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Effects of low molecular weight polysaccharide from sargassum thunbergii against palmitic acid-induced intracellular lipid accumulation in 3t3-L1 adipocyte and HepG2 cells

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Food science and Human Wellness 2024年第4期13卷 2244-2252页

作者： Hyo-Geun Lee d.P.Nagahawatta m.J.m.s.Kurera Kyung-mo song Yun-sang Choi You-Jin Jeon min-Cheol Kang department of marine Life sciences Jeju National UniversityJeju 63243Republic of Korea department of Biotechnology Faculty of Agriculture and Plantation ManagementWayamba University of Sri LankaMakanduraGonawila(NWP)60170Sri Lanka Research Group of Food Processing Korea Food Research Institute245Wanju 55365Republic of Korea

Low molecular weight polysaccharides can be isolated from sargassum thunbergii(LmPst)and in vitro experiments were conducted to evaluate the inhibitory effects on lipids.two natures of LmPst were attained from s.thunbergii and appraised their LmPst on palmitic acid(PA)induced lipid accretion in Hep G2,and 3t3-L1 cells.LmPst treatment lessened lipid deposition and intracellular free fatty acid and triglyceride intensities in PA-treated above mentioned cells.the mechanistic study publicized that LmPst2 significantly suppressed adipogenesis and stimulated the PA-treated 3t3-L1 cells occupied in the lipolysis pathway.Furthermore,in PA-treated Hep G2 cells,the free fatty acid oxidation was significantly increased by LmPst2.Given these constructive properties of LmPst2 from s.thunbergii,is a potential candidate for diminishing the intracellular lipids,and for a therapeutic agent in those conditions.

关键词： sargassum thunbergii Low molecular weight polysaccharide Lipid accumulation Obesity Liver steatosis

smILE soft X-ray Imager flight model CCd370 pre-flight device characterisation

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Earth and Planetary Physics 2024年第1期8卷 25-38页

作者： s.Parsons d.J.Hall O.Hetherington t.W.Buggey t.Arnold m.W.J.Hubbard A.Holland Centre for Electronic Imaging the Open UniversityMilton KeynesMK76AAUK

throughout the smILE mission the satellite will be bombarded by radiation which gradually damages the focal plane devices and degrades their performance.In order to understand the changes of the CCd370s within the soft X-ray Imager,an initial characterisation of the devices has been carried out to give a baseline performance level.three CCds have been characterised,the two flight devices and the flight spa re.this has been carried out at the Open University in a bespo ke cleanroom measure ment facility.the results show that there is a cluster of bright pixels in the flight spa re which increases in size with tempe rature.However at the nominal ope rating tempe rature(-120℃) it is within the procure ment specifications.Overall,the devices meet the specifications when ope rating at -120℃ in 6 × 6 binned frame transfer science mode.the se rial charge transfer inefficiency degrades with temperature in full frame mode.However any charge losses are recovered when binning/frame transfer is implemented.

关键词： CCd soft X-ray imager characterisation smILE

the CCd instrument background of the smILE sXI

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Earth and Planetary Physics 2024年第1期8卷 15-24页

作者： m.W.J.Hubbard O.Hetherington d.J.Hall t.W.Buggey s.Parsons t.Arnold A.Holland C.Pagani s.sembay Centre for Electronic Imaging The Open UniversityMilton KeynesMK76AAUK X-ray and Observational Astronomy Group Department of Physics&AstronomyUniversity of LeicesterLE17RHUK

the EsA and CAs smILE mission orbit is highly elliptical and will pass through multiple radiation environments.the soft X-ray Imager(sXI)instrument aboard has a radiation shutter door designed to close when the surrounding radiation flux is high.the shutter door will close when passing below an altitude threshold to protect against trapped particles in the Earth’s Van Allen Belts.therefore,two radiation environments can be approximated based on the shutter door position:open and closed.the instrument background for the CCds(Charge-Coupled devices)that form the focal plane array of the sXI were evaluated for the two environments.due to the correlation of the space environment with the solar cycle,the solar minima and maxima,the background was also evaluated at these two extremes.the results demonstrated that the highest instrument background will occur during solar minima due to the main contributing source being Galactic Cosmic Rays(GCRs).It was also found that the open background was highest for solar minima and that the closed background was highest during solar maxima.this is due to the radiation shutter door acting as a scattering centre and the changes in the energy flux distribution of the GCRs between the two solar extremes.

关键词： instrument background X-ray astronomy space radiation

QCd sum rule study of J^(P)=1^(±)exotic states with two heavy quarks in the molecular picture

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Chinese Physics C 2024年第6期48卷 31-37页

作者： t.m.Aliev s.Bilmis m.savcı department of Physics Middle East Technical UniversityAnkara06800Turkey tUBItAK ULAKBIm Ankara06510Turkey

In this study,the spectroscopic parameters of exotic molecular states composed of mesons containing two heavy quarks(scalar-axial and pseudoscalar-axial meson combinations)are investigated within the QCd sum rules.Our findings reveal that molecular states containing charm quarks do not form bound states,whereas states with b-quarks can form exotic molecular states.this observation has significant implications for understanding the structure of these exotic states.

关键词： QCd sum rules exotic mesons molecular states

search for production of dark fermion candidates in association with heavy neutral gauge boson decaying to dimuon in proton-proton collisions at√s=8 teV using Cms open data

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Chinese Physics C 2024年第4期48卷 6-13页

作者： Y.mahmoud H.Abdallah m.t.Hussein s.Elgammal Centre for theoretical physics The British University in EgyptEgypt Physics department Faculty of ScienceCairo UniversityEgypt

In this study,we conducted a search for dark matter using a part of the data recorded by the Cms experiment during run-I of the LHC in 2012 with a center of mass energy of 8 teV and an integrated luminosity of 11.6 fb−1.these data were gathered from the Cms open data.dark matter,in the framework of the simplified model(mono-Z′),can be produced from proton-proton collisions in association with a new hypothetical gauge boson,Z′.thus,the search was conducted in the dimuon plus large missing transverse momentum channel.One benchmark scenario of mono-Z′,which is known as light vector,was used for interpreting the Cms open data.No evidence of dark matter was observed,and exclusion limits were set on the masses of dark matter and Z′at 95%confidence level.

关键词： dark matter large hadron collider Cms open data search for new physics dark fermion

Chebyshev polynomial-based Ritz method for thermal buckling and free vibration behaviors of metal foam beams

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Applied mathematics and mechanics(English Edition) 2024年第5期45卷 891-910页

作者： N.d.NGUYEN t.N.NGUYEN Faculty of Civil Engineering Ho Chi Minh City University of Technology and EducationHo Chi Minh City 71309Viet Nam Faculty of Engineering and technology Kien Giang UniversityChau Thanh 92000Viet Nam

this study presents the Chebyshev polynomials-based Ritz method to examine the thermal buckling and free vibration characteristics of metal foam beams.the analyses include three models for porosity distribution and two scenarios for thermal distribution.the material properties are assessed under two conditions,i.e.,temperature dependence and temperature independence.the theoretical framework for the beams is based on the higher-order shear deformation theory,which incorporates shear deformations with higher-order polynomials.the governing equations are established from the Lagrange equations,and the beam displacement fields are approximated by the Chebyshev polynomials.Numerical simulations are performed to evaluate the effects of thermal load,slenderness,boundary condition(BC),and porosity distribution on the buckling and vibration behaviors of metal foam beams.the findings highlight the significant influence of temperature-dependent(td)material properties on metal foam beams'buckling and vibration responses.

关键词： Ritz method Chebyshev function buckling vibration metal foam beam higher-order beam theory(HOBt)

Aerodynamics of a tandem-Bladed Axial Compressor Rotor under Circumferential distortion at different Rotational speeds

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Journal of thermal science 2024年第4期33卷 1340-1356页

作者： Amit KUmAR Jerry t.JOHN A.m.PRAdEEP R.A.d.AKKERmANs dragan KOZULOVIC department of Aerospace Engineering Indian Institute of Technology Bombay department of Automotive and Aeronautical Engineering Hamburg University of Applied Sciences Institute of Jet Propulsion Bundeswehr University Munich

For most aircraft engines,inflow distortion is inevitable.Inflow distortion is known to degrade the aerodynamic performance and stable operating limits of a compressor.tandem rotor configuration is an arrangement that effectively controls the growth of the boundary layer over the suction surface of the blade.therefore,a higher total pressure rise can be achieved through this unconventional design approach involving the splitting of the blade into forward and aft sections.It is expected that the effect of inlet flow distortion would be more severe for a tandem-rotor design due to the greater flow turning inherent in such designs.However,this aspect needs to be thoroughly examined.the present study discusses the effect of circumferential distortion on the tandem-rotor at different rotational speeds.Full-annulus RANs simulations using ANsYs CFX are used in the present study.the performance of the rotor at a particular flow coefficient and different rotational speeds is compared.the total pressure and efficiency are observed to drop at lower mass flow rates under the influence of circumferential distortion.the loss region in each blade passage is mainly associated with the blade wake,tip leakage vortex,secondary flow,and boundary layer.However,their contribution varies from passage to passage,particularly in the distorted sector.At the lower span,the wake width is found to be higher than that at a higher span.due to the redistribution of the mass flow,the circumferential extent reduces at a higher span.In the undistorted sector,the strength of the tip leakage vortex is significantly higher at the design rotational speed than at lower speeds.the distortion near the tip region promotes an early vortex breakdown even at the design operating condition.this adversely affects the total pressure,efficiency,and stall margin.Under clean flow conditions,this phenomenon is only observed near the stall point.At the design operating condition,the breakdown of the forward rotor tip leakage vortex is detected in four blade passages

关键词： tandem rotor circumferential distortion loss tip leakage vortex vortex breakdown diffusion factor aerodynamics of compressor blade

Evaluation of red soil-bentonite mixtures for compacted clay liners

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Journal of Rock mechanics and Geotechnical Engineering 2024年第2期16卷 697-710页

作者： A.s.devapriya t.thyagaraj department of Civil Engineering Indian Institute of Technology MadrasChennai600036India

Compacted clay liners are an integral part of the waste landfills,which are provided to contain the leachate within the landfills and protect the surrounding environment.Generally,locally available natural soils are used for the construction of compacted clay liners if they satisfy the design criteria.However,not all soils in their natural state satisfy all the design criteria for the liner materials.thus,there is a definite need to modify the locally available natural soils by blending with bentonite to meet the required design criteria for the liners.In view of this,the present study evaluates the suitability of an Indian red soil enhanced with bentonite as a liner material.to achieve this,a series of experiments were carried out using locally available red soil and bentonite.First,the suitability of the red soil was evaluated as a liner material.the experimental results showed that the red soil met all the selection criteria stipulated by the Environmental Protection Agencies(EPAs)for the liners except the hydraulic conductivity criterion.therefore,the red soil was mixed with bentonite contents of 10%,20%and 30%,and the red soil-bentonite mixtures were evaluated for their suitability for liners in their compacted state.Further,as the liners in the arid and semi-arid regions are subjected to moisture variations due to seasonal moisture fluctuations and other factors,the red soil-bentonite mixtures were subjected to wetdry cycles,and their suitability was evaluated after wet-dry cycles.the experimental results revealed that all the red soil-bentonite mixtures met the stipulated EPA criteria for the liners in the as-compacted state.However,the red soil-bentonite mixtures with 20%and 30%bentonite contents only satisfied the hydraulic conductivity requirement even after wet-dry cycles.the experimental findings were supplemented with the microstructural insights captured through digital camera images,scanning electron microscopy(sEm),and mercury intrusion porosimetry(mIP)studies.

关键词： Compacted clay lines Hydraulic conductivity Wet-dry cycles microstructure

Radioisotope production using lasers:From basic science to applications

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matter and Radiation at Extremes 2024年第3期9卷 31-44页

作者： m.R.d.Rodrigues A.Bonasera m.scisciò J.A.Pérez-Hernández m.Ehret F.Filippi P.L.Andreoli m.Huault H.Larreur d.singappuli d.molloy d.Raffestin m.Alonzo G.G.Rapisarda d.Lattuada G.L.Guardo C.Verona Fe.Consoli G.Petringa A.mcNamee m.La Cognata s.Palmerini t.Carriere m.Cipriani G.di Giorgio G.Cristofari R.de Angelis G.A.P.Cirrone d.margarone L.Giuffrida d.Batani P.Nicolai K.Batani R.Lera L.Volpe d.Giulietti s.Agarwal m.Krupka s.singh Fa.Consoli Cyclotron Institute Texas A&M UniversityCollege StationTexas 77840USA Laboratori Nazionali del sud Istituto Nazionale di Fisica Nucleare(LNS-INFN)CataniaItaly ENEA Fusion and Technologies for Nuclear Safety and Security Department-CFrascatiItaly Centro de Láseres Pulsados(clpu) VillamayorSpain Universidad de salamanca SalamancaSpain Centre Lasers Intenses et Applications(CELIA) Universitéde BordeauxCNRSCEATalenceFrance HB11 Energy Holdings Pty FreshwaterNew South WalesAustralia school of mathematics and Physics Queen’s University BelfastBelfastUnited Kingdom dipartimento di Fisica e Astronomia“E.majorana ”Università di CataniaCataniaItaly Facoltàdi Ingegneria e Architettura Universitàdegli Studi di Enna“Kore”EnnaItaly dipartimento di Ingegneria Industriale Universitàdi Roma“Tor Vergata”RomaItaly dipartimento di Fisica e Geologia Universitàdegli Studi di PerugiaPerugiaItaly Istituto Nazionale di Fisica Nucleare Sezione di PerugiaPerugiaItaly ELI Beamlines Facility the Extreme Light Infrastructure ERICDolni BrezanyCzech Republic EtsIA Universidad Politécnica de MadridMadridSpain dipartimento Fisica “E.Fermi”Universitàdi Pisa and INFNPisaItaly FZU–Institute of Physics of Czech Academy of sciences PragueCzech Republic Institute of Plasma Physics of Czech Academy of sciences PragueCzech Republic

the discovery of chirped pulse amplification has led to great improvements in laser technology,enabling energetic laser beams to be compressed to pulse durations of tens of femtoseconds and focused to a few micrometers.Protons with energies of tens of meV can be accelerated using,for instance,target normal sheath acceleration and focused on secondary targets.Under such conditions,nuclear reactions can occur,with the production of radioisotopes suitable for medical application.the use of high-repetition lasers to produce such isotopes is competitive with conventional methods mostly based on accelerators.In this paper,we study the production of^(67)Cu,^(63)Zn,^(18)F,and^(11)C,which are currently used in positron emission tomography and other applications.At the same time,we study the reactions^(10)B(p,α)^(7)Be and^(70)Zn(p,4n)^(67)Ga to put further constraints on the proton distributions at different angles,as well as the reaction^(11)B(p,α)^(8)Be relevant for energy production.the experiment was performed at the 1 PW laser facility at VegaⅢin salamanca,spain.Angular distributions of radioisotopes in the forward(with respect to the laser direction)and backward directions were measured using a high purity germanium detector.Our results are in reasonable agreement with numerical estimates obtained following the approach of Kimura and Bonasera[Nucl.Instrum.methods Phys.Res.,sect.A 637,164–170(2011)].

关键词： purity estimates backward