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第九届全国日地空间物理学术讨论会

作者：王家龙王同江汪景琇 N.Nitta G.L.Slater t.kosugi 中科院北京天文台 Lockheed Martin Solar and Astrophysics Lab. CA 94304.USA Institute of Space and Astronautical Science Kanagawa 229SagamiharaJapan

日冕物质抛射(CME)是空间天气的重要扰动源的看法,已被普遍接受.CME的研究不仅可以改进我们对超级太阳活动现象的认识,还能提高我们对日地扰动事件的预测能力.在SOHO卫星观测之前,因缺乏CME在低日冕和日面二维成像观测,很难估计每次 CME...

日冕物质抛射(CME)是空间天气的重要扰动源的看法,已被普遍接受.CME的研究不仅可以改进我们对超级太阳活动现象的认识,还能提高我们对日地扰动事件的预测能力.在SOHO卫星观测之前,因缺乏CME在低日冕和日面二维成像观测,很难估计每次 CME 向行星际空间以磁云形式输出的质量和磁能,也不容易作日地事件的——对应认证.本文中,我们提出了一个使用SOHO的LASCO、EIt(195 A)和 MDI(全日面磁场)的观测资料,估算CME的日面基部尺度、抛出物质的质量以及其所含磁能的方法,并且将该方法应用于1998年5月2日事件.

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Radiotherapy and Chemotherapy in t2N0 Glottic Cancer: Does Chemotherapy Improve Local Control?

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Journal of Cancer therapy 2013年第2期4卷 513-517页

作者： takashi kosugi Kazunori Suzuki Kenta Konishi Hotaka Nonaka Hiroyuki Mineta Department of Otorhinolaryngology Hamamatsu University School of Medicine Hamamatsu Japan Department of Radiology Hamamatsu University School of Medicine Hamamatsu Japan

Purpose: to compare concurrent chemoradiotherapy with radiotherapy in t2N0 glottic cancer. Materials and Methods: thirty nine patients were treated with radiotherapy alone. In detail, 30 patients treated between 1985 and 1995, and 9 patients treated between 1995 and 2010 were included in the radiotherapy alone group. Between 1995 and 2010, 22 patients were treated with concurrent chemoradiotherapy. Conventional fractionation was applied in 19 patients in the radiotherapy group and in 1 patient in the chemoradiotherapy group. Hyperfractionation was applied to 20 patients in the radiotherapy group and to 21 patients in the chemoradiotherapy group. total dose ranged from 64 Gy to 76.8 Gy in the radiotherapy group and from 66 Gy to 76.8 Gy in the chemoradiotherapy group. Cisplatin or carboplatin was administered in the chemoradiotherapy group. Results: there were no differences in the 5-year preservation rate of vocal function (82.8% vs 87.4%, p = 0.652), local control rate (77.2% vs 92.9%, p = 0.163), and 5-year overall survival rate (86.4% vs 90.2%, p = 0.497) between the radiotherapy and chemoradiotherapy groups. Conclusion: In t2N0 glottic cancer, no difference was observed between radiotherapy alone and concurrent chemoradiotherapy groups.

关键词： t2 Glottic Cancer Radiation therapy Chemotherapy Voice Preservation Local Control

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点尿钠／钾对血压和肾功能变化的预测价值

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中华高血压杂志 2018年第3期26卷 298-298页

作者： tabara Y takahashi Y Setoh K Kawaguchi t.kosugi S Nakayama t Matsuda F 陈云叶鹏 the Nagahama study group

尿钠／钾是一个简单的反映钠负荷的指标，横断面研究显示尿钠／钾（即使用时点尿进行测量）与血压水平相关。本文采用大样本队列研究，评估点尿钠／钾对血压和肾功能纵向变化的预后意义。方法：从一般人群中纳入研究对象7063人，在基线... 详细信息

尿钠／钾是一个简单的反映钠负荷的指标，横断面研究显示尿钠／钾（即使用时点尿进行测量）与血压水平相关。本文采用大样本队列研究，评估点尿钠／钾对血压和肾功能纵向变化的预后意义。方法：从一般人群中纳入研究对象7063人，在基线和随访5年后测量临床指标。

关键词：肾功能变化血压水平尿钠预测价值钾队列研究纵向变化一般人群

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Pedunculated gastric tube interposition in an esophageal cancer patient with prepyloric adenocarcinoma

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World Journal of Gastrointestinal Oncology 2011年第5期3卷 75-78页

作者： tatsuo Kanda Yu Sato Kazuhito Yajima Shin-ichi kosugi Atsushi Matsuki takashi Ishikawa takeo Bamba Hajime Umezu tsutomu Suzuki Katsuyoshi Hatakeyama Division of Digestive and General Surgery Niigata University Graduate School of Medical and Dental Sciences Division of Cellular and Molecular Pathology Niigata University Graduate School of Medical and Dental Sciences Department of Nursing School of Health ScienceNiigata University

Gastric carcinoma is one of the malignancies that are most frequently associated with esophageal *** describe herein our device for advanced esophageal cancer associated with early gastric cancer in the antrum.A 57-year-old man presenting with dysphagia and upper abdominal pain was admitted to our *** examinations revealed locally advanced squamous cell carcinoma (SCC) of the middle thoracic esophagus (t3N0M0 Stage ⅡA) and mucosal signetring cell carcinoma of the gastric antrum (t1N0M0 Stage ⅠA).Although the gastric tumor appeared to be an intramucosal carcinoma,its margin was obscure,so endoscopic en-bloc resection was considered *** chose surgical resection of the gastric tumor as well as the esophageal SCC after neoadjuvant chemotherapy with 5-fluorouracil and cisplatin for advanced esophageal *** transthoracic esophagectomy with three-field lymph node dissection,the gastric carcinoma was removed by gastric antrectomy,which preserved the right gastroepiploic vessels,and a pedunculated short gastric tube was used as the esophageal ***-eight months after the surgery,the patient is well with no evidence of cancer *** it minimizes surgical stress and organ sacrifice,gastric tube interposition is a potentially useful technique for esophageal cancer associated with localized early gastric cancer.

关键词： Antrectomy Early gastric cancer Esophageal cancer Esophageal reconstruction Gastric tube

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氟尿嘧啶、阿霉素和顺铂/奈达铂作为新化疗方案治疗晚期食管癌的疗效和毒性

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世界核心医学期刊文摘（胃肠病学分册） 2005年第12期1卷 57-57页

作者： kosugi S.- I. Kanda t. Nakagawa S. 赵菊辉 Division of Digestive and General Surgery Niigata University Graduate School of Medical and Dental Sciences 1- 757 Asahimachi- dori Niigata City 951- 8510 Japan

Objective. Patients with advanced esophageal carcinoma including clinical t4 tumor, extensive lymph node metastasis, or intramural metastasis have a dismal prognosis, despite recent multimodality treatments. the aim of this study was to evaluate the efficacy and toxicity of neoadjuvant chemotherapy using fluorouracil, doxorubicin, and cisplatin or nedaplatin (FAP/N)- in these patients. Material and methods. twenty- six patients were enrolled in this study. the first 9 patients received 600 mg/m2 fluorouracil on days 1- 7 and days 29- 35, and 30 mg/m2 doxorubicin and 60 mg/m2 cisplatin on days 1 and 29 (FAP). the next 17 patients received modified FAP, in which 50 mg/m2 nedaplatin was given instead of cisplatin (FAN). Results. Grade 3 or 4 toxicities developed in 6 patients (23.1% ) during chemotherapy, but there was no discontinuation of treatment. the clinical response rate was 46.2% . twenty- one patients (80.8% ) underwent esop- hagectomy, and R0 resection was achieved in 16 patients (61.5% ). the 1- year survival rates of 26 patients, 21 patients with resectable tumor, 16 with R0 resection, and 12 clinical responders, were 31.3% , 32.1% , 33.3% , and 45.5% , respectively, each with a median survival time of 9 months. the median progression- free survival time of 26 patients was 6 months; in 16 patients with R0 resection progression- free survival was 6.5 months. there was no correlation between the recurrence pattern and tumor spread before treatment. Conclusions. FAP/N was found to have acceptable toxicities and the ability to control locoregional tumors, but made little contribution to patient survival. the efficacy of this treatment for patients with advanced esophageal carcinoma, however, may not yet be apparent.

关键词：晚期食管癌奈达铂尿嘧啶食管切除术淋巴结转移肿瘤复发肿瘤进展临床分期存活时间存活期

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毒蛇咬伤病人的血小板聚集功能初探

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蛇志 2005年第3期17卷 145-148页

作者：李其斌余奇松黄光武甘廷庆小杉忠诚广西医科大学一附院急诊科蛇伤救治中心广西南宁530021 日本国立琉球大学医学部

目的为了探讨血液毒及混合毒类毒蛇咬伤病人的血小板功能情况,了解临床中毒发病机理。方法对近年来在本院急诊科确诊的五步蛇(Da.),蝮蛇(Ah.),眼镜蛇(Nn.),眼镜王蛇(Oh.),蝰蛇(Vr.),烙铁头(tm.)和竹叶青(ts.)等各种血液毒及混合毒类毒... 详细信息

目的为了探讨血液毒及混合毒类毒蛇咬伤病人的血小板功能情况,了解临床中毒发病机理。方法对近年来在本院急诊科确诊的五步蛇(Da.),蝮蛇(Ah.),眼镜蛇(Nn.),眼镜王蛇(Oh.),蝰蛇(Vr.),烙铁头(tm.)和竹叶青(ts.)等各种血液毒及混合毒类毒蛇咬伤17例病人25个血样,进行最大血小板聚集率(MAR)的检查和分析研究。结果除了Da未见MAR下降外(仅1例1个样品),其余各蛇种咬伤的样品均有下降。在获得未经治疗(抗蛇毒血清)的15个样品的检查结果中,进行统计分析,Vr、tm以及Ah的MAR比正常人对照组(51.3±16.0)%明显下降。结论蛇毒中的血小板集聚抑制因子,可引起蛇伤患者体内血小板聚集功能下降,血小板处于无用状态,结果有些蛇伤病人DIC样综合征时出现严重出血而无明显微循环血栓形成致器官受损的临床症状。

关键词：蛇伤蛇毒中毒血小板聚集率 DIC样综合征

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