Suppressing NLRP3 Inflammasome

在线全文

学校读者我要写书评

暂无评论

Current Medical Science 2023年第1期43卷 58-68页

作者： yan-zhao WEI Shuang yang Wei LI yan-hong tANG Department of Cardiology Renmin Hospital of Wuhan UniversityWuhan430060China Cardiovascular Research Institute Wuhan UniversityWuhan430060China Hubei Key Laboratory of Cardiology Wuhan430060China Department of Cardiology Wuhan No.1 HospitalWuhan Hospital of Traditional Chinese and Western MedicineWuhan430022China

Objective the AtP responsive P2 purinergic receptors can be subdivided into metabotropic P2X family and ionotropic P2y *** these,P2X3 is a type of P2X receptor which is specifically expressed on nerves,especially on pre-ganglionic sensory *** study investigates whether gefapixant possesses the potential of inhibiting cardiac sympathetic hypersensitivity to protect against cardiac remodeling in the context of myocardial *** the Sprague-Dawley rats were divided randomly into three groups:sham group-myocardial infarction group,and myocardial infarction with gefapixant treatment *** infarction was induced by left anterior descending branch *** gefapixant solution was intraperitoneally injected each time per day for 7 days and the appropriate dosage of gefapixant was determined according to the results of hematoxylin-eosin(HE)staining and myocardial injury *** of cardiac function were assessed by echocardiograph and cardiac fibrosis was evaluated by Western blotting and immunofluorescence staining of collagen I and collagen *** sympathetic innervation was detected by norepinephrine concentration(pg/mL),in-vivo electrophysiology,and typical sympathetic *** cell infiltration was shown from immunofluorescence staining and pro-inflammatory signaling pathway activation was checked by immunohistology,quantitative realtime PCR(qPCR)and Western *** It was found that gefapixant injection of 10 mg/kg per day had the highest dosage-efficacy ***,gefapixant treatment improved cardiac pump function as shown by increased LVEF and LVFS,and decreased LVIDd and *** expression levels of collagen I and collagen III,and tNF-αwere all decreased by P2X3 ***,the decreased activation of nucleotide-binding and oligomerization domain-like receptors family pyrin-domain-containing 3(NLRP3)inflammasome and subsequent cleavage of caspase-1 which modula

关键词： myocardial infarction P2X3 inhibition gefapixant nucleotide-binding and oligomerization domain-like receptors family pyrin-domain-containing 3 inflammasome sympathetic nerve

常规社区管理联合中医健康管理对慢性心力衰竭患者短期预后的改善效果研究

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

重庆医学 2024年第6期53卷 901-905,911页

作者：吴燕婷李萍杨娅鸿黄栗锋上海市胸科医院/上海交通大学医学院附属胸科医院人力资源部上海200030 上海浦东新区光明中医医院院办上海201200 贵州医科大学公共卫生学院贵阳550025 同济大学医学院上海200090

目的研究常规社区管理联合中医健康管理对慢性心力衰竭(CHF)患者短期预后的改善效果。方法选取上海市两家综合性医院和两家中医医院2019年1-12月出院且居住在医院周边3公里内的CHF患者139例,以及按80%比例抽取2019年1-12月于上述医院... 详细信息

目的研究常规社区管理联合中医健康管理对慢性心力衰竭(CHF)患者短期预后的改善效果。方法选取上海市两家综合性医院和两家中医医院2019年1-12月出院且居住在医院周边3公里内的CHF患者139例,以及按80%比例抽取2019年1-12月于上述医院周边3公里内的4所社区卫生服务中心就诊且被三级医院明确诊断的CHF患者141例。共计纳入280例CHF患者,其中排除14例,失访脱落7例,最终259例CHF患者纳入分析。采用实用性临床试验法,将CHF患者根据距离中医医院的远近及个人意愿分入干预组和对照组,于2021年6-12月进行常规社区管理或联合中医健康管理干预。通过调查问卷法,确定常规社区管理联合中医健康管理对患者短期预后和心功能改善效果。结果 259例CHF患者平均年龄为(74±8)岁。经倾向性评分匹配后,共90对患者匹配成功。再入院在基层医疗机构水平上不存在聚集性,干预组患者6个月再入院率低于对照组(χ^(2)=10.414,P=0.001),干预组美国纽约心脏病协会(NyHA)分级总体下降明显,生活质量量表评分和N末端B型利钠肽原(Nt-proBNP)水平改善效果明显优于对照组,差异有统计学意义(P<0.05)。结论常规社区管理联合中医健康管理能改善CHF患者短期预后,为基层提供有效的健康管理策略。

关键词：慢性心力衰竭中医健康管理社区管理倾向性评分

工商资本下乡的多维效应及其发生根源探析——基于湖北省y县的经验调查

在线全文

学校读者我要写书评

暂无评论

华中农业大学学报（社会科学版） 2019年第6期 106-113,164,165页

作者：杨磊华中科技大学公共管理学院

工商资本下乡对“三农”的影响引起了广泛争论,形成了市场效率和小农理性两种具有张力的价值取向。通过对湖北省y县的经验调查,发现工商资本下乡具有增长效应、分化效应、排斥效应和断裂效应,基层政府、工商资本主体和大户主导的农业产... 详细信息

工商资本下乡对“三农”的影响引起了广泛争论,形成了市场效率和小农理性两种具有张力的价值取向。通过对湖北省y县的经验调查,发现工商资本下乡具有增长效应、分化效应、排斥效应和断裂效应,基层政府、工商资本主体和大户主导的农业产业化模式排斥了普通农户参与的经济机会,给乡村政治和治理的稳定性带来了诸多风险。这些效应产生的重要根源在于基层政府在政策资源分配时具有“抓大扶强”的价值追求,工商资本主体“强势分利”的经济逻辑对普通农户具有排斥性,而资源禀赋不足的普通农户则坚守着“小农理性”的生计原则,结果便是普通农户与工商资本主体间利益联结机制的失衡。在乡村振兴和城乡融合发展的新时代背景下,既要利用工商资本推动农业产业化转型,也要重视小农经济的内生发展,充分保护农村社会“蓄水池”的承载功能。

关键词：资本下乡多维效应农民分化小农理性

在线全文

学校读者我要写书评

暂无评论

共振相干激发的最新实验研究(英文)

原子核物理评论 2002年第2期19卷 213-217页

作者： toshiyuki Azuma t.Ito y.takabayashi C.Kondo K.Komaki y.yamazaki y.yamazaki E.takada t.Murakami 东京Metropolitan大学物理系东京大学艺术与科学研究院物理研究所理化研究所原子物理实验室国立放射科学研究所

在满足沟道效应条件下 ,高能离子在穿过晶体时 ,离子穿过的是周期性的原子序列或者有序平面阵列 .在入射离子的坐标系中 ,离子感受到一种振动场的作用 .如果与此振动频率相关的能量与离子的电子态跃迁能量相匹配 ,则离子有可能被激发 ,... 详细信息

在满足沟道效应条件下 ,高能离子在穿过晶体时 ,离子穿过的是周期性的原子序列或者有序平面阵列 .在入射离子的坐标系中 ,离子感受到一种振动场的作用 .如果与此振动频率相关的能量与离子的电子态跃迁能量相匹配 ,则离子有可能被激发 ,这种现象就称为共振相干激发 (RCE) .1998年 ,成功地观测到了类氢Ar17+ 离子以相对论速度穿过Si晶体时 ,其 1s电子到n =2态的共振激发 .此后 ,有关出射离子电荷态分布以及退激X射线谱的实验研究取得了很大进展 ,近期的实验研究还观测到了类氢离子的 1s电子到更高电子态 (n =3,4 ,5 )的RCE和更重离子的RCE ,以及类氦离子的RCE .这些实验结果有助于详细研究这种共振现象 .实验结果表明 ,RCE也能够作为研究高精度原子谱学的一种潜在的工具 .

关键词：共振相干激发实验研究沟道重离子原子物理学高能离子振动频率