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the Fifth China International Congress on thoracic and Cardiovasculal Surgery

作者： R.Neirotti D.Jones R.Hackbarth G.Fosse t.steffens M.Oosterheert DeVos Children’s Hospital 100 Michigan N.E.MC-117Grand RapidsMI 49503USA DeVos Children’s Hospital 100 Michigan N.E.MC-117Grand RapidsMI 49503USA DeVos Children’s Hospital 100 Michigan N.E.MC-117Grand RapidsMI 49503USA DeVos Children’s Hospital 100 Michigan N.E.MC-117Grand RapidsMI 49503USA DeVos Children’s Hospital 100 Michigan N.E.MC-117Grand RapidsMI 49503USA DeVos Children’s Hospital 100 Michigan N.E.MC-117Grand RapidsMI 49503USA

＜正＞ Objective:to evaluate the impact of early extubation（within six hours post-operatively）onchildren undergoing congenital heart *** of the problems following surgery are related tothe endotracheal tube,mechanical ventilation,and interventions necessary to maintain ***-ods:717 consecutive patients from 4/93 t0 1/98 were reviewed.66 premature infants with isolatedductus ligation and five patients with preexisting respiratory conditions precluding extubation were *** records were *** data on 638 patients was evaluated using ***:Extubation occurred within six hours in 81.5%（76.2% in the operating room）.Median agewas 22 *** weight was 11kg.

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Stimulation of tNF receptor type 2 expands regulatory t cells and ameliorates established collagen-induced arthritis in mice

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Cellular & Molecular Immunology 2019年第1期16卷 65-74页

作者： Vanessa Lamontain tobias Schmid Dorothea Weber-steffens David Zeller Zsuzsa Jenei-Lanzl Harald Wajant Rainer H Straub Daniela N Männel Institute of Immunology University of Regensburg93042 RegensburgGermany Laboratory of Experimental Rheumatology and Neuroendocrine Immunology Department of Internal MedicineUniversity Hospital Regensburg93042 RegensburgGermany Division of Molecular Internal Medicine Department of Internal Medicine IIUniversity Hospital Würzburg97070 WürzburgGermany

tumor necrosis factor(tNF)and its receptors tNF receptor type 1(tNFR1)and type 2(tNFR2)have a central role in chronic inflammatory *** tNFR1 mainly confers inflammation,activation of tNFR2 elicits not only pro-inflammatory but also anti-inflammatory *** this study,we wanted to investigate the anti-inflammatory therapeutic potential of selective activation of tNFR2 in mice with established collageninduced *** with established arthritis induced by immunization with bovine collagen type II were treated with six injections of the tNFR2-specific agonist tNCsctNF80,given every second *** days after treatment cessation,the cell compositions of bone marrow,spleen and lymph nodes were *** were visually scored until day 30 after the start of therapy and the degree of joint inflammation was determined by *** with tNCsctNF80 increased arthritis-induced *** effect was seen on the infiltration rate of inflammatory immature myeloid cells and on the reduction of lymphoid cells in secondary lymphoid *** treatment,frequency of regulatory t(treg)cells in the CD4+t-cell population was increased in both spleen and inguinal lymph *** addition,the expression of tNFR2 on treg cells was *** clinical score started to improve 1 week after cessation treatment and remained lower 30 days after initiation of *** histological score also revealed amelioration of joint inflammation in tNCsctNF80-treated versus control *** of tNFR2 might provide a suitable therapeutic strategy in autoimmune arthritis by increasing the numbers of regulatory cell types,in particular treg cells,and by attenuation of arthritis.

关键词： collagen type II-induced arthritis regulatory t cells tNF tNF receptor type 2 tNFR2-specific agonist tNCsctNF80

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Adequate Diagnostic Performance of Combined [¹⁸F]-Fluormethylcholine PEt-Ct with Diffusion-Weighted MRI in Primary Staging of High Risk Prostate Cancer

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Advances in Molecular Imaging 2016年第1期6卷 1-9页

作者： Pieter L. Jager R. Jorn Beukinga tjard D. de Haan Martijn F Boomsma Ben E. Laddé Miranda van t Veer-ten Kate Ad H. J. Oostdijk Martijn G. steffens Department of Nuclear Medicine Zwolle Netherlands Department of Urology Zwolle Netherlands Department of Radiology Zwolle Netherlands Department of Pathology Zwolle Netherlands

Introduction: [18F]-fluoro-methylcholine (FCH) PEt/Ct and MRI with diffusion-weighted MRI (DW-MRI) have insufficient performance in lymph node staging of primary prostate cancer by themselves, but the combination may perform better. We aim to prospectively determine the diagnostic performance of combined FCH PEt and MRI for lymph node staging. Methods: this was a single site study of diagnostic accuracy in a well-defined group of 21 consecutive high-risk primary prostate cancer patients (>30% chance of lymph node metastases) in a large community hospital. We performed FCH PEt/Ct and MRI with DW-MRI prior to endoscopic extended pelvic lymph node dissection (EPLND). PEt was fused and interpreted together with various MRI image sets (t1, t2, DWIBS) and was only scored positive when a lymph node seen on MRI coincided with increased focal FCH uptake on PEt. Findings were compared with detailed histological evaluation, on a per-patient and per-region level. We calculated sensitivity, specificity, positive and negative predictive value of combined PEt-MRI. Results: 14 out of 21 patients had metastatic lymph nodes with 37 out of 164 evaluable regions harboring metastases. On a per-patient analysis, PEt-MRI had a sensitivity/specificity of 79/100% with a PPV/NPV of 100/77%. On a per-region analysis (n = 164) these figure were 65/99% and 96/91%, respectively. Conclusions: Combined DW-MRI and FCH PEt/Ct has a very high positive predictive value in high risk prostate cancer patients. If confirmed in larger series a positive combined scan may safely allow cancellation of surgical staging in selected patients, depending on local protocols in N1 M0 patients.

关键词： Positron Emission tomography Diffusion-Weighted Imaging Fluor-Methyl-Choline Prostate Cancer Primary Staging

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Field-tuned quantum effects in a triangular-lattice Ising magnet

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Science Bulletin 2022年第1期67卷 38-44,M0003页

作者： Yayuan Qin Yao Shen Changle Liu Hongliang Wo Yonghao Gao Yu Feng Xiaowen Zhang Gaofeng Ding Yiqing Gu Qisi Wang Shoudong Shen Helen C.Walker Robert Bewley Jianhui Xu Martin Boehm Paul steffens Seiko Ohira-Kawamura Naoki Murai Astrid Schneidewind Xin tong Gang Chen Jun Zhao State Key Laboratory of Surface Physics and Department of Physics Fudan UniversityShanghai 200433China Condensed Matter Physics and Materials Science Department Brookhaven National LaboratoryUptonNew York 11973USA Shanghai Qizhi Institute Shanghai 200232China Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China Materials and Life Science Division J-PARC CenterTokaiIbaraki 319-1195Japan Physik-Institut Universität ZürichZürich CH-8057Switzerland ISIS Facility Rutherford Appleton LaboratorySTFCChiltonDidcotOxon OX110QXUK Helmholtz-Zentrum Berlin für Materialien und Energie GmbH Berlin D-14109Germany Institut Laue-Langevin Grenoble 9Cedex 38042France Jülich Centre for Neutron Science(JCNS)at Heinz Maier-Leibnitz Zentrum(MLZ) Forschungszentrum Jülich GmbHGarching 85748Germany Department of Physics and HKU-UCAS Joint Institute for theoretical and Computational Physics at Hong Kong The University of Hong KongHong KongChina Institute of Nanoelectronics and Quantum Computing Fudan UniversityShanghai 200433China Shanghai Research Center for Quantum Sciences Shanghai 201315China Collaborative Innovation Center of Advanced Microstructures Nanjing UniversityNanjing 210093China

We report thermodynamic and neutron scattering measurements of the triangular-lattice quantum Ising magnet tmMgGaO_(4)in longitudinal magnetic *** experiments reveal a quasi-plateau state induced by quantum *** state exhibits an unconventional non-monotonic field and temperature dependence of the magnetic order and excitation *** the high field regime where the quantum fluctuations are largely suppressed,we observed a disordered state with coherent magnon-like excitations despite the suppression of the spin excitation *** detailed semi-classical calculations,we are able to understand these behaviors quantitatively from the subtle competition between quantum fluctuations and frustrated Ising interactions.

关键词： Neutron scattering Quantum magnet Magnetic frustration transverse field Ising model

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