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American Journal of Analytical Chemistry 2010年第3期1卷 95-101页

作者： Durga mallikarjuna rao tippa N. Singh 不详

A simple, fast, precise, accurate and rugged stability indicating high performance liquid chromatography (HPLC) method has been developed for simultaneous estimation of Amoxicillin and Clavulanic acid from injectable dosage form. the stability indicating capability of the method was proven by subjecting the drugs to stress conditions as per ICH recommended test conditions such as alkaline and acid hydrolysis, oxidation, photolysis, thermal degradation and resolution of the degradation products formed therein. the separation was obtained using a mobile phase composition at a ratio of 95:5 (v/v) of pH 5.0 buffer and methanol on Inertsil C18 column (250 × 4.0 mm, 4 μm) with UV detection at 220 nm at a flow rate of 1 ml/minute. the photodiode array detector was used for stress studies. the order of elution of peaks was Clavulanic acid followed by Amoxicillin. the linear calibration range was found to be 79.51 to 315.32 μg/ml for Amoxicillin and 17.82 to 67.90 μg/ml for Clavulanic acid. the Amoxicillin and Clavulanic acid were found to be stable in solution up to 24 hours. the method validation data showed excellent results for precision, linearity, specificity, limit of detection, limit of quantification and robustness. the present method can be successfully used for routine quality control and stability studies.

关键词： Amoxicillin Clavulanic Acid HPLC Stability Indicating

SGDJ-001新型助航灯光电缆套装接头的应用

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民航学报 2024年第2期8卷 63-68页

作者：饶旗广东省机场管理集团有限公司工程指挥部

本文分析了SGDJ-001新型助航灯光电缆套装接头的结构特点、性能，与其他电缆接头及其施工工艺进行了比较，分析了其优缺点。SGDJ-001新型助航灯光电缆套装接头可以解决目前因助航灯光电缆接头易引起的故障问题。SGDJ-001新型助航灯光电... 详细信息

本文分析了SGDJ-001新型助航灯光电缆套装接头的结构特点、性能，与其他电缆接头及其施工工艺进行了比较，分析了其优缺点。SGDJ-001新型助航灯光电缆套装接头可以解决目前因助航灯光电缆接头易引起的故障问题。SGDJ-001新型助航灯光电缆套装接头（包括插头和插座）采用特殊的结构工艺，灌装的主要原料有端羟基聚二甲基硅氧烷、甲基硅油、聚醚多元醇等，配置快速低温固化催化剂，材料制备的双组份胶体，固化后同时具有优良的耐热性、附着力、电绝缘性和介电性能，能使助航灯光电缆接插头配件更加优良，解决了目前机场行业中，助航灯光电缆接头质量不稳定、施工制作效率低下等问题。经测试，本文介绍的这种新型助航灯光电缆接头及其工艺，其结构和电气性能均符合《MH/t6009-2016助航灯光电缆插头和插座》标准。胶体的粘接力性能、电绝缘性能、固化时间和高低温度性能，均可以满足不同使用场景及环境[1]。

关键词：助航灯光助航灯光电缆接头灌封工艺电缆冷缩接头工艺电缆热缩接头工艺

列车荷载作用下CRtS Ⅲ型板式无砟轨道层间离缝水力特性研究

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中南大学学报（自然科学版） 2024年第7期55卷 2600-2611页

作者：宋力饶佳琪刘冉蒋丽忠余志武中南大学土木工程学院湖南长沙410075 高速铁路建造技术国家工程研究中心湖南长沙410075

在雨水充沛或排水不畅地区,积水会造成无砟轨道层间离缝扩展显著加速。针对含层间离缝的CRtS Ⅲ型板式无砟轨道的水力特性问题,建立列车荷载与水耦合作用下的CRtS Ⅲ型板式无砟轨道-离缝积水双向瞬态流固耦合计算模型,揭示无砟轨道层间... 详细信息

在雨水充沛或排水不畅地区,积水会造成无砟轨道层间离缝扩展显著加速。针对含层间离缝的CRtS Ⅲ型板式无砟轨道的水力特性问题,建立列车荷载与水耦合作用下的CRtS Ⅲ型板式无砟轨道-离缝积水双向瞬态流固耦合计算模型,揭示无砟轨道层间离缝内动水压力和水流速度的分布及其峰值的变化规律,并分析列车轴重、行车速度、离缝形态及积水深度对动水压力和水流速度的影响。研究结果表明:随着列车的趋近与远离,层间离缝内固定点处的动水压力与水流速度呈周期性的正负交替变化;动水压力沿着离缝出口方向逐渐减小,其峰值发生在离缝尖端处,而水流速度沿着离缝出口方向逐渐增大,其峰值发生在离缝出口处;动水压力与水流速度峰值随列车轴重增加而线性增大,轴重每增加1 t,动水压力和水流速度峰值分别增加2.850 kPa、0.085 m/s;动水压力峰值与车速呈二次方增大关系,而在车速小于300 km/h时水流速度峰值与车速基本上呈线性关系,超过该车速后流速增长趋势较之前更大;动水压力、水流速度峰值与离缝开口量呈反比关系;动水压力与水流速度峰值都随着离缝深度和离缝积水深度增加而显著增大,且两者都与离缝深度呈3次多项式增大关系,与离缝积水深度呈2次方增大关系。研究结果可为CRtS Ⅲ型板式无砟轨道在列车荷载与水耦合作用下的层间离缝扩展分析以及养护维修工作提供依据和参考。

关键词： CRtSⅢ型板式无砟轨道层间离缝流固耦合动水压力水流速度

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二甲双胍胃肠道不良反应及其新型缓释制剂的临床应用

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中华糖尿病杂志 2024年第7期16卷 827-831页

作者：饶翀崔丽梅肖新华清华大学附属垂杨柳医院内分泌科北京100022 中国医学科学院、北京协和医院内分泌科、国家卫生健康委员会内分泌重点实验室北京100730

二甲双胍广泛应用于2型糖尿病(t2DM)的治疗。二甲双胍的胃肠道反应较为常见,其确切机制尚不明确,可能与其转运蛋白、增加肠道内葡萄糖摄取及乳酸水平、增加肠内胆汁酸池、肠道菌群等相关。二甲双胍缓释片与二甲双胍速释片降糖疗效类似,... 详细信息

二甲双胍广泛应用于2型糖尿病(t2DM)的治疗。二甲双胍的胃肠道反应较为常见,其确切机制尚不明确,可能与其转运蛋白、增加肠道内葡萄糖摄取及乳酸水平、增加肠内胆汁酸池、肠道菌群等相关。二甲双胍缓释片与二甲双胍速释片降糖疗效类似,同时能有效减少胃肠道反应的发生。二甲双胍缓释片的制作工艺主要包括羟丙基甲基纤维素(HPMC)凝胶骨架结构、微孔或单孔渗透泵技术及胃漂浮技术。该文就二甲双胍胃肠道反应及相关机制研究、二甲双胍缓释片的种类、二甲双胍缓释片与二甲双胍速释片疗效对比等进行阐述。

关键词：糖尿病,2型二甲双胍缓释片不良反应

Influence of local stiffeners and cutout shapes on the vibration and stability characteristics of quasi-isotropic laminates under hygro-thermo-mechanical loadings

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Defence technology（防务技术） 2022年第12期18卷 2107-2124页

作者： t.Rajanna K.S.Subash Chandra K.Venkata rao Department of Civil Engineering B.M.S College of EngineeringBengaluru560019India Research Scholar B.M.S College of EngineeringBengaluru560019India Department of Mechanical Engineering B.M.S Evening College of EngineeringBengaluru560019India Department of Mechanical Engineering Government PolytechnicBagepalli561207India

the perforated stiffened panel is generally found as a sub-component of sophisticated *** fundamental purpose of this panel is to withstand against buckling under complicated loading and environmental ***,an accurate knowledge of critical buckling behaviour of stiffened panels is very much essential for a reliable and lightweight structural *** this paper,the focus is on quasi-laminated panels with different cutout shapes of various sizes and their responses to hygrothermal environments under nonlinearly varying edge loads and is compared with the locally stiffened *** this,the modelling of the panel and stiffener is done by adopting nine-noded heterosis plate elements and three noded beam elements *** stiffener formulation is suitably modified in order to take the torsional effect also into consideration along with the effect of shear ***,the plate and the stiffener elements are treated separately,and then the displacement compatibility is maintained between them by using the transformation *** a given loading and geometric discontinuity,the stress distribution within the perforated panel is highly non-uniform in nature and hence a dynamic approach has been used to calculate buckling loads by adopting two sets of boundary conditions,one set for pre-buckling stress analysis and the second set for buckling *** different quasi-isotropic stacking sequences are deliberated in this work by varying different ply-orientation in each *** study also addresses the effect of various parameters such as nonlinear loads,hygro-thermal loads,cutout size and shapes,position of cutout,stiffener parameters,stacking sequences,thickness of plate and boundary conditions.

关键词： Locally stiffened panels Buckling Vibration Cutouts Heterosis Hygrothermal environment

维生素E联合黄体酮注射液治疗先兆流产患者的效果

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中国民康医学 2024年第5期36卷 69-72页

作者：饶卫梅信阳一五四医院妇产科河南信阳464000

目的:分析维生素E联合黄体酮注射液治疗先兆流产患者的效果。方法:回顾性分析2021年3月至2022年3月该院收治的70例先兆流产患者的临床资料,依据治疗方法不同将其分为观察组和对照组,每组35例,对照组给予黄体酮注射液治疗,观察组给予维生... 详细信息

目的:分析维生素E联合黄体酮注射液治疗先兆流产患者的效果。方法:回顾性分析2021年3月至2022年3月该院收治的70例先兆流产患者的临床资料,依据治疗方法不同将其分为观察组和对照组,每组35例,对照组给予黄体酮注射液治疗,观察组给予维生素E联合黄体酮注射液治疗。比较两组临床疗效和保胎成功率,治疗前后子宫胎盘灌注状态及性激素、辅助性t细胞(th)1/th2细胞因子和血清学指标水平。结果:治疗后,观察组治疗总有效率和保胎成功率均高于对照组,人绒毛膜促性腺激素、孕酮、雌二醇、白细胞介素(IL)-4水平高于对照组,血流搏动指数、血流阻力指数及血清γ干扰素、IL-2水平均低于对照组,差异有统计学意义(Pth1/th2细胞因子状态,利于改善妊娠结局,效果优于单纯黄体酮注射液治疗。

关键词：先兆流产维生素E 黄体酮保胎性激素血清学

Dietary Green tea Extract and Antioxidants Improve Insulin Secretory Functions of Pancreatic β-Cells in Mild and Severe Experimental Rodent Model of Chronic Pancreatitis

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Open Journal of Endocrine and Metabolic Diseases 2024年第2期14卷 53-72页

作者： Galande Sheethal Ranjeet K. tokala Pavan Pondugala Krishna Vemula Vijayalakshmi Venkatesan Pothani Suresh Surya Satyanarayana Singh Guduru Venkat rao Duvvur Nageshwar Reddy Mitnala Sasikala Basic Science and translational Research Division Asian Healthcare Foundation AIG Hospitals Hyderabad India Division of Cell and Molecular Biology National institute of Nutrition Hyderabad India National Animal Resource Facility for Biomedical Research Hyderabad India Department of Biochemistry Osmania University Hyderabad India Department of Surgical Gastroenterology Asian Institute of Gastroenterology Hyderabad India Department of Gastroenterology Asian Institute of Gastroenterology Hyderabad India

Chronic pancreatitis (CP) is a progressive inflammatory disorder of the pancreas. It is predominantly idiopathic (with an unknown cause) in India and mostly due to alcohol in the West. Diabetes that occur secondary to chronic pancreatitis (t3c Diabetes) is often brittle, and is difficult to attain normoglycemia with conventional treatment requiring multiple doses of insulin. Mild and severe model of CP was induced in mice by repeated intraperitoneal injections of cerulein and L-arginine respectively with an intent to study islet dysfunction and develop therapeutic strategy in animal models of CP. Dietary intervention of epigallocatechin-3-gallate (EGCG) was tested in both the models of CP for its beneficial effects on insulin secretory functions. Pancreata collected upon euthanasia were used to study alterations in the morphology of pancreatic parenchyma and inflammation by staining with H&E and fibrotic changes by Masson’s trichrome and picrosirius staining. Insulin secretory functions of islets were evaluated to test the efficacy of the dietary intervention on β-cell functions. Intraperitoneal glucose tolerance test was performed to monitor the glucose homeostasis before and after the dietary intervention. Both the models resulted in CP with dispersed acini, inflammation and fibrosis. the loss of acini and extent of fibrosis was more in L-arginine model. 2-fold improvement in glucose-stimulated insulin secretory functions of islets was observed with 0.5% EGCG dietary intervention in cerulein model of CP and 1.6-fold in L-arginine model of CP. A further improvement in insulin secretion by 3.2-fold was observed with additional dietary supplements like N-acetyl cysteine, curcumin in combination with EGCG. Our results thus demonstrate and highlight the therapeutic potential of dietary green tea (EGCG) supplementation in reversing islet dysfunction and improving glucose homeostasis in experimental chronic pancreatitis in mice.

关键词： Dietary Intervention C57BL6/J Mice Epigallocatechin-3-Gallate N-Acetyl Cysteine Curcumin Chronic Pancreatitis Islets Glucose Stimulated Insulin Secretion

rao Algorithms-Based Structure Optimization for Heterogeneous Wireless Sensor Networks

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Computers, Materials & Continua 2024年第1期78卷 873-897页

作者： Shereen K.Refaay Samia A.Ali Moumen t.El-Melegy Louai A.Maghrabi Hamdy H.El-Sayed Faculty of Computers and Artificial Intelligence Sohag UniversitySohag82524Egypt Faculty of Engineering Assiut UniversityAssiut711745Egypt College of Engineering University of Business and TechnologyJeddah23411Saudi Arabia

the structural optimization of wireless sensor networks is a critical issue because it impacts energy consumption and hence the network’s *** studies have been conducted for homogeneous networks,but few have been performed for heterogeneouswireless sensor *** paper utilizes rao algorithms to optimize the structure of heterogeneous wireless sensor networks according to node locations and their initial *** proposed algorithms lack algorithm-specific parameters and metaphorical *** proposed algorithms examine the search space based on the relations of the population with the best,worst,and randomly assigned *** proposed algorithms can be evaluated using any routing protocol,however,we have chosen the well-known routing protocols in the literature:Low Energy Adaptive Clustering Hierarchy(LEACH),Power-Efficient Gathering in Sensor Information Systems(PEAGSIS),Partitioned-based Energy-efficient LEACH(PE-LEACH),and the Power-Efficient Gathering in Sensor Information Systems Neural Network(PEAGSIS-NN)recent routing *** compare our optimized method with the Jaya,the Particle Swarm Optimization-based Energy Efficient Clustering(PSO-EEC)protocol,and the hybrid Harmony Search Algorithm and PSO(HSA-PSO)*** efficiencies of our proposed algorithms are evaluated by conducting experiments in terms of the network lifetime(first dead node,half dead nodes,and last dead node),energy consumption,packets to cluster head,and packets to the base *** experimental results were compared with those obtained using the Jaya optimization *** proposed algorithms exhibited the best *** proposed approach successfully prolongs the network lifetime by 71% for the PEAGSIS protocol,51% for the LEACH protocol,10% for the PE-LEACH protocol,and 73% for the PEGSIS-NN protocol;Moreover,it enhances other criteria such as energy conservation,fitness convergence,packets to cluster head,and packets to the base sta

关键词： Wireless sensor networks rao algorithms optimization LEACH PEAGSIS

Benefciation studies on recovery and in-depth characterization of ilmenite from red sediments of badlands topography of Ganjam District,Odisha,India

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International Journal of Mining Science and technology 2013年第5期23卷 725-731页

作者： t.Laxmi Satya Sai Srikant D.S.rao R.Bhima rao Mineral Processing Department CSIR-Institute of Minerals and Materials Technology Department of Electronics and Communication Engineering SRM University Aryan College of Engineering and technology

this paper deals with the recovery of ilmenite mineral from red sediments of badlands topography and suggested flowsheet with material *** results of these investigations reveal that the red sediment samples contain 33.2%total heavy mineral,in which ilmenite mineral concentrate is 28.71%(by weight).the ilmenite concentrate recovered from red sediment sample by physical benefciation process,which included scrubbing,desliming,gravity concentration,magnetic and electrostatic separation,contains 99.41%grade with 97.3%*** ilmenite mineral concentrate recovered from red sediments is also suitable for industrial *** characterization studies on ilmenite reveal that the tiO2percentage is marginally increasing from 46.69%to 47.86%with increasing magnetic intensity from0.46 to 1.55 t.

关键词： Red sediments Badlands topography Ilmenite Benefciation Characterization

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盾构工作井碳排放构成及减碳路径研究

城市道桥与防洪 2024年第10期 276-282,M0025,M0026页

作者：饶倩王鑫上海城投公路投资(集团)有限公司上海市200335 上海市城市建设设计研究总院(集团)有限公司上海市200125

结合漕宝路快速路新建工程,采用定额清单分析法,对合川路盾构工作井碳排放量进行核算。通过对碳排放量构成和主要来源的分析,得到了工作井结构按照不同分类模式下的碳排放占比,并提出针对性的减碳路径和方法。研究结果表明,在建材生产... 详细信息

结合漕宝路快速路新建工程,采用定额清单分析法,对合川路盾构工作井碳排放量进行核算。通过对碳排放量构成和主要来源的分析,得到了工作井结构按照不同分类模式下的碳排放占比,并提出针对性的减碳路径和方法。研究结果表明,在建材生产运输和建造阶段,盾构工作井碳排放总量可达到20850 t CO_(2)。按材料、机械和人工分类,各部分碳排放占比约为87.7%、11.9%和0.4%。建材生产运输阶段的碳排放量远高于施工阶段的机械能耗和人工碳排放量之和。尽管降水井的质量占比较小,但其对所在分部工程的碳排放计算有较大影响,是碳排放核算需要考虑的因素。接缝止水材料、防水材料的质量占比、碳排放占比均很小,可根据碳排放核算精度要求适当考虑或忽略不计。在基础设施建设方面,可以从低碳建材使用、建材和土方运输机械电动化、鼓励施工机械能源采用生物柴油、提高建筑垃圾资源化管理水平、提高措施项目的周转材料利用率等方面出发,有效降低碳排放。

关键词：盾构工作井建设期碳排放构成减碳路径