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MR扩散加权成像评价肾纤维化:单侧输尿管梗阻鼠模型研究

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国际医学放射学杂志 2010年第4期 382-383页

作者： O.togao S.Doi M.Kuro-o t.masaki N.Yorioka M.takahashi 李宁 the Advanced Imaging Research Center UT Southwestern Medical Center2201 Inwood RdDallasTX 75390-8542Japan

目的利用MR成像对单侧输尿管梗阻(UUO)鼠模型进行检测,评价表观扩散系数(ADC)是否随肾纤维化进展而改变及其与肾纤维化的病理组织学变化的相关性。材料与方法该研究经动

关键词：加权成像 ADC 肾纤维化输尿管梗阻 MR 鼠模型单侧

Electro-optic 3D snapshot of a laser wakefield accelerated kilo-ampere electron bunch

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Light(Science & Applications) 2024年第5期13卷 823-834页

作者： Kai Huang Zhan Jin Nobuhiko Nakanii tomonao Hosokai masaki Kando Kansai Institute for Photon Science(KPSI) National Institutes for Quantum Science and Technology(QST)KyotoJapan. Laser Accelerator R&D Innovative Light Sources DivisionRIKEN SPring-8 CenterHyogoJapan. SANKEN Osaka UniversityOsakaJapan

Laser wakefield acceleration,as an advanced accelerator concept,has attracted great attentions for its ultrahigh acceleration gradient and the capability to produce high brightness electron *** three-dimensional(3D)density serves as an evaluation metric for the particle bunch quality and is intrinsically related to the applications of an *** its significance,this parameter has not been experimentally measured in the investigation of laser wakefield *** report on an electro-optic 3D snapshot of a laser wakefield electron bunch at a position outside the *** 3D shape of the electron bunch was detected by simultaneously performing optical transition radiation imaging and electro-optic *** 3D structures to a few micrometer levels were reconstructed using a genetic *** electron bunch possessed a transverse size of less than 30 *** current profile shows a multi-peak *** main peak had a duration oft>1 *** maximum electron 3D number density was~9×10^(21)m^(-3).this research demonstrates a feasible way of 3D density monitoring on femtosecond kilo-ampere electron bunches,at any position of a beam transport line for relevant applications.

关键词： laser acceleration field

Immunotherapy for esophageal cancer:Where are we now and where can we go

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World Journal of Gastroenterology 2024年第19期30卷 2496-2501页

作者： Yoshiaki Shoji Kazuo Koyanagi Kohei Kanamori Kohei tajima Mika Ogimi Yamato Ninomiya Miho Yamamoto Akihito Kazuno Kazuhito Nabeshima takayuki Nishi masaki Mori Department of Gastroenterological Surgery Tokai University School of MedicineKanagawa 259-1193Japan

Immune checkpoint inhibitor therapy has dramatically improved patient prognosis,and thereby transformed the treatment in various cancer types including esophageal squamous cell carcinoma(ESCC)in the past *** antibodies that selectively inhibit programmed cell death-1(PD-1)activity has now become standard of care in the treatment of ESCC in metastatic settings,and has a high expectation to provide clinical benefit during perioperative ***,anti-cytotoxic t-lymphocyte–associated protein 4(CtLA-4)monoclonal antibody has also been approved in the treatment of recurrent/metastatic ESCC in combination with anti-PD-1 *** understanding of the existing evidence of immune-based treatments for ESCC,as well as recent clinical trials on various combinations with chemotherapy for different clinical settings including neoadjuvant,adjuvant,and metastatic diseases,may provide future prospects of ESCC treatment for better patient outcomes.

关键词： Esophageal cancer Immunotherapy Immune checkpoint inhibitor Programmed cell death-1 Anti-cytotoxic t-lymphocyte-associated protein 4 Neoadjuvant therapy Adjuvant therapy Clinical trials Combination therapy

Diagonal reflection symmetries and universal four-zero texture

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Chinese Physics C 2021年第4期45卷 87-97页

作者： masaki J.S.Yang Department of Physics Saitama UniversityShimo-okuboSakura-kuSaitama338-8570Japan

In this paper,we consider a set of new symmetries in the SM:diagonal reflection symmetries Rm_(u,v)^(*),R=m_(u,v),m_(d,e)^(*)=mde with R=diag(-1,1,1).these generalized CP symmetries predict the Majorana phases to beα_(2.3)/2-0π/*** of diagonal reflection symmetries implies a broken chiral U(1)po symmetry only for the first *** axion scale is suggested to be(θ_(u,d))~△Gut√m_(u,dm_(c,s))/v-10^(12)[GeV].By combining the symmetries with the four-zero texture,the mass eigenvalues and mixing matrices of quarks and leptons are reproduced *** scheme predicts the normal hierarchy,the Dirac phase ocp≈203°,and|ml|≈2.5 or 6.2[meV].In this scheme,the type-I seesaw mechanism and a given neutrino Yukawa matrix Y_(y)completely determine the structure of the right-handed neutrino mass M_(R).A u-y unification predicts the mass eigenvalues to be(M_(RI),M_(R2),M_(R3))=(O(10^(5)).O(10^(9)),O(10^(14))[Gev].

关键词： μ-t reflection symmetry four-zero texture generalized CP symmetry

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Grain refining in weld metal using short-pulsed laser ablation during CW laser welding of 2024-t3 aluminum alloy

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International Journal of Extreme Manufacturing 2019年第4期1卷 34-41页

作者： masaki Kasuga tomokazu Sano Akio Hirose Division of Materials and Manufacturing Science Graduate School of EngineeringOsaka University2-1 Yamada-okaSuitaOsaka 565-0871Japan

the 2024 aluminum alloy is used extensively in the aircraft and aerospace industries because of its excellent mechanical ***,the weldability of 2024 aluminum alloy is generally low because it contains a high number of solutes,such as copper(Cu),magnesium(Mg),and manganese(Mn),causing solidification *** high speed welding of 2024 aluminum alloy without the use of filler is achieved,the applicability of 2024 aluminum alloys will *** refining is one of the methods used to prevent solidification cracking in weld metal,although it has never been achieved for high-speed laser welding of 2024 aluminum alloy without ***,we propose a short-pulsed,laser-induced,grain-refining method during continuous wave laser welding without ***-on-plate welding was performed on a 2024-t3 aluminum alloy at a welding speed of 1 m min−1 with a single mode fiber laser at a wavelength of 1070 nm and power of 1 *** in and around the molten pool were irradiated with nanosecond laser pulses at a wavelength of 1064 nm,pulse width of 10 ns,and pulse energy of 430 *** grain-refinement effect was confirmed when laser pulses were irradiated on the molten *** grain-refinement region was formed in a semicircular shape along the solid–liquid *** of the vertical section indicate that the grain-refinement region reached a depth of 1 mm along the solid–liquid *** Vickers hardness test results demonstrated that the hardness increased as a result of grain refinement and that the progress of solidification cracking was suppressed in the grain refinement region.

关键词： 2024 aluminum alloy hot cracking laser welding grain refinement dendrite fragmentation short pulsed laser laser ablation

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Miniaturization of Bubbles by Shock Waves in Gas-Liquid two-phase Flow in the Venturi tube

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Journal of thermal Science 2021年第3期30卷 1068-1076页

作者： JIANG Xin YASUNOBU tsuyoshi NAKAMURA Arisa SHIMAZU masaki National Institute of technology Kitakyushu College KitakyushuFukuoka 802-0985Japan

Fine bubbles have been widely applied in many fields such as industry,medical engineering and ***,many attentions have been paid to the study of fine bubble generations in order to increase the yield while decrease the ***,the generation process of fine bubbles is a quite complicated process in which multiple hydrodynamic forces are interacted in the gas-liquid two-phase *** studies focus on the techniques of the converging-diverging nozzle(venturi tube)generator,which is famous for its simple and cheap features,and generates fine bubbles by using the miniaturization phenomenon of bubbles occurring in the venturi ***,the impact conditions on the amount and size of bubbles such as nozzle geometry and bleed air haven’t been investigated *** this work,we implement many experiments on the venturi tube fine bubble generators with different geometries and generating conditions,and evaluate different factors impacting the production components such as the volume and the bubble *** experimental results show that the supersonic flow filed in the venturi tube promotes the miniaturization of the bubbles,and the convergent angle of the nozzle and air bleed have a great impact on the size and volume of bubbles.

关键词： fine bubble shock wave gas-liquid two-phase flow venturi tube

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