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clinical profile and outcomes in very elderly patients with atrial fibrillation anticoagulated with rivaroxaban: data from the EmIR study

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Journal of geriatric cardiology 2024年第7期21卷 723-732页

作者： Francisco marín manuel Anguita Sánchez Iñaki Lekuona marcelo Sanmartín Fernán-dez Vivencio Barrios carlos Perez muñoz Juan cosín-Sales Alejandro IPérez cabeza Vanesa Roldán Schilling carles Rafols Priu Esteban Orenes-Piñero maría Asunción Es-teve-Pastor Department of cardiology Hospital Clínico Universitario Virgen de la ArrixacaIMIB-ArrixacaUniversity of MurciaCIBERCVMurciaSpain Department of cardiology Hospital Reina Sofía CórdobaIMIBICUniversity of CordobaCIBERCVCórdobaSpain Hospital galdakao-Usansolo BizkaiaSpain Department of cardiology Hospital Uni-versitario Ramony CajalCIBERCVMadridSpain Department of cardiology University Hospital Ramóny CajalAl-caláUniversityMadridSpain medical center La capillita Sanlúcar de Barrameda.Private cardiology clinicJerez de la FronteraSpain Department of cardiology Hospital Arnau de VilanovaValenciaSpain Department of car-diology Virgen de la Victoria University HospitalCIBERCV.MalagaSpain Department of Haematology Hospital Clínico Universitario Virgen de la ArrixacaUniversity of MurciaMurciaSpain Department of medical Affairs Bayer HispaniaBarcelonaSpain Department of Biochemistry and molecular Biology-A University of MurciaMurciaSpain

Objectives to analyze the clinical profile,adequacy of treatment with rivaroxaban and outcomes in octogenarians with atrial fibrillation(AF),taking rivaroxaban in clinical *** Observational and non-interventional study that included AF adults recruited from 79 Spanish centers,anticoagulated with rivaroxaban ≥ 6 months before being *** were analyzed according to age(≥ 80 vs.t *** Out of 1433 patients,453(31.6%) were octogenarians at *** to younger patients,octogenarians had more comorbidities,higher cHA2DS2-VASc(4.5 ± 1.3 vs.3.0 ± 1.4;P cores(2.0 ± 1.0 vs.1.4 ± 1.0;P the dose of rivaroxaban was adequately prescribed in 83.4% of patients,but more frequently in the younger population(71.1% vs.89.1%;P = 0.039).After a mean follow-up of 2.2 ± 0.6 years,annual rates of stroke + systemic embolism + transient ischemic attack,mAcE,cardiovascular death and major bleeding were 1.03%,1.24%,1.03% and 1.75%,respectively,in octogenarian *** for progressive heart failure death and major bleeding,rates of outcomes in octogenarians were similar compared to younger *** octogenarians,the concomitant use of antiplatelet agents and non-severe dementia were independently associated with the development of ischemic stroke,whereas previous coronary revascularization and heart failure with mAcE,and higher HAS-BLED score with major *** In clinical practice,around one third of patients taking rivaroxaban are *** patients have many comorbidities and a high thromboembolic *** that,rates of adverse events remain *** is adequately prescribed in the majority of octogenarians.

关键词： patients atrial bleeding

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clinical features of chronic kidney disease in dogs with the serological presence of Leptospira spp.,Ehrlichia canis,and Anaplasma phagocytophilum

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Animal Diseases 2024年第3期4卷 224-230页

作者： claire A.Vázquez‑manzanilla maría F.cárdenas‑marrufo Eduardo gutiérrez‑Blanco matilde Jiménez‑coello Nelly R.Pech‑Sosa Antonio Ortega‑Pacheco Departamento de Salud Animal y medicina Preventiva Facultad de Medicina Veterinaria y ZootecniaCampus de Ciencias Biológicas y AgropecuariasUniversidad Autónoma de YucatánMéridaYucatán 97100México Unidad Interinstitucional de Investigación clínica y Epidemiológica Facultad de MedicinaUniversidad Autónoma de YucatánMéridaYucatán 97000México

chronic kidney disease is commonly diagnosed in dogs,and clinical signs may be aggravated when infected agents are *** this case report,33 dogs with chronic kidney disease were clinically evaluated and serologically tested for Leptospira spp.,Ehrlichia canis,and Anaplasma *** seroprevalence for Leptospira *** 39.4%.the most frequent serovars found were Pyrogenes,canicola,Bratislava and Australis,with serological titers between 1:100 to 1:*** signs included fever,depression,decreased body condition,vomiting and hema‑*** laboratory fndings were anemia,leukocytosis,thrombocytopenia,increased liver enzymes,urea and creatinine,hyperbilirubinemia and *** leptospira seronegative dogs were positive for one or both monitored homoparasites(i.e.,*** and ***);only three leptospira seropositive dogs were positive for one or both *** also suggest that endemic hemoparasites of dogs should be moni‑tored in dogs with a kidney condition for a better clinical picture of the patients and therapeutic approach.

关键词： Anaplasma chronic kidney disease Dog Ehrlichia Leptospira

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Quality evaluation of Nothofagus pumilio seeds linked to forest management and climatic events

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Ecological Processes 2024年第1期13卷 98-107页

作者： Julian Rodríguez-Souilla Jimena E.chaves maría Vanessa Lencinas Juan manuel cellini Fidel A.Roig Pablo L.Peri guillermo martinez Pastur Laboratorio de Recursos Agroforestales Centro Austral de Investigaciones Científicas (CADIC) Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET ) Laboratorio de Investigaciones en maderas (LImAD) Universidad Nacional de la Plata (UNLP) Instituto Argentino de Nivología Glaciología y Ciencias Ambientales (IAN-IGLA) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Instituto Nacional de tecnología Agropecuaria (INtA) Universidad Nacional de la Patagonia Austral (UNPA) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET )

Background Forest ecosystems undergo significant transformations due to harvesting and climate fluctuations, emphasizing the critical role of seeding in natural regeneration and long-term structural preservation. climate change further amplifies these dynamics, affecting phenology across species and regions. In tierra del Fuego(Argentina), Nothofagus pumilio(lenga) forests represent the most important timber resource, and it is managed through different silvicultural strategies. this species demonstrates notable post-disturbance regeneration, yet seed fall exhibits signifi-cant variability, leading to variations in seed quality(e.g., viability). this study aims to assess fluctuations in N. pumilio seed quality, determine how it varies concerning forest management strategies, annual productivity, and the co-occurrence of climatic phenomena including El Ni?o-Southern Oscillation(ENSO) and the Southern Annular mode(SAm).Results Viable seeds represented 18.4% of the total, notably higher in unharvested than in managed areas. con-versely, empty seeds were more prevalent in harvested areas(> 75%). Seed quality exhibited significant differences across silvicultural treatments, except for insect-predated seeds, which had similar proportions across all areas, though dispersed retention showed higher predation. When considering years with varying production levels, high-production years favoured full and viable seeds, particularly in unharvested forests and aggregated retention, while low-production years saw reduced viability across all treatments. Quadratic models revealed that viability increased with seed production, where unharvested forests achieved the highest values. climate variability influenced seed proportions, where ENSO+/SAm+ promoting more full and viable seeds, while ENSO–/SAm+ favoured non-predated seeds, especially in unharvested *** Seed quality varies among treatments and years with different levels of seeding. Variations in seed qual-ity, l

关键词： Forest management Seeding climate change Extreme event Patagonia

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Radiative heat transfer analysis of a concave porous fin under the local thermal non-equilibrium condition:application of the clique polynomial method and physics-informed neural networks

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Applied mathematics and mechanics(English Edition) 2024年第9期45卷 1613-1632页

作者： K.cHANDAN K.KARtHIK K.V.NAgARAJA B.c.PRASANNAKUmarA R.S.VARUN KUmar t.mUHAmmAD Amrita School of Artificial Intelligence Amrita Vishwa VidyapeethamBengaluru 560035KarnatakaIndia Department of Studies in mathematics Davangere UniversityDavangere 577002KarnatakaIndia computational Science Lab Amrita School of EngineeringAmrita Vishwa VidyapeethamBengaluru 560035KarnatakaIndia Department of Pure and Applied mathematics School of Mathematical SciencesSunway UniversityPetaling Jaya 47500Malaysia Department of mathematics College of ScienceKing Khalid UniversityAbha 61413Saudi Arabia

the heat transfer through a concave permeable fin is analyzed by the local thermal non-equilibrium(LtNE)*** governing dimensional temperature equations for the solid and fluid phases of the porous extended surface are modeled,and then are nondimensionalized by suitable dimensionless ***,the obtained nondimensional equations are solved by the clique polynomial method(cPm).the effects of several dimensionless parameters on the fin's thermal profiles are shown by graphical ***,the current study implements deep neural structures to solve physics-governed coupled equations,and the best-suited hyperparameters are attained by comparison with various network *** results of the cPm and physicsinformed neural network(PINN)exhibit good agreement,signifying that both methods effectively solve the thermal modeling problem.

关键词： heat transfer fin porous fin local thermal non-equilibrium(LtNE)model physics-informed neural network(PINN)

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Refractive outcomes after V4c toric collamer lens implantation over 1y of follow-up

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International Journal of Ophthalmology(English edition) 2024年第7期17卷 1322-1330页

作者： Humberto carreras-Díaz Josefina Reñones de Abajo maría del Rosario carreras-Díaz Amalia Lorente-Velázquez Vithas Eurocanarias Las Palmas de Gran Canaria 35004Spain University Hospital of girona Doctor Josep trueta Gerona 17007Spain Departament of Optometry and Vision Faculty of Optics and OptometryComplutense University of MadridMadrid 28040Spain

AIm:to evaluate refractive outcomes and corneal astigmatism changes after toric implantable collamer lens with a central port(V4c t-IcL)implantation over 1y of ***:A retrospective study was performed including 50 eyes of 50 patients that underwent V4c t-IcL ***(UDVA)and corrected(cDVA)distance visual acuities,refraction,refractive and corneal astigmatism changes and corneal coupling correction were evaluated preoperatively,1 and 12mo *** analysis was used for astigmatism *** of adjustment(cAdj)was calculated for corneal coupling ***:the mean UDVA achieved was 0.03 logmar at 1mo and remained unchanged throughout the whole follow-up(P=0.193).At the last visit,84%of the eyes achieved a cDVA of 0.00 logmar or *** spherical equivalent refraction(SEQ),96%of eyes were ranges of±1.00 D and 84%of them within±0.50 ***,94%of eyes had a remaining refractive cylinder within±1.00 D and 78%of them within±0.50 ***,SEQ and refractive cylinder,remain stable over the postoperative follow-up(P=1.000 and P=0.660,respectively).In terms of surgically induced astigmatism(SIA),no statistically significant differences were found over the follow-up(P=0.102)and under correction was found with a correction index lower than the unit at each visit.A keratometric astigmatism induced of 0.59±0.53(vector mean:0.26×73º)D was reached at the last *** significant changes in terms of corneal astigmatism orientation were reported over post-surgery visits(P=0.129 and P=0.097 at 1 and 12mo respectively).No clinical significance was found for cAdj on with-the-rule *** postoperative complications resulting from the surgery were ***:Refractive outcomes suggest that the V4c t-IcL implantation for correction of myopic astigmatism was satisfactory in terms of effectiveness,safety,and stability during 1y of *** astigmatism induced by the incision around 0.5 D is achieved

关键词： V4c toric collamer lens corneal astigmatism surgically induced astigmatism corneal coupling

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A modular microfluidic platform to study how fluid shear stress alters estrogen receptor phenotype in ER+breast cancer cells

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microsystems & Nanoengineering 2024年第1期10卷 287-299页

作者： Braulio Andrés Ortega Quesada Jonathan cuccia Rachael coates Blake Nassar Ethan Littlefield Elizabeth c.martin Adam t.melvin cain Department of chemical Engineering Louisiana State UniversityBaton RougeLA 70803USA Department of chemical and Biological Engineering Clemson UniversityClemsonSC 29634USA Biological and Agricultural Engineering Louisiana State UniversityBaton RougeLA 70803USA Department medicine Section Hematology and Medical OncologyTulane UniversityNew OrleansLA 70118USA

metastatic breast cancer leads to poor prognoses and worse outcomes in patients due to its invasive behavior and poor response to *** is still unclear what biophysical and biochemical factors drive this more aggressive phenotype in metastatic cancer;however recent studies have suggested that exposure to fluid shear stress in the vasculature could cause *** this study a modular microfluidic platform capable of mimicking the magnitude of fluid shear stress(FSS)found in human vasculature was designed and *** device provides a platform to evaluate the effects of FSS on mcF-7 cell line,an estrogen receptor positive(ER+)breast cancer cell line,during circulation in the *** of the effects of FSS on mcF-7 cells was carried out utilizing two approaches:single cell analysis and bulk *** single cell analysis,cells were trapped in a microarray after exiting the serpentine channel and followed by immunostaining on the device(on-chip).Bulk analysis was performed after cells were collected in a microtube at the outlet of the microfluidic serpentine channel for western blotting(off-chip).It was found that cells exposed to an FSS magnitude of 10 dyn/cm^(2) with a residence time of 60 s enhanced expression of the proliferation marker Ki67 in the mcF-7 cell line at a single cell *** understand possible mechanisms for enhanced Ki67 expression,on-chip and off-chip analyses were performed for pro-growth and survival pathways ERK,AKt,and JAK/*** demonstrated that after shearing the cells phosphorylation of p-AKt,p-mtOR,and p-StAt3 were ***,there was no change in p-ERK1/*** is a mediator of ER rapid signaling,analysis of phosphorylated ERαwas carried out and no significant differences between sheared and non-sheared populations were *** together these results demonstrate that FSS can increase phosphorylation of proteins associated with a more aggressive phenotype in circulating cancer *** findin

关键词： fluid breast estrogen

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Promotion of structural plasticity in area V2 of visual cortex prevents against object recognition memory deficits in aging and Alzheimer's disease rodents

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Neural Regeneration Research 2024年第8期19卷 1835-1841页

作者： Irene Navarro-Lobato mariam masmudi-martín manuel F.López-Aranda Juan F.López-téllez gloria Delgado Pablo granados-Durán celia gaona-Romero marta carretero-Rey Sinforiano Posadas maría E.Quiros-Ortega Zafar U.Khan Laboratory of Neurobiology Centro de Investigaciones Médico Sanitarias(CIMES)University of MalagaMalagaSpain Department of medicine Faculty of MedicineUniversity of MalagaMalagaSpain centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas(cIBERNED) Institute of Health Carlos IIIMadridSpain the Donders Institute for Brain cognition and Behaviour Radboud UniversityNijmegenThe Netherlands the Brain metastasis group National Cancer Research Centre(CNIO)MadridSpain the Department of Neurobiology University of California-Los AngelesLos AngelesCAUSA

memory deficit,which is often associated with aging and many psychiatric,neurological,and neurodegenerative diseases,has been a challenging issue for *** till now,all potential drug candidates have failed to produce satisfa ctory ***,in the search for a solution,we found that a treatment with the gene corresponding to the RgS14414protein in visual area V2,a brain area connected with brain circuits of the ventral stream and the medial temporal lobe,which is crucial for object recognition memory(ORm),can induce enhancement of *** this study,we demonstrated that the same treatment with RgS14414in visual area V2,which is relatively unaffected in neurodegenerative diseases such as Alzheimer s disease,produced longlasting enhancement of ORm in young animals and prevent ORm deficits in rodent models of aging and Alzheimer’s ***,we found that the prevention of memory deficits was mediated through the upregulation of neuronal arbo rization and spine density,as well as an increase in brain-derived neurotrophic factor(BDNF).A knockdown of BDNF gene in RgS14414-treated aging rats and Alzheimer s disease model mice caused complete loss in the upregulation of neuronal structural plasticity and in the prevention of ORm *** findings suggest that BDNF-mediated neuronal structural plasticity in area V2 is crucial in the prevention of memory deficits in RgS14414-treated rodent models of aging and Alzheimer’s ***,our findings of RgS14414gene-mediated activation of neuronal circuits in visual area V2 have therapeutic relevance in the treatment of memory deficits.

关键词： behavioral performance brain-derived neurotrophic factor cognitive dysfunction episodic memory memory circuit activation memory deficits memory enhancement object recognition memory prevention of memory loss regulator of g protein signaling

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coupling Aquaculture—crop Productions and Using of Water Drained from Ponds Rearing clarias gariepinus as Fertilizer for Okra Production (Abelmoschus esculentus var. clemson spineless, L. moench)

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Open Journal of Applied Sciences 2024年第9期14卷 2628-2647页

作者： Louis Dossou magblénou Justin Kantoussan césar Bassène Dieynaba Yacine mar gueye Hamath Sy Laboratoire des Sciences Biologiques Agronomiques et de Modlisation des Systmes Complexes (LaBAM) UFR des Sciences Agronomiques de lAquaculture et des Technologies Alimentaires (UFR S2ATA) Dpartement Aquaculture Universit Gaston Berger (UGB) Saint-Louis Senegal Laboratoire des Sciences Biologiques Agronomiques et de Modlisation des Systmes Complexes (LaBAM) UFR des Sciences Agronomiques de lAquaculture et des Technologies Alimentaires (UFR S2ATA) Dpartement Productions Vgtales et Agronomie (PVA) Universit Gaston Berger (UGB) Saint-Louis Senegal

the present study concerns the revalorization of drained water from aquaculture ponds rearing clarias gariepinus on okra crops. the rearing was carried out at the farm of gaston Berger University in 100 m2 ponds. In each pond, the individuals of c. garipinus with an average weight of 6 ± 0.3 g were stocked at a density of 11 per m2. the water temperature and pH were measured during the experiment. the control fishing is carried out every month to monitor variations in the weight and size of reared individuals. the plant production is carried out in elementary plots measuring 3 m × 1.5 m. Each plot was fertilized with either: drained water from c. gariepinus rearing (DWc), poultry droppings (PD), cow dung (cD) and mineral fertilizer (NPK). treatments are carried out in tripliqua with either river water (RW), RW + the recommended dose of NPK (RD-NPK), RW + RD-PD, RW + RD-cD, DWc, DWc + 25% RD-NPK, DWc + 50% RD-NPK, DWc + 75% RD-NPK, DWc + 25% RD-PD, DWc + 50% RD-PD, DWc + 75% RD-PD, DWc + 25% RD-cD, DWc + 50% RD-cD, DWc + 75% RD-cD. growth parameters and yield of okra were determined. the average temperature in the rearing environment was 27.6 ± 1.5˚c and pH 7.9 ± 1.1. After six (06) months of rearing, c. gariepinus individuals reached an average weight of 850.12 ± 1.3 g and an average height of 52.44 ± 1.1 cm. the daily weight gain and specific growth rates over this period were 3.9 g per day and 2.8% per day, respectively. the treatment t1 (RW + DR-NPK) gave the highest mean collar diameter and mean plant height with 2.3 ± 0.9 cm and 61.6 ± 32 cm, respectively. In t4 (DWc), the mean height of plants was 38.8 ± 23.5 cm and mean collar diameter 1.4 ± 0.8 cm. the growth performance in t4 was comparable to that of RD-cD (t3), but different from RD-NPK (t1) and RD-PD (t2). the highest average number, average weight, average length and average diameter of fruits were noted in treatments t13 (RW + RD-75%cD) and t7 (DWc + 75% RD-NPK). the best yields were noted in t1 (RW +

关键词： Integrated Aquaculture Drained Water Fertilization c. gariepinus Okra

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Long-term trends in the abundance and breeding performance in Adélie penguins:the Argentine Ecosystem monitoring Program

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Advances in Polar Science 2024年第1期35卷 132-140页

作者： mariana A.JUÁRES Anahím.SILVEStRO Brenda c.ALFONSO m.mercedes SANtOS Departamento Biología de Predadores tope Instituto Antártico Argentino(IAA)Buenos Aires B1650CSPArgentina consejo Nacional de Investigaciones científicas y técnicas(cONIcEt) Buenos Aires C1425FQBArgentina Laboratorios Anexos Facultad de Ciencias Naturales y MuseoUniversidad Nacional de La PlataLa Plata B1904AMAArgentina INEDES(cONIcEt-UNLu) Buenos Aires C1425FQBArgentina Facultad de ciencias Naturales y museo Universidad Nacional de La PlataLa Plata B1900FWAArgentina Instituto Antártico Argentino(IAA) Buenos Aires B1650CSPArgentina

In this work,we report long-term trends in the abundance and breeding performance of Adélie penguins(Pygoscelis adeliae)nesting in three Antarctic colonies(i.e.,at martin Point,South Orkneys Islands;Stranger Point/cabo Funes,South Shetland Islands;and Esperanza/Hope Bay in the Antarctic Peninsula)from 1995/96 to 2022/*** yearly count data of breeding groups selected,we observed a decline in the number of breeding pairs and chicks in crèche at all colonies ***,the magnitude of change was higher at Stranger Point than that in the remaining ***,the index of breeding success,which was calculated as the ratio of chicks in crèche to breeding pairs,exhibited no apparent trend throughout the study ***,it displayed greater variability at martin Point compared to the other two colonies under *** the number of chicks in crèche of Adélie penguins showed a declining pattern,the average breeding performance was similar to that reported in gentoo penguin colonies,specifically,those undergoing a population increase(even in sympatric colonies facing similar local conditions).consequently,it is plausible to assume a reduction of the over-winter survival as a likely cause of the declining trend observed,at least in the Stranger Point and Esperanza ***,we cannot rule out local effects during the breeding season affecting the Adélie population of martin Point.

关键词： long-term monitoring Adélie penguin breeding pairs chicks crèched breeding success population trends

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Bloom-forming cyanobacteria and dinoflagellates in five Argentinian reservoirs:multi-year sampling

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Water Biology and Security 2024年第1期3卷 28-36页

作者： Florencia Soledad Alvarez Dalinger Borja claudia Nidia Veronica Laura Lozano Liliana Beatriz morana maría monica Salusso Facultad de ciencias Naturales Universidad Nacional de SaltaAvenida Bolivia 5150Salta4400Argentina consejo Nacional de Investigaciones científicas y t'ecnicas(cONIcEt) Godoy Cruz 2290Ciudad Autonoma de Buenos AiresArgentina

Harmful algal blooms are important threats to reservoir *** a 15-year period,we sampled five Argentinian reservoirs to identify the responsible species for harmful algal blooms and determine the water quality factors driving their *** reservoirs exhibit diverse morphological and hydrological characteristics and are distributed across varying climatic *** blooms included an array of species,including toxin producers such as Raphidiopsis raciborskii,Aphanizomenon gracile,and microcystis *** contrast,dinoflagellate blooms were predominantly characterized by *** cyanobacterial blooms primarily occurred in the shallower reservoirs located in warmer regions,whereas dinoflagellate blooms occurred where temperatures were *** most intense blooms occurred during the summer,and although cyanobacterial and chlorophyte blooms co-occurred,they never coexisted with dinoflagellate *** identified cyanotoxins in the reservoirs over the past three years,a phenomenon previously unreported in the *** that these reservoirs are drinking water sources for human populations,ongoing and systematic monitoring is needed to protect public *** the proliferation of algae and cyanobacteria in reservoirs requires resource management at the watershed level,and in the case of the Itiyuro and El Limon,requires binational management with Bolivia.

关键词： HABs Freshwater South America toxins

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