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the Modern Information technologies and Visualization Methods for Analysis of Computer simulation Results for Complex Plasma

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Communications in Computational Physics 2014年第4期15卷 981-995页

作者： t.s.ramazanov s.K.Kodanova M.K.Issanova N.Kh.Bastykova Zh.A.Moldabekov IEtP Al-Farabi Kazakh National University71Al-Farabi av.Almaty050040Kazakhstan

In this paper we present a software package based on modern information technologies that allows rapid analysis and visualization of the properties of complex *** properties of plasma are simulated by two *** of all,we have applied the molecular dynamics simulation method which numerically solves the equations of motions for plasma ***,we calculate microscopic properties of plasma by using the Boltzmann equation with additional relations,initial and boundary conditions.

关键词： Molecular dynamics simulation method modern information technology software package program software

Relaxation of non-isothermal hot dense plasma parameters

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Matter and Radiation at Extremes 2018年第1期3卷 40-49页

作者： s.K.Kodanova M.K.Issanova s.M.Amirov t.s.ramazanov A.tikhonov Zh.A.Moldabekov Institute for Experimental and theoretical Physics Al-Farabi Kazakh National University71 Al-Farabi Str.050040 AlmatyKazakhstan Institute of Applied sciences and It 40-48 Shashkin Str.050038 AlmatyKazakhstan Nazarbayev University Kabanbay Batyr Ave.53Astana 010000Kazakhstan

the relaxation of temperature,coupling parameters,the excess part of equation of state,and the correlation energy of the non-isothermal hot dense plasmas are considered on the basis of the method of effective interaction *** electroneion effective interaction potential for the hot dense plasma is *** accuracy of description of the dense plasma properties by the effective electroneion interaction potential is demonstrated by the agreement of the derived quantities like stopping power and transport coefficients calculated using our methodology with the results of the finite-temperature Kohn-sham density-functional theory molecular dynamics,and orbital-free molecular dynamics results as well as with the data obtained using other theoretical approaches.

关键词： Dense plasma Effective potentials temperature relaxation stopping power transport

Free vibration and transient response of double curved beams connected by intermediate straight beams

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 37-62页

作者： R.A.JAFARI-tALOOKOLAEI H.GHANDVAR E.JUMAEV s.KHAtIR t.CUONG-LE school of Mechanical Engineering Babol Noshirvani University of Technology Department of Mechanical Engineering Faculty of Engineering New Uzbekistan University University of Business and science Center for Engineering Application and technology solutions Ho Chi Minh City Open University

this paper investigates the free vibration and transient response of interconnected structures including double curved beams and intermediate straight beams,which are all constructed from functionally graded porous(FGP) materials. the strain potential and kinetic energies of each beam along with the work done by the external force are calculated. Additionally, a higher-order beam element is introduced to derive stiffness and mass matrices, along with the force vector. the curved and straight beams are discretized, and their assembled stiffness, mass matrices, and force vectors, are *** conditions at the joints are used to derive the total matrices of the entire structure. subsequently, the natural frequencies and transient response of the system are determined. the accuracy of the mathematical model and the self-developed computer program is validated through the comparison of the obtained results with those of the existing literature and commercial software ANsYs, demonstrating excellent ***, a comprehensive study is conducted to investigate the effects of various parameters on the free vibration and transient response of the considered structure.

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Investigation of self-generated magnetic ﬁeld and dynamics of a pulsed plasma ﬂow

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Plasma science and technology 2022年第5期24卷 146-153页

作者： Aigerim tAZHEN Merlan DOsBOLAYEV tlekkabul ramazanov Institute of Experimental and theoretical Physics Al-Farabi Kazakh National UniversityAlmaty 050040Kazakhstan

Due to the growing interest in studying the compression and disruption of the plasma filament in magnetic fusion devices and Z-pinches, this work may be important for new developments in the field of controlled thermonuclear fusion. Recently, on a coaxial plasma accelerator, we managed to obtain the relatively long-lived(~300 μs) plasma filaments with its self-magnetic field. this was achieved after modification of the experimental setup by using high-capacitive and lowinductive energy storage capacitor banks, as well as electrical cables with low reactive impedance. Furthermore, we were able to avoid the reverse reflection of the plasma flux from the end of the plasma accelerator by installing a special plasma-absorbing target. thus, these constructive changes of the experimental setup allowed us to investigate the physical properties of the plasma filament by using the comprehensive diagnostics including Rogowski coil,magnetic probes, and Faraday cup. As a result, such important plasma parameters as density of ions and temperature of electrons in plasma flux, time dependent plasma filament’s azimuthal magnetic field were measured in discharge gap and at a distance of 23.5 cm from the tip of the cathode. In addition, the current oscillograms and Ⅰ–Ⅴ characteristics of the plasma accelerator were obtained. In the experiments, we also observed the charge separation during the acceleration of plasma flow via oscillograms of electron and ion beam currents.

关键词： coaxial plasma accelerator pulsed plasmaﬂow self magneticﬁeld electron density electron temperature Faraday cup magnetic probe

Revisiting cerebral endothelial cells in Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy Department of Neurosurgery University Hospital BonnBonnGermany

Alzheimer’s disease(AD)is the most common neurodegenerative disorder characterized by slow and progressive decline of cognitive and memory *** only approximately 5%of the cases,AD is familial,as often predisposed by genetic mutations(Hoogmartens et al.,2021),while sporadic AD accounts for approximately 95%of the *** amyloid cascade hypothesis is one of the fundamental hypotheses put out to explain AD pathogenesis as dysregulated homeostasis of amyloid-β(Aβ)peptides that leads to the accumulation of Aβplaques in the parenchyma,an anatomical hallmark of AD.

关键词： Alzheimer Aβ cerebral

A systematic review of progenitor survival and maturation in Parkinsonian models

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Neural Regeneration Research 2025年第11期20卷 3172-3178页

作者： Giulia Comini Eilís Dowd Pharmacology&therapeutics and Galway Neuroscience Center University of GalwayGalwayIreland

stem cell-based brain repair is a promising emergent therapy for Parkinson's disease based on years of foundational research using human fetal donors as a cell *** current therapeutic options for patients,this approach has the potential to provide longterm stem cell–derived reconstruction and restoration of the dopaminergic input to denervated regions of the brain allowing for restoration of certain functions to *** ultimate clinical success of stem cell–derived brain repair will depend on both the safety and efficacy of the approach and the latter is dependent on the ability of the transplanted cells to survive and differentiate into functional dopaminergic neurons in the Parkinsonian *** the pre-clinical literature suggests that there is considerable variability in survival and differentiation between studies,the aim of this systematic review was to assess these parameters in human stem cell-derived dopaminergic progenitor transplant studies in animal models of Parkinson's disease.A defined systematic search of the PubMed database was completed to identify relevant studies published up to March *** screening,76 articles were included in the analysis from which 178 separate transplant studies were *** these,graft survival could be assessed in 52 studies and differentiation in 129 ***,we found that graft survival ranged fromto 500% of cells transplanted,with a median of 51%of transplanted cells surviving in the brain;while dopaminergic differentiation of the cells ranged from 0% to 46% of cells transplanted with a median of 3%.this systematic review suggests that there is considerable scope for improvement in the differentiation of stem cell-derived dopaminergic progenitors to maximize the therapeutic potential of this approach for patients.

关键词： cell replacement therapy differentiation embryonic stem cells graft induced pluripotent stem cells Parkinson's disease survival transplant

Conceptual design of 2MJ capacitive energy storage

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Defence technology（防务技术） 2018年第5期14卷 622-627页

作者： R.F.ramazanov B.E.Fridman K.s.Kharcheva O.V.Komarov R.A.serebrov D.V.Efremov scientific Research Institute of Electrophysical Apparatus Saint Petersburg196641Russia

the conceptual design of the capacitive energy storage intended for operation in laboratory conditions is considered. this capacitive energy storage includes the capacitor cells of 200 kJ stored energy, each incorporating one self-healing high-energy-density capacitor, one semiconducting switch unit on the basis of Light triggered thyristors(Ltt) and the pulse diodes, as well as the toroid inductor. Power supply of the capacitive energy storage is provided by high voltage(HV) 3 x 10 kV, 50 Hz industrial electrical network, using the HV power transformer and phase-controlled rectifier. special design for the capacitor cell and the module of capacitor cells is proposed, which provides easy access to all components of the capacitor cells during operation and maintenance. Control system of the capacitive energy system has a hierarchic structure and includes programmable logic controller(PLC), programmer for non-synchronous triggering of capacitor cells discharges and data acquisition system.

关键词： Capacitors Energy storage Pulse power systems

Deciphering the mechanobiology of microglia in traumatic brain injury with advanced microsystems

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Neural Regeneration Research 2025年第8期20卷 2304-2306页

作者： Anthony Procès sylvain Gabriele Univ.Grenoble Alpes InsermU1216Grenoble Institut des NeurosciencesGrenobleFrance Mechanobiology&Biomaterials Group CIRMAPResearch Institute for BiosciencesUniversity of MonsMonsBelgium

Advanced microsystems in traumatic brain injury research:traumatic brain injury(tBI)results from a mechanical insult to the brain,leading to neuronal and axonal damage and subsequently causing a secondary *** minutes ... 详细信息

关键词： traumatic injury damage

Emerging structures and dynamic mechanisms ofγ-secretase for Alzheimer’s disease

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Neural Regeneration Research 2025年第1期20卷 174-180页

作者： Yinglong Miao Michael s.Wolfe Computational Medicine Program and Department of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of Medicinal Chemistry University of KansasLawrenceKSUSA

γ-secretase,called“the proteasome of the membrane,”is a membrane-embedded protease complex that cleaves 150+peptide substrates with central roles in biology and medicine,including amyloid precursor protein and the Notch family of cell-surface *** inγ-secretase and amyloid precursor protein lead to early-onset familial Alzheimer’s disease.γ-secretase has thus served as a critical drug target for treating familial Alzheimer’s disease and the more common late-onset Alzheimer’s disease as ***,critical gaps remain in understanding the mechanisms of processive proteolysis of substrates,the effects of familial Alzheimer’s disease mutations,and allosteric modulation of substrate cleavage byγ-*** this review,we focus on recent studies of structural dynamic mechanisms ofγ-*** mechanisms,including the“Fit-stay-trim,”“sliding-Unwinding,”and“tilting-Unwinding,”have been proposed for substrate proteolysis of amyloid precursor protein byγ-secretase based on all-atom molecular dynamics *** an incorrect registry of the Notch1 substrate was identified in the cryo-electron microscopy structure of Notch1-boundγ-secretase,molecular dynamics simulations on a resolved model of Notch1-boundγ-secretase that was reconstructed using the amyloid precursor protein-boundγ-secretase as a template successfully capturedγ-secretase activation for proper cleavages of both wildtype and mutant Notch,being consistent with biochemical experimental *** approach could be potentially applied to decipher the processing mechanisms of various substrates byγ-*** addition,controversy over the effects of familial Alzheimer’s disease mutations,particularly the issue of whether they stabilize or destabilizeγ-secretase-substrate complexes,is ***,an outlook is provided for future studies ofγ-secretase,including pathways of substrate binding and product release,effects of modulators on familial Alzheimer’s disease mutations

关键词： Alzheimer’s disease amyloid precursor protein cryo-EM structures drug design intramembrane proteolysis molecular dynamics Notch