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显示屏的大规模集成化

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发光学报 1976年第2期 34-50页

作者： t.p.brody 傅坤玉西屋研究实验室

固体器件和电路在真空管曾占统治地位的大部分电子学领域里已经获得了一个重要的位置,同时也开辟了一个真空管所不能适用的电子学应用的新领域,如电子计算机和计算器。不过,在固体工艺的胜利进军中,

关键词：有源矩阵西屋液晶材料光电材料象元薄膜晶体管矩阵电路显示屏

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prospective evaluation of ^(18)F-FDG positron emission tomography in the preoperative staging of patients with hepatic colorectal metastases

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Hepatobiliary Surgery and Nutrition 2022年第4期11卷 539-554页

作者： tim Akhurst Mithat Gönen Raymond E.Baser Lawrence H.Schwartz Scott tuorto Lynn A.brody Anne Covey Karen t.Brown Steven M.Larson Yuman Fong Department of Radiology Memorial Sloan-Kettering Cancer CenterNew YorkNYUSA peter MacCallum Cancer Centre VictoriaAustralia Department of Epidemiology and Biostatistics Memorial Sloan-Kettering Cancer CenterNew YorkNYUSA Department of Surgery Memorial Sloan-Kettering Cancer CenterNew YorkNYUSA

Background:Despite considerable advances in preoperative imaging,up to one-third of patients operatively explored for hepatic colorectal metastases are unexpectedly found to harbor unresectable intrahepatic or extrahepatic ***:the current study is a prospective,blinded study comparing utility of[18F]2-fluoro-2-deoxyglucose positron emission tomography(18F-FDG-pEt)to computed tomography(Ct)and Ct arterial portography(CtAp)as preoperative ***:the 125 planned subjects were *** seen on FDG-pEt alone changed therapy for 23 of 125 patients(18%).FDG-pEt confirmed other radiologic findings in 16 cases(13%),for an overall influence on therapy in 39 cases(31%).FDG-pEt was the most sensitive diagnostic imaging test for extrahepatic cancer;it was 80-90%sensitive for extrahepatic cancer and 70-90%*** the 28 cases of unresectable disease due to extrahepatic disease,FDG-pEt findings solely changed therapies in 16 cases(57%)and influenced therapy in seven other cases(25%).Of the 21 unresectable cases due to extent of intrahepatic disease,FDG-pEt did not solely change therapy in ***,FDG-pEt had the lowest sensitivity for hepatic sites compared with Ct or *** particular,small(tumors were particularly poorly detected by *** area under the receiver operating characteristic(ROC)curve for small tumors was 0.58 and for patients on chemotherapy it was 0.66,a modest improvement over no ***:FDG-pEt is an important test for preoperative staging of patients with hepatic colorectal metastases,affecting treatment decisions in nearly one-third of *** high yield is due mainly to detection of extrahepatic *** is therefore recommended in patients with extrahepatic lesions suspected to be disseminated cancer or those with high risk for extrahepatic *** is not a good test for identification of small tumors in the liver.

关键词： positron emission tomography(pEt) computed tomography(Ct) colorectal hepatic metastases surgery

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Multi-Flow Optimization Model for Design of a Shared Backup path protected Network

Multi-Flow Optimization Model for Design of a Shared Backup ...

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2008 IEEE International Conference on Communications(ICC 2008)

作者： brody todd John Doucette Dept.of Mechanical Engineering University of AlbertaEdmontonABCanada T6G 2G8 and TRLabs7th Floor ECERF9107-116 Street NWEdmontonABCanada T6G 2V4

Designing optimal shared backup path protected networks is a difficult and time-consuming task,and considerable research has been done to develop near optimal heuristics and algorithms that will solve the SBpp model without extensive computing power,but by definition,such methods are *** paper introduces a slight modification to the SBpp problem that allows it to be optimally solved using conventional ILp *** allowing working and backup paths to follow multiple routes,the new SBpp model eliminates the numerous 1/0 variables in the conventional *** fundamental characteristics of SBpp remain intact,with the problem altering only slightly but it allows ILp solvers to find an optimal solution in a time measured in seconds to minutes compared to the days or longer needed for conventional models.

关键词： network restoration and protection,shared backup path protection,network design,network optimization,network reliability,network availability

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Interacting with α7 nAChR is a new mechanism for AChE to enhance the inflammatory response in macrophages

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Acta pharmaceutica Sinica B 2020年第10期10卷 1926-1942,2020页

作者： Etta Y.L.Liu Yingjie Xia Xiangpeng Kong Maggie S.S.Guo Anna X.D.Yu brody Z.Y.Zheng Shinghung Mak Miranda L.Xu Karl W.K.tsim Key Laboratory of Food Quality and Safety of Guangdong province College of Food ScienceSouth China Agricultural UniversityGuangzhou 510642China Shenzhen Key Laboratory of Edible and Medicinal Bioresources the Hong Kong University of Science and TechnologyShenzhen 518057China Division of Life Science Center for Chinese Medicinethe Hong Kong University of Science and TechnologyHong kongChina

Acetylcholine(ACh)regulates inflammation viaα7 nicotinic acetylcholine receptor(α7 nAChR).Acetylcholinesterase(AChE),an enzyme hydrolyzing ACh,is expressed in immune cells suggesting non-classical function in inflammatory ***,the expression of pRiMA-linked G4 AChE was identified on the surface of *** lipopolysaccharide-induced inflammatory processes,AChE was upregulated by the binding of NF-κB onto the ACHE ***,the overexpression of G4 AChE inhibited ACh-suppressed cytokine release and cell migration,which was in contrast to that of applied AChE ***,a DNA construct without enzymatic activity,was adopted to identify the protein role of AChE in immune *** of G4 AChEmt induced cell migration and inhibited ACh-suppressed cell *** co-localization ofα7 nAChR and AChE was found in macrophases,suggesting the potential interaction ofα7 nAChR and ***,immunoprecipitation showed a close association ofα7 nAChR and AChE protein in cell ***,the novel function of AChE in macrophage by interacting withα7 nAChR was *** with hydrolysis of ACh,AChE plays a direct role in the regulation of inflammatory *** such,AChE could serve as a novel target to treat age-related diseases by antiinflammatory responses.

关键词： Macrophage AChE Cholinergic anti-inflammatory pathway α7 nAChR

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对参与生物医学研究者给予经济补偿对青少年及其父母的影响

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世界核心医学期刊文摘（儿科学分册） 2005年第8期1卷 38-39页

作者： Scherer D.G. brody J.L. Annett R.D. 平智广 114 Simpson Hall College of Education University of New Mexico Albuquerque NM 87131 United States Dr.

Objective: to examine the impact of financial compensation on pediatric asthm a research participation decision- making and determine whether perceptions of fair compensation differed for parents and adolescents, lower and higher income participants, and compensation- informedand uninformed participants in minimal and above minimal risk researc h. Study design: Adolescents (n = 36) with asthma and their parents reviewed 7 p ediatric asthma research protocols, decided whether they would choose to partici pate, and provided estimates of “ fair" compensation for their participation. C hi- square, analysis of variance, and analysis of covariance were used to deter mine the affects of compensation on participation and whether various respondent s differed in the perceptions of fair compensation. Results: Financial compensat ion did not affect participation decisions. Estimates of fair compensation were lower for adolescents, lower income respondents, and participants who were na ve about potential compensation. Fair compensation estimates were higher than ac tual compensation for minimal risk studies and lower for above minimal risk stud ies. Conclusions: Financial compensation may be a minor consideration in pediatr ic research participation decision- making. Still, differences in how pediatric researchers and their prospective participants judge fair compensation create t he potential for undue influence. pediatric researchers should use caution when determining a reasonable financial compensation for research participation.

关键词：医学研究者认知方面儿科研究方差分析研究工作

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physiology of in-situ arterial revascularization in coronary artery bypass grafting: preoperative,intraoperative and postoperative factors and influences

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World Journal of Cardiology 2016年第11期8卷 623-637页

作者： t Bruce Ferguson Jr CV Sciences East Carolina Heart InstituteEast Carolina Diabetes and Obesity InstituteBrody School of Medicine at East Carolina University

Surgical revascularization with coronary artery bypass grafting(CABG) has become established as the most effective interventional therapy for patients with moderately severe and severe stable ischemic heart disease(SIHD). this recommendation is based on traditional 5-year outcomes of mortality and avoidance of myocardial infarction leading to reintervention and/or cardiac death. However, these results are confounded in that they challenge the traditional CABG surgical tenets of completeness of anatomic revascularization, the impact of arterial revascularization on late survival, and the lesser impact of secondary prevention following CABG on late outcomes. Moreover, the emergence of physiologic-based revascularization with percutaneous cardiovascular intervention as an alternative strategy for revascularization in SIHD raises the question of whether there are similar physiologic effects in CABG. Finally, the ongoing ISCHEMIA trial is specifically addressing the importance of the physiology of moderate or severe ischemia in optimizing therapeutic interventions in SIHD. So it is time to address the role that physiology plays in surgical revascularization. the long-standing anatomic framework for surgical revascularization is no longer sufficient to explain the mechanisms for short-term and long-term outcomes in CABG. Novel intraoperative imaging technologies have generated important new data on the physiologic blood flow and myocardial perfusion responses to revascularization on an individual graft and global basis. Long-standing assumptions about technical issues such as competitive flow are brought into question by real-time visualization of the physiology of revascularization. Our underestimation of the impact of Guideline Directed Medical therapy, or Optimal Medical therapy, on the physiology of preoperative SIHD, and the full impact of secondary prevention on post-intervention SIHD, must be better understood. In this review, these issues are addressed through the

关键词：冠的动脉绕过 grafting 动脉的 revascularization 心肌的灌注外科的结果 Intraoperative 成像

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21世纪促进健康和预防疾病的新模式

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英国医学杂志中文版 2008年第4期11卷 236-238页

作者： Robert N Butler Richard A Miller Daniel perry Bruce A Cames t Franklin William Christine Cassel Jacob brody Marie A Bernard Linda partridge thomas Kirkwood George M Martin S Jay Olshansky 周财亮(译) 张拓红(校) International Longevity Center New York USA University of Michigan Arm Arbor MI USA Alliance for Aging Resea Washington DCUSA University of Oklahoma Oklahoma City OKUSA University of Rochester School of Medicineand Denfistry NY USA American Board oflntemal Medicine Philadelphia PA USA University of Illinois at Chicago 1603 West Taylor Street Chicago IL 60612 USA Institute of Healthy Ageing University College London London Institute for Ageing and Health Newcastle University Newcastle American Federation for Aging Research Scatde WA USA 不详

随着年龄的增长，人类患病的可能性逐渐增加。因此，本文作者Robert Butler和他的同事认为干预人体衰老进程比治疗单个疾病更有效。

关键词：预防疾病健康衰老进程治疗单

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