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^(32)P后标法分析二氯胺基酚-DNA加合物

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癌变．畸变．突变 1997年第5期9卷 266-270页

作者：衡正昌 t.ong 华西医科大学环境卫生教研室

本研究以核酸酶Ｐ１和正丁醇增强的３２Ｐ后标法分析了２，４—二氯—６—胺基酚（ＤＣＡＰ）染毒的Ｖ７９细胞ＤＮＡ加合物。试验结果：在核酸酶Ｐ１富集方式下，观察到４种ＤＣＡＰ诱发的ＤＮＡ加合物，其含量分别为３８．７、７１．... 详细信息

本研究以核酸酶Ｐ１和正丁醇增强的３２Ｐ后标法分析了２，４—二氯—６—胺基酚（ＤＣＡＰ）染毒的Ｖ７９细胞ＤＮＡ加合物。试验结果：在核酸酶Ｐ１富集方式下，观察到４种ＤＣＡＰ诱发的ＤＮＡ加合物，其含量分别为３８．７、７１．５、８５．７和２２．４／１０８单核苷酸；而正丁醇萃取法，未检出加合物。该结果表明：ＤＣＡＰ具有与哺乳动物细胞ＤＮＡ产生共价结合的能力，与ＤＮＡ共价结合可能是ＤＣＡＰ产生遗传危害和致癌的基本途径。由于ＤＣＡＰ是致癌性农药（８３—１除草剂）在体内的主要代谢产物，ＤＮＡ加合物分析可能成为８３—１除草剂暴露人群监测的重要生物标志。本文还对两种富集方法的敏感性进行了讨论，提出：化合物的极性可能是选用正丁醇富集法的主要依据。

关键词：毒物分析磷32后标法二氯胺基酚 DNA加合物

柴油机车排出的颗粒提取物对V79细胞DNA损伤的研究

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癌变·畸变·突变 1999年第6期 328-329页

作者：邢绥光 M.J.Keane t.ong NationalInstituteforOccupationalSafelyandHealth!WV26505U.S.A 新疆医科大学组织胚胎学教研室!乌鲁木齐830054

Apolipoprotein E elicits targetdirected miRNA degradation to maintain neuronal integrity

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Neural Regeneration Research 2025年第9期20卷 2577-2578页

作者： Jiazi tan Chin-tong ong temasek Life Sciences Laboratory National University of SingaporeSingapore Department of Biological Sciences National University of SingaporeSingapore

Apolipoprotein E has diverse functions in neurons:Apolipoprotein E(ApoE)is a glycoprotein that primarily regulates lipid metabolism and transport in the central nervous *** are three predominant human ApoE protein isoforms with cysteine and arginine substitutions at amino acid positions 112 and 158 that impact their lipidation and related functions(Flowers and Rebeck,2020).ApoE2 is characterized by Cys112 and Cys158,ApoE3 by Cys112 and Arg158,whereas ApoE4 contains Arg112 and Arg158.

关键词： metabolism glycoprotein maintain

“Super-heterojunctioned” thermoelectric polymers

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Chinese Chemical Letters 2025年第2期36卷 32-33页

作者： Hanying Li Wee-Liat.ong MOE Key Laboratory of Macromolecular Synthesis and Functionalization International Research Center for X PolymersDepartment of Polymer Science and Engineering Zhejiang University ZJU-UIUC Institute College of Energy Engineering Zhejiang University

Given the increasing demand for distributed electricity, there is a burning desire to harvest electricity from renewable sources using environmentally friendly methods. thermoelectric (tE) materials can meet this requirement not only because of their ability to convert heat directly into electricity, enabling energy harvesting from waste heat and natural heat resources, but also because more than 60%of the energy is lost as waste heat [1]. the discovery of the tE effect dates back to the 1820s when t. M. Seebeck observed electricity generation at the junction of two conductors with different temperatures. Additionally, when a voltage is applied to tE materials, they can create a temperature difference to enable solid-state cooling (known as the Peltier effect).therefore, the tE effect promises both sustainable energy solutions and temperature control technologies. Over the past two decades,the urgent demand for powering ubiquitous Internet of things devices has sparked significant interest in flexible thermoelectrics(F-tEs), which raises an intriguing question:Is the intrinsically flexible polymer an important candidate for state-of-the-art F-tEs applications?

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GENOtOXIC AND HEMAtOtOXIC EFFECtS OF BENZENE ON BONE MARROW AND SPLEEN CELLS OF RAtS

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癌变．畸变．突变 1991年第S1期3卷 167-167页

作者： X.C.Shi X.G.Xing H.K.Bi V.Hochberg t.ong Institute of Microbiology and Epidemiology BeijingNational Institute for Occupational Sfety and Healty Morgantown WV.USANational Institute for Occupational Sfety and Healty Morgantown WV.USANational Institute for Occupational Sfety and Healty Morgantown WV.USANational Institute for Occupational Sfety and Healty Morgantown WV.USA

Experiments were conducted to investigate thegenotoxicity and hematotoxicity of benzene in ***-Dawley male rats were treated with benzeneintraperitoneally at 220,440,and 880 mg/kg *** were sacrificed at 24,48,and 72ha... 详细信息

关键词： exchanges benzene sampled hematopoietic spleen

苯并芘、环磷酰胺及长春新碱诱发骨髓红细胞微核和造血抑制

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癌变·畸变·突变 1995年第5期 277-277页

作者：石笑春王治乔Ｔ．Ｏｎｇ美国职业安全与健康研究所北京药理毒理研究所

苯并芘、环磷酰胺及长春新碱诱发骨髓红细胞微核和造血抑制石笑春，王治乔，Ｔ．Ｏｎｇ２（北京药理毒理研究所１００８５０美国职业安全与健康研究所ＮＩＯＳＨ）我们已报道了“四种典型化合物诱发大鼠骨髓细胞微核”并发现单次腹腔染... 详细信息

苯并芘、环磷酰胺及长春新碱诱发骨髓红细胞微核和造血抑制石笑春，王治乔，Ｔ．Ｏｎｇ２（北京药理毒理研究所１００８５０美国职业安全与健康研究所ＮＩＯＳＨ）我们已报道了“四种典型化合物诱发大鼠骨髓细胞微核”并发现单次腹腔染毒后２４和４８ｈ二个取样时间的合理...

关键词：苯并芘多核芳香烃环磷酰胺癌得星免疫抑制剂长春新碱骨髓造血系统红细胞微核造血抑制染毒

Enhancing Plant Resilience to Abiotic Stress:the Power of Biostimulants

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Phyton-International Journal of Experimental Botany 2025年第1期94卷 1-31页

作者： Su-Ee Lau Lucas Wei tze Lim Mohd Fadhli Hamdan Colin Chan Noor Baity Saidi Janna ong-Abdullah Boon Chin tan Centre for Research in Biotechnology for Agriculture Universiti MalayaKuala Lumpur50603Malaysia Faculty of Science Universiti MalayaKuala Lumpur50603Malaysia School of Biological Sciences Universiti Sains MalaysiaGeorge Town11800Malaysia School of Biology Faculty of Applied SciencesUiTM Shah AlamShah Alam40450Malaysia Department of Biotechnology Faculty of Applied SciencesUCSI UniversityCheras56000Malaysia Department of Cell and Molecular Biology Faculty of Biotechnology and Biomolecular SciencesUniversiti Putra MalaysiaSerdang43400Malaysia

Abiotic stresses such as drought,heat,salinity,and heavy metal contamination severely affect global agricultural *** 2005 and 2015,droughts caused losses of approximately USD 29 billion in developing countries,and from 2008 to 2018,droughts accounted for over 34%of crop and livestock yield losses,totaling about USD 37 *** support the growing human population,agricultural output must increase substantially,necessitating a 60%–100%rise in crop productivity to meet the escalating *** address environmental challenges,organic,inorganic,and microbial biostimulants are increasingly employed to enhance plant resilience through various morphological,physiological,and biochemical *** biostimulants enhance plant resilience under abiotic stress through mechanisms such as abscisic acid signaling modulation,which regulates stomatal closure to reduce water loss during drought and heat ***,they aid in scavenging reactive oxygen species and stabilizing ion channels,mitigating oxidative damage,and maintaining ionic balance under stress conditions such as *** review summarizes recent advancements in applying these biostimulants,focusing on their roles in triggering morphological,physiological,biochemical,and molecular changes that collectively enhance plant resilience under stress *** also includes a bibliometric analysis of all articles published on biostimulants from 2019 to 2024 and explores future research *** was placed on optimizing biostimulant formulations and understanding their synergistic effects to maximize their efficacy under various stress *** integrating biostimulants into agricultural practices,we can adopt a sustainable strategy to safeguard crop productivity in the face of climate change and environmental stressors.

关键词： Abiotic stress crop improvement microbial plant growth promoting rhizobacteria protein hydrolysate seaweed

testing Cotton gravity as dark matter substitute with weak lensing

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Science China(Physics,Mechanics & Astronomy) 2025年

作者： Geyu Mo Qingqing Wang Xin Ren Weitong Yan Qinxun Li Yen Chin ong Wentao Luo CAS Key Laboratory for Researches in Galaxies and Cosmology School of Astronomy and Space ScienceUniversity of Science and Technology of China Department of Astronomy School of Physical Sciences University of Science and Technology of China Department of Physics Tokyo Institute of Technology Universita¨ts-Sternwarte Fakulta¨t fu¨r Physik Ludwig-Maximilians Universita¨t Mu¨nchen Center for Gravitation and Cosmology College of Physical Science and Technology Yangzhou University School of Aeronautics and Astronautics Shanghai Jiao Tong University

Harada proposed a modified theory of gravity called Cotton gravity, and argued that it successfully explains the rotation curves of 84 galaxies without the need for dark matter. In this work, we use the galaxy-galaxy lensing technique to test whether the modification effect of Cotton gravity can indeed be a viable substitute for dark matter. Using the spherically symmetric solution of Cotton gravity, we obtain the deflection angle via the Gauss-Bonnet theorem and the weak lensing shear. We use five galaxy catalogs divided into 5 stellar mass bins from the Sloan Digital Sky Survey Data Release 7(SDSS DR7), each further divided into blue star-forming galaxy and red passive galaxy sub-catalogs. We find that Cotton gravity on its own has a significant deviation from the measured galaxy-galaxy lensing signals, thus it cannot replace the role of dark matter. If we consider the combination of dark matter and Cotton gravity, the modification is tightly constrained. Our analysis also applies to other modified gravity theories whose an additional linear term appears in the Schwarzschild solution.

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苯对大鼠骨髓和脾细胞的遗传毒性和血液学毒性

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癌变．畸变．突变 1991年第2期3卷 115-115页

作者：石笑春邢绥光 H.K.Bi V.Hochberg t.ong 军事医学科学院微生物流行病研究所美国职业安全与健康研究所(MIOSH)

Sprague-Dawley雄性大鼠单次腹腔注射苯220、440和880毫克/公斤体重,24、48和72小时处死动物,取样制作标本。通过检查骨髓和脾细胞的微核与姐妹染色单体互换(SCE)的频率测定其遗传学毒性;通过观察骨髓细胞的形态并分析红系和粒系细胞的... 详细信息

Sprague-Dawley雄性大鼠单次腹腔注射苯220、440和880毫克/公斤体重,24、48和72小时处死动物,取样制作标本。通过检查骨髓和脾细胞的微核与姐妹染色单体互换(SCE)的频率测定其遗传学毒性;通过观察骨髓细胞的形态并分析红系和粒系细胞的异常中期分裂相、粒系与红系的比值(M/E)

关键词：遗传毒性脾细胞血液学毒性大鼠染色单体互换粒系细胞微核中期分裂空泡样变造血系统