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Beginning from the end:the presynaptic terminal as a pathomechanism hub in frontotemporal dementia and amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第11期20卷 3217-3218页

作者： laura Huggon Emma l.Clayton UK Dementia Research Institute at King’s College london LondonUK Department of Basic and Clinical Neuroscience Institute of Psychiatry Psychology&NeuroscienceKing’s College LondonLondonUK

Frontotemporal dementia and amyotrophic lateral sclerosis:Frontotemporal dementia(F t D)and amyo t rophic lateral sclerosis(AlS)are neurodegenerative diseases with significant overlapping *** these neurodegenerative diseases affect different neuronal populations(with FtD affecting neurons of the frontal and temporal lobes,and AlS affecting upper and lower motor neurons),these two diseases are complexly *** and AlS exist on a disease spectrum,with shared genetic causes,clinical presentations,and pathologies.

关键词： diseases amyotrophic sclerosis

Multiple sclerosis is at a checkpoint: advancing the program

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Neural Regeneration Research 2025年第3期20卷 811-812页

作者： Brandon C.Smith Jessica l.Williams Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Biological Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Multiple sclerosis(MS) is a chronic inflammatory and demyelinating disease of the central nervous system(CNS). Patients with MS experience sensory and motor function loss due to myelin and/or axon damage perpetuated b... 详细信息

关键词： Hauser sclerosis damage

Generation of brain vascular heterogeneity:recent advances from the perspective of angiogenesis

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Neural Regeneration Research 2025年第7期20卷 2013-2014页

作者： Nathanael J.lee Ryota l.Matsuoka Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Molecular Medicine Cleveland Clinic Lerner College of MedicineCase Western Reserve UniversityClevelandOHUSA

Heterogeneous proper t i es of vascular endothelial cells in the brain:the brain displays large energy dynamics and consumption,and this high level of metabolic demands is fulfilled by a continuous supply of glucose and oxygen through its vascular *** vasculature consists of highly divergent blood vessel branches,giving rise to a dense network of capillaries that supply blood to all cells across the *** elaborated vascular network is thought to develop via angiogenesis,a process in which new blood vessels grow from pre-existing *** capillaries exhibit organotypic features distinct from other tissues and are formed primarily by two major endothelial cell(EC)types:those that form the semi-permeable blood-brain barrier(BBB)and those that develop highly permeable pores known as fenestrae(Matsuoka et al.,2022).the structural and functional differences between BBB and fenestrated vascular ECs represent a fundamental feature of brain vasculature and form the foundation for both brain function and homeostasis.

关键词： angiogenesis homeostasis network

transport mechanism in chemically reactive hybrid nanofluid flow containing gyrotactic micro-organisms over a curved oscillatory surface

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 177-192页

作者： M.NAVEED M.IMRAN t.ASGHAR Z.ABBAS Department of Mathematics Division of Science and TechnologyUniversity of Education Department of Mathematics The Islamia University of Bahawalpur

this paper examines the transport analysis, including both heat transfer and mass transfer, in hybrid nanofluid flow containing gyrotactic microorganisms towards a curved oscillatory surface. the influence of magnetic fields is also inspected in terms of their physical characteristics. to depict the phenomena of transport, modified versions of both Fick's and Fourier's laws are used. Additionally, the characteristics of both heterogeneous and homogeneous chemical reactions are also incorporated. Utilizing a curvilinear coordinate system, the flow problem is formulated as partial differential equations(PDEs)for momentum, concentration, microorganism field, and energy. An analytical solution to the obtained flow equations is achieved utilizing the homotopy analysis method(HAM).the effects of significant flow parameters on the pressure and microorganism fields, velocity, oscillation velocity, concentration, and temperature distributions are shown via graphs. Furthermore, the variations in skin friction, mass transfer rate, heat transfer rate, and local motile number due to different involved parameters are presented in tables and are analyzed in detail. Graphical results indicate that the curves of velocity and temperature fields are enhanced as the values of the solid volume fraction variables *** is also verified that the concentration rate field decreases as the values of the homogeneous reaction strength parameter and the radius of curvature parameter increase, and it increases with the Schmidt number and the heterogeneous reaction strength *** outcomes show a favorable response of the motile number to advanced values of the Peclet number, the Schmidt number, the microorganism difference parameter, and the bio-convective lewis number.

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Context-dependent integrated stress resistance promotes a global invasive pest

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Insect Science 2022年第6期29卷 1790-1804页

作者： Vimbai l.tarusikirwa ross N.Cuthbert Reyard Mutamiswa Casper Nyamukondiwa Department of Biological Sciences and Biotechnology Botswana International University of Science and TechnologyPalapyeBotswana GEOMAR Helmholtz-Zentrum fur Ozeanforschung Kiel KielGermany School of Biological Sciences Queen's University BelfastNorth ern IrelandUnited Kingdom Department of Zoology and Entomology University of the Free StateBloemfonteinSouth Africa tugwi-Mukosi Multidisciplinary Research Institute Midlands State UniversityGweruZimbabwe Department of Zoology and Entomology.Rhodes University MakhandaSouth Africa

In nature,insects concurrently face multiple environmental stressors,a sce-nario likely increasing with climate *** stress resistance(ISR)thus often improves fitness and could drive invasiveness,but how physiological mechanisms influ-ence invasion has lacked ***,we investigated cross-tolerance to abiotic stress factors which may influence range limits in the South American tomato pinworm a global invader that is an ecologically and socially damaging crop ***,we tested the effects of prior rapid cold-and heat-hardening(RCH and RHH),fasting,and desiccation on cold and heat tolerance traits,as well as starvation and desiccation sur-vivability between *** life *** effects on critical thermal minima(Ct_(min))and maxima(Ct_(max))were inconsistent,showing significantly deleterious effects of RCH on adult Ct_(max) and Ct_(min) and,conversely,beneficial acclimation effects of RCH on larval Ct_(min).While no beneficial effects of desiccation acclimation were recorded for desiccation tolerance,fasted individuals had significantly higher survival in adults,whereas fasting negatively affected larval ***,fasted and desiccation acclimated adults had significantly higher starvation tolerance,showing strong evidence for *** results show context-dependent ISR traits that may promote *** fitness and *** the frequent overlapping occurrence of these divergent stressors,ISR reported here may thus partly elucidate the observed rapid global spread of *** into more stressful environments than *** information is vital in determining the underpinnings of multistressor responses,which are fundamental in forecasting species responses to changing environments and management responses.

关键词： acclimation cross-talk cross-tolerance invasive species thermal tolerance tomato leaf miner

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the Moon

Acta Geochimica 2016年第1期35卷 1-13页

作者： ross taylor australian national university CanberraAustralia

Recent geochemical and geophysical data from the Moon enable a revision of earlier interpretations regarding lunar origin, structure and bulk composition. Earth and Moon show many similarities among their isotopic compositions, but they have evolved in totally dissimilar ways, probably related to the deficiency of water and volatile elements in the Moon as well as the vast differences in size and internal pressure. Some global geochemical differences from the Earth such as volatile depletion based on K/U ratios have been established. However, all current lunar samples come from differentiated regions, making the establishment of a bulk composition more reliant on bulk geophysical properties or isotopic similarities; it remains unclear how the latter arose or relate to whole Moon composition. the lack of fractionation effects among the refractory and super-refractory elements indicates that the proto-lunar material seems unlikely to have been vaporized while the presence of volatile elements may place lower limits on proto-lunar temperatures. the apparent lack of geochemical evidence of an impacting body enables other possible impactors, such as comets, to be considered. Although the origin of the Moon remains currently unknown, it is generally believed that the Moon originated as the result of a giant impact on the Earth.

关键词： lunar origin Grand tack model Apollo Volatite elements

Aortic valve replacement reduces mortality in moderate aortic stenosis:a systematic review and meta-analysis

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Journal of Geriatric Cardiology 2023年第1期20卷 61-67页

作者： Kyle B Franke Dimple Bhatia ross l Roberts-thomson Peter J Psaltis Adelaide Medical School The University of AdelaideAdelaideAustralia Vascular Research Centre Lifelong Health ThemeSouth Australian Health and Medical Research InstituteAdelaideAustralia Department of Cardiology Royal Adelaide HospitalAdelaideAustralia

BACKGROUND With the introduction of transcatheter aortic valve replacement and an evolving understanding of the natural progression and history of aortic stenosis,the potential for earlier intervention in appropriate patients is promising;however,the benefit of aortic valve replacement in moderate aortic stenosis remains *** Pubmed,Embase,and the Cochrane library databases were searched up until 30th of December 2021 using keywords including moderate aortic stenosis and aortic valve *** reporting all-cause mortality and outcomes in early aortic valve replacement(AVR)compared to conservative management in patients with moderate aortic stenosis were *** ratios were generated using random-effects meta-analysis to determine effect *** 3470 publications were screened with title and abstract review,which left 169 articles for full-text *** these studies,7 met inclusion criteria and were included,totalling 4,827 *** studies treated AVR as a time-dependent co-variable in cox-regression multivariate analysis of all-cause *** with surgical or transcatheter AVR was associated with a 45% decreased risk of all-cause mortality(HR=0.55[0.42-0.68],I2=51.5%,Pll studies were representative of the overall cohort with appropriate sample sizes,with no evidence of publication,detection,or information biases in any of the *** In this systematic review and meta-analysis,we report a 45% reduction in all-cause mortality in patients with moderate aortic stenosis who were treated with early aortic valve replacement compared to a strategy of conservative *** control trials are awaited to determine the utility of AVR in moderate aortic stenosis.

关键词： aortic stenosis analysis

Nutritional epidemiology methods and related statistical challenges and opportunities

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Statistical theory and Related Fields 2018年第1期2卷 2-10页

作者： ross l.Prentice Ying Huang Fred Hutchinson Cancer Research Center and University of Washington SeattleWAUSA

the public health importance of nutritional epidemiology research is discussed,along withmethodological challenges to obtaining reliable information on dietary approaches to chronicdisease *** issues in assessing dietary intake need to be addressed toobtain reliable disease association ***-reported dietary data typically incorporatemajor random and systematic *** biomarkers offer potential for more reliable analyses,but biomarkers have been established only for a few dietary variables,and these may be tooexpensive to apply to all participants in large epidemiologic cohorts.A possible way forwardinvolves additional nutritional biomarker development using high-dimensional metabolomicprofiling,using blood and urine specimens,in conjunction withfurther development of statisticalapproaches for accommodating measurement error with failure time response *** the opportunity to contribute greatly to worldwide public health through the development of statistical methods to address these nutritional epidemiology research challenges,asis elaborated in this contribution.

关键词： Chronic disease epidemiology failure time data hazard ratio measurement error metabolomics nutritional biomarker regression calibration

Force and impulse multi-sensor based on flexible gate dielectric field effect transistor

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 214-220页

作者： Chao tan Junling lü Chunchi Zhang Dong liang lei Yang Zegao Wang College of Materials Science and Engineering Sichuan UniversityChengdu 610065China the 54th Research Institute of China Electronics technology Group Corporation Shijiazhuang 050081China

Nowadays,force sensors play an important role in industrial production,electronic information,medical health,and many other ***-dimensional material-based filed effect transistor(2D-FEt)sensors are competitive with nano-level size,lower power consumption,and accurate ***,few of them has the capability of impulse detection which is a path function,expressing the cumulative effect of the force on the particle over a period of *** we fabricated the flexible polymethyl methacrylate(PMMA)gate dielectric MoS_(2)-FEt for force and impulse sensor *** systematically investigated the responses of the sensor to constant force and varying forces,and achieved the conversion factors of the drain current signals(I_(ds))to the detected impulse(I).the applied force was detected and recorded by I_(ds)with a low power consumption of~30 *** sensitivity of the device can reach~8000%and the 4×1 sensor array is able to detect and locate the normal force applied on ***,there was almost no performance loss for the device as left in the air for two months.

关键词： flexible gate dielectric transistor force sensor impulse sensor force sensor array