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滤泡性甲状腺癌皮肤转移:4例病例报道及文献回顾

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世界核心医学期刊文摘（皮肤病学分册） 2005年第12期1卷 26-27页

作者： Quinn t.r. Duncan L.M. Zembowicz A. Faquin W.C. 李政霄 Dr. Pathology Services Inc. 640 Memorial Drive Cambridge MA 02139 United States

Cutaneous metastasis of follicular carcinoma of the thyroid is very rare, and when it occurs, can exhibit a variety of histologic appearances. the 4 cases presented here were identified from the surgical pathology files of the James Homer Wright Laborat.r.es of Pathology at the Massachusetts General Hospital (MGH). the cases consisted of 4 patients, 3 men and 1 woman, aged 52 to 75 years, with cutaneousmetastasis of follicular thyroid carcinoma. the tumors include a conventional follicular carcinoma, a follicular carcinoma with anaplastic transformation following initial metastasis, the first.r.ported cutaneous metastases of a follicular carcinoma with oncocytic feat.r.s (Hü rthle cell carcinoma), and a follicular carcinoma with a prominent insular carcinoma component. All 4 tumors were widely invasive within the thyroid gland. Sites of dermal metastases included a post- thyroidectomy scar, scalp, and sacral skin. t.r.e metastases retained the morphologic and immunocytochemical feat.r.s of the primary thyroid tumors. However, in one case there was high- grade transformation to anaplastic carcinoma following treatment of a sacral metastasis with accompanying loss of the charact.r.stic immunophenotype of follicular thyroid carcinoma. Awareness of the varied morphologies of metastatic follicular thyroid carcinoma to the skin may prompt immunohistochemical analysis and the request for a complete clinical hist.r., ultimately preventing misdiagnosis.

关键词：滤泡性甲状腺癌滤泡性癌文献回顾甲状腺肿瘤首例报道甲状腺切除术后瘢痕瘤细胞免疫细胞化学麻萨诸塞

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糖尿病足溃疡短期局部外用维A酸治疗的疗效

世界核心医学期刊文摘（皮肤病学分册） 2006年第2期2卷 21-22页

作者： tom W.L. Peng D.H. Allaei A. t.r. Hata 党倩丽 University of California San Diego Perlman Ambulatory Care CenterMailcode 0974 9350 Campus Point Dr San Diego CA 92037 United StatesDr.

Objective: to det.r.ine the efficacy and safety of short- contact administration of topical tretinoin on foot ulcers in patients with diabetes. Design: randomized, double- blind, placebocontrolled trial. Setting: Outpatient clinic at a Vet.r.ns Affairs medical cent.r. Patients: twenty- four volunteers with diabetic foot ulcers but without evidence of peripheral art.r.al disease or infection. Int.r.entions: Patients were randomized to 4 weeks of daily treatment with either topical 0.05% tretinoin solution (retin- A) or placebo saline solution. Photographs and assessment of wound size and appearance were assessed every 2 weeks for a total of 16 weeks. Main Outcome Measures: the proportion of ulcers that healed in each group and the degree of change in ulcer size. results: twenty- two patients, with a total of 24 foot ulcers, completed the study. At the end of 16 weeks, 2 (18% ) of 11 ulcers in the control group and 6 (46% ) of 13 ulcers in the tretinoin treatment group healed completely. topical tretinoin therapy significantly decreased ulcer area and depth compared with placebo treatment over the 16weeks of the study (P r surface area; P=.02 for depth). Adverse effects mainly consisted of mild pain at the ulcer site. Conclusions: Short- contact application of topical tretinoin improved the healing of foot ulcers in patients with diabetes. the tretinoin therapy was generally well tolerated, without serious local or systemic adverse effects.

关键词：糖尿病足溃疡溃疡面积足部溃疡安慰剂对照周围动脉酸洗剂临床门诊不良反应

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南非东德里方丹选金厂磨机衬板的评述

国外金属矿山 1991年第4期16卷 51-52页

作者： t.r.特维德尔 J.W.克劳斯 t.V.汤姆斯熊瓒恩南非东德里方丹金矿公司迪尔克拉尔金矿公司

本文论述了装有提升条的大直径砾磨机简体衬板成本效益最佳材料的研究结果。该研究是南非东德里方丹选金厂研究项目的一部分。据发现,锰钢和铬钢衬板较之软铸钢和白铁衬板更具成本效益。

关键词：选金厂磨矿机衬板寿命

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防治胡椒黑翅叶的杀虫剂

热带农业科技 1991年第2期 16-16页

作者： Kumar t.r. 李维锐印度

在印度喀拉拉邦进行了一个大田药效试验,把九种死虫剂(浓度0.05％)喷在危害胡椒果穗的黑翅叶(Longit.r.us nigripennis)成虫或蛾上,九种杀虫剂对黑翅叶均有效,以甲胺磷和硫丹效果最好,其次是甲基对硫磷、久效磷、磷胺、异丙胺磷、... 详细信息

在印度喀拉拉邦进行了一个大田药效试验,把九种死虫剂(浓度0.05％)喷在危害胡椒果穗的黑翅叶(Longit.r.us nigripennis)成虫或蛾上,九种杀虫剂对黑翅叶均有效,以甲胺磷和硫丹效果最好,其次是甲基对硫磷、久效磷、磷胺、异丙胺磷、喹硫磷、乐果和异吸硫磷Ⅱ。

关键词：翅叶胡椒

轻度视乳头水肿及假性视乳头水肿患者视网膜神经纤维层的OCt研究

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世界核心医学期刊文摘（眼科学分册） 2005年第8期1卷 40-40页

作者： Karam E.Z. Hedges t.r. 邢咏新 New England Eye Center Box 381 750 Washington Street Boston MA 02111 United States Dr.

Aims: to det.r.ine the degree to which optical coherence tomography (OCt) can distinguish differences in retinal nerve fibre layer (rNFL) thickness between ey es with mild papilloedema, pseudopapilloedema, and normal findings. Methods: 13 patients with mild papilloedema, 11 patients with congenitally crowded optic ner ves, and 17 normal subjects underwent neuro-ophthalmic examination, automated v isual field testing, and fundus photography. Spinal fluid pressure measurements were obtained in a subgroup of five patients with pseudopapilloedema and 11 pati ents with mild papilloedema. Circular OCt scans using a diamet.r.of 3.38 mm surr ounding the optic disc were performed in each eye of patients and subjects. Fund us photographs were analysed by two observers who diagnosed crowding or papilloe dema and graded amounts of swelling. Findings were assessed by descriptive stati stics and variance analysis. results: rNFL thickness was great.r.in me superior and inferior quadrants and showed a high degree of correlation between each grou p of patients and subjects. A statistically significant difference was found in mean rNFL thickness between both groups of patients with optic disc swelling and normal subjects. However, there was not a statistical difference in mean nerve fibre layer thickness between patients with papilloedema and those with congenit ally crowded optic nerves. Conclusions: OCt demonstrates measurable differences in nerve fibre layer thickness between normal subjects and patients with either papilloedema or pseudopapilloedema. However, OCt does not appear to differentiat e between those individuals with congenitally crowded optic nerves and those wit h mild papilloedema caused by increased intracranial pressure.

关键词：假性视乳头水肿 OCt研究自动视野计眼底照相 rNFL 视神经纤维摄影检查脑脊液压力神经眼科学描述性统计学

Free vibration and transient.r.sponse of double curved beams connected by int.r.ediate straight beams

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 37-62页

作者： r.A.JAFArI-tALOOKOLAEI H.GHANDVAr E.JUMAEV S.KHAt.r.t.CUONG-LE School of Mechanical Engineering Babol Noshirvani University of Technology Department of Mechanical Engineering Faculty of Engineering New Uzbekistan University University of Business and Science Cent.r.for Engineering Application and technology Solutions Ho Chi Minh City Open University

this paper investigates the free vibration and transient.r.sponse of int.r.onnected struct.r.s including double curved beams and int.r.ediate straight beams,which are all constructed from functionally graded porous(FGP) mat.r.als. the strain potential and kinetic energies of each beam along with the work done by the ext.r.al force are calculated. Additionally, a higher-order beam element is introduced to derive stiffness and mass matrices, along with the force vect.r. the curved and straight beams are discretized, and their assembled stiffness, mass matrices, and force vect.r., are *** conditions at the joints are used to derive the total matrices of the ent.r. struct.r.. Subsequently, the nat.r.l frequencies and transient.r.sponse of the system are det.r.ined. the accuracy of the mathematical model and the self-developed comput.r.program is validated t.r.ugh the comparison of the obtained results with those of the existing lit.r.t.r. and commercial software ANSYS, demonstrating excellent ***, a comprehensive study is conducted to investigate the effects of various paramet.r. on the free vibration and transient.r.sponse of the considered struct.r..

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SEAS(辛伐他汀和依泽替米贝应用于主动脉瓣狭窄)研究的设计和基线特征

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世界核心医学期刊文摘（心脏病学分册） 2007年第8期3卷 34-34页

作者： rossebφ A.B. Pedersen t.r. Allen C. 赵君 Dr.Division of Cardiology Aker UniversityHospital Oslo Norway

主动脉瓣狭窄和动脉粥样硬化性疾病有很多共同的危险因素,尤其是高胆固醇血症。在组织学上,病变的瓣膜似乎具有与动脉粥样硬化斑块非常相似的炎症区域。降脂治疗对主动脉瓣狭窄(AS)进展的影响尚不清楚,而且尚没有相关的随机治疗试验评... 详细信息

主动脉瓣狭窄和动脉粥样硬化性疾病有很多共同的危险因素,尤其是高胆固醇血症。在组织学上,病变的瓣膜似乎具有与动脉粥样硬化斑块非常相似的炎症区域。降脂治疗对主动脉瓣狭窄(AS)进展的影响尚不清楚,而且尚没有相关的随机治疗试验评价这类患者中的心血管发病率和死亡率。SEAS(辛伐他汀和依泽替米贝应用于主动脉瓣狭窄)是一项随机、双盲、安慰剂对照的多中心研究,旨在在至少4年的研究期内观察辛伐他汀40m g/d或依泽替米贝10m g/d的降脂治疗对跨瓣射血峰值速度为2.5～4.0m/s的无症状AS患者的作用。主要的疗效指标为主动脉瓣手术和缺血性血管事件,包括心血管疾病死亡;次要终点为利用超声心动图观察的对AS进展的影响。

关键词：主动脉瓣狭窄 SEAS 降脂治疗心血管发病率次要终点高胆固醇血症粥样硬化斑块随机治疗疗效

临床医生可使用床旁超声原型成像预测非酒精性脂肪肝的发生

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世界核心医学期刊文摘（胃肠病学分册） 2006年第12期2卷 6-6页

作者： riley III t.r. Mendoza A. Bruno M.A. 陈瑜 MC 045 PO Box 850HersheyPA 17022United States Dr.

this study was designed to test whether ultrasound can be used to diagnose nonalcoholic fatty liver disease(NAFLD) utilizing a *** collected 115 ultrasounds.A prototype was chosen that.r.presented NAFLD;5 feat.r.s of NAFLD prototype were *** were read blinded to diagnosis as matching prototype or not.A 20-minute teaching session was made to a group of 15 *** ultrasounds were presented for comparison to prototype with intraobserver reliability *** 20 patients shown by liver biopsy to have NAFLD,16 were successfully predicted by comparison to the prototype(sensitivity 80%) .In 94 of 95 cases,ultrasound predicted those without NAFLD(specificity 99%) .the positive predictive value was 94% and negative predictive value 96%.training results showed substantial agreement with a kappa score of 0.76 with 95% of cases identified *** conclusion,physicians can apply a bedside ultrasound to identify NAFLD when compared to prototype.

关键词：酒精性脂肪肝临床医生培训结果阴性预测值阳性预测值肝活检特异度于非临床医师

Coarse to Fine: the role of Severe Plastic Deformation in Advancing titanium-Based Medical Implants - A Comprehensive review

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Journal of Wuhan University of technology(Mat.r.als Science) 2025年第1期40卷 295-306页

作者： Dragana r Mihajlović Bojan I Međo Ivana Lj Cvijović-Alagić Veljko r Djokić Faculty of technology and Metallurgy University of BelgradeKarnegijeva 411120 BelgradeSerbia Vinča Institute of Nuclear Sci-ences-National Institute of the republic of Serbia University of Belgrade11001BeogradSerbia Innovation Centre of the Faculty of technology and Metallurgy Karnegijeva 411120 BelgradeSerbia

this paper describes severe plastic deformation(SPD)procedures,which are utilized to form an ultrafine-grained struct.r. in metallic *** the SPD process,a solid mat.r.al sample is subjected to very high loads without a significant change in sample *** the present work,the high-pressure t.r.ion(HPt)process,as one of the SPD techniques,which achieves a high degree of deformation and ensures refinement of the microstruct.r.,will be discussed in more *** that grain size control is accepted as a method to obtain mat.r.als with desired charact.r.stics,an overview of the properties of ultrafine-grained titanium-based biomat.r.als to be used in medicine is ***,particular attention is dedicated to the influences of HPt process paramet.r.,primarily hydrostatic pressure,and number of revolutions during t.r.ion,on the grain size and physical and mechanical charact.r.stics(modulus of elasticity,microhardness,and tensile properties),corrosion resistance,and biocompatibility of the titanium-based biomat.r.als.A review of the lit.r.t.r. indicates that titanium-based mat.r.als obtained by the SPD process show improved mechanical and physical properties without losing biocompatibility and corrosion resistance,which suggests that these methods of obtaining implants are something that should be further developed in the fut.r..

关键词： high-pressure t.r.ion process ultrafine-grained titanium-based mat.r.als electrochemical anodization physical properties mechanical properties