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High Power Laser Science and Engineering 2021年第4期9卷 144-159页

作者： A.Laso Garcia H.Höppner A.Pelka C.Bähtz E.Brambrink S.Di Dio Cafiso J.Dreyer S.Göde M.Hassan t.kluge J.Liu M.Makita D.Möller M.Nakatsutsumi t.R.Preston G.Priebe H.-P.Schlenvoigt J.-P.Schwinkendorf M.šmíd A.-M.talposi M.toncian U.Zastrau U.Schramm t.E.Cowan t.toncian Helmholtz-Zentrum Dresden-Rossendorf 01328 DresdenGermany European XFEL 22869 SchenefeldGermany Extreme Light Infrastructure-Nuclear Physics and Faculty of Physics University of Bucharest077126 MagureleRomania technische Universität Dresden 01062 DresdenGermany

High-energy and high-intensity lasers are essential for pushing the boundaries of *** development has allowed leaps forward in basic research areas,including laser±plasma interaction,high-energy density science,metrology,biology and medical *** Helmholtz International Beamline for Extreme Fields user consortium contributes and operates two high-peak-power optical lasers using the high energy density instrument at the European X-ray free electron laser(EuXFEL)*** lasers will be used to generate transient extreme states of density and temperature to be probed by the X-ray *** paper introduces the ReLaX laser,a short-pulse high-intensity ti:Sa laser system,and discusses its characteristics as available for user *** will also present the first experimental commissioning results validating its successful integration into the EuXFEL infrastructure and viability as a relativisticintensity laser driver.

关键词： X-ray free electron laser high-intensity laser relativistic intensity laser ti:Sa laser

targets for high repetition rate laser facilities:needs,challenges and perspectives

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High Power Laser Science and Engineering 2017年第3期5卷 10-40页

作者： I.Prencipe J.Fuchs S.Pascarelli D.W.Schumacher R.B.Stephens N.B.Alexander R.Briggs M.Büscher M.O.Cernaianu A.Choukourov M.De Marco A.Erbe J.Fassbender G.Fiquet P.Fitzsimmons C.Gheorghiu J.Hund L.G.Huang M.Harmand N.J.Hartley A.Irman t.kluge Z.Konopkova S.Kraft D.Kraus V.Leca D.Margarone J.Metzkes K.Nagai W.Nazarov P.Lutoslawski D.Papp M.Passoni A.Pelka J.P.Perin J.Schulz M.Smid C.Spindloe S.Steinke R.torchio C.Vass t.Wiste R.Zaffino K.Zeil t.tschentscher U.Schramm t.E.Cowan Lawrence Berkeley National Laboratory USA 25Institute of Microelectronics of Barcelona National Center of Microelectronic Spanish Research Council Spain 26University of St. Andrews UK

A number of laser facilities coming online all over the world promise the capability of high-power laser experiments with shot repetition rates between 1 and 10 Hz. target availability and technical issues related to the interaction environment could become a bottleneck for the exploitation of such facilities. In this paper, we report on target needs for three different classes of experiments: dynamic compression physics, electron transport and isochoric heating, and laser-driven particle and radiation sources. We also review some of the most challenging issues in target fabrication and high repetition rate operation. Finally, we discuss current target supply strategies and future perspectives to establish a sustainable target provision infrastructure for advanced laser facilities.

关键词： high-energy density physics target design and fabrication

Impact of Pollutant Concentration and Particle Deposition on the Radiative Flow of Casson-Micropolar Fluid between Parallel Plates

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 665-690页

作者： Ghaliah Alhamzi Badr Saad t.Alkahtani Ravi Shanker Dubey Vinutha Kalleshachar Neelima Nizampatnam Department of Mathematics and Statistics College of ScienceImam Mohammad Ibn Saud Islamic University(IMSIU)Riyadh11564Saudi Arabia Department of Mathematics College of ScienceKing Saud UniversityRiyadh11989Saudi Arabia Department of Mathematics Amity School of Applied SciencesAmity University RajasthanJaipur302002RajasthanIndia Department of Studies in Mathematics Davangere UniversityDavangere577002India Department of Electronics and Communication Engineering Amrita School of EngineeringAmrita Vishwa VidyapeethamBengaluru560035India

Assessing the behaviour and concentration of waste pollutants deposited between two parallel plates is essential for effective environmental *** the effectiveness of treatment methods in reducing pollution scales is made easier by analysing waste discharge *** waste discharge concentration analysis is useful for assessing how effectively wastewater treatment techniques reduce pollution *** study aims to explore the Casson micropolar fluid flow through two parallel plates with the influence of pollutant concentration and thermophoretic particle *** explore the mass and heat transport features,thermophoretic particle deposition and thermal radiation are *** governing equations are transformed into ordinary differential equations with the help of suitable similarity *** Runge-Kutta-Fehlberg’s fourthfifth order technique and shooting procedure are used to solve the reduced set of equations and boundary *** integration of a neural network model based on the Levenberg-Marquardt algorithm serves to improve the accuracy of predictions and optimize the analysis of *** outcomes are displayed to analyze the characteristics of the relevant dimensionless parameters in the current *** reveal that concentration upsurges as the micropolar parameter *** concentration reduces with an upsurge in the thermophoretic *** upsurge in the external pollutant source variation and the local pollutant external source parameters enhances mass *** surface drag force declines for improved values of porosity and micropolar parameters.

关键词： Micropolar fluid thermal radiation porous medium thermophoretic particle deposition waste discharge concentration

two become one:combination of two risk factors in a new glaucoma animal model

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Neural Regeneration Research 2024年第5期19卷 982-983页

作者： Nils kluge Sabrina Reinehr Experimental Eye Research Institute University Eye HospitalRuhr-University BochumBochumGermany

Glaucoma is a group of eye diseases characterized by progressive loss of retinal ganglion cells(RGCs)and optic nerve *** this process,the visual field is reduced,and blindness may ultimately ***,glaucoma is the second leading cause of blindness,with about 80 million people *** is a multifactorial disease and due to its complexity,the exact pathomechanisms are not fully understood ***,different risk factors,such as elevated intraocular pressure(IOP),age,or myopia,have been identified to date(EGS,2021).

关键词： elevated exact glaucoma

Effects of external temperature and dead volume on laboratory measurements of pore pressure and injected volume in a rock fracture

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Journal of Rock Mechanics and Geotechnical Engineering 2022年第5期14卷 1461-1469页

作者： Yinlin Ji Christian kluge Hannes Hofmann Guido Blöcher Helmholtz Centre Potsdam GFZ German Research Centre for GeosciencesPotsdam14473Germany State Key Laboratory of Coal Resources and Safe Mining China University of Mining and TechnologyXuzhou221116China

the accurate evaluation of pore pressure and injected volume is crucial for the laboratory characterization of hydromechanical responses of rock fractures. this study reports a series of laboratory experiments to systematically demonstrate the effects of external temperature and dead volume on laboratory measurements of pore pressure and injected volume in a rock fracture. We characterize the hydraulic aperture of the fracture as a function of effective normal stress using the exponential aperture *** model is then employed to predict the pore pressure change and injected volume in the fracture without the influences of external temperature and dead volume. the external temperature changes in the cyclic loading test due to the Joule-thompson effect for fluids. the effect of external temperature on pore pressure change in the fracture can be well explained by thermal pressurization of fluids. Our results also show that the external dead volume can significantly lower the pore pressure change in the fracture during the cyclic loading test under undrained conditions. the injected volume can also be substantially enlarged due to the external dead volume in a typical pore pressure system. Internal measurement of the pore pressure in the fracture using a fiber optic sensor cannot exclude the influences of external temperature and dead volume, primarily because of the good hydraulic communication between the fracture and pore pressure system. this study suggests that the effects of external temperature and dead volume on pore pressure response and injected volume should be evaluated for accurate laboratory characterization and inter-laboratory comparison.

关键词： Fracture aperture thermal pressurization External dead volume Pressure attenuation Injected volume Fiber optic sensor

Fecal microbiota transplantation in allergic diseases

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World Journal of Methodology 2025年第2期15卷 83-91页

作者： Ece tüsüzÖnata ÖnerÖzdemir Division of Pediatric Allergy and Immunology Medical FacultySakarya UniversityAdapazarı54100SakaryaTürkiye

Microorganisms such as bacteria,fungi,viruses,parasites living in the human intestine constitute the human intestinal *** refers to composi-tional and quantitative changes that negatively affect healthy gut *** recent years,with the demonstration that many diseases are associated with dysbiosis,treatment strategies targeting the correction of dysbiosis in the treat-ment of these diseases have begun to be *** microbiota trans-plantation(FMt)is the process of transferring faeces from a healthy donor to another recipient in order to restore the gut microbiota and provide a therapeutic *** studies have gained popularity after probiotic,prebiotic,symbiotic studies in the treatment of dysbiosis and related *** has emerged as a potential new therapy in the treatment of allergic diseases as it is associated with the maintenance of intestinal microbiota and immunological balance(t helper 1/t helper 2 cells)and thus suppression of allergic *** this article,the definition,application,safety and use of FMt in allergic diseases will be discussed with current data.

关键词： Microbiota Dysbiosis Faecal microbiota transplantation Allergic diseases

Surgical site soft tissue thickness as a predictor of complications following arthroplasty

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World Journal of Methodology 2025年第2期15卷 62-73页

作者： Kevin A Wu Faheem Pottayil Crystal Jing Ankit Choudhury Albert t Anastasio Department of Orthopaedic Surgery Duke University HospitalDurhamNC 27710United States Department of Orthopaedic Surgery Medical College of Georgia at Augusta UniversityAugustaGA 30912United States Department of Orthopaedic Surgery Medical College of WisconsinMilwaukeeWI 53226United States

Appreciation of soft-tissue thickness(Stt)at surgical sites is an increasingly recognized aspect of arthroplasty procedures as it may potentially impacting postoperative *** research has focused on the predictive value of preoperative Stt measurements for complications following various forms of arthroplasty,particularly infections,across procedures such as total knee,hip,shoulder,and ankle *** studies have indicated that increased Stt is associated with a higher risk of complications,including infection and wound healing *** assessment of Stt before surgery could play a crucial role in identifying patients at a higher risk of complications and may be instru-mental in guiding preoperative planning to optimize outcomes in arthroplasty *** measurement techniques and further research are essential to enhance the reliability and clinical utility of Stt assessment for arthro-plasty surgery.

关键词： Soft-tissue thickness Arthroplasty Surgical complications total knee arthroplasty total hip arthroplasty total shoulder arthroplasty total ankle arthroplasty Preoperative assessment Wound healing Infection risk

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Ein Liebesversuch

德语人文研究 2011年第3期 9-12+8页

作者： Alexander kluge

Als das billigste Mittel,in den Lagern Massensterilisationen durchzuführen,erschien 1943 R*** war,ob die so erzielte Unfruchtbarkeit nachhaltig *** führten einen mnnlichen und einen weiblichen Gefangenen zu eine... 详细信息

关键词： der Ein Liebesversuch

Immunohistochemical expression of matrix metalloproteinase-9 and 13 in oral squamous cell carcinoma and their role in predicting lymph node metastasis

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World Journal of Methodology 2025年第2期15卷 108-116页

作者： Bhari Sharanesha Manjunatha Keshav t Handge Vandana Sandeep Shah Yasser Eid Al-thobaiti Deepak Gowda Sadashivappa Pateel Department of Basic Oral Medicine and Allied Dental Sciences Taif UniversityAt`Taif 26571MakkahSaudi Arabia Department of Oral and Maxillofacial Pathology Dr.Vasantrao Pawar Medical CollegeHospital and Research CentreNashik 423101MaharashtraIndia Department of Oral Pathology and Microbiology KM Shah Dental College and HospitalSumandeep VidyapeethVadodara 391760GujaratIndia Department of Oral and Maxillofacial Surgery and Diagnostic Sciences Faculty of DentistryTaif UniversityAl-Haweiah 26571 MakkahSaudi Arabia Department of Oral Pathology and Microbiology Faculty of DentistryMAHSA UniversitySelangor 42610Malaysia

BACKGROUND One of the main characteristics of oral squamous cell carcinoma(OSCC)is that it metastasizes to cervical lymph nodes frequently with a high degree of local invasiveness.A primary feature of malignant tumors is their penetration of neighboring tissues,such as lymphatic and blood arteries,due to the tumor cells'capacity to break down the extracellular matrix(ECM).Matrix metalloproteinases(MMPs)constitute a family of proteolytic enzymes that facilitate tissue remo-deling and the degradation of the ***-9 and MMP-13 belong to the group of extracellular matrix degrading enzymes and their expression has been studied in OSCC because of their specific ***-13,a collagenase family member,is thought to play an essential role in the MMP activation cascade by breaking down the fibrillar collagens,whereas MMP-9 is thought to accelerate the growth of *** MMP-13 expression has been associated with tumor behavior and patient prognosis in a number of malignant *** authors wish to thank Jadhav KB for his valuable opinion during the preparation of the manuscript.

关键词： Matrix metalloproteinases Oral squamous cell carcinoma tumor staging Immunohistochemistry Invasion Lymph node metastasis tNM stage

Atomic-physics techniques for nuclear physics

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Atomic-physics techniques for nuclear physics