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Predictive factors for efficacy of testosterone replacement therapy for late-onset hypogonadism in Japanese men:a preliminary report

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Asian Journal of Andrology 2023年第5期25卷 587-590页

作者： Nobuyuki kondoh Yohei Kaizuka Seiji Nagasawa Yoshikazu togo Shingo Yamamoto Department of Urology Kawanishi City Medical CenterKawanishiHyogo 6660017Japan Department of Urology Hyogo Medical UniversityNishinomiyaHyog 6638501Japan

Although testosterone replacement therapy(tRt)is the first-choice method used worldwide for late-onset hypogonadism(LOH),clinical benefits are not seen in all *** study was conducted to determine the predictors of tRt efficacy for ***-six patients who visited our Men’s Health Clinic(Kawanishi City Medical Center,Kawanishi and Hyogo Medical University,Nishinomiya,Hyogo,Japan)between November 2003 and June 2021 with data available before and after tRt were *** were divided into responders(Group 1;n=45,accounting for 80.4%)and nonresponders(Group 2;n=11,accounting for 19.6%)based on the clinical response to tRt,including patient *** noted before tRt included age,body mass index,aging males’symptoms score,sexual health inventory for men,luteinizing hormone,follicular-stimulating hormone,testosterone,free testosterone,prolactin(PRL),estradiol(E2),and testosterone/estradiol(t/E2)ratio in *** statistical analysis,a multivariable logistic regression model was *** analysis revealed PRL(odds ratio tORI:0.9624;95%confidence interval[Cl]:0.9316-0.9943,Pt/E2 ratio(OR:1.1312;95%Cl:1.0106-1.2661,Pto be predictive *** analyses showed that t/E2 ratio was an independent predictive factor(OR:1.1593;95%Cl:1.0438-1.2875,Pthe present results suggest that a low value for t/E2 ratio may predict a reduced response to *** t/E2 ratio threshold to predict nonresponders based on receiver-operating characteristics(ROC)curve analysis was shown to be *** additional studies with larger number of patients are necessary,we propose the determination of serum E2 level and testosterone level prior to performing tRt.

关键词： estradiol late-onset hypogonadism predictive factor testosterone treatment

Multiplexed bioluminescence imaging of cancer cell response to hypoxia and inflammation in the caudal-artery injection model of bone metastasis during zoledronic acid treatment

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Journal of Cancer Metastasis and treatment 2021年第1期7卷 69-80页

作者： Misa Minegishi takahiro Kuchimaru Kenji Nakagawa tatsuhiro Isozaki Satoshi Fujimori tetsuya Kadonosono Shinae Kizaka-kondoh School of Life Science and technology Tokyo Institute of TechnologyKanagawa 226-8501Japan Center for Molecular Medicine Jichi Medical UniversityTochigi 329-0498Japan.

Aim:therapeutic agents suppressing bone remodeling have been clinically approved to delay metastatic progression and skeletal-related events in patients with bone ***,therapeutic agents including zoledronic acid(ZA)are insufficient to regress established bone ***,new treatment strategies are desired,and unraveling the status of cancer cells during bone metastatic progression will help develop therapeutic ***:We developed a unique multiplexed reporter system for bioluminescent imaging(MRS-BLI)using three luciferase reporter *** system allows for the noninvasive and quantitative monitoring of tumor growth and activities of nuclear factor-kappa B(NF-κB)and hypoxia-inducible factor(HIF),which are the key transcriptional factors in response to inflammation and hypoxia,***-3/MRS-BLI,a human prostate cancer cell line that stably retains the MRS-BLI reporter genes,was applied to the caudal-artery injection model of bone metastasis to observe the status of cancer cells during bone metastasis development and ZA treatment(th).Results:MRS-BLI reveals key events during the bone metastasis development:NF-κB and HIF are activated in cancer cells after migration to the bone marrow and are transiently reduced,followed by rapid activation before proliferation *** treatment suppresses the growth of metastasized cancer cells by suppressing NF-κB and HIF activities that may be indirectly induced by osteoclast ***:By visualizing the NF-κB and HIF activities of PC-3/MRS-BLI in bone,MRS-BLI has enabled new discoveries regarding the regulation of bone *** analysis of the progression of bone metastases using MRS-BLI may provide important information for developing new therapeutic strategies.

关键词： Bone metastasis multiplexed bioluminescence imaging zoledronic acid nuclear factor-kappa B hypoxia inducible factor

ROR2 regulates the survival of murine osteosarcoma cells in lung capillaries

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Journal of Cancer Metastasis and treatment 2020年第1期6卷 611-621页

作者： Diem thi Phuong tran takahiro Kuchimaru Mongkol Pongsuchart Kha the Nguyen John Clyde Co Soriano tetsuya Kadonosono Shinae Kizaka-kondoh School of Life Science and technology Tokyo Institute of TechnologyYokohama 226-8501Japan Center for Molecular Medicine Jichi Medical UniversityTochigi 329-0498Japan

Aim:Lung metastasis is a leading cause of death in patients with osteosarcoma(OS).No effective therapy exists that improves the five-year overall survival rate of OS patients with ***,finding novel therapeutic targets will help develop new treatment strategies for OS patients with lung ***:Based on analysis of gene expression profiles between sublines of the Dunn OS LM8 cell line with high(LM8-H)and low(LM8-L)metastatic ability,we have identified Wnt signal-related genes that play an important role in lung metastasis of *** of the genes was investigated by establishing sublines of gene knockout and assessing their metastatic ability using a mouse lung metastasis *** molecular mechanism underlying the function of the genes was further investigated by in vitro ***:We have identified that receptor tyrosine kinase-like orphan receptor 2(ROR2),a receptor of the non-canonical Wnt signaling pathway,was involved in OS cell survival in lung capillaries during ***8-H knocked out of Ror2(H/Ror2-KO)significantly reduced lung metastasis by decreasing the viability in lung capillaries 48 h after intravenous *** vitro study revealed that ROR2 increased anoikis resistance through AKt *** of ROR2 expression in H/Ror2-KO cells restored their metastatic ability and viability in lung ***:the results demonstrate a novel ROR2 function in OS lung metastasis and may inform new treatment strategies for OS patients.

关键词： Osteosarcoma lung metastasis cell survival lung capillary ROR2

急性加重的特发性肺纤维化:HRCt评分预测死亡率

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国际医学放射学杂志 2012年第2期 190-190页

作者： K.Fujimoto H.taniguchi t.Johkoh Y.kondoh K.Ichikado H.Sumikawa 罗伟 Department of Radiology Kurume University School of Medicineand Center for Diagnostic ImagingKurume University Hospital67 Asahi-machiKurumeFukuoka 830-0011Japan

目的探讨急性加重的特发性肺纤维化(AEx-IPF)病人的HRCt表现与死亡率的关系。方法回顾性分析60例AEx-IPF病人,分成两组,独立观察HRCt表现类型、分布及范围,计算急性加重的HRCt评分则基于正常密度区和异常

关键词：特发性肺纤维化疾病加重弥漫性肺泡损伤高分辨率Ct 死亡率