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Computer Modeling in Engineering & Sciences 2016年第4期111卷 303-333页

作者： M.Ohsaki t.miyamura J.Y.Zhang Department of Architecture and Architectural Engineering Kyoto UniversityKyoto-Daigaku KatsuraNishikyoKyoto 615-8540Japan Department of Computer Science Nihon University1 NakagawaraTokusadaTamuraKoriyama 963-8642Japan Department of Architecture and Urban Design Nagoya City University2-1-10 Kita-ChigusaChigusaNagoya 464-0083Japan

A simple constitutive model,called semi-implicit model,for cyclic loading is proposed for steel materials used for structures such as building frames in civil engineering.the constitutive model is implemented in the E-Simulator,which is a software package for large-scale seismic response analysis.the constitutive relation is defined in an algorithmic manner based on the piecewise linear combined isotropic-kinematic hardening.Different rules are used for the first and subsequent loading states to incorporate characteristics such as yield plateau and Bauschinger effect of rolled mild steel materials.An optimization method is also presented for parameter identification from the results of cyclic and monotonic loading tests.therefore,the proposed model is readily applicable to practical elastoplastic analysis of building frames.Accuracy of the model is demonstrated in an example of a cantilever subjected to various types of cyclic loading.

关键词： Combined isotropic-kinematic hardening Piecewise linear hardening Steel material Parameter optimization Cyclic load

Regulation of microRNA by hepatitis B virus infection and their possible association with control of innate immunity

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World Journal of Gastroenterology 2014年第23期20卷 7197-7206页

作者： Xia Jiang tatsuo Kanda Shuang Wu Masato Nakamura tatsuo miyamura Shingo Nakamoto Arup Banerjee Osamu Yokosuka Department of Gastroenterology and Nephrology Graduate School of MedicineChiba UniversityChiba 260-8677Japan Department of Molecular Virology Graduate School of MedicineChiba UniversityChiba 260-8677Japan Vaccine and Infectious Disease Research Center and translational Health Science and technology Institute Gurgaon-122016HaryanaIndia

Hepatitis B virus(HBV)chronically infects more than350 million people worldwide.HBV causes acute and chronic hepatitis,and is one of the major causes of cirrhosis and hepatocellular carcinoma.there exist complex interactions between HBV and the immune system including adaptive and innate immunity.tolllike receptors(tLRs)and tLR-signaling pathways are important parts of the innate immune response in HBV infections.It is well known that tLR-ligands could suppress HBV replication and that tLRs play important roles in anti-viral defense.Previous immunological studies demonstrated that HBV e antigen(HBeAg)is more efficient at eliciting t-cell tolerance,including production of specific cytokines IL-2 and interferon gamma,than HBV core antigen.HBeAg downregulates cytokine production in hepatocytes by the inhibition of MAPK or NF-κB activation through the interaction with receptor-interacting serine/threonine protein kinase.MicroRNAs(miRNAs)are also able to regulate various biological processes such as the innate immune response.When the expressions of approximately 1000 miRNAs were compared between human hepatoma cells HepG2 and HepG2.2.15,which could produce HBV virion that infects chimpanzees,using real-time Rt-PCR,we observed several different expression levels in miRNAs related to tLRs.Although we and others have shown that HBV modulates the host immune response,several of the miRNAs seem to be involved in the tLR signaling pathways.the possibility that alteration of these miRNAs during HBV infection might play a critical role in innate immunity against HBV infection should be considered.this article is intended to comprehensively review the association between HBV and innate immunity,and to discuss the role of miRNAs in the innate immune response to HBV infection.

关键词： Hepatitis B virus HepG2.2.15 Innate immunity Micro

Human CD4^- CD8^- Invariant Natural Killer t Cells Promote IgG Secretion from B Cells Stimulated by Cross-Linking of their Antigen Receptors

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World Journal of Vaccines 2016年第2期6卷 34-41页

作者： tomomitsu Miyasaka Yurie Watanabe Yukiko Akahori Namiko miyamura Keiko Ishii Yuki Kinjo Yoshitsugu Miyazaki tian-Yi Liu Yasushi Uemura Kazuyoshi Kawakami Department of Medical Microbiology Mycology and Immunology Tohoku University Graduate School of Medicine Sendai Japan Department of Chemotherapy and Mycoses National Institute of Infectious Diseases Tokyo Japan Division of Immunology Aichi Cancer Center Research Institute (ACCRI) Nagoya Japan Key Laboratory of Cancer Center Chinese PLA General Hospital Beijing China Division of Cancer Immunotherapy Exploratory Oncology Research & Clinical Trial Center National Cancer Center (NCC) Kashiwa Japan

Immunoglobulin (Ig) M production can be induced by the interaction of thymus-independent type-2 (tI-2) antigen (Ag) with B cell Ag receptors (BCRs) without the involvement of conventional t cells;for IgG production through the same process, however, a second signal is required. Previous studies have reported that invariant natural killer t (iNKt) cells may be responsible for the second signal involved in IgG production. In the present study, we addressed whether human iNKt cells could participate in the production of Ig against tI-2 Ag in vitro. two major distinct subsets of human iNKt cells, CD4+ CD8β- (CD4) and CD4- CD8β- [double negative (DN)] cells, were generated from peripheral blood monocytes from a healthy volunteer. BCR engagement, triggered by anti-IgM antibody stimulation, examined here as a model of BCR engagement triggered by tI-2 Ag, induced abundant IgM production by B cells. Both CD4 and DN iNKt cells reduced IgM production and conversely enhanced IgG production in a dose-dependent manner. In addition, IgG production by CD19+CD27- (naïve) and CD19+CD27+ (memory) B cells was predominantly promoted by DNiNKt cells rather than CD4 iNKt cells;nevertheless, IgM production by both B cell subsets was similarly reduced by either subset of iNKt cells. these results suggest that the DN iNKt subsets may preferentially promote Ig class switching by B cells upon stimulation with tI-2 Ag.

关键词： Invariant Natural Killer t Cells tI-2 Antigen B Cells IgM IgG

Platelet count and sustained virological response in hepatitis C treatment

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World Journal of Hepatology 2013年第4期5卷 182-188页

作者： tatsuo Kanda Keizo Kato Akihito tsubota Nobuo takada takayoshi Nishino Shigeru Mikami tatsuo miyamura Daisuke Maruoka Shuang Wu Shingo Nakamoto Makoto Arai Keiichi Fujiwara Fumio Imazeki Osamu Yokosuka Department of Gastroenterology and Nephrology Graduate School of MedicineChiba UniversityChiba 260-8677Japan Department of Gastroenterology Narita Red Cross HospitalNarita 286-8523Japan Institute of Clinical Medicine and Research Jikei University School of MedicineKashiwa 277-8567Japan Department of Gastroenterology Toho University Sakura Medical CenterSakura 285-8741Japan Department of Gastroenterology Tokyo Women's Medical University Yachiyo Medical CenterYachiyo 276-8524Japan Department of Medicine Kikkoman HospitalNoda 270-0116Japan

AIM:to examine the epidemiological data,hematological safety and treatment responses of peginterferonalpha 2a plus ribavirin therapy for hepatitis C.MEtHODS:Between March 2008 and February 2011,196 hepatitis C virus(HCV)genotype 1 infected Japanese(127 treatment-naive and 69 treatment-experienced patients)patients treated with peginterferonalpha 2a plus ribavirin were enrolled.We examined the epidemiological data and treatment responses were retrospectively analyzed in terms of hematological safety.HCV RNA was measured by the COBAS taqMan HCV test.RESULtS:Overall sustained virological response(SVR)rates of treatment-naive and treatment-experienced patients were 56% and 39%,respectively.Multivariate logistic regression analysis showed that SVR was attained independently of early virological response in both treatment-naive and treatment-experienced patients.SVR rates did not differ between the pretreatment hemoglobin treatment-naive patients,the SVR rate of the pretreatment platelet count tly lower than that of the pretreatment platelet count ≥ 130000/μL group.CONCLUSION:Attention should be paid to potential thrombocytopenia in the treatment of chronic hepatitis C patients.

关键词： Anemia Antiviral treatment Chronic hepatitis C Platelet count Sustained virological response

Non-infectious pulmonary complication after stem cell transplantation and genetic background

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Non-infectious pulmonary complication after stem cell transp...

Complete regression of subcutaneous and cutaneous metastatic melanoma with high-dose intralesional interleukin 2 in combination with topical imiquimod and retinoid cream

第十届亚太国际骨髓移植会议

作者： Onizuka M Kishi K Ando K Hotta t.miyamura K Kodera Y Suyun Li Inoko H Department of Hematology and Rheumatology tokai University School of Medicine Kanagawa Japan Department of Hematology and Rheumatology tokai University School of Medicine Kanagawa Japan Department of Hematology and Rheumatology tokai University School of Medicine Kanagawa Japan Department of Hematology and Rheumatology tokai University School of Medicine Kanagawa Japan Bone Marrow transplantation Center Japanese Red Cross Nagoya First Hospital AichiJapan Bone Marrow transplantation Center Japanese Red Cross Nagoya First Hospital AichiJapan Department of Molecular Life Sciences tokai University School of Medicine KanagawaJapan Department of Molecular Life Sciences tokai University School of Medicine KanagawaJapan

＜正＞Objectives: Non-infectious pulmonary dysfunction （NIPD） represents a common and often fatal complication of hematopoietic stem cell transplantation （HSCt）. In order to predict the risk factor of developing NIPD before transplantation, we investigated genetic polymorphisms of some candidate genes and compared the frequency of developing NIPD with the allele frequency.

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中国神经肿瘤杂志 2011年第1期9卷 65-65页

作者： Garcia MS Ono Y Martinez SR Chen SL Goodarzi H Phan t Wehrli LN miyamura Y Fung MA Maverakis E Departments of Dermatology Surgery Division of Surgical Oncology University of California Davis School of Medicine Department of Veteran Affairs Northern California Health Care System Sacramento California USA

there are limited treatment options for metastatic melanoma, which is almost universally fatal. We report the successful treatment of 64 of 64 cutaneous and subcutaneous melanoma metastases in three patients using high-dose (22 million units per 1.2 ml) intralesional interleukin 2 (IL-2) in combination with topical imiquimod and a retinoid cream. Before intralesional therapy, all patients had been treated surgically and were no longer considered surgical candidates.

关键词：黑色素瘤咪喹莫特白细胞介素2 高剂量转移性维甲酸皮肤外用

核心结合因子t(8;21)型和inv(16)型急性髓细胞白血病患者造血干细胞移植效果

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中华移植杂志（电子版） 2009年第4期3卷 335-335页

作者：周立群来晓瑜 Kuwatsuka Y miyamura K Suzuki R 不详

急性髓细胞白血病(AML)核心结合因子包括t(8;21)(q22;q22)和 inv(16)(p13q22)/t(16;16)(p13;q22)两大类,其中inv(16)在临床上被认为是较好的细胞遗传学分型标准.许多小样本的研究报道,t(8;21)型AML患者行造血干细胞移植(HSCt)的效果较in... 详细信息

急性髓细胞白血病(AML)核心结合因子包括t(8;21)(q22;q22)和 inv(16)(p13q22)/t(16;16)(p13;q22)两大类,其中inv(16)在临床上被认为是较好的细胞遗传学分型标准.许多小样本的研究报道,t(8;21)型AML患者行造血干细胞移植(HSCt)的效果较inv(16)型AML患者差.日本的研究者统计了日本HSCt移植登记中心1996～2004年的数据,发现255例t(8;21)型和83例inv(16)型AML成人患者接受了HSCt,inv(16)型受者的整体效果优于t(8;21)型受者.

关键词：急性髓细胞白血病 HSCt 异基因 inv 核心结合因子患者造血干细胞移植