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A new design of dual-constituent triangular lattice metamaterial with unbounded thermal expansion

Acta Mechanica Sinica 2019年第3期35卷 507-517页

作者： y.C.Zhang y.J.Liang S.t.Liu y.D.su State Key Laboratory of Structural Analysis for Industrial Equipment Dalian University of TechnologyDalian 116024China New Functional Structural Design and Verification Key Laboratory of Aeronautical technology Shenyang 110035China

triangular lattice metamaterials composed of bi-layer curved rib elements (called the Lehman-Lakes lattice) possess unbounded thermal expansion, high stiffness and impossibility of thermal buckling, which are highly desirable in many engineering structural applications subjected to large fluctuations in temperature. However, the requirement of such lattice metamaterial is that it must be a hinged joint in order to achieve the bending deformation upon heating freely, which directly leads to poor manufacturability, especially in small dimensions. In this study, a new design of dual-constituent triangular lattice metamaterial (DtLM) with good manufacturability is proposed to achieve the identical unbounded thermal expansion. In this lattice, a special bi-layer curved rib element where layer one is partially covered by layer two is presented, where the hinge joints are not necessary because the flexural rigidity in the single-layer part is much smaller than that in the bi-layer part, and the desirable thermal bending deformation can be achieved. A sample fabricated by additive manufacturing is given in order to show the good manufacturability;simultaneously, the multifunctional performance of the tailored DtLM with zero, large positive or negative coefficient of thermal expansion (CtE) can remain excellent, as well as the Lehman-Lakes lattice. Examples illustrate that the DtLM with zero CtE has about 34.2% improvement in stiffness and meanwhile has 17% reduction in weight compared with the Lehman-Lakes lattice. the stiffness of the DtLM has a moderate reduction when achieving the same large positive or negative CtE. In addition, the thermomechanical properties of the DtLM are given by the closed-form analytical solution and their effectiveness is verified by the detailed numerical simulation.

关键词： Metamaterial Zero thermal expansion Lattice material Multifunctional design Additive manufacturing

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Enhanced superelasticity and reversible elastocaloric effect in nano-grained Niti alloys with low stress hysteresis

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Chinese Physics B 2024年第5期33卷 557-562页

作者：周敏王维苏浩健胡忠军李来风 Key Laboratory of Cryogenic Science and technology Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China Songshan Lake materials Laboratory Dongguan 523808China

Solid-state cooling technologies have been considered as potential alternatives for vapor compression cooling *** search for refrigeration materials displaying a unique combination of pronounced caloric effect,low hysteresis,and high reversibility on phase transformation was very active in recent ***,we achieved increase in the elastocaloric reversibility and decrease in the friction dissipation of martensite transformations in the superelastic nano-grained Niti alloys obtained by cold rolling and annealing treatment,with very low stress hysteresis(6.3 MPa)under a large applied strain(5%).Large adiabatic temperature changes(△t_(max)=16.3 K atε=5%)and moderate COP_(mater)values(maximum COP_(mater)=11.8 atε=2%)were *** present nano-grained Niti alloys exhibited great potential for applications as a highly efficient elastocaloric material.

关键词： elastocaloric effect stress hysteresis superelasticity Niti alloy

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美国两党对华政策的基本共识与关键分歧

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国际展望 2024年第1期16卷 37-53,158,159页

作者：苏刘强上海国际问题研究院上海200233

自2018年美国对华政策转向强硬以来,特朗普政府与拜登政府都主张对华战略竞争。这表明美国两党的对华政策达成基本共识,将中国作为“主要挑战与对手”,逐渐偏离过去的对华“接触政策”,转而采取以竞争为主的对华政策。尽管美国两党的对... 详细信息

自2018年美国对华政策转向强硬以来,特朗普政府与拜登政府都主张对华战略竞争。这表明美国两党的对华政策达成基本共识,将中国作为“主要挑战与对手”,逐渐偏离过去的对华“接触政策”,转而采取以竞争为主的对华政策。尽管美国两党的对华政策在转向强硬方面具有共识,都以战略竞争概括其对华政策,但在对华强硬程度上存在分歧,且两党在对华战略定位、政策目标、竞争强度与合作意愿方面也不尽相同。美国两党对华政策的关键分歧,就是民主党试图坚持对华战略竞争,同时确保中美竞争不失控;共和党则倾向于对华更激烈的竞争,对华政策具有较强的对抗色彩。美国两党对华政策出现分歧,既有两党背后的利益群体与价值观存在差异的深层原因,也有两党政策精英的对华交往水平存在差异的因素。未来,美国两党对华政策的分歧将继续存在,也有趋同演进的可能。中国需积极应对,加强与美国保守派的政策交流,尽快确立发展中美关系的指导原则,尽力牵制共和党对华战略中的消极倾向,推动中美关系朝着健康、稳定的方向发展。

关键词：中美关系美国两党基本共识关键分歧战略竞争

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Heterogeneously elevated branched-chain/aromatic amino acids among new-onset type-2 diabetes mellitus patients are potentially skewed diabetes predictors

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World Journal of Diabetes 2024年第1期15卷 53-71页

作者： Min Wang yang Ou Xiang-Lian yuan Xiu-Fang Zhu Ben Niu Zhuang Kang Bing Zhang Anwar Ahmed Guo-Qiang Xing Heng su School of Chemical Science and technology Yunnan UniversityKunming 650091Yunnan ProvinceChina Department of Endocrinology The First People’s Hospital of Yunnan ProvinceKunming 650032Yunnan ProvinceChina Clinical Laboratory Nanchong Central Hospital&The Second Clinical Medical College of North Sichuan Medical UniversityNanchong 637000Sichuan ProvinceChina Department of Preventive Medicine and Biostatistics Uniformed Services University of the Health SciencesBethesdaMD 20814United States the Affiliated Hospital and Second Clinical Medical College North Sichuan Medical UniversityNanchong 637000Sichuan ProvinceChina Department of Research and Development Lotus *** LLCGaithersburgMD 20878United States

BACKGROUND the lack of specific predictors for type-2 diabetes mellitus(t2DM)severely impacts early intervention/prevention *** branched-chain amino acids(BCAAs:Isoleucine,leucine,valine)and aromatic amino acids(AAAs:tyrosine,tryptophan,phenylalanine)show high sensitivity and specificity in predicting diabetes in animals and predict t2DM 10-19 years before t2DM onset in clinical ***,improvement is needed to support its clinical *** to evaluate the effects of body mass index(BMI)and sex on BCAAs/AAAs in new-onset t2DM individuals with varying body *** Ninety-seven new-onset t2DM patients(mal weight(NW),n=33,BMI=22.23±1.60;overweight,n=42,BMI=25.9±1.07;obesity(OB),n=22,BMI=31.23±2.31]from the First People’s Hospital of yunnan Province,Kunming,China,were ***-way and 2-way ANOVAs were conducted to determine the effects of BMI and sex on BCAAs/*** Fasting serum AAAs,BCAAs,glutamate,and alanine were greater and high-density lipoprotein(HDL)was lower(Pt2DM patients than in NW-t2DM patients,especially in male OB-t2DM ***,histidine,leucine,methionine,and lysine were greater in male patients than in female ***,histidine,alanine,glutamate,lysine,valine,methionine,leucine,isoleucine,tyrosine,phenylalanine,and tryptophan were significantly correlated with abdominal adiposity,body weight and BMI,whereas isoleucine,leucine and phenylalanine were negatively correlated with *** Heterogeneously elevated amino acids,especially BCAAs/AAAs,across new-onset t2DM patients in differing BMI categories revealed a potentially skewed prediction of t2DM *** higher BCAA/AAA levels in obese t2DM patients would support t2DM prediction in obese individuals,whereas the lower levels of BCAAs/AAAs in NW-t2DM individuals may underestimate t2DM risk in NW *** potentially skewed t2DM prediction should be considered when BCAAs/AAAs are to

关键词： Hyperaminoacidemia Branched-chain/aromatic amino acids New-onset type-2 diabetes Predictor Obesity Sex

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Study on Characteristics of a High-Precision Cold Gas Micro thruster

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Engineering（科研） 2024年第1期16卷 38-45页

作者： Zhaoli Wang Changbin Guan Xudong Wang Weijie Zheng Longfei su Advanced Space Propulsion Lab Beijing Institute of Control Engineering Beijing China

In order to improve the reliability of the spacecraft micro cold gas propulsion system and realize the precise control of the spacecraft attitude and orbit, a micro-thrust, high-precision cold gas thruster is carried out, at the same time due to the design requirements of the spacecraft, this micro-thrust should be continuous working more than 60 minutes, the traditional solenoid valve used for the thrusts can’t complete the mission, so a long-life micro latching valve is developed as the control valve for this micro thruster, because the micro latching valve can keep its position when it cuts off the outage. Firstly, the authors introduced the design scheme and idea of the thruster. Secondly, the performance of the latching valve and the flow characteristics of the nozzle were simulated. Finally, from the experimental results and compared with the numerical study, it shows that the long-life micro cold gas thruster developed in this paper meets the mission requirements.

关键词： High-Precision Micro thruster Performance Flow Characteristic Experiment

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Cyclic Dinucleotide Self-Assembled Nanoparticles as a Carrier-Free Delivery Platform for StING-Mediated Cancer Immunotherapy

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CCS Chemistry 2024年第1期6卷 177-195页

作者： Lang Zhao Shao-Hua Zhuo tian-yang Wang Jun-Jun Wu Jing-yun su Wen-Hao Li Bo-Dou Zhang yan-Mei Li Key Lab of Bioorganic Phosphorus Chemistry&Chemical Biology Department of ChemistryTsinghua UniversityBeijing 100084 Beijing Institute for Brain Disorders Beijing 100069 Center for Synthetic and Systems Biology Tsinghua UniversityBeijing 100084

Cyclic dinucleotides(CDNs)are natural agonists of the stimulator of interferon genes(StING),which is an attractive immunotherapy ***,CDNs and their derivatives are being investigated ***,the poor bioavailability of exogenous CDNs has limited their application in *** nanocarriers are widely used for cytosolic delivery of CDNs,their loading capacity is insufficient,and their complicated composition and purification process raises bio-compatibility ***,we report a super-simplified CDN self-assembly strategy for carrier-free delivery of *** the presence of excess K^(+),CDNs form oligomers which further self-assemble with divalent metal ions(such as Mn^(2+))to form nanoparticles(NPs)in aqueous *** demonstrate that the self-assembled CDN NPs promote cellular uptake of CDNs and enhance tumor immunogenicity by remodeling the tumor microenvironment,inducing immunogenic tumor cell death and increasing tumorinfiltrating lymphocytes,which is conducive to the generation of tumor neoantigen-specific t-cell *** also demonstrate that the use of CDN NPs alone or in combination with immune checkpoint blockades inhibits tumor growth,highlighting the fact that CDN NPs are a potent platform for cancer immunotherapy.

关键词： cyclic dinucleotide StING carrierfree delivery tumor immunogenicity cancer immunotherapy

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Design of double negativity elastic metamaterial

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International Journal of Smart and Nano materials 2015年第1期6卷 61-72页

作者： y.C.su C.t.sun School of Aeronautics and Astronautics Purdue UniversityWest Lafay

A metamaterial model that possesses simultaneously negative effective mass density and negative effective young’s modulus is proposed in this *** curves and dynamic responses of the model are *** the double negative frequency region,it is demonstrated that the phase velocity is *** addition,it was found that the band gap region of the metamaterial can be predicted accurately by taking parts of single-unit cell to analyze the steady-state *** design is also fabricated by a 3D printer.

关键词： acoustic metamaterial double negativity local resonance negative mass negative modulus

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MMC器件损耗分布与电容电压纹波综合优化方法

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电力工程技术 2024年第3期43卷 32-41页

作者：苏田田路茂增马新喜赵艳雷张厚升山东理工大学电气与电子工程学院山东淄博255030

逆变工况下,半桥子模块下部绝缘栅双极晶体管(insulated gate bipolar transistor,IGBt)(简称t_(2)管)损耗占比较大,减小其损耗有利于提升设备运行可靠性。同时,抑制电容电压纹波有利于减小电容需求及提高功率密度。然而,现有优化控制... 详细信息

逆变工况下,半桥子模块下部绝缘栅双极晶体管(insulated gate bipolar transistor,IGBt)(简称t_(2)管)损耗占比较大,减小其损耗有利于提升设备运行可靠性。同时,抑制电容电压纹波有利于减小电容需求及提高功率密度。然而,现有优化控制策略未关注损耗分布优化及电容电压纹波间的矛盾,难以兼顾设备运行可靠性及功率密度。为此,文中提出兼顾减小t_(2)管损耗及抑制电容电压纹波的综合优化方法。首先,通过分析电荷量对器件损耗及电容电压纹波的影响路径,阐述减小t_(2)管的通态损耗与抑制电容电压纹波间的内在矛盾。接着,通过引入罚函数,建立计及t_(2)管损耗及电容电压纹波的综合目标函数。然后,以主动旁路策略为例,通过分析二倍频环流与三次谐波电压注入对t_(2)管损耗和电容电压纹波的影响规律,提出基于二倍频环流及三次谐波电压注入的综合优化方法。最后,在matLAB/Simulink及PLECS中搭建仿真模型进行验证。仿真结果表明:该综合优化方法兼顾了t_(2)管损耗与电容电压纹波优化,一定程度上增加了设备可靠性与设备的功率密度。

关键词：半桥型模块化多电平换流器(MMC) 损耗分布电容电压纹波二倍频环流三次谐波电压主动旁路

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N6-methyladenosine methylation regulates the tumor microenvironment of Epstein-Barr virus-associated gastric cancer

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2555-2570页

作者： yu Zhang Fang Zhou Ming-yu Zhang Li-Na Feng Jia-Lun Guan Ruo-Nan Dong yu-Jie Huang su-Hong Xia Jia-Zhi Liao Kai Zhao Department of Gastroenterology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030Hubei ProvinceChina Institute of Liver and Gastrointestinal Diseases Hubei Key Laboratory of Hepato-Pancreato-Biliary DiseasesTongji Hospital of Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030Hubei ProvinceChina Department of Pharmacy Wuhan Fourth HospitalWuhan 430030Hubei ProvinceChina

BACKGROUND N6-methyladenosine(m6A)methylation modification exists in Epstein-Barr virus(EBV)primary infection,latency,and lytic *** also modifies EBV latent genes and lytic ***-associated gastric cancer(EBVaGC)is a distinctive molecular subtype of *** hypothesized EBV and m6A methylation regulators interact with each other in EBVaGC to differentiate it from other types of *** to investigate the mechanisms of m6A methylation regulators in EBVaGC to determine the differentiating factors from other types of *** First,the Cancer Gene Atlas and Gene Expression Omnibus databases were used to analyze the expression pattern of m6A methylation regulators between EBVaGC and EBV-negative GC(EBVnGC).Second,we identified Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)functional enrichment of m6A-related differentially expressed *** quantified the relative abundance of immune cells and inflammatory factors in the tumor microenvironment(tME).Finally,cell counting kit-8 cell proliferation test,transwell test,and flow cytometry were used to verify the effect of insulin-like growth factor binding protein 1(IGFBP1)in EBVaGC cell *** m6A methylation regulators were involved in the occurrence and development of *** with EBVnGC,the expression levels of m6A methylation regulators Wilms tumor 1-associated protein,RNA binding motif protein 15B,CBL proto-oncogene like 1,leucine rich pentatricopeptide repeat containing,heterogeneous nuclear ribonucleoprotein A2B1,IGFBP1,and insulin-like growth factor 2 binding protein 1 were significantly downregulated in EBVaGC(Pthe overall survival rate of EBVaGC patients with a lower expression level of IGFBP1 was significantly higher(P=0.046).GO and KEGG functional enrichment analyses showed that the immunity pathways were significantly activated and rich in immune cell infiltration in *** with EBVnGC,the infiltration of activated CD4+t cells,activated CD8+t cel

关键词： N6-methyladenosine methylation tumor microenvironment Epstein-Barr virus Gastric cancer Insulin-like growth factor binding protein 1

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Evaluation of in situ spoilage ability of common facultative anaerobic bacteria and confirmation of volatile spoilage markers in vacuum-packaged lamb

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Food Science and Human Wellness 2024年

作者： Xiangyuan Wen Dequan Zhang su Wang Zhiyuan Xiao Xin Li Debao Wang Wei yang Chengjun Min Chengli Hou Institute of Food Science and technology， Chinese Academy of Agricultural Sciences， Key Laboratory of Agro-Products Quality and Safety Control in Storage and transport Process， Ministry of Agriculture and Rural Affairs Institute of Agricultural Product Processing and Nutritional Health， Chinese Academy of Agricultural Sciences (Cangzhou) sunrise material Co.， Ltd Jiangyin Beijing Ershang Meat Food Group Co.， Ltd

Microbial growth causes lamb spoilage. this study explored the spoilage ability of Latilactobacillus sakei (L. sakei)， Serratia proteamaculans (S. proteamaculans) and Hafnia proteus (H. proteus) in vacuum-packed raw lamb， including growth ability， degradation of protein and lipid， and change of volatile organic compounds (VOCs) profile， meanwhile screened the key VOCs produced by the targeted strains with meat background excluding， finally confirmed the volatile spoilage marker of vacuum-packaged lamb by comparing with our previous work. the results showed that L. sakei， S. proteamaculans and H. proteus had excellent growth ability. L. sakei inoculated group significantly reduced the pH value， showed higher tCA-soluble peptides content， and excellently degraded sarcoplasmic and myofibrillar proteins. About free amino acids， L. sakei significantly degraded serine， arginine and aspartic acid， while S. proteamaculans and H. proteus significantly degraded serine and lysine. In addition， L. sakei had a strongest effect on promoting free fatty acids production， followed by S. proteamaculans and finally H. proteus. Evaluating from various indicators， the co-culture of the three strains did not have any effect. the key volatiles produced by L. sakei were 1-hexanol， acetic acid and hexanoic aicd， S. proteamaculans were 1-hexanol and acetoin， and H. proteus was 1-hexanol， acetic acid and acetoin. In the end， 1-hexanol， hexanoic acid and acetoin were proven to be spoilage markers for vacuum-packaged and chilled lamb. this study can provide fundamental information for inhibiting and rapid identification of spoilage in vacuum-packaged lamb.

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