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MRCP and MRI findings in 9 patients with autoimmune pancreatitis

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World Journal of Gastroenterology 2006年第18期12卷 2919-2922页

作者： terumi Kamisawa Pong-Yui Chen Yuyang tu Hitoshi Nakajima Naoto Egawa Kouji tsuruta Atsutake okamoto Noriko Kamata Department of Internal Medicine Tokyo Metropolitan Komagome Hospital Bukyo-ku Tokyo Japan Department of Surgery Tokyo Metropolitan Komagome Hospital Bunkyo-ku Tokyo Japan Department of Radiology Tokyo Metropolitan Komagome Hospital Bunkyo-ku Tokyo Japan

AIM： to evaluate magnetic resonance cholangiopancreatography （HRCP） findings in conjunction with magnetic resonance （MR） images in autoimmune pancreatitis （AIP） patients. MEtHODS： Nine patients with AIP underwent HRI, HRCP, endoscopic retrograde cholangiopancreatography （ERCP）, computed tomography, and ultrasonography. the HRCP and MR images taken before and after steroid therapy were reviewed and compared with other imaging modalities. the HRCP findings of the AIP cases were compared to those of 10 cases with carcinoma of the head of the pancreas.RESULtS： On MRCP, the narrowed portion of the main pancreatic duct noted on ERCP was not visualized, while the non-involved segments of the main pancreatic duct were visualized. the degree of upstream dilatation of the proximal main pancreatic duct was milder than that seen in cases of pancreatic carcinoma. Stenosis or obstruction of the lower bile duct was detected in 8 patients. MR images showed enlargement of the pancreas with decreased signal intensity on t1- weighted MR images, increased signal intensity on t2- weighted MR images, and, in 3 patients, a hypointense capsule-like rim. After steroid therapy, the previously not visualized portion of the main pancreatic duct was seen, along with improvement of the bile duct stenosis. Pancreatic enlargement decreased, and the abnormal signal intensity on both t1- and t2-weighted MR images became isointense.CONCLUSION： MRCP cannot differentiate irregular narrowing of the main pancreatic duct seen with AIP from stenosis of the main pancreatic duct seen with pancreatic carcinoma. However, MRCP findings in conjunction with MR imaging of pancreatic enlargement that shows abnormal signal intensity on t1- and t2- weighted MR images are useful in supporting a diagnosis of AIP.

关键词： Autoimmune pancreatitis Magnetic resonance cholangiopancreatography Magnetic resonance

直径9.8mm的超细型结肠镜进行全结肠检查

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世界核心医学期刊文摘（胃肠病学分册） 2005年第12期1卷 43-44页

作者： okamoto M. Kawabe t. Kato J. 赵菊辉 Department of Gastroenterology Faculty of Medicine University of Tokyo 7- 3- 1Hongo Bunkyo- ku Tokyo 113- 8655 Japan Dr.

Background: the pediatric colonoscope is superior to the standard colonoscope in some patients with a fixed,angulated colon. A colonoscope thinner than the pediatric one is thought to out- perform even the pediatric colonoscope in such cases. this study was conducted to assess the efficacy of an ultrathin colonoscope, 9.8 mm in diameter, comparing it with pediatric and standard colonoscopes. Methods: three types of colonoscopes were used: ultrathin, pediatric, and standard. A total of 287 consecutive patients were assigned to three groups: ultrathin (n = 94), pediatric (n = 98), and standard (n = 95). First assessment was the ratio of cecal intubation and the reasons for unsuccessful colonoscopy. the second was the time to cecal intubation. Results: Cecal intubation rates were not different among three groups (96% in each). the main reasons for failed colonoscopy were looping in the ultrathin group, and angulation or stricture in the pediatric and standard groups. Mean time to the cecum was slightly longer in the ultrathin group (6.5 minutes) than the pediatric group (5.6 minutes) and standard group (6.1 minutes), but there were no significant differences among three groups. Conclusion: Colonoscopy with the ultrathin colono- scope was as successful as with the pediatric and standard colonoscopes. the advantage of the ultrathin colonoscope might be notable in cases with stricture or severe angulation.

关键词：结肠镜检全结肠肠腔狭窄次要指标肠狭窄评价指标

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老年患者右侧结肠易发扁平型早期结肠直肠癌

世界核心医学期刊文摘（胃肠病学分册） 2005年第10期1卷 17-18页

作者： okamoto M. Kawabe t. Yamaji Y. 赵天智 Department of Gastroenterology Faculty of Medicine University of Tokyo 7-3-1 Hongo Bunkyo-ku 113-8655 Tokyo Japan Dr.

BACKGROUND: Flat-type colorectal cancer is frequently reported in Japan and Europe, but its clinical features remain obscure. thus, we investigated the clinical features of flat-type early colorectal cancer with respect to tumor location and patient age and compared them with those of polypoid-type early and advanced cancer. MEtHODS: Between January 1999 and June 2001, total colonoscopy was performed in 6,178 patients (mean age, 61 years; 4,290 males and 1,888 females). Of these patients, 402 patients with 429 colorectal cancers were found: 202 at advanced stage (invading beyond muscularis propria) and 227 at early stage (carcinoma in situ or invading within submucosa). Early-stage cancer was classified into two macroscopic subgroups: flat-type and polypoid-type. RESULtS: Out of 227 early cancers, 44 were flat type and 183 were polypoid. Flat-type early cancer was more frequently located in the right colon (57 percent, 25/44) than polypoid-type cancer (19 percent, 35/183; P tous component in flat-type early cancer was less frequent than in polypoid-type cancer (23 percent vs. 92 percent, P the proportion of right-sided colon in flat-type early cancer increased with age (33 percent in patients ≤59 years, 50 percent in patients between 60 and 69 years, and 72 percent in patients ≥70 years), whereas polypoid-type early cancer showed minimal change (16 percent, 18 percent, and 25 percent, respectively). An increase in the proportion of right-sided colon with age was also found in advanced cancer (20 percent, 38 percent, and 52 percent, respectively). CONCLUSION: the incidence of flat-type early cancer in right-sided colon increased with age, similar to the pattern of advanced cancer. this suggests that flat-type early cancer may be a precursor of advanced cancer in the right colon, especially in older people.

关键词：结肠直肠癌扁平型早期癌息肉型固有肌层原位癌肿瘤位置全结肠内镜检查黏膜下层

Removal of diminutive colorectal polyps: A prospective randomized clinical trial between cold snare polypectomy and hot forceps biopsy

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World Journal of Gastroenterology 2017年第2期23卷 328-335页

作者： Yoriaki Komeda Hiroshi Kashida toshiharu Sakurai George tribonias Kazuki okamoto Masashi Kono Mitsunari Yamada teppei Adachi Hiromasa Mine tomoyuki Nagai Yutaka Asakuma Satoru Hagiwara Shigenaga Matsui tomohiro Watanabe Masayuki Kitano takaaki Chikugo Yasutaka Chiba Masatoshi Kudo Department of Gastroenterology and Hepatology Kindai University Faculty of Medicine Department of Pathology Kindai University Faculty of Medicine Clinical Research Center Kindai University Hospital

AIMto compare the efficacy and safety of cold snare polypectomy (CSP) and hot forceps biopsy (HFB) for diminutive colorectal *** prospective, randomized single-center clinical trial included consecutive patients ≥ 20 years of age with diminutive colorectal polyps 3-5 mm from December 2014 to October 2015. the primary outcome measures were en-bloc resection (endoscopic evaluation) and complete resection rates (pathological evaluation). the secondary outcome measures were the immediate bleeding or immediate perforation rate after polypectomy, delayed bleeding or delayed perforation rate after polypectomy, use of clipping for bleeding or perforation, and polyp retrieval rate. Prophylactic clipping after polyp removal wasn’t routinely *** hundred eight patients were randomized into the CSP (102), HFB (106) and 283 polyps were evaluated (CSP: 148, HFB: 135). the en-bloc resection rate was significantly higher with CSP than with HFB [99.3% (147/148) vs 80.0% (108/135), P the complete resection rate was significantly higher with CSP than with HFB [80.4% (119/148) vs 47.4% (64/135), P the immediate bleeding rate was similar between the groups [8.6% (13/148) vs 8.1% (11/135), P = 1.000], and endoscopic hemostasis with hemoclips was successful in all cases. No cases of perforation or delayed bleeding occurred. the rate of severe tissue injury to the pathological specimen was higher HFB than CSP [52.6% (71/135) vs 1.3% (2/148), P trieval failure was encountered CSP (7), HFB (2).CONCLUSIONCSP is more effective than HFB for resecting diminutive polyps. Further long-term follow-up study is required.

关键词： Cold snare polypectomy Colonoscopy Polypectomy Colorectal diminutive polyps Hot forceps biopsy

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新型2.0L高效柴油机的开发

汽车与新动力 2013年第6期45卷 26-32页

作者： Chisaki J Yoshijima K Kikuchi t Morinaka S Yamada K okamoto M Oda t Manabe K 闫红梅

丰田汽车公司致力于应用高可靠、低成本的基础技术来开发兼具驾驶乐趣和高燃油效率的车辆。开发侧重于燃烧特性和摩擦的逐步改进,最大限度地利用新型2.0 L高效柴油机的最大潜力。自2011年11月以来,这种新型发动机已在世界各地的市场推出... 详细信息

丰田汽车公司致力于应用高可靠、低成本的基础技术来开发兼具驾驶乐趣和高燃油效率的车辆。开发侧重于燃烧特性和摩擦的逐步改进,最大限度地利用新型2.0 L高效柴油机的最大潜力。自2011年11月以来,这种新型发动机已在世界各地的市场推出,被用于Avensis、Auris、RAV4和Verso等车型。概述了新型发动机及其技术要点。

关键词：柴油机燃油效率电控可变机油泵双室油底壳

Dose escalation of external beam radiotherapy for high-risk prostate cancerdImpact of multiple high-risk factor

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Asian Journal of Urology 2019年第2期6卷 192-199页

作者： Rei Umezawa Koji Inaba Satoshi Nakamura Akihisa Wakita Hiroyuki okamoto Keisuke tsuchida tairo Kashihara Kazuma Kobayashi Ken Harada Kana takahashi Naoya Murakami Yoshinori Ito Hiroshi Igaki Keiichi Jingu Jun Itami Department of Radiation Oncology National Cancer Center HospitalChuo-kuTokyoJapan Department of Radiation Oncology Tohoku University Graduate School of MedicineSendaiJapan

Objective:to retrospectively investigate the treatment outcomes of external beam radiotherapy with androgen deprivation therapy(ADt)in high-risk prostate cancer in three radiotherapy dose ***:Between 1998 and 2013,patients with high-risk prostate cancer underwent threedimensional conformal radiotherapy or intensity-modulated radiotherapy of 66 Gy,72 Gy,or 78 Gy with ***-specific antigen(PSA)relapse was defined using the Phoenix *** relapse-free survival(PRFS)was evaluated in each radiotherapy dose ***,high-risk patients were divided into H-1(patients with multiple high-risk factors)and H-2(patients with a single high-risk factor)as risk ***:two hundred and eighty-nine patients with a median follow-up period of 77.3 months were analyzed in this *** median duration of ADt was 10.1 ***,Gleason score,t stage,and radiotherapy dose influenced PRFS with statistical significance both in univariate and multivariate *** 4-year PRFS rates in Group-66 Gy,Group-72 Gy and Group-78 Gy were 72.7%,81.6%and 90.3%,*** rates in the H-1 subgroup differed with statistical significance with an increasing radiotherapy dose having a more favorable PRFS,while PRFS rates in H-2 subgroup did not differ with increase in radiotherapy ***:Dose escalation for high-risk prostate cancer in combination with ADt improved *** for patients in the H-1 subgroup was poor,but dose escalation in those patients was beneficial,while dose escalation in the H-2 subgroup was not proven to be effective for improving PRFS.

关键词： Prostate cancer External beam radiotherapy Dose escalation Biochemical control

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新型高速棒线轧机传动与控制系统

新型高速棒线轧机传动与控制系统

2005中国钢铁年会

作者： toshifumi Kuri Ken okamoto 东芝三菱电器系统公司东芝三菱电器系统公司长材部

年产50万t的新型高速棒线轧机于2005年1月在韶钢松山集团公司成功投产,该轧线为单线式线材轧机,主要生产高级别的线材。生产线由18架轧机、8道次无扭线材轧机和4道次定径机组成。东芝三菱电器系统公司（tMEIC）为该轧机配置了最先进的... 详细信息

年产50万t的新型高速棒线轧机于2005年1月在韶钢松山集团公司成功投产,该轧线为单线式线材轧机,主要生产高级别的线材。生产线由18架轧机、8道次无扭线材轧机和4道次定径机组成。东芝三菱电器系统公司（tMEIC）为该轧机配置了最先进的交流传动系统和自动化控制系统。

关键词：高速棒线轧机轧机传动控制系统交流传动系统轧机自动化

来源： cnki会议评论

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电炉底吹EF—KGC工艺

涟钢科技与管理 1995年第3期 56-61页

作者： N. Mimura H. Washio M. Usuzaka t. okamoto H. toritani 李洁

1 概述在现代炼钢业中,转炉(BOF)主要目标是通过钢水搅拌的冶金反应来提高效率,直到最近,电炉炼钢集中重点放在通过采用大容量变压器、大容量炉子、废钢予热器和富氧燃烧器来提高冶炼能力。然而,从搅拌钢水的冶金反应方面来看,则几乎没... 详细信息

1 概述在现代炼钢业中,转炉(BOF)主要目标是通过钢水搅拌的冶金反应来提高效率,直到最近,电炉炼钢集中重点放在通过采用大容量变压器、大容量炉子、废钢予热器和富氧燃烧器来提高冶炼能力。然而,从搅拌钢水的冶金反应方面来看,则几乎没有取得什么改进。

关键词：耐火材料电炉炼钢电弧炉喷嘴底吹冶金反应钢水搅拌单位电耗冶金效果水模型试验

Advances in inducing adaptive immunity using cell-based cancer vaccines: clinical applications in pancreatic cancer

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World Journal of Gastroenterology 2016年第18期22卷 4446-4458页

作者： Mikio Kajihara Kazuki takakura tomoya Kanai Zensho Ito Yoshihiro Matsumoto Shigetaka Shimodaira Masato okamoto toshifumi Ohkusa Shigeo Koido Division of Gastroenterology and Hepatology Department of Internal Medicine the Jikei University School of Medicine (Kashiwa Hospital) Cell Processing Center Shinshu University Hospital Department of Advanced Immunotherapeutics Kitasato University School of Pharmacy Institute of Clinical Medicine and Research The Jikei University School of Medicine

the incidence of pancreatic ductal adenocarcinoma(PDA) is on the rise, and the prognosis is extremely poor because PDA is highly aggressive and notoriously difficult to treat. Although gemcitabine- or 5-fluorouracil-based chemotherapy is typically offered as a standard of care, most patients do not survive longer than 1 year. therefore, the development of alternative therapeutic approaches for patients with PDA is imperative. As PDA cells express numerous tumor-associated antigens that are suitable vaccine targets, one promising treatment approach is cancer vaccines. During the last few decades, cell-based cancer vaccines have offered encouraging results in preclinical studies. Cell-based cancer vaccines are mainly generated by presenting whole tumor cells or dendritic cells to cells of the immune system. In particular, several clinical trials have explored cell-based cancer vaccines as a promising therapeutic approach for patients with PDA. Moreover, chemotherapy and cancer vaccines can synergize to result in increased efficacies in patients with PDA. In this review, we will discuss both the effect of cell-based cancer vaccines and advances in terms of future strategies of cancer vaccines for the treatment of PDA patients.

关键词： Pancreatic cancer Dendritic cell whole tumor cell Cancer vaccine Cytotoxic t lymphocyte