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Numerical analysis of the effects of vesicle distribution characteristics on the engineering properties of volcanic rocks

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Journal of Rock Mechanics and Geotechnical Engineering 2023年第12期15卷 3094-3104页

作者： P.L.P.Wasantha Z.Heng t.xu College of Sport Health and EngineeringVictoria UniversityMelbourneVIC3011Australia Institute for Sustainable Industries and Liveable Cities Victoria UniversityMelbourneVIC3011Australia Center for Rock Instability and Seismicity Research Northeastern UniversityShenyang110819China

Vesicles can be of different sizes and shapes and can be randomly distributed within vesicular volcanic rocks. this study investigates the variation of engineering properties of vesicular rocks due to the changes in vesicle distribution characteristics for different cases of bulk porosity and vesicle diameter using a systematic numerical simulation program using the finite element method-based rock failure process analysis (RFPA) software. Models with uniform-size vesicles and combinations of different proportions of different-sized vesicles were considered to resemble natural vesicular rocks more closely, and ten different random vesicle distributions were tested for each case. Increasing bulk porosity decreased the uniaxial compressive strength (UCS) and elastic modulus of the specimens, and the specimens with the lowest bulk porosity showed the greatest range of UCS values in the case of uniform-size vesicles. the effect of vesicle diameter on UCS showed an unsystematic response which was understood to be a result of different vesicle distribution patterns, some of which facilitated a shear failure. Specimens with multiple-size vesicles in different proportions revealed that the variation of UCS due to vesicle distribution characteristics is minimum when the bulk porosity is equally shared by different size vesicles. In addition, when the proportion of smaller-sized vesicles is higher, UCS showed an increase compared to that of the equal proportion of different size vesicles case at low porosities, but a decrease at higher porosities. Variation of elastic modulus showed minor, unsystematic fluctuations as a function of vesicle diameter and different proportions of different-sized vesicles, and the range for different vesicle distribution patterns was narrow in general. Overall, the findings of this study recommend cautious use of the engineering properties determined through a limited number of laboratory tests on vesicular rocks.

关键词： Vesicular rocks Porosity Vesicle size and distribution Numerical simulation Mechanical characteristics

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HIGH-CURRENt PULSED ELECtRON BEAM: RAPID SURFACE ALLOYING AND WEAR RESIStANCE IMPROVEMENt

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Acta Metallurgica Sinica(English Letters) 2003年第4期16卷 276-282页

作者： J.xu H.W.Liu Z.R.Zhou C.Dong A.M.Wu S.Z.Hao A.M.Zhang t.xu tribologyResearchInstitute SouthwestJiaotongUniversityChengdu610031ChinaManuscriptreceived25November2002 StateKeyLab.forMaterialsModificationbyLaser IonandElectronBeamsDalianUniversityofTech-nologyDalian116024China StateKeyLaboratoryofSolidLubrication LanzhouInstituteofChemicalPhysicsTheChineseAcademyofSciencesLanzhou730000China

the present paper reports the rapid surface alloying induced by the bombardment of high-current pulsed electron beam. two kinds of substrate materials were examined to show this effect. the first sample was a pure Al metal pre-coated with fine carbon powders prior to the bombardment, and the second alloy is the D2-Crl2MolVl mould steel pre-coated with Cr, ti, and tiN powders. the surface elements diffuse about several micrometers into the substrate materials only after several bombardments. tribological behaviors of these samples were characterized and significant improvement in wear resistance was found. Finally, a tEM analysis reveals the presence of stress waves generated by coupled thermal and stress fields, which was considered as the main cause of the enhanced properties.

关键词： high-current pulsed electron beam surface alloying tribology fretting wear

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Solid-state alloying of Al-Mg alloys by accumulative roll-bonding:Microstructure and properties

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Journal of Materials Science & technology 2022年第30期125卷 238-251页

作者： X.M.Mei Q.S.Mei J.Y.Li C.L.Li L.Wan F.Chen Z.H.Chen t.xu Y.C.Wang Y.Y.tan School of Power and Mechanical Engineering Wuhan UniversityWuhan 430072China Key Laboratory of Hydraulic Machinery transients(Wuhan University) Ministry of EducationWuhan 430072China School of Mechanical Engineering Wuhan Polytechnic UniversityWuhan 430023China

In this study,a novel solid-state alloying approach was adopted to fabricate Al-Mg alloys with high Mg contents(C_(Mg)) by accumulative roll-bonding(ARB)of Al and Mg elemental materials to ultrahigh *** results showed that the degree of alloying increased with the increase of ARB cycles and a supersaturatedα-Al solid solution accompanied with nanoprecipitates was formed in the Al-Mg alloys by ARB to 70 *** as-prepared Al-Mg alloys exhibited enhanced mechanical properties,with a maximum tensile strength of∼615 MPa and a tensile elongation of∼10%at C_(Mg)=13 wt.%.the high strength can be attributed to different mechanisms,namely solid solution strengthening,grain boundary strengthening,dislocation strengthening,and precipitation *** Al-Mg alloys showed increased work hardening with increasing C_(Mg),due to the enhanced formation of ***,no obvious drop in the intergranular corrosion(IGC)resistance was found in the Al-Mg alloys with C_(Mg) up to 13 wt.%.Moreover,sensitization treatment was found to induce little decrease in the IGC resistance of the Al-Mg alloys with C_(Mg)≤13 wt.%.We found that the excellent IGC resistance was due to the suppression of grain boundary precipitation by the preferred formation of precipitates within the grains that were induced by *** study indicated the novelty of the present solid-state alloying approach to achieving a superior combination of high mechanical properties and IGC resistance in Al-Mg alloys.

关键词： Solid-state alloying Al-Mg alloys Mechanical properties IGC resistance ARB

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浙江花岗岩的工程岩石学研究(英文)

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地质与资源 2005年第3期14卷 176-180页

作者： Moustafa El Omella1 C.A.tang t.xu 东北大学岩石破裂诱发地震研究中心

对浙江省花岗岩的岩相学特征及力学性质进行了研究以确定它们之间的关系.矿物学研究显示出花岗岩的交代蚀变特征,这可以反映在岩石的力学性质上.岩石材料的物理性质决定其工程学性质,在相关定量参数确定的情况下,可以预测岩石材料的工... 详细信息

对浙江省花岗岩的岩相学特征及力学性质进行了研究以确定它们之间的关系.矿物学研究显示出花岗岩的交代蚀变特征,这可以反映在岩石的力学性质上.岩石材料的物理性质决定其工程学性质,在相关定量参数确定的情况下,可以预测岩石材料的工程学性质.镜下观察、硬度、密度、孔隙度及点负荷强度均可作为所研究花岗岩的定量参数.上述每个因素都可提供岩石工程学的可靠预测.岩石的物理性质受岩石成分及蚀变状态控制,而岩石的工程学性质和力学特征是其物理性质的函数.

关键词：花岗岩工程岩石学岩相学蚀变矿物浙江省

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Studies of laser-plasma interaction physics with low-density targets for direct-drive inertial confinement fusion on the Shenguang III prototype

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Matter and Radiation at Extremes 2021年第2期6卷 54-66页

作者： V.t.tikhonchuk t.Gong N.Jourdain O.Renner F.P.Condamine K.Q.Pan W.Nazarov L.Hudec J.Limpouch R.Liska M.Krus F.Wang D.Yang S.W.Li Z.C.Li Z.Y.Guan Y.G.Liu t.xu X.S.Peng X.M.Liu Y.L.Li J.Li t.M.Song J.M.Yang S.E.Jiang B.H.Zhang W.Y.Huo G.Ren Y.H.Chen W.Zheng Y.K.Ding K.Lan S.Weber ELI-Beamlines Institute of PhysicsCzech Academy of Sciences25241 Dolni BrezanyCzech Republic Centre Lasers Intenses et Applications University of Bordeaux-CNRS-CEA33405 TalenceFrance Laser Fusion Research Center China Academy of Engineering PhysicsMianyang 621900China Institute of Plasma Physics Czech Academy of Sciences18200 PragueCzech Republic Independent Foam target Supplier CarnoustieDD76DPUnited Kingdom Faculty of Nuclear Sciences and Physical Engineering Czech Technical University in Prague11519 PragueCzech Republic Institute of Applied Physics and Computational Mathematics Beijing 100088China Center for Applied Physics and technology Peking UniversityBeijing 100871China School of Science Xi’an Jiaotong UniversityXi’an 710049China

the physics of laser-plasma interaction is studied on the Shenguang III prototype laser facility under conditions relevant to inertial confinement fusion designs.A sub-millimeter-size underdense hot plasma is created by ionization of a low-density plastic foam by four high-energy(3.2 kJ)laser *** interaction beam is fired with a delay permitting evaluation of the excitation of parametric instabilities at different stages of plasma *** diagnostics are used for plasma characterization,scattered radiation,and accelerated *** experimental results are analyzed with radiation hydrodynamic simulations that take account of foam ionization and *** measured level of stimulated Raman scattering is almost one order of magnitude larger than that measured in experiments with gasbags and hohlraums on the same installation,possibly because of a greater plasma *** amplification is achieved in high-intensity speckles,indicating the importance of implementing laser temporal smoothing techniques with a large bandwidth for controlling laser propagation and absorption.

关键词： density. interaction scattered

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C-X-C chemokine receptor type 5+CD8+t cells as immune regulators in hepatitis Be antigen-positive chronic hepatitis B under interferonalpha treatment

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World Journal of Gastroenterology 2025年第3期31卷 73-83页

作者： Zhen-Yu xu Zhong-Shang Dai Guo-Zhong Gong Min Zhang Department of Infectious Diseases Second Xiangya HospitalCentral South UniversityChangsha 410011Hunan ProvinceChina Institute of Hepatology and Department of Infectious Diseases The Second Xiangya HospitalCentral South UniversityChangsha 410011Hunan ProvinceChina

BACKGROUND C-X-C chemokine receptor type 5(CXCR5)+CD8+t cells represent a unique immune subset with dual roles,functioning as cytotoxic cells in persistent viral infections while promoting B cell *** their importance,the specific role of CXCR5+CD8+t cells in chronic hepatitis B(CHB),particularly during interferon-alpha(IFN-α)treatment,is not fully *** study aims to elucidate the relationship between CXCR5+CD8+t cells and sustained serologic response(SR)in patients undergoing 48 weeks of pegylated IFN-α(peg-IFN-α)treatment for *** to elucidate the relationship between CXCR5+CD8+t cells and sustained SR in patients undergoing 48 weeks of peg-IFN-αtreatment for *** this study enrolled 60 patients with hepatitis Be antigen(HBeAg)-positive CHB undergoing 48 weeks of peg-IFN-α*** were assessed for eligibility based on criteria such as persistent HBsAg-positive status for at least six months,HBeAb-negative,hepatitis B virus DNA levels exceeding 2×104 copies/mL,and alanine aminotransferase(ALt)levels between 2 and 10 times the upper limit of *** samples were collected at baseline and at weeks 12,24,48,and a 24-week treatment-free follow-up(week 72)to measure serum interleukin(IL)-21 concentration via ELISA and to analyze CXCR5 and programmed death-ligand 1(PD-L1)expression on CD8+t cells by flow cytometry,CXCR5 is a chemokine receptor that directs immune cells to specific tissues,while PD-L1 is a protein that regulates immune responses by inhibiting t cell *** Patients with CHB exhibited significantly lower levels of circulating CXCR5+CD8+t cells compared to healthy controls(Ptably,CXCR5+CD8+t cells were prominently expressed in patients who achieved sustained SR compared to non-SR(NSR).A significant correlation was observed between CXCR5 and PD-L1 expression(r=-0.189,P=0.002).However,there was no significant correlation between serum IL-21 levels and CXCR5+CD8+lymphocytes(r=-0.03,P=0.62

关键词： C-X-C chemokine receptor type 5 Programmed death-ligand 1 Interleukin-21 Pegylated interferon-alpha Chronic hepatitis B

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基于MRI影像分析咀嚼肌间隙受侵对鼻咽癌病人预后评估的价值

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国际医学放射学杂志 2014年第6期 585-585页

作者： G.Y.Zhang Y.Huang X.Y.Cai X.P.Chen t.xu Y.J.Wang 冉淑华 Cancer Center Cancer Research InstituteFoshan HospitalSun Yat-sen University

摘要目的探讨基于MRI影像分析鼻咽癌病人咀嚼肌间隙受侵的方法并研究其在评估接受调强放疗的病人预后的价值。材料与方法本研究经伦理委员会通过,所有受试者

关键词：咀嚼肌间隙受侵 MRI 影像分析病人鼻咽癌

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Increased excitatory amino acid transporter 2 levels in basolateral amygdala astrocytes mediate chronic stress–induced anxiety-like behavior

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Neural Regeneration Research 2025年第6期20卷 1721-1734页

作者： Xirong xu Shoumin xuan Shuai Chen Dan Liu Qian Xiao Jie tu Shenzhen Key Laboratory of Neuroimmunomodulation for Neurological Diseases Shenzhen-Hong Kong Institute of Brain ScienceShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong ProvinceChina CAS Key Laboratory of Brain Connectome and Manipulation Brain Cognition and Brain Disease Institute(BCBDI)Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong ProvinceChina Guangdong Provincial Key Laboratory of Brain Connectome and Behavior the Brain Cognition and Brain Disease Institute(BCBDI)Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong ProvinceChina University of Chinese of Academy of Sciences BeijingChina Faculty of Life and Health Sciences Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong ProvinceChina

the conventional perception of astrocytes as mere supportive cells within the brain has recently been called into question by empirical evidence, which has revealed their active involvement in regulating brain function and encoding behaviors associated with ***, astrocytes in the basolateral amygdala have been found to play a role in the modulation of anxiety-like behaviors triggered by chronic stress. Nevertheless, the precise molecular mechanisms by which basolateral amygdala astrocytes regulate chronic stress–induced anxiety-like behaviors remain to be fully elucidated. In this study, we found that in a mouse model of anxiety triggered by unpredictable chronic mild stress, the expression of excitatory amino acid transporter 2 was upregulated in the basolateral amygdala. Interestingly, our findings indicate that the targeted knockdown of excitatory amino acid transporter 2 specifically within the basolateral amygdala astrocytes was able to rescue the anxiety-like behavior in mice subjected to stress. Furthermore, we found that the overexpression of excitatory amino acid transporter 2 in the basolateral amygdala, whether achieved through intracranial administration of excitatory amino acid transporter 2agonists or through injection of excitatory amino acid transporter 2-overexpressing viruses with GfaABC1D promoters, evoked anxiety-like behavior in mice. Our single-nucleus RNA sequencing analysis further confirmed that chronic stress induced an upregulation of excitatory amino acid transporter 2 specifically in astrocytes in the basolateral amygdala. Moreover, through in vivo calcium signal recordings, we found that the frequency of calcium activity in the basolateral amygdala of mice subjected to chronic stress was higher compared with normal *** knocking down the expression of excitatory amino acid transporter 2 in the basolateral amygdala, the frequency of calcium activity was not significantly increased, and anxiety-like behavior was ob

关键词： anxiety astrocytes basolateral amygdala behavior dihydrokainic acid excitatory amino acid transporter 2 fiber photometry glutamate LDN-212320 transporter

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Peripheral blood RNA biomarkers can predict lesion severity in degenerative cervical myelopathy

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Neural Regeneration Research 2025年第6期20卷 1764-1775页

作者： Zhenzhong Zheng Jialin Chen Jinghong xu Bin Jiang Lei Li Yawei Li Yuliang Dai Bing Wang Department of Spine Surgery The Second Xiangya Hospital of Central South UniversityChangshaHunan ProvinceChina

Degenerative cervical myelopathy is a common cause of spinal cord injury,with longer symptom duration and higher myelopathy severity indicating a worse *** numerous studies have investigated serological biomarkers for acute spinal cord injury,few studies have explored such biomarkers for diagnosing degenerative cervical *** study involved 30 patients with degenerative cervical myelopathy(51.3±7.3 years old,12 women and 18 men),seven healthy controls(25.7±1.7 years old,one woman and six men),and nine patients with cervical spondylotic radiculopathy(51.9±8.6 years old,three women and six men).Analysis of blood samples from the three groups showed clear differences in transcriptomic *** analysis identified 128 differentially expressed genes that were enriched in patients with neurological *** least absolute shrinkage and selection operator analysis,we constructed a five-gene model(tBCD,tPM2,PNKD,EIF4G2,and AP5Z1)to diagnose degenerative cervical myelopathy with an accuracy of 93.5%.One-gene models(tCAP and SDHA)identified mild and severe degenerative cervical myelopathy with accuracies of 83.3%and 76.7%,*** of two immune cell types(memory B cells and memory-activated CD4^(+)t cells)predicted levels of lesions in degenerative cervical myelopathy with 80%*** results suggest that peripheral blood RNA biomarkers could be used to predict lesion severity in degenerative cervical myelopathy.

关键词： biomarkers candidate genes degenerative cervical myelopathy gene expression analysis immune cell types neurological disabilities peripheral blood RNA profiles spinal cord injury

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Search for electron-antineutrinos associated with gravitational-wave events GW150914,GW151012,GW151226,GW170104,GW170608,GW170814,and GW170817 at Daya Bay

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Chinese Physics C 2021年第5期45卷 190-201页

作者： F.P.An A.B.Balantekin H.R.Band M.Bishai S.Blyth G.F.Cao J.Cao J.F.Chang Y.Chang H.S.Chen S.M.Chen Y.Chen Y.X.Chen J.Cheng Z.K.Cheng J.J.Cherwinka M.C.Chu J.P.Cummings O.Dalager F.S.Deng Y.Y.Ding M.V.Diwan t.Dohnal J.Dove M.Dvorak D.A.Dwyer J.P.Gallo M.Gonchar G.H.Gong H.Gong W.Q.Gu J.Y.Guo L.Guo X.H.Guo Y.H.Guo Z.Guo R.W.Hackenburg S.Hans M.He K.M.Heeger Y.K.Heng A.Higuera Y.K.Hor Y.B.Hsiung B.Z.Hu J.R.Hu t.Hu Z.J.Hu H.X.Huang X.t.Huang Y.B.Huang P.Huber D.E.Jaffe K.L.Jen X.L.Ji X.P.Ji R.A.Johnson D.Jones L.Kang S.H.Kettell S.Kohn M.Kramer t.J.Langford J.Lee J.H.C.Lee R.t.Lei R.Leitner J.K.C.Leung F.Li J.J.Li Q.J.Li S.Li S.C.Li W.D.Li X.N.Li X.Q.Li Y.F.Li Z.B.Li H.Liang C.J.Lin G.L.Lin S.Lin J.J.Ling J.M.Link L.Littenberg B.R.Littlejohn J.C.Liu J.L.Liu C.Lu H.Q.Lu J.S.Lu K.B.Luk X.B.Ma X.Y.Ma Y.Q.Ma C.Marshall D.A.Martinez Caicedo K.t.MeDonald R.D.McKeown Y.Meng J.Napolitano D.Naumov E.Naumova J.P.Ochoa-Ricoux A.OIshevskiy H.-R.Pan J.Park S.Patton J.C.Peng C.S.J.Pun F.Z.Qi M.Qi X.Qian N.Raper J.Ren C.Morales Reveco R.Rosero B.Roskovec X.C.Ruan H.Steiner J.L.Sun t.tmej K.treskov W.-H.tse C.E.tull B.Viren V.Vorobel C.H.Wang J.Wang M.Wang N.Y.Wang R.G.Wang W.Wang W.Wang X.Wang Y.Wang Y.F.Wang Z.Wang Z.Wang Z.M.Wang H.Y.Wei L.H.Wei L.J.Wen K.Whisnant C.G.White H.L.H.Wong E.Worcester D.R.Wu F.L.Wu Q.Wu W.J.Wu D.M.Xia Z.Q.Xie Z.Z.Xing J.L.xu t.xu t.xue C.G.Yang L.Yang Y.Z.Yang H.F.Yao M.Ye M.Yeh B.L.Young H.Z.Yu Z.Y.Yu B.B.Yue S.Zeng Y.Zeng L.Zhan C.Zhang F.Y.Zhang H.H.Zhang J.W.Zhang Q.M.Zhang X.t.Zhang Y.M.Zhang Y.X.Zhang Y.Y.Zhang Z.J.Zhang Z.P.Zhang Z.Y.Zhang J.Zhao L.Zhou H.L.Zhuang J.H.Zou Instiute of Modern Physics East China University of Science and TechnologyShanghai 200237 University of Wisconsin MadisonWisconsin 53706 Wright Laboratory and Department of Physics Yale UniversityNew HavenConnecticut 06520 Brookhaven National Laboratory UptonNew York 11973 Department of Physics National Taiwan UniversityTaipei Institute of High Energy Physics Beijing 100049 National United University Miao-Li Department of Engineering Physics Tsinghua UniversityBejing 100084 Shenzhen University Shenzhen 518060 Sun Yat-Sen(Zhongshan)University Guangzhou North China Electric Power University Bejjing 102206 Chinese University of Hong Kong Hong Kong 999077 Siena College LoudonvilleNew York 12211 Department of Physics and Astronomy University of CaliforniaIrvineCaliformia 92697 University of Science and technology of China Hefei 230026 Charles University Faculty of Mathematics and PhysicsPrague Department of Physics University of llinois at Urbana-ChampaignUrbanaIlinois 61801 Lawrence Berkeley National Laboratory BerkeleyCalifornia 94720 Department of Physics Illinois Institute of TechnologyChicagoIllinois 60616 Joint Institute for Nuclear Research DubnaMoscow Region Beijing Normal University Beijing 100875 Department of Nuclear Science and technology School of Energy and Power EngineeringXi'an Jiaotong UniversityXi'an 710049 Department of Physics University of HoustonHoustonTexas 77204 China Institute of Atomic Energy Beijing 102413 Shandong University Jinan 250100 Guangxi University Nanning 530004 Center for Neutrino Physics Virginia TechBlacksburgVirginia 24061 Institute of Physics National Chiao-Tung UniversityHsinchu Department of Physics University of CincinnatiCincinnatiOhio 45221 Department of Physies Collge of Science and TechnologyTemple UniversityPhiladelphiaPennsylvania 19122 Dongguan University of technology Dongguan 523808 Department of Physics University of CaliforniaBerkeleyCalifornia 94720 Department of Physics The University of Hong KongPokfulamHong Kong 999077 School

the establishment of a possible connection between neutrino emission and gravitational-wave(GW)bursts is important to our understanding of the physical processes that occur when black holes or neutron stars *** the Daya Bay experiment,using the data collected from December 2011 to August 2017,a search was per-formed for electron-antineutrino signals that coincided with detected GW events,including GW150914,GW151012,GW151226,GW170104,GW170608,GW 170814,and GW *** used three time windows of±10,±500,and±1000 s relative to the occurrence of the GW events and a neutrino energy range of 1.8 to 100 MeV to search for correlated neutrino *** detected electron-antineutrino candidates were consistent with the expected background rates for all the three time *** monochromatic spectra,we found upper limits(90%confidence level)of the electron-antineutrino fluence of(1.13-2.44)×10^(11)cm^(-2)at 5 MeV to 8.0×10^(7)cm^(-2)at 100 MeV for the three time w *** the assumption of a Fermi-Dirac spectrum,the upper limits were found to be(5.4-7.0)×10^(9)cm^(2)for the three time windows.

关键词： grav itational waves electron-antineutrinos fluence upper limit

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