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Identification of Proteins and genes Associated with Hedgehog signaling Pathway Involved in Neoplasm Formation Using text-Mining Approach

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Big Data Mining and Analytics 2024年第1期7卷 107-130页

作者： Nadezhda Yu.Biziukova sergey M.Ivanov oga A.tarasova Department of Bioinformatics Institute of Biomedical ChemistryMoscow 119121Russia Department of Bioinformatics Pirogov Russian National Research Medical UniversityMoscow 117997Russia

Analysis of molecular mechanisms that lead to the development of various types of tumors is essential for biology and medicine,because it may help to find new therapeutic opportunities for cancer treatment and cure including personalized treatment *** of the pathways known to be important for the development of neoplastic diseases and pathological processes is the Hedgehog signaling pathway that normally controls human embryonic *** accumulation of various types of biological data,including interactions between proteins,regulation of genes transcription,proteomics,and metabolomics experiments results,allows the application of computational analysis of these big data for identification of key molecular mechanisms of certain diseases and pathologies and promising therapeutic *** aim of this study is to develop a computational approach for revealing associations between human proteins and genes interacting with the Hedgehog pathway components,as well as for identifying their roles in the development of various types of *** automatically collect sets of abstract texts from the NCBI PubMed bibliographic *** recognition of the Hedgehog pathway proteins and genes and neoplastic diseases we use a dictionary-based named entity recognition approach,while for all other proteins and genes machine learning method is *** association extraction,we develop a set of semantic *** complete the results of the text analysis with the gene set enrichment *** identified key pathways that may influence the Hedgehog pathway and their roles in tumor development are then verified using the information in the literature.

关键词： text-mining data mining Hedgehog pathway neoplastic processes enrichment analysis pathology molecularmechanisms

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Harnessing therapeutic potential of induced pluripotent stem cell–derived endothelial cells for remyelination in the central nervous system

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Neural Regeneration Research 2025年第6期20卷 1715-1716页

作者： Dan Ma nona Pop Aston Medical school College of Health and Life SciencesAston UniversityBirminghamUK

Myelin is the protective sheath surrounding nerve fibers, and its damage(demyelination) occurs in many central nervous system(CNs) diseases, including multiple sclerosis(Ms), traumatic injury, neurodegenerative diseases such as Alzheimer's disease, and mental disorders such as schizophrenia(Barateiro et al., 2016). Repair of damaged myelin sheaths(remyelination) often fails in Ms, leading to neuronal loss and irreversible functional deficits.

关键词： myelin protective diseases

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Effect of radiative loss mechanisms on FIR thermometric parameters of Nd^(3+)-doped lithium tellurite glasses

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Journal of Rare Earths 2024年第7期42卷 1250-1257,I0002页

作者： C.Y.Morassuti A.P.L silva L.A.O.nunes s.M.Lima L.H.C.Andrade Optical and Photothermal spectroscopy group(gEOF) Center for Studies in Natural Resources(CERNA)State University of Mato Grosso do Sul(UEMS)C.P.351DouradosMSBrazil Renato Archer Information technology Center Dom Pedro I Highway(SP-65)Km 1436-Chácaras Campos dos AmaraisCampinasSPBrazil Institute of Physics of são Carlos University of São PauloSão CarlosSPBrazil

Nd^(3+)-doped tellurite glasses are promising materials for thermometers based on the fluorescence intensity ratio(FIR)***,at high Nd^(3+)concentrations,energy transfer(Et)processes such as optical reabsorption and cross-relaxation can affect the Nd^(3+)emission,which has been little explored in the ***,the present work investigated the use of Nd^(3+)-doped tellurite glass(samples doped with Nd^(3+)at 0.2 mol%,0.5 mol%,2.0 mol%,and 4.0 mol%)in fluorescence thermometers,in the temperature range from 299 to 371 *** results indicate a strong dependence of the FIR parameters on the Nd^(3+)concentration,due to changes in the emission band profiles caused by optical reabsorption of the Nd^(3+)emissions and cross-relaxation processes.A decrease of the relative sensitivity of the ratio^(4)F_(5/2)→^(4)I_(9/2)/^(4)F_(3/2)→^(4)I_(9/2)is observed for samples doped with higher amounts of Nd^(3+).the maximum relative sensitivity at 299 K is 3.00%/K,which is the highest value among the reported Nd^(3+)ions.

关键词： Nd^(3+)-doped tellurite glass Fluorescence intensity ratio Optical thermometry Judd-Ofelt Rare earths

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Conducting Polymer-Based e-Refinery for sustainable Hydrogen Peroxide Production

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Energy & Environmental Materials 2024年第2期7卷 334-342页

作者： Zhixing Wu Penghui Ding Viktor gueskine Robert Boyd Eric Daniel g■owacki Magnus odén Xaνier Crispin Magnus Berggren Emma M.Björk Mikhail Vagin Nanostructured Materials Department of PhysicsChemistry and Biology(IFM)Linköping UniversitySE 58183LinköpingSweden Laboratory of Organic Electronics Department of Science and Technology(ITN)Linköping UniversitySE 60174NorrköpingSweden

Electrocatalysis enables the industrial transition to sustainable production of chemicals using abundant precursors and electricity from renewable ***-centralized production of hydrogen peroxide(H_(2)O_(2))from water and oxygen of air is highly desirable for daily life and *** report an effective electrochemical refinery(e-refinery)for H_(2)O_(2)by means of electrocatalysis-controlled comproportionation reaction(2_(H)O+o→2HO),feeding pure water and oxygen *** nickel(Ⅱ)oxide(NiO)was used as electrocatalyst for oxygen evolution reaction(OER),producing oxygen at the *** polymer poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate)(PEDOt:Pss)drove the oxygen reduction reaction(ORR),forming H_(2)O_(2)on the *** reactions were evaluated in both half-cell and device *** performance of the H_(2)O_(2)e-refinery,assembled on anion-exchange solid electrolyte and fed with pure water,was limited by the unbalanced ionic *** of the operation conditions allowed a conversion efficiency of 80%.

关键词： conducting polymer hydrogen peroxide nickel(Ⅱ)oxide oxygen evolution reaction oxygen reduction reaction

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On some topological Properties of Normed Boolean Algebras

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Advances in Pure Mathematics 2024年第5期14卷 367-387页

作者： Vesna gotovac Đogaš Faculty of science University of Split Split Croatia

this paper concerns the compactness and separability properties of the normed Boolean algebras (N.B.A.) with respect to topology generated by a distance equal to the square root of a measure of symmetric difference between two elements. the motivation arises from studying random elements talking values in N.B.A. those topological properties are important assumptions that enable us to avoid possible difficulties when generalising concepts of random variable convergence, the definition of conditional law and others. For each N.B.A., there exists a finite measure space ( E,ℰ,μ ) such that the N.B.A. is isomorphic to ( ℰ ˜ , μ ˜ ) resulting from the factorisation of initial σ-algebra by the ideal of negligible sets. We focus on topological properties ( ℰ ˜ , μ ˜ ) in general setting when μ can be an infinite measure. In case when μ is infinite, we also consider properties of ℰ ˜ fin ⊆ ℰ ˜ consisting of classes of measurable sets having finite measure. the compactness and separability of the N.B.A. are characterised using the newly defined terms of approximability and uniform approximability of the corresponding measure space. Finally, conditions on ( E,ℰ,μ ) are derived for separability and compactness of ℰ ˜ and ℰ ˜ fin .

关键词： Compact Locally Compact Polish space separable

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Clinical Evaluation of two Interferon-gamma Release Assays for Diagnostic tests of tuberculosis Infection in a tertiary Hospital: Clinical Evaluation of two IgRAs for tB Infection

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Journal of tuberculosis Research 2024年第3期12卷 129-141页

作者： Yoshihiro Kobashi toru oga Department of Respiratory Medicine Kawasaki Medical School Kurashiki Japan

Background: the aim of this study was to evaluate the usefulness of two interferon-gamma release assays (IgRAs) (QuantiFERON-tB Plus (QFt-plus) and *** assay) for patients suspected of having tuberculosis (tB) infection as supportive methods for diagnosing tB. Patients and Methods: the subjects consisted of 45 patients who required clinical differentiation of tB disease from June 2019 to August 2023. the final clinical diagnoses were: 14 patients with active tB disease, 4 with latent tB infection (LtBI), 17 with old (cured) tB disease, and 10 with pulmonary nontuberculous mycobacterial (NtM) disease. We used the two IgRAs for these patients and evaluated the data according to the manufacturer’s guidelines for interpretation or FDA-approved cutoffs. Results: Among the total of 14 patients with active tB disease (mean age: 64 years old, male: 9, and female: 5), a positive response was noted in 10 patients (71%) on QFt-plus and 9 (64%) on ***. Four patients with a negative response on QFt-plus and *** were elderly or cancer patients with lymphocytopenia or hypoalbuminemia. All four patients with LtBI showed a positive response (100%) on both QFt-plus and ***. Among the seventeen patients with old (cured) tB disease, a positive response was noted in 8 patients (47%) on QFt-plus and 9 (53%) on ***. All patients with pulmonary NtM disease showed a negative response on both QFt-plus and ***. Conclusions: A false-negative response on QFt-plus as well as *** was recognized in elderly patients and patients with an immunosuppressed condition, and half of patients with old (cured) tB showed no negative conversion after the completion of treatment through this study. Although it was recently reported that the positive response rate on QFt-plus of patients with active tB disease was high, we consider it necessary to be careful in diagnosing tB infection using IgRAs for patients with severe underlying diseases in a tertiary hospital based

关键词： QFt-Plus t-sPOt.tB Diagnosis of tuberculosis tertiary Hospital

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Privacy-Preserving Healthcare and Medical Data Collaboration service system Based on Blockchain and Federated Learning

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Computers, Materials & Continua 2024年第8期80卷 2897-2915页

作者： Fang Hu siyi Qiu Xiaolian Yang ChaoleiWu Miguel Baptista nunes Hui Chen College of Information Engineering Hubei University of Chinese MedicineWuhan430065China College of Information Engineering Zhongnan University of Economics and LawWuhan430073China school of Advanced technologies Xi’an Jiaotong-Liverpool UniversitySuzhou215400China school of Information Management Central China Normal UniversityWuhan430079China

As the volume of healthcare and medical data increases from diverse sources,real-world scenarios involving data sharing and collaboration have certain challenges,including the risk of privacy leakage,difficulty in data fusion,low reliability of data storage,low effectiveness of data sharing,*** guarantee the service quality of data collaboration,this paper presents a privacy-preserving Healthcare and Medical Data Collaboration service system combining Blockchain with Federated Learning,termed *** system is composed of three layers:Data extraction and storage,data management,and data *** on healthcare and medical data,a healthcare and medical blockchain is constructed to realize data storage,transfer,processing,and access with security,real-time,reliability,and *** improved master node selection consensus mechanism is presented to detect and prevent dishonest behavior,ensuring the overall reliability and trustworthiness of the collaborative model training ***,healthcare and medical data collaboration services in real-world scenarios have been discussed and *** further validate the performance of FL-HMChain,a Convolutional Neural Network-based Federated Learning(FL-CNN-HMChain)model is investigated for medical image *** model achieves better performance compared to the baseline Convolutional Neural Network(CNN),having an average improvement of 4.7%on Area Under Curve(AUC)and 7%on Accuracy(ACC),***,the probability of privacy leakage can be effectively reduced by the blockchain-based parameter transfer mechanism in federated learning between local and global models.

关键词： Blockchain technique federated learning healthcare and medical data collaboration service privacy preservation

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Evaluation of red soil-bentonite mixtures for compacted clay liners

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Journal of Rock Mechanics and geotechnical Engineering 2024年第2期16卷 697-710页

作者： A.s.Devapriya t.thyagaraj Department of Civil Engineering Indian Institute of Technology MadrasChennai600036India

Compacted clay liners are an integral part of the waste landfills,which are provided to contain the leachate within the landfills and protect the surrounding ***,locally available natural soils are used for the construction of compacted clay liners if they satisfy the design ***,not all soils in their natural state satisfy all the design criteria for the liner ***,there is a definite need to modify the locally available natural soils by blending with bentonite to meet the required design criteria for the *** view of this,the present study evaluates the suitability of an Indian red soil enhanced with bentonite as a liner *** achieve this,a series of experiments were carried out using locally available red soil and ***,the suitability of the red soil was evaluated as a liner *** experimental results showed that the red soil met all the selection criteria stipulated by the Environmental Protection Agencies(EPAs)for the liners except the hydraulic conductivity ***,the red soil was mixed with bentonite contents of 10%,20%and 30%,and the red soil-bentonite mixtures were evaluated for their suitability for liners in their compacted ***,as the liners in the arid and semi-arid regions are subjected to moisture variations due to seasonal moisture fluctuations and other factors,the red soil-bentonite mixtures were subjected to wetdry cycles,and their suitability was evaluated after wet-dry *** experimental results revealed that all the red soil-bentonite mixtures met the stipulated EPA criteria for the liners in the as-compacted ***,the red soil-bentonite mixtures with 20%and 30%bentonite contents only satisfied the hydraulic conductivity requirement even after wet-dry *** experimental findings were supplemented with the microstructural insights captured through digital camera images,scanning electron microscopy(sEM),and mercury intrusion porosimetry(M

关键词： Compacted clay lines Hydraulic conductivity Wet-dry cycles Microstructure

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Physics of porous materials under extreme laser-generated conditions

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Matter and Radiation at Extremes 2024年第3期9卷 1-3页

作者： V.t.tikhonchuk s.Weber Extreme Light Infrastructure ERIC ELI Beamlines Facility25241 DolníBrezanyCzech Republic CELIA University of Bordeaux33405 TalenceFrance

Porous materials offer unique possibilities for the production of plasmas with controlled density profiles for experiments on laser–matter *** are of growing relevance to many applications,such as inertial confinement fusion,fundamental research,and secondary *** the processes of transformation of a porous solid into a plasma is of fundamental interest and is needed for producing materials with desired properties.

关键词： interaction. properties. porous

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Designated critical habitats for *** species are not protected from climate and land-use change

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geography and sustainability 2024年第3期5卷 482-490页

作者： Aimee Delach Laura A.nunes Alex Borowicz theodore C.Weber Center for Conservation Innovation Defenders of Wildlife113017th Street NWWashingtonD.C.20036United States

Designation of critical habitat is an important conservation tool for species listed as threatened or endangered under the United states(U.s.)Endangered species Act(EsA).While this is an important protective mechanism,lands designated as critical habitat could still be subject to degradation and fragmentation if they are not also in a protected status that prioritizes biodiversity ***,most designations of critical habitat do not explicitly take climate change into *** objective of our study was to determine whether and to what extent critical habitats for species listed under the EsA are located within protected areas and areas previously identified as climate refugia or climate corridors,to inform management strategies to better conserve and recover these *** mapped the designated critical habitats of 153 EsA-listed species and measured their overlap with previously-identified areas of climate refugia and corridors(CRC),and also with lands designated as nature-protected by *** survey’s gap Analysis Project(gAP status 1 or 2)and working lands with wildlife habitat potential(gAP status 3).Only 18%of all designated critical habitat is located on lands that are both in CRC and nature-protected,and only 9%of species had over half of their designated critical habitats in such lands.84%of species hadtheir critical habitats with these *** habitats may therefore not fulfill their essential role of helping imperiled species persist and recover.

关键词： Endangered species Act Critical habitat Climate refugia Climate corridors Protected areas Biodiversity conservation

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