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Robust AUC maximization for classification with pairwise confidence comparisons

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Frontiers of Computer Science 2024年第4期18卷 73-83页

作者： Haochen SHI Mingkun XIE Shengjun huang College of Computer Science and technology Nanjing University of Aeronautics and AstronauticsNanjing 211106China College of Electronic and Information Engineering Nanjing University of Aeronautics and AstronauticsNanjing 211106China MIIt Key Laboratory of Pattern Analysis and Machine Intelligence Nanjing 211106China

Supervised learning often requires a large number of labeled examples,which has become a critical bottleneck in the case that manual annotating the class labels is *** mitigate this issue,a new framework called pairwise comparison(Pcomp)classification is proposed to allow training examples only weakly annotated with pairwise comparison,i.e.,which one of two examples is more likely to be *** previous study solves Pcomp problems by minimizing the classification error,which may lead to less robust model due to its sensitivity to class *** this paper,we propose a robust learning framework for Pcomp data along with a pairwise surrogate loss called *** provides an unbiased estimator to equivalently maximize AUC without accessing the precise class ***,we prove the consistency with respect to AUC and further provide the estimation error bound for the proposed *** studies on multiple datasets validate the effectiveness of the proposed method.

关键词： method pairwise weakly

Recent progress in side chain engineering of Y-series non-fullerene molecule and polymer acceptors

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Science China Chemistry 2024年第3期67卷 788-805页

作者： Li tian Chunchen Liu Fei huang School of Materials Science and Engineering Henan University of TechnologyZhengzhou 450001China Institute of Polymer Optoelectronic Materials and Devices State Key Laboratory of Luminescent Materials and DevicesSouth China University of TechnologyGuangzhou 510640China

Organic solar cells(OSCs) have drawn considerable attention in the last decade due to the great potential of light weight,flexibility, and low-cost solution processing. Particularly, Y-series non-fullerene acceptors(NFAs) including small molecular acceptors(SMAs) and polymerized small molecular acceptors(PSMAs) have become research hot spots due to their excellent power conversion efficiency. Side chain engineering is crucial to adjust the solubility and crystallinity of NFAs, which will significantly affect the morphology of active layers and the efficiency of OSCs. However, the understanding of side chain engineering on NFAs is still limited and lacks a systematic review. this review aims to provide a brief summary of the recent developments in side chain engineering of NFAs, with a special focus on the design and application of Y-series SMAs and PSMAs for high-efficiency non-fullerene organic solar cells(NF-OSCs). In addition, the review also points out challenges and provides useful guidance regarding side chain regulation for Y-series NFAs.

关键词： organic solar cell Y-series non-fullerene acceptors side chain engineering

wNt7A promotes tumorigenesis of head and neck squamous cell carcinoma via activating FZD7/JAK1/StAt3 signaling

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International Journal of Oral Science 2024年第1期16卷 85-96页

作者： Qingling huang Yi Xiao ting Lan Youguang Lu Li huang Dali Zheng Department of Biochemistry and Molecular Biology School of Basic Medical SciencesFujian Medical UniversityFuzhouChina Fujian Key Laboratory of Oral Diseases School and Hospital of StomatologyFujian Medical UniversityFuzhouChina Department of Preventive Dentistry School and Hospital of StomatologyFujian Medical UniversityFuzhouChina Department of Dentistry The First Affiliated Hospital of Fujian Medical UniversityFuzhouChina

wnt signaling are critical pathway involved in organ development, tumorigenesis, and cancer progression. wNt7A, a member of the wnt family, remains poorly understood in terms of its role and the underlying molecular mechanisms it entails in head and neck squamous cell carcinoma (HNSCC). According to the Cancer Genome Atlas (tCGA), transcriptome sequencing data of HNSCC, the expression level of wNt7A in tumors was found to be higher than in adjacent normal tissues, which was validated using Real-time Rt-PCR and immunohistochemistry. Unexpectedly, overexpression of wNt7A did not activate the canonical wnt-β-catenin pathway in HNSCC. Instead, our findings suggested that wNt7A potentially activated the FZD7/JAK1/StAt3 signaling pathway, leading to enhanced cell proliferation, self-renewal, and resistance to apoptosis. Furthermore, in a patient-derived xenograft (PDX) tumor model, high expression of wNt7A and phosphorylated StAt3 was observed, which positively correlated with tumor *** findings underscore the significance of wNt7A in HNSCC progression and propose the targeting of key molecules within the FZD7/JAK1/StAt3 pathway as a promising strategy for precise treatment of HNSCC.

关键词： wNt squamous tumorigenesis

Mechanism of acupuncture in attenuating cerebral ischaemia-reperfusion injury based on nuclear receptor coactivator 4 mediated ferritinophagy

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Journal of traditional Chinese Medicine 2024年第2期44卷 345-352页

作者： ZHANG Xinchang huang Zheng huang Peiyan YANG Mengning ZHANG Zhihui NI Guangxia College of Acupuncture-Moxibustion and tuina Nanjing University of Chinese MedicineNanjing 210023China Key Laboratory of Acupuncture and Medicine Research of Ministry of Education Nanjing University of Chinese MedicineNanjing 210023China

OBJECtIVE:to explore the effect of acupuncture treatment on cerebral ischaemia-reperfusion injury(CIRI)and reveal the underlying mechanism of the effect based on nuclear receptor coactivator 4(NCOA4)mediated ***:Sprague-Dawley male rats were divided into four groups:the sham group,model group,acupuncture group,and sham acupuncture *** 2 h of middle cerebral artery occlusion(MCAO),reperfusion was performed for 24 h to induce *** rats were treated with acupuncture at the Neiguan(PC6)and Shuigou(GV26)*** neurological function was evaluated by taking their Bederson scores at 2 h after ischaemia and 24 h after *** chloride staining was applied to assess the cerebral infarct volume at 24 h after *** malondialdehyde(MDA)and ferrous iron(Fe^(2+))levels were observed after 24 h of reperfusion using an assay *** blotting was performed to detect the expression of NCOA4 and ferritin heavy chain 1(FtH1)at 24 h after ***,the colocalization of ferritin with neurons,NCOA4 with microtubule-associated protein 1 light chain 3(LC3),and NCOA4 with ferritin was visualized using immunofluorescence ***:Acupuncture significantly improved neurological function and decreased cerebral infarct volume in the acupuncture *** CIRI,the expression of NCOA4,LC3 and FtH1 was increased,which enhanced ferritinophagy and induced an inappropriate accumulation of Fe^(2+)and MDA in the ischaemic ***,acupuncture dramatically downregulated the expression of NCOA4,LC3 and FtH1,inhibited the overactivation of ferritinophagy,and decreased the levels of MDA and Fe^(2+).CONCLUSIONS:Acupuncture can inhibit NCOA4-mediated ferritinophagy and protect neurons against CIRI in a rat model.

关键词： acupuncture ferritinophagy ferroptosis ferritin nuclear receptor coactivator 4 cerebral ischaemia-reperfusion injury

triad-displaced ULAs configuration for non-circular sources with larger continuous virtual aperture and enhanced degrees of freedom

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Journal of Systems Engineering and Electronics 2024年第1期35卷 81-93页

作者： SHAIKH Abdul Hayee DANG Xiaoyu huang Daqing College of Electronic and Information Engineering Nanjing University of Aeronautics and AstronauticsNanjing 211106China

Non-uniform linear array(NULA)configurations are well renowned due to their structural ability for providing increased degrees of freedom(DOF)and wider array aperture than uniform linear arrays(ULAs).these characteristics play a significant role in improving the direction-of-arrival(DOA)estimation ***,most of the existing NULA geometries are primarily applicable to circular sources(CSs),while they limitedly improve the DOF and continuous virtual aperture for noncircular sources(NCSs).toward this purpose,we present a triaddisplaced ULAs(tdis-ULAs)configuration for *** tdisULAs structure generally consists of three ULAs,which are appropriately *** proposed antenna array approach fully exploits the non-circular characteristics of the *** the same number of elements,the tdis-ULAs design achieves more DOF and larger hole-free co-array aperture than its sparse array ***,the number of uniform DOF,optimal distribution of elements among the ULAs,and precise element positions are uniquely determined by the closed-form ***,the proposed array also produces a filled resulting *** simulations are conducted to show the performance advantages of the proposed tdis-ULAs configuration over its counterpart designs.

关键词： direction-of-arrival(DOA)estimation sparse array non-circular source(NCS) sum co-array difference co-array degrees of freedom(DOF)

Risk Assessment of Deep-water Horizontal X-tree Installation

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China Ocean Engineering 2024年第2期38卷 210-220页

作者： MENG wen-bo FU Guang-ming huang Yi LIU Shu-jie huang Liang GAOYong-hai CNOOC China Limited Zhanjiang BranchZhanjiang 524057China Key Laboratory of Unconventional Oil and Gas Development Ministry of Education(China University of Petroleum(East China))Qingdao 266580China

Due to the high potential risk and many influencing factors of subsea horizontal X-tree installation,to guarantee the successful completion of sea trials of domestic subsea horizontal X-trees,this paper established a modular risk evaluation model based on a fuzzy fault ***,through the analysis of the main process oftree down and combining the Offshore&Onshore Reliability Data(OREDA)failure statistics and the operation procedure and the data provided by the job,the fault tree model of risk analysis of the tree down installation was ***,by introducing the natural language of expert comprehensive evaluation and combining fuzzy principles,quantitative analysis was carried out,and the fuzzy number was used to calculate the failure probability of a basic event and the occurrence probability of a top ***,through a sensitivity analysis of basic events,the basic events of top events significantly affected were determined,and risk control and prevention measures for the corresponding high-risk factors were proposed for subsea horizontal X-tree down installation.

关键词： subsea horizontal X-tree risk assessment fuzzy fault tree modular risk evaluation model

Percarbonate activation catalyzed by nanoblocks of basic copper molybdate for antibiotics degradation: High performance, degradation pathways and mechanism

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Chinese Chemical Letters 2024年第10期35卷 401-404页

作者： Xiaotao Jin Yanlan wang Yingping huang Di huang Xiang Liu Engineering Research Center of Eco-Environment in three Gorges Reservoir Region of Ministry of Education College of Materials and Chemical EngineeringChina Three Gorges University Department of chemistry and chemical engineering Liaocheng University

Sodium percarbonate（Na2CO3·1.5H2O2, SPC） has been extensively employed as a solid substitute of H2O2for Fenton process in water treatment, because of its high stability during the production, transport, storage and usage. In addition, SPC can be applied in a wider range of work pH, it is also applied as a buffer in Fenton reaction for preventing a drop in pH. Herein, we have synthesized basic copper molybdate（BCM） nanoblocks with the molecular formula of Cu3（MoO4）2（OH）2as an efficient and heterogeneous catalyst for antibiotics degradation via percarbonate activation. First, fully physical characterizations confirmed BCM nanocomposite exhibited a structure of nanoblocks. we also found that BCM/SPC system could work in a much wider pH range, compared with H2O2. then, BCM/SPC system presented a good anti-interference ability for natural organic matter in OtC degradation. EPR results and Quenching tests confirmed that the co-presence of·CO3-,·O2-,1O2and·OH in BCM/SPC system.

关键词： Copper molybdate Fenton process Nanoblocks Sodium percarbonate water treatment

Strip method to construct a two-dimensional quasilattice witheight-fold symmetry

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Chinese Physics B 2024年第9期33卷 462-465页

作者： weishen huang Xiujun Fu School of Physics and Optoelectronics South China University of TechnologyGuangzhou 510640China

Based on the substitution rule and symmetry, we propose a method to generate an octagonal quasilattice consisting ofsquare and rhombus tiles. Local configurations and Ammann lines are used to guide the growth of the tiles in a quasiperiodicorder. the structure obtained is a perfect eight-fold symmetric quasilattice, which is confirmed by the radial distributionfunction and the diffraction pattern.

关键词： quasicrystals eight-fold symmetry Ammann–Beenker tiling

SnapshotPrune: A Novel Bitcoin-Based Protocol toward Efficient Pruning and Fast Node Bootstrapping

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tsinghua Science and technology 2024年第4期29卷 1037-1052页

作者： Pengfei huang Xiaojun Ren teng huang Arthur Sandor Voundi Koe Duncan S wong Hai Jiang Institute of Artificial Intelligence and Blockchain Guangzhou UniversityGuangzhou 510006China Institute of Artificial Intelligence and Blockchain Guangzhou UniversityGuangzhou 510006Chinaand also with Pazhou LabGuangzhou 510330China

Node synchronization is essential for the stability of the Bitcoin network. Critics have raised doubts about the ability of a new node to quickly and efficiently synchronize with the Bitcoin network and alleviate the storage pressure from existing full nodes to stockpile new data. Basic pruning and other techniques have been explored to address these concerns but have been insufficient to reduce node synchronization delay and effectively suppress the growth of synchronized data. In this study, we propose SnapshotPrune, a novel pruning and synchronization protocol that achieves fast node bootstrapping in the Bitcoin blockchain. Real Bitcoin historical data are leveraged to measure the synchronization time and monitor the network traffic during node bootstrapping. the protocol requires data downloads that are 99.70% less than Bitcoin Core, 81% less than CoinPrune, and 60% less than SnapshotSave, thereby saving 97.23% of download time. Findings show that the proposed design enhances the storage efficiency and reduces the node synchronization delay compared with existing techniques. we hypothesize that the efficiency of this protocol increases with the block height.

关键词： synchronization blockchain Unspent transaction Output(UtXO)pruning snapshot fast bootstrapping