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Neural Regeneration Research 2025年第2期20卷 366-377页

作者： samuel Abokyi Dennis Yan-yin tse school of Optometry The Hong Kong Polytechnic UniversityKowloonHong Kong Special Administrative RegionChina Research Center for sHARP Vision The Hong Kong Polytechnic UniversityKowloonHong Kong Special Administrative RegionChina Center for Eye and Vision Research Sha TinHong Kong Special Administrative RegionChina

Retinal aging has been recognized as a significant risk factor for various retinal disorders,including diabetic retinopathy,age-related macular degeneration,and glaucoma,following a growing understanding of the molecular underpinnings of their *** comprehensive review explores the mechanisms of retinal aging and investigates potential neuroprotective approaches,focusing on the activation of transcription factor *** meta-analyses have demonstrated promising outcomes of transcription factor EB-targeted strategies,such as exercise,calorie restriction,rapamycin,and metformin,in patients and animal models of these common retinal *** review critically assesses the role of transcription factor EB in retinal biology during aging,its neuroprotective effects,and its therapeutic potential for retinal *** impact of transcription factor EB on retinal aging is cell-specific,influencing metabolic reprogramming and energy homeostasis in retinal neurons through the regulation of mitochondrial quality control and nutrient-sensing *** vascular endothelial cells,transcription factor EB controls important processes,including endothelial cell proliferation,endothelial tube formation,and nitric oxide levels,thereby influencing the inner blood-retinal barrier,angiogenesis,and retinal ***,transcription factor EB affects vascular smooth muscle cells,inhibiting vascular calcification and *** retinal pigment epithelial cells,transcription factor EB modulates functions such as autophagy,lysosomal dynamics,and clearance of the aging pigment lipofuscin,thereby promoting photoreceptor survival and regulating vascular endothelial growth factor A expression involved in *** cell-specific functions of transcription factor EB significantly impact retinal aging mechanisms encompassing proteostasis,neuronal synapse plasticity,energy metabolism,microvasculature,and inflammation,ultimately offering pro

关键词： age-related macular degeneration anti-aging interventions autophagy calorie restriction diabetic retinopathy exercise glaucoma neuromodulation phagocytosis photoreceptor outer segment degradation retinal aging transcription factor EB

Flow, thermal criticality and transition of a reactive third-grade fluid in a pipe with Reynolds' model viscosity

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Journal of Hydrodynamics 2016年第1期28卷 84-94页

作者： samuel s.OKOYA Department of Mathematics Obafemi Awolowo University

Neglecting the consumption of the material, a steady incompressible flow of an exothermic reacting third-grade fluid with viscous heating in a circular cylindrical pipe is numerically studied for both cases of constant viscosity and Reynolds＇ viscosity model. the coupled ordinary differential equations governing the flow in cylindrical coordinates, are transformed into dimensionless forms using appropriate transformations, and then solved numerically. solutions using Maple are presented in tabular form and given in terms of dimensionless central fluid velocity and temperature, skin friction and heat transfer rate for three parametric values in the Reynolds＇ case. the numerical results for the velocity and temperature fields are also presented through graphs. Bifurcations are discussed using shooting method. Comparisons are also made between the present results and those of previous work, and thus verify the validity of the provided numerical solutions. Important properties of thermal criticality are provided for variable viscosity parameter and reaction order. Further numerical results are presented in the form of tables and graphs for transition of physical parameters, while varying certain flow and fluid material parameters. Also, the flow behaviour of the reactive fluid of third-grade is compared with those of the Newtonian reactive fluid.

关键词： non-Newtonian fluids third-grade fluid thermal transition heat generation temperature dependent viscosity numerical solutions

Fukushima wastewater release:unanswered questions and global concerns

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International Journal of Agricultural and Biological Engineering 2024年第2期17卷 289-290页

作者： samuel Ariyo Okaiyeto Parag Prakash sutar arun sMujumdar Hongwei Xiao College of Engineering China Agricultural UniversityBeijing 100083China Department of Food Process Engineering National Institute of Technology RourkelaRourkela 769008India Department of Bioresource Engineering McGill UniversitySte.Anne de BellevueQuebecCanada

the decision by Japan to begin discharging the Fukushima wastewater into the ocean on August 24,2023 was followed by protests from several countries,including China,Russia,Korea,Vietnam,and deep concerns from the international *** decision is related to the aftermath of the Fukushima Daiichi nuclear disaster that occurred in 2011,which destroyed the cooling system of the nuclear power plant and caused the reactor cores to *** water was used to cool down the reactors fuel rods;about 1.3 million cubic meters contaminated water with highly radioactive material was generated,which can fill more than 500 Olympic swimming pools[1].In order to reduce the levels of radioactivity,an Advanced Liquid Processing system(ALPs)was used to remove most radioactive contaminants from *** works by circulating water through a system of tanks and filters,which removes specific contaminants such as cesium and strontium,using a multi-step process that includes coagulation,flocculation,ion exchange,and absorption[1].Japan's government and some scientists have argued that the ALPs-treated water is safe for release into the *** to their claims,the discharged water poses minimal risk to human health and the ***,concerns about the long-term effects of this discharge remain in scientists′minds.

关键词： Fukushima wastewater nuclear disaster discharge radioactive contaminants

Chatbots:a critical look into the future of the academia

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International Journal of Agricultural and Biological Engineering 2024年第2期17卷 287-288页

作者： samuel Ariyo Okaiyeto arun s.Mujumdar Parag Prakash sutar Wei Liu Junwen Bai Hongwei Xiao College of Engineering China Agricultural UniversityBeijing 100083China Department of Bioresource Engineering McGill UniversitySte.Anne de BellevueQuebecCanada Department of Food Process Engineering National Institute of Technology RourkelaRourkela 769008India school of Artificial Intelligence Beijing University of Posts and TelecommunicationsBeijing 100876China school of Food and Biological Engineering Jiangsu UniversityZhenjiang 212013China

Like every other societal domain,science faces yet another reckoning caused by a bot called ChatGPt(Chat Generative Pre-trained transformer).ChatGPt was introduced in November 2022 to produce messages that seem like they were written by humans and are *** the release of the latest version of ChatGPt called GPt-4,and other similar models such as Google Bard,Chatsonic,Collosal Chat,these chatbots combine several(about 175 billion)neural networks pre-trained on large Language Models(LLMs),allowing them to respond to user promptings just like ***-4 for example can admit its mistakes and confront false assumptions thanks to the dialogue style,which also enables it to write essays and to keep track of the context of a discussion while it is ***,users may be deceived by the human-like text structure of the AI models to believe that it came from a human origin[1].these chatbot models could be better,even though they generate text with a high level of ***,they produce inappropriate or wrong responses,resulting in faulty inferences or ethical *** article will discuss some fundamental strengths and weaknesses of this Artificial intelligence(AI)system concerning scientific research.

关键词： ChatGPt AI generative models academia ethical and moral restraints

Hydraulic jump and choking of flow in pipe with a change of slope

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Journal of Hydrodynamics 2022年第6期34卷 1044-1066页

作者： Rui Zeng s.samuel Li Department of Building Civil and Environmental EngineeringConcordia UniversityMontrealCanada

this paper investigates hydraulic jumps in sloping pipes by means of wall-resolved large eddy simulation(LEs).the purpose is to achieve an improved understanding of jump behaviours driven by pipe discharge and *** LEs model predicts the hydraulic jump as a 3-D two-phase flow,with air as the gas phase and water as the liquid *** predictions yield instantaneous velocity and pressure fields as well as fluid volume *** instantaneous flow variables allow ensemble averages,which quantify the internal structures and integral properties of the hydraulic *** predicted instantaneous velocity shows spectra in consistency with the well-known Kolmogorov−5/3 *** ensemble averages of air and water velocities,free-surface profile,roller length and aeration length,compare well with available experimental *** jump behaviours are *** aspects such as free-surface fluctuation and jump-toe oscillation resemble the classical hydraulic jump on horizontal *** like the 3-D distributions of core jet,vorticity and aeration are much more *** on the pipe discharge and slope,the resulting jump can be a complete or an incomplete *** incomplete hydraulic jump causes choked flow *** has severe consequences on drainage conditions in sewer pipes laid on sloping *** paper proposes using the Okubo-Weiss parameter as a new way to subtly delineate the region of hydraulic *** is much more efficient and less ambiguous,compared with traditional visual inspections.

关键词： Hydraulic jump sloping pipe two-phase bubbly flow large eddy simulation(LEs) choking of flow Okubo-Weiss parameter

COMPARIsON OF EMIttED EMIssIONs BEtWEEN tRENCHLEss PIPE REPLACEMENt AND OPEN CUt UtILItY CONstRUCtION

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Journal of Green Building 2009年第2期4卷 126-140页

作者： samuel t.Ariaratnam shaik s.sihabuddin Ira A.Fulton school of Engineering Arizona State UniversityTempeAZ Metcalf Builders Inc. 751 Basque WayCarson CityNV

Currently,there is a worldwide trend towards reducing emissions into the environment generated by human *** emissions into the atmosphere are a major measure of the impact on *** construction indus-try is a major producer of such emissions due in part to the magnitude of operations and the vast array of *** urbanization has resulted in a need for the installation of an expanded underground network of infrastruc-ture that includes gas,water,wastewater,pipelines,power,and communications ***,engineers are faced with engaging the construction option that not only provides the best cost advantage,but also considers environmental sensitivities to create the most sustainable *** of pollutants such as carbon dioxide(CO_(2)),carbon monoxide(CO),nitrogen oxide(NO_(X)),total organic compounds(tOC),and sulfur oxide(sO_(X))have been identiﬁed by the United states Environmental Protection Agency as critical to sustainable *** paper describes an approach for quantifying airborne emissions that is demonstrated through a comparison of two construction methods for installing a wastewater *** was discovered that the option involving a traditional open cut method resulted in an overall average of about 80%greater emissions compared to trenchless pipe ***ﬁndings of this paper should assist the utility construction industry in technology selection to minimize environmental impacts.

关键词： environmental trenchless technology emissions underground construction

targeting α7 nicotinic acetylcholine receptors: a future potential for neuroprotection from traumatic brain injury

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Neural Regeneration Research 2015年第10期10卷 1552-1554页

作者： samuel s.shin C.Edward Dixon Department of Neurological surgery University of Pittsburgh Medica Center

traumatic brain injury （tBI） poses a significant socioeconomic burden in the world. the long lasting consequences in cognitive impairments are often underreported and its mechanisms are unclear. In this perspective, cholinergic dysfunction and thera-peutic strategy targeting this will be reviewed. Novel agents that can target specific subtype of acetylcholine receptors have been developed over the recent years and are at various stages of development, which include AR-R 17779, Gts-21, ssR- 180711A, AR-R17779, and PNU-282987. A detailed review on this topic has been previously published （shin and Dixon, 2015）.

关键词： tBI nicotinic acetylcholine receptors targeting a future potential for neuroprotection from traumatic brain injury ACh

Analysis of sampling Error Uncertainties and trends in Maximum and Minimum temperatures in China

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Advances in Atmospheric sciences 2014年第2期31卷 263-272页

作者： HUA Wei samuel s.P.sHEN WANG Huijun Nansen-Zhu International Research Centre Institute of Atmospheric Physics Chinese Academy of Sciences Department of Atmospheric sciences Chengdu University of Information Technology University of the Chinese Academy of sciences Department of Mathematics and statistics San Diego State University

In this paper we report an analysis of sampling error uncertainties in mean maximum and minimum temperatures （tmax and tmin） carried out on monthly,seasonal and annual scales,including an examination of homogenized and original data collected at 731 meteorological stations across China for the period *** of the gridded data and national average,linear trends and their uncertainties,as well as the homogenization effect on uncertainties are *** is shown that the sampling error variances of homogenized tmax and tmin,which are larger in winter than in summer,have a marked northwest-southeast gradient distribution,while the sampling error variances of the original data are found to be larger and *** and tmin increase in all months of the year in the study period 1951-2004,with the largest warming and uncertainties being 0.400℃ （10 yr）-1 ＋ 0.269℃ （10 yr）-1 and 0.578℃ （10 yr）-1 ＋ 0.211℃ （10 yr）-1 in February,and the least being 0.022℃ （10 yr）-1 ＋ 0.085℃ （10 yr）-1 and 0.104℃ （10 yr）-1 ＋0.070℃ （10 yr）-1 in *** can remove large uncertainties in the original records resulting from various non-natural changes in China.

关键词： sampling error uncertainty maximum temperature minimum temperature temperature trend

Reduced graphene oxide supersonically sprayed on wearable fabric and decorated with iron oxide for supercapacitor applications

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Journal of Materials science & technology 2021年第23期82卷 47-56页

作者： Ali Aldalbahi Edmund samuel Bander s.Alotaibi Hany El-Hamshary sam s.Yoon Department of Chemistry College of ScienceKing Saud UniversityRiyadh11451Saudi Arabia school of Mechanical Engineering Korea UniversitySeoul136-713Republic of Korea

We demonstrate the fabrication of wearable supercapacitor *** electrodes were applied to wearable fabric by supersonically spraying the fabric with reduced graphene oxide(r GO)followed by decoration with iron oxide(Fe_(2)O_(3))nanoparticles via a hydrothermal *** integration of iron oxide with r GO flakes on wearable fabric demonstrates immense potential for applications in high-energystorage *** synergetic impact of the intermingled r GO flakes and Fe_(2)O_(3) nanoparticles enhances the charge transport within the composite electrode,ultimately improving the overall electrochemical *** advantage of the porous nature of the fabric,electrolyte diffusion into the active r GO and Fe_(2)O_(3) materials was significantly enhanced and subsequently increased the electrochemical interfacial *** effect of the Fe_(2)O_(3) concentration on the overall electrochemical performance was *** optimal composition yields a specific capacitance of 360 F g^(-1) at a current density of 1 Ag^(-1) with a capacitance retention rate of 89%after 8500 galvanostatic cycles,confirming the long-term stability of the Fe_(2)O_(3)/r GO fabric electrode.

关键词： supersonic spraying Conductive textile Wearable energy devices Reduced graphene oxide Iron oxide supercapacitor